Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.6280202 |
| Normalized Enrichment Score (NES) | -1.3089188 |
| Nominal p-value | 0.027964206 |
| FDR q-value | 0.15411991 |
| FWER p-Value | 0.699 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | HAO1 | hydroxyacid oxidase 1 [Source:HGNC Symbol;Acc:HGNC:4809] | 50 | 4.496 | 0.0324 | No |
| 2 | ATXN1 | ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] | 402 | 2.605 | 0.0425 | No |
| 3 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 420 | 2.552 | 0.0612 | No |
| 4 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 474 | 2.422 | 0.0780 | No |
| 5 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 586 | 2.157 | 0.0911 | No |
| 6 | CH25H | cholesterol 25-hydroxylase [Source:HGNC Symbol;Acc:HGNC:1907] | 789 | 1.834 | 0.0995 | No |
| 7 | GCLM | glutamate-cysteine ligase modifier subunit [Source:HGNC Symbol;Acc:HGNC:4312] | 818 | 1.790 | 0.1121 | No |
| 8 | AQP9 | aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] | 1332 | 1.295 | 0.1080 | No |
| 9 | BCAR3 | BCAR3 adaptor protein, NSP family member [Source:HGNC Symbol;Acc:HGNC:973] | 1409 | 1.242 | 0.1153 | No |
| 10 | TFCP2L1 | transcription factor CP2 like 1 [Source:HGNC Symbol;Acc:HGNC:17925] | 1884 | 1.003 | 0.1100 | No |
| 11 | LIPE | lipase E, hormone sensitive type [Source:HGNC Symbol;Acc:HGNC:6621] | 2424 | 0.771 | 0.1012 | No |
| 12 | PEX11A | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] | 2728 | 0.669 | 0.0980 | No |
| 13 | ABCA8 | ATP binding cassette subfamily A member 8 [Source:HGNC Symbol;Acc:HGNC:38] | 3037 | 0.595 | 0.0942 | No |
| 14 | ISOC1 | isochorismatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24254] | 3177 | 0.560 | 0.0946 | No |
| 15 | PEX12 | peroxisomal biogenesis factor 12 [Source:HGNC Symbol;Acc:HGNC:8854] | 3544 | 0.471 | 0.0883 | No |
| 16 | PEX19 | peroxisomal biogenesis factor 19 [Source:HGNC Symbol;Acc:HGNC:9713] | 3765 | 0.429 | 0.0855 | No |
| 17 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 3792 | 0.422 | 0.0880 | No |
| 18 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 4110 | 0.358 | 0.0821 | No |
| 19 | SLC27A2 | solute carrier family 27 member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 4899 | 0.200 | 0.0623 | No |
| 20 | AR | androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] | 5026 | 0.173 | 0.0602 | No |
| 21 | GNMT | glycine N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4415] | 5134 | 0.162 | 0.0585 | No |
| 22 | PEX13 | peroxisomal biogenesis factor 13 [Source:HGNC Symbol;Acc:HGNC:8855] | 5385 | 0.112 | 0.0526 | No |
| 23 | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 7581 | 0.000 | -0.0068 | No |
| 24 | ALDH8A1 | aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471] | 8265 | 0.000 | -0.0252 | No |
| 25 | GSTK1 | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] | 9367 | 0.000 | -0.0550 | No |
| 26 | SLC23A1 | solute carrier family 23 member 1 [Source:HGNC Symbol;Acc:HGNC:10974] | 9558 | 0.000 | -0.0602 | No |
| 27 | NEDD4 | NEDD4 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727] | 10183 | 0.000 | -0.0770 | No |
| 28 | AKR1D1 | aldo-keto reductase family 1 member D1 [Source:HGNC Symbol;Acc:HGNC:388] | 11253 | 0.000 | -0.1059 | No |
| 29 | AGXT | alanine--glyoxylate and serine--pyruvate aminotransferase [Source:HGNC Symbol;Acc:HGNC:341] | 11873 | 0.000 | -0.1227 | No |
| 30 | CYP39A1 | cytochrome P450 family 39 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:17449] | 12282 | 0.000 | -0.1337 | No |
| 31 | HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5217] | 12417 | 0.000 | -0.1373 | No |
| 32 | TTR | transthyretin [Source:HGNC Symbol;Acc:HGNC:12405] | 12535 | 0.000 | -0.1405 | No |
| 33 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2653] | 15240 | 0.000 | -0.2136 | No |
| 34 | DIO1 | iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883] | 15751 | 0.000 | -0.2274 | No |
| 35 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16099 | 0.000 | -0.2368 | No |
| 36 | SERPINA6 | serpin family A member 6 [Source:HGNC Symbol;Acc:HGNC:1540] | 17729 | 0.000 | -0.2808 | No |
| 37 | OPTN | optineurin [Source:HGNC Symbol;Acc:HGNC:17142] | 17974 | 0.000 | -0.2874 | No |
| 38 | BMP6 | bone morphogenetic protein 6 [Source:HGNC Symbol;Acc:HGNC:1073] | 19001 | 0.000 | -0.3152 | No |
| 39 | HSD17B6 | hydroxysteroid 17-beta dehydrogenase 6 [Source:HGNC Symbol;Acc:HGNC:23316] | 19698 | 0.000 | -0.3340 | No |
| 40 | NR1I2 | nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] | 19880 | 0.000 | -0.3389 | No |
| 41 | NR1H4 | nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967] | 19904 | 0.000 | -0.3395 | No |
| 42 | KLF1 | Kruppel like factor 1 [Source:HGNC Symbol;Acc:HGNC:6345] | 20583 | 0.000 | -0.3579 | No |
| 43 | BBOX1 | gamma-butyrobetaine hydroxylase 1 [Source:HGNC Symbol;Acc:HGNC:964] | 20854 | 0.000 | -0.3652 | No |
| 44 | CYP7B1 | cytochrome P450 family 7 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2652] | 21000 | 0.000 | -0.3691 | No |
| 45 | CYP7A1 | cytochrome P450 family 7 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2651] | 21022 | 0.000 | -0.3697 | No |
| 46 | SULT2B1 | sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] | 23603 | 0.000 | -0.4394 | No |
| 47 | SULT1B1 | sulfotransferase family 1B member 1 [Source:HGNC Symbol;Acc:HGNC:17845] | 23912 | 0.000 | -0.4478 | No |
| 48 | PIPOX | pipecolic acid and sarcosine oxidase [Source:HGNC Symbol;Acc:HGNC:17804] | 24815 | 0.000 | -0.4721 | No |
| 49 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] | 25532 | 0.000 | -0.4915 | No |
| 50 | ABCA6 | ATP binding cassette subfamily A member 6 [Source:HGNC Symbol;Acc:HGNC:36] | 26697 | 0.000 | -0.5230 | No |
| 51 | ABCA4 | ATP binding cassette subfamily A member 4 [Source:HGNC Symbol;Acc:HGNC:34] | 26700 | 0.000 | -0.5230 | No |
| 52 | SLCO1A2 | solute carrier organic anion transporter family member 1A2 [Source:HGNC Symbol;Acc:HGNC:10956] | 26749 | 0.000 | -0.5243 | No |
| 53 | ABCA9 | ATP binding cassette subfamily A member 9 [Source:HGNC Symbol;Acc:HGNC:39] | 27615 | -0.047 | -0.5474 | No |
| 54 | ABCG8 | ATP binding cassette subfamily G member 8 [Source:HGNC Symbol;Acc:HGNC:13887] | 28044 | -0.109 | -0.5581 | No |
| 55 | SLC23A2 | solute carrier family 23 member 2 [Source:HGNC Symbol;Acc:HGNC:10973] | 28141 | -0.126 | -0.5598 | No |
| 56 | PEX11G | peroxisomal biogenesis factor 11 gamma [Source:HGNC Symbol;Acc:HGNC:20208] | 29318 | -0.299 | -0.5893 | No |
| 57 | DIO2 | iodothyronine deiodinase 2 [Source:HGNC Symbol;Acc:HGNC:2884] | 29587 | -0.339 | -0.5940 | No |
| 58 | CYP46A1 | cytochrome P450 family 46 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2641] | 29801 | -0.368 | -0.5970 | No |
| 59 | SLC22A18 | solute carrier family 22 member 18 [Source:HGNC Symbol;Acc:HGNC:10964] | 29817 | -0.371 | -0.5947 | No |
| 60 | ACSL1 | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] | 29886 | -0.380 | -0.5936 | No |
| 61 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 30037 | -0.403 | -0.5947 | No |
| 62 | SLC27A5 | solute carrier family 27 member 5 [Source:HGNC Symbol;Acc:HGNC:10999] | 30159 | -0.421 | -0.5948 | No |
| 63 | PHYH | phytanoyl-CoA 2-hydroxylase [Source:HGNC Symbol;Acc:HGNC:8940] | 30180 | -0.425 | -0.5921 | No |
| 64 | ABCA5 | ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35] | 30238 | -0.436 | -0.5904 | No |
| 65 | RBP1 | retinol binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9919] | 30495 | -0.476 | -0.5937 | No |
| 66 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 31304 | -0.611 | -0.6110 | No |
| 67 | NR0B2 | nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961] | 31934 | -0.738 | -0.6225 | Yes |
| 68 | PEX7 | peroxisomal biogenesis factor 7 [Source:HGNC Symbol;Acc:HGNC:8860] | 32137 | -0.789 | -0.6220 | Yes |
| 69 | SOAT2 | sterol O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:11178] | 32191 | -0.808 | -0.6174 | Yes |
| 70 | PNPLA8 | patatin like phospholipase domain containing 8 [Source:HGNC Symbol;Acc:HGNC:28900] | 32376 | -0.858 | -0.6159 | Yes |
| 71 | EFHC1 | EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16406] | 32656 | -0.931 | -0.6165 | Yes |
| 72 | PECR | peroxisomal trans-2-enoyl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:18281] | 32863 | -0.994 | -0.6146 | Yes |
| 73 | PEX6 | peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:HGNC:8859] | 33106 | -1.065 | -0.6131 | Yes |
| 74 | PEX1 | peroxisomal biogenesis factor 1 [Source:HGNC Symbol;Acc:HGNC:8850] | 33137 | -1.073 | -0.6059 | Yes |
| 75 | LONP2 | lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] | 33462 | -1.176 | -0.6058 | Yes |
| 76 | NUDT12 | nudix hydrolase 12 [Source:HGNC Symbol;Acc:HGNC:18826] | 33580 | -1.223 | -0.5998 | Yes |
| 77 | CAT | catalase [Source:HGNC Symbol;Acc:HGNC:1516] | 33693 | -1.263 | -0.5933 | Yes |
| 78 | ACSL5 | acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526] | 33933 | -1.348 | -0.5897 | Yes |
| 79 | GNPAT | glyceronephosphate O-acyltransferase [Source:HGNC Symbol;Acc:HGNC:4416] | 34752 | -1.676 | -0.5992 | Yes |
| 80 | NPC1 | NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897] | 34827 | -1.709 | -0.5884 | Yes |
| 81 | AMACR | alpha-methylacyl-CoA racemase [Source:HGNC Symbol;Acc:HGNC:451] | 34865 | -1.728 | -0.5764 | Yes |
| 82 | PXMP2 | peroxisomal membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:9716] | 34959 | -1.778 | -0.5655 | Yes |
| 83 | ABCG4 | ATP binding cassette subfamily G member 4 [Source:HGNC Symbol;Acc:HGNC:13884] | 34961 | -1.781 | -0.5522 | Yes |
| 84 | ABCD3 | ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] | 34996 | -1.803 | -0.5396 | Yes |
| 85 | PEX16 | peroxisomal biogenesis factor 16 [Source:HGNC Symbol;Acc:HGNC:8857] | 35100 | -1.865 | -0.5283 | Yes |
| 86 | SCP2 | sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] | 35197 | -1.928 | -0.5165 | Yes |
| 87 | PEX26 | peroxisomal biogenesis factor 26 [Source:HGNC Symbol;Acc:HGNC:22965] | 35231 | -1.953 | -0.5027 | Yes |
| 88 | MLYCD | malonyl-CoA decarboxylase [Source:HGNC Symbol;Acc:HGNC:7150] | 35235 | -1.955 | -0.4881 | Yes |
| 89 | RETSAT | retinol saturase [Source:HGNC Symbol;Acc:HGNC:25991] | 35244 | -1.959 | -0.4736 | Yes |
| 90 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 35346 | -2.023 | -0.4611 | Yes |
| 91 | ALDH9A1 | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] | 35435 | -2.084 | -0.4479 | Yes |
| 92 | HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol;Acc:HGNC:18324] | 35451 | -2.098 | -0.4325 | Yes |
| 93 | HSD17B4 | hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] | 35788 | -2.359 | -0.4239 | Yes |
| 94 | FDXR | ferredoxin reductase [Source:HGNC Symbol;Acc:HGNC:3642] | 35875 | -2.440 | -0.4079 | Yes |
| 95 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383] | 35904 | -2.462 | -0.3902 | Yes |
| 96 | CROT | carnitine O-octanoyltransferase [Source:HGNC Symbol;Acc:HGNC:2366] | 35999 | -2.552 | -0.3735 | Yes |
| 97 | RXRA | retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] | 36090 | -2.641 | -0.3561 | Yes |
| 98 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 36096 | -2.647 | -0.3364 | Yes |
| 99 | ABCA3 | ATP binding cassette subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:33] | 36121 | -2.676 | -0.3169 | Yes |
| 100 | FADS1 | fatty acid desaturase 1 [Source:HGNC Symbol;Acc:HGNC:3574] | 36193 | -2.746 | -0.2982 | Yes |
| 101 | HACL1 | 2-hydroxyacyl-CoA lyase 1 [Source:HGNC Symbol;Acc:HGNC:17856] | 36238 | -2.787 | -0.2785 | Yes |
| 102 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 36309 | -2.858 | -0.2589 | Yes |
| 103 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 36612 | -3.282 | -0.2424 | Yes |
| 104 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) [Source:HGNC Symbol;Acc:HGNC:11003] | 36625 | -3.312 | -0.2179 | Yes |
| 105 | ABCD1 | ATP binding cassette subfamily D member 1 [Source:HGNC Symbol;Acc:HGNC:61] | 36748 | -3.516 | -0.1948 | Yes |
| 106 | DHCR24 | 24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859] | 36761 | -3.535 | -0.1686 | Yes |
| 107 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] | 36762 | -3.536 | -0.1420 | Yes |
| 108 | PAOX | polyamine oxidase [Source:HGNC Symbol;Acc:HGNC:20837] | 36783 | -3.592 | -0.1156 | Yes |
| 109 | RXRG | retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] | 36896 | -3.878 | -0.0895 | Yes |
| 110 | CYP27A1 | cytochrome P450 family 27 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2605] | 36928 | -3.964 | -0.0605 | Yes |
| 111 | PFKM | phosphofructokinase, muscle [Source:HGNC Symbol;Acc:HGNC:8877] | 36954 | -4.025 | -0.0310 | Yes |
| 112 | ABCD2 | ATP binding cassette subfamily D member 2 [Source:HGNC Symbol;Acc:HGNC:66] | 37065 | -4.613 | 0.0007 | Yes |
