Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.4493645 |
| Normalized Enrichment Score (NES) | 1.1983058 |
| Nominal p-value | 0.054054055 |
| FDR q-value | 0.13200013 |
| FWER p-Value | 0.322 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | CFB | complement factor B [Source:HGNC Symbol;Acc:HGNC:1037] | 24 | 4.783 | 0.0460 | Yes |
| 2 | PDGFB | platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] | 67 | 4.339 | 0.0872 | Yes |
| 3 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 86 | 4.162 | 0.1272 | Yes |
| 4 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 100 | 4.044 | 0.1663 | Yes |
| 5 | F9 | coagulation factor IX [Source:HGNC Symbol;Acc:HGNC:3551] | 166 | 3.630 | 0.2000 | Yes |
| 6 | THBS1 | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] | 227 | 3.279 | 0.2303 | Yes |
| 7 | PLEK | pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] | 286 | 3.006 | 0.2581 | Yes |
| 8 | SERPINB2 | serpin family B member 2 [Source:HGNC Symbol;Acc:HGNC:8584] | 396 | 2.630 | 0.2808 | Yes |
| 9 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 412 | 2.569 | 0.3054 | Yes |
| 10 | WDR1 | WD repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12754] | 531 | 2.277 | 0.3244 | Yes |
| 11 | MMP2 | matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] | 581 | 2.162 | 0.3442 | Yes |
| 12 | MAFF | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] | 611 | 2.130 | 0.3642 | Yes |
| 13 | FBN1 | fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] | 792 | 1.832 | 0.3772 | Yes |
| 14 | MMP14 | matrix metallopeptidase 14 [Source:HGNC Symbol;Acc:HGNC:7160] | 828 | 1.782 | 0.3936 | Yes |
| 15 | GNG12 | G protein subunit gamma 12 [Source:HGNC Symbol;Acc:HGNC:19663] | 843 | 1.767 | 0.4104 | Yes |
| 16 | ANXA1 | annexin A1 [Source:HGNC Symbol;Acc:HGNC:533] | 1311 | 1.309 | 0.4106 | Yes |
| 17 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 1387 | 1.254 | 0.4208 | Yes |
| 18 | C3 | complement C3 [Source:HGNC Symbol;Acc:HGNC:1318] | 1539 | 1.177 | 0.4281 | Yes |
| 19 | SERPINC1 | serpin family C member 1 [Source:HGNC Symbol;Acc:HGNC:775] | 1572 | 1.161 | 0.4386 | Yes |
| 20 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 1685 | 1.099 | 0.4463 | Yes |
| 21 | FYN | FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] | 2216 | 0.850 | 0.4402 | Yes |
| 22 | RABIF | RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] | 2240 | 0.841 | 0.4478 | Yes |
| 23 | MASP2 | mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 2696 | 0.676 | 0.4421 | Yes |
| 24 | ARF4 | ADP ribosylation factor 4 [Source:HGNC Symbol;Acc:HGNC:655] | 2743 | 0.666 | 0.4473 | Yes |
| 25 | MSRB2 | methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061] | 2948 | 0.614 | 0.4478 | Yes |
| 26 | PLAT | plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051] | 3267 | 0.535 | 0.4444 | Yes |
| 27 | PREP | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] | 3438 | 0.498 | 0.4447 | Yes |
| 28 | CTSO | cathepsin O [Source:HGNC Symbol;Acc:HGNC:2542] | 3444 | 0.496 | 0.4494 | Yes |
| 29 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 3792 | 0.422 | 0.4441 | No |
| 30 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 3891 | 0.402 | 0.4454 | No |
| 31 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 4193 | 0.340 | 0.4405 | No |
| 32 | F3 | coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541] | 4390 | 0.297 | 0.4381 | No |
| 33 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 4573 | 0.262 | 0.4358 | No |
| 34 | F10 | coagulation factor X [Source:HGNC Symbol;Acc:HGNC:3528] | 4585 | 0.258 | 0.4380 | No |
| 35 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 4947 | 0.189 | 0.4301 | No |
| 36 | DUSP14 | dual specificity phosphatase 14 [Source:HGNC Symbol;Acc:HGNC:17007] | 4972 | 0.184 | 0.4312 | No |
| 37 | ITIH1 | inter-alpha-trypsin inhibitor heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:6166] | 5052 | 0.169 | 0.4307 | No |
| 38 | GDA | guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212] | 5181 | 0.156 | 0.4288 | No |
| 39 | THBD | thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] | 5202 | 0.152 | 0.4297 | No |
| 40 | MMP15 | matrix metallopeptidase 15 [Source:HGNC Symbol;Acc:HGNC:7161] | 5219 | 0.147 | 0.4307 | No |
| 41 | KLF7 | Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] | 5487 | 0.096 | 0.4244 | No |
| 42 | P2RY1 | purinergic receptor P2Y1 [Source:HGNC Symbol;Acc:HGNC:8539] | 5609 | 0.070 | 0.4218 | No |
| 43 | ADAM9 | ADAM metallopeptidase domain 9 [Source:HGNC Symbol;Acc:HGNC:216] | 5907 | 0.010 | 0.4139 | No |
| 44 | APOC3 | apolipoprotein C3 [Source:HGNC Symbol;Acc:HGNC:610] | 9856 | 0.000 | 0.3070 | No |
| 45 | APOC2 | apolipoprotein C2 [Source:HGNC Symbol;Acc:HGNC:609] | 9858 | 0.000 | 0.3070 | No |
| 46 | APOC1 | apolipoprotein C1 [Source:HGNC Symbol;Acc:HGNC:607] | 9859 | 0.000 | 0.3070 | No |
| 47 | F13B | coagulation factor XIII B chain [Source:HGNC Symbol;Acc:HGNC:3534] | 10577 | 0.000 | 0.2876 | No |
| 48 | KLKB1 | kallikrein B1 [Source:HGNC Symbol;Acc:HGNC:6371] | 10846 | 0.000 | 0.2804 | No |
| 49 | TMPRSS6 | transmembrane serine protease 6 [Source:HGNC Symbol;Acc:HGNC:16517] | 11250 | 0.000 | 0.2694 | No |
| 50 | PROZ | protein Z, vitamin K dependent plasma glycoprotein [Source:HGNC Symbol;Acc:HGNC:9460] | 11297 | 0.000 | 0.2682 | No |
| 51 | PROC | protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451] | 11315 | 0.000 | 0.2677 | No |
| 52 | ACOX2 | acyl-CoA oxidase 2 [Source:HGNC Symbol;Acc:HGNC:120] | 12027 | 0.000 | 0.2485 | No |
| 53 | MEP1A | meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015] | 12211 | 0.000 | 0.2435 | No |
| 54 | MBL2 | mannose binding lectin 2 [Source:HGNC Symbol;Acc:HGNC:6922] | 15531 | 0.000 | 0.1537 | No |
| 55 | C8B | complement C8 beta chain [Source:HGNC Symbol;Acc:HGNC:1353] | 15598 | 0.000 | 0.1519 | No |
| 56 | C8A | complement C8 alpha chain [Source:HGNC Symbol;Acc:HGNC:1352] | 15599 | 0.000 | 0.1519 | No |
| 57 | C8G | complement C8 gamma chain [Source:HGNC Symbol;Acc:HGNC:1354] | 15601 | 0.000 | 0.1519 | No |
| 58 | HTRA1 | HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476] | 15625 | 0.000 | 0.1513 | No |
| 59 | CFD | complement factor D [Source:HGNC Symbol;Acc:HGNC:2771] | 15701 | 0.000 | 0.1493 | No |
| 60 | CFI | complement factor I [Source:HGNC Symbol;Acc:HGNC:5394] | 15702 | 0.000 | 0.1493 | No |
| 61 | DCT | dopachrome tautomerase [Source:HGNC Symbol;Acc:HGNC:2709] | 15955 | 0.000 | 0.1425 | No |
| 62 | C2 | complement C2 [Source:HGNC Symbol;Acc:HGNC:1248] | 16027 | 0.000 | 0.1405 | No |
| 63 | C9 | complement C9 [Source:HGNC Symbol;Acc:HGNC:1358] | 16032 | 0.000 | 0.1404 | No |
| 64 | F2 | coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535] | 16075 | 0.000 | 0.1393 | No |
| 65 | F12 | coagulation factor XII [Source:HGNC Symbol;Acc:HGNC:3530] | 16377 | 0.000 | 0.1311 | No |
| 66 | F11 | coagulation factor XI [Source:HGNC Symbol;Acc:HGNC:3529] | 16378 | 0.000 | 0.1311 | No |
| 67 | FGA | fibrinogen alpha chain [Source:HGNC Symbol;Acc:HGNC:3661] | 16613 | 0.000 | 0.1248 | No |
| 68 | FGG | fibrinogen gamma chain [Source:HGNC Symbol;Acc:HGNC:3694] | 16614 | 0.000 | 0.1248 | No |
| 69 | FN1 | fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] | 16655 | 0.000 | 0.1237 | No |
| 70 | OLR1 | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] | 16665 | 0.000 | 0.1235 | No |
| 71 | GP9 | glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] | 17065 | 0.000 | 0.1127 | No |
| 72 | TIMP3 | TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822] | 17073 | 0.000 | 0.1125 | No |
| 73 | HRG | histidine rich glycoprotein [Source:HGNC Symbol;Acc:HGNC:5181] | 17420 | 0.000 | 0.1031 | No |
| 74 | HNF4A | hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024] | 17597 | 0.000 | 0.0984 | No |
| 75 | SERPING1 | serpin family G member 1 [Source:HGNC Symbol;Acc:HGNC:1228] | 17713 | 0.000 | 0.0953 | No |
| 76 | SERPINA1 | serpin family A member 1 [Source:HGNC Symbol;Acc:HGNC:8941] | 17724 | 0.000 | 0.0950 | No |
| 77 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 17876 | 0.000 | 0.0909 | No |
| 78 | BMP1 | bone morphogenetic protein 1 [Source:HGNC Symbol;Acc:HGNC:1067] | 19006 | 0.000 | 0.0603 | No |
| 79 | MMP7 | matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174] | 19029 | 0.000 | 0.0598 | No |
| 80 | MMP1 | matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] | 19032 | 0.000 | 0.0597 | No |
| 81 | MMP8 | matrix metallopeptidase 8 [Source:HGNC Symbol;Acc:HGNC:7175] | 19041 | 0.000 | 0.0595 | No |
| 82 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 19916 | 0.000 | 0.0358 | No |
| 83 | HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008] | 19957 | 0.000 | 0.0347 | No |
| 84 | PLG | plasminogen [Source:HGNC Symbol;Acc:HGNC:9071] | 19991 | 0.000 | 0.0339 | No |
| 85 | C1QA | complement C1q A chain [Source:HGNC Symbol;Acc:HGNC:1241] | 20049 | 0.000 | 0.0323 | No |
| 86 | LEFTY2 | left-right determination factor 2 [Source:HGNC Symbol;Acc:HGNC:3122] | 20164 | 0.000 | 0.0292 | No |
| 87 | KLK8 | kallikrein related peptidase 8 [Source:HGNC Symbol;Acc:HGNC:6369] | 20607 | 0.000 | 0.0173 | No |
| 88 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 20835 | 0.000 | 0.0111 | No |
| 89 | F2RL2 | coagulation factor II thrombin receptor like 2 [Source:HGNC Symbol;Acc:HGNC:3539] | 21051 | 0.000 | 0.0053 | No |
| 90 | GP1BA | glycoprotein Ib platelet subunit alpha [Source:HGNC Symbol;Acc:HGNC:4439] | 23138 | 0.000 | -0.0511 | No |
| 91 | CPN1 | carboxypeptidase N subunit 1 [Source:HGNC Symbol;Acc:HGNC:2312] | 23502 | 0.000 | -0.0610 | No |
| 92 | TFPI2 | tissue factor pathway inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11761] | 24848 | 0.000 | -0.0974 | No |
| 93 | PRSS23 | serine protease 23 [Source:HGNC Symbol;Acc:HGNC:14370] | 25130 | 0.000 | -0.1050 | No |
| 94 | ITGA2 | integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] | 26292 | 0.000 | -0.1364 | No |
| 95 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 26857 | 0.000 | -0.1516 | No |
| 96 | SPARC | secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219] | 27219 | 0.000 | -0.1614 | No |
| 97 | CPQ | carboxypeptidase Q [Source:HGNC Symbol;Acc:HGNC:16910] | 27554 | -0.036 | -0.1701 | No |
| 98 | GNB2 | G protein subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:4398] | 28352 | -0.157 | -0.1901 | No |
| 99 | CPB2 | carboxypeptidase B2 [Source:HGNC Symbol;Acc:HGNC:2300] | 28428 | -0.167 | -0.1905 | No |
| 100 | C1R | complement C1r [Source:HGNC Symbol;Acc:HGNC:1246] | 28446 | -0.170 | -0.1893 | No |
| 101 | HPN | hepsin [Source:HGNC Symbol;Acc:HGNC:5155] | 28492 | -0.176 | -0.1888 | No |
| 102 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 28584 | -0.187 | -0.1895 | No |
| 103 | TF | transferrin [Source:HGNC Symbol;Acc:HGNC:11740] | 28695 | -0.202 | -0.1905 | No |
| 104 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 28721 | -0.208 | -0.1891 | No |
| 105 | S100A13 | S100 calcium binding protein A13 [Source:HGNC Symbol;Acc:HGNC:10490] | 28785 | -0.214 | -0.1888 | No |
| 106 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 28978 | -0.245 | -0.1916 | No |
| 107 | CTSH | cathepsin H [Source:HGNC Symbol;Acc:HGNC:2535] | 29157 | -0.272 | -0.1937 | No |
| 108 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629] | 29390 | -0.310 | -0.1970 | No |
| 109 | PEF1 | penta-EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30009] | 29421 | -0.314 | -0.1947 | No |
| 110 | MST1 | macrophage stimulating 1 [Source:HGNC Symbol;Acc:HGNC:7380] | 29444 | -0.319 | -0.1922 | No |
| 111 | RGN | regucalcin [Source:HGNC Symbol;Acc:HGNC:9989] | 29570 | -0.337 | -0.1923 | No |
| 112 | CRIP2 | cysteine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2361] | 29960 | -0.393 | -0.1990 | No |
| 113 | MMP11 | matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157] | 30641 | -0.502 | -0.2125 | No |
| 114 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 30895 | -0.541 | -0.2141 | No |
| 115 | USP11 | ubiquitin specific peptidase 11 [Source:HGNC Symbol;Acc:HGNC:12609] | 31528 | -0.657 | -0.2248 | No |
| 116 | SIRT2 | sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] | 31763 | -0.702 | -0.2243 | No |
| 117 | COMP | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:HGNC:2227] | 31821 | -0.709 | -0.2189 | No |
| 118 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 31918 | -0.735 | -0.2143 | No |
| 119 | CAPN5 | calpain 5 [Source:HGNC Symbol;Acc:HGNC:1482] | 32230 | -0.817 | -0.2148 | No |
| 120 | DUSP6 | dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] | 32246 | -0.823 | -0.2072 | No |
| 121 | PROS1 | protein S [Source:HGNC Symbol;Acc:HGNC:9456] | 32570 | -0.905 | -0.2071 | No |
| 122 | VWF | von Willebrand factor [Source:HGNC Symbol;Acc:HGNC:12726] | 32816 | -0.980 | -0.2042 | No |
| 123 | CSRP1 | cysteine and glycine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2469] | 33274 | -1.119 | -0.2056 | No |
| 124 | CAPN2 | calpain 2 [Source:HGNC Symbol;Acc:HGNC:1479] | 33541 | -1.207 | -0.2011 | No |
| 125 | ISCU | iron-sulfur cluster assembly enzyme [Source:HGNC Symbol;Acc:HGNC:29882] | 33762 | -1.286 | -0.1945 | No |
| 126 | CASP9 | caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511] | 34001 | -1.372 | -0.1875 | No |
| 127 | CTSE | cathepsin E [Source:HGNC Symbol;Acc:HGNC:2530] | 34521 | -1.570 | -0.1863 | No |
| 128 | LTA4H | leukotriene A4 hydrolase [Source:HGNC Symbol;Acc:HGNC:6710] | 34765 | -1.683 | -0.1764 | No |
| 129 | SH2B2 | SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:17381] | 34814 | -1.703 | -0.1611 | No |
| 130 | S100A1 | S100 calcium binding protein A1 [Source:HGNC Symbol;Acc:HGNC:10486] | 34894 | -1.749 | -0.1462 | No |
| 131 | LRP1 | LDL receptor related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692] | 35450 | -2.098 | -0.1408 | No |
| 132 | ANG | angiogenin [Source:HGNC Symbol;Acc:HGNC:483] | 35625 | -2.216 | -0.1239 | No |
| 133 | CFH | complement factor H [Source:HGNC Symbol;Acc:HGNC:4883] | 36327 | -2.890 | -0.1147 | No |
| 134 | PLAU | plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] | 36579 | -3.237 | -0.0899 | No |
| 135 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 36606 | -3.271 | -0.0587 | No |
| 136 | GSN | gelsolin [Source:HGNC Symbol;Acc:HGNC:4620] | 36666 | -3.381 | -0.0274 | No |
| 137 | F8 | coagulation factor VIII [Source:HGNC Symbol;Acc:HGNC:3546] | 36940 | -3.979 | 0.0041 | No |
