Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.7437705 |
| Normalized Enrichment Score (NES) | 1.8512938 |
| Nominal p-value | 0.0 |
| FDR q-value | 7.7001017E-4 |
| FWER p-Value | 0.001 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 1 | 4.994 | 0.0517 | Yes |
| 2 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 39 | 4.636 | 0.0987 | Yes |
| 3 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 43 | 4.568 | 0.1459 | Yes |
| 4 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 45 | 4.558 | 0.1931 | Yes |
| 5 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 91 | 4.106 | 0.2344 | Yes |
| 6 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] | 111 | 3.966 | 0.2750 | Yes |
| 7 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 128 | 3.902 | 0.3150 | Yes |
| 8 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 145 | 3.779 | 0.3537 | Yes |
| 9 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 241 | 3.211 | 0.3844 | Yes |
| 10 | CD14 | CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] | 251 | 3.171 | 0.4170 | Yes |
| 11 | CD36 | CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] | 277 | 3.030 | 0.4477 | Yes |
| 12 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 311 | 2.881 | 0.4766 | Yes |
| 13 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 371 | 2.705 | 0.5030 | Yes |
| 14 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 454 | 2.468 | 0.5264 | Yes |
| 15 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 496 | 2.371 | 0.5498 | Yes |
| 16 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 510 | 2.341 | 0.5737 | Yes |
| 17 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 514 | 2.328 | 0.5977 | Yes |
| 18 | HAX1 | HCLS1 associated protein X-1 [Source:HGNC Symbol;Acc:HGNC:16915] | 564 | 2.200 | 0.6192 | Yes |
| 19 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 595 | 2.141 | 0.6406 | Yes |
| 20 | PIK3R5 | phosphoinositide-3-kinase regulatory subunit 5 [Source:HGNC Symbol;Acc:HGNC:30035] | 685 | 1.975 | 0.6586 | Yes |
| 21 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 802 | 1.811 | 0.6742 | Yes |
| 22 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 848 | 1.758 | 0.6912 | Yes |
| 23 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 858 | 1.747 | 0.7091 | Yes |
| 24 | FAS | Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] | 1320 | 1.304 | 0.7101 | Yes |
| 25 | BAK1 | BCL2 antagonist/killer 1 [Source:HGNC Symbol;Acc:HGNC:949] | 1376 | 1.261 | 0.7217 | Yes |
| 26 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 1685 | 1.099 | 0.7248 | Yes |
| 27 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 1724 | 1.075 | 0.7349 | Yes |
| 28 | HMOX1 | heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] | 1793 | 1.038 | 0.7438 | Yes |
| 29 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 2485 | 0.746 | 0.7328 | No |
| 30 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] | 2835 | 0.640 | 0.7300 | No |
| 31 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 2890 | 0.626 | 0.7350 | No |
| 32 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 3309 | 0.525 | 0.7292 | No |
| 33 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 3736 | 0.433 | 0.7222 | No |
| 34 | IL9R | interleukin 9 receptor [Source:HGNC Symbol;Acc:HGNC:6030] | 4537 | 0.269 | 0.7033 | No |
| 35 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 4688 | 0.239 | 0.7018 | No |
| 36 | IL13RA1 | interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] | 4926 | 0.194 | 0.6974 | No |
| 37 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 5016 | 0.176 | 0.6968 | No |
| 38 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 5174 | 0.156 | 0.6941 | No |
| 39 | DNTT | DNA nucleotidylexotransferase [Source:HGNC Symbol;Acc:HGNC:2983] | 5656 | 0.060 | 0.6818 | No |
| 40 | CBL | Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541] | 5769 | 0.040 | 0.6792 | No |
| 41 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 5869 | 0.017 | 0.6767 | No |
| 42 | LTBR | lymphotoxin beta receptor [Source:HGNC Symbol;Acc:HGNC:6718] | 7615 | 0.000 | 0.6295 | No |
| 43 | CNTFR | ciliary neurotrophic factor receptor [Source:HGNC Symbol;Acc:HGNC:2170] | 8429 | 0.000 | 0.6075 | No |
| 44 | TNFRSF21 | TNF receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] | 8898 | 0.000 | 0.5949 | No |
| 45 | CRLF2 | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | 10620 | 0.000 | 0.5484 | No |
| 46 | LEPR | leptin receptor [Source:HGNC Symbol;Acc:HGNC:6554] | 11127 | 0.000 | 0.5347 | No |
| 47 | PLA2G2A | phospholipase A2 group IIA [Source:HGNC Symbol;Acc:HGNC:9031] | 11361 | 0.000 | 0.5284 | No |
| 48 | CSF2RA | colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] | 11653 | 0.000 | 0.5205 | No |
| 49 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13380 | 0.000 | 0.4739 | No |
| 50 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 13696 | 0.000 | 0.4654 | No |
| 51 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 13996 | 0.000 | 0.4573 | No |
| 52 | EBI3 | Epstein-Barr virus induced 3 [Source:HGNC Symbol;Acc:HGNC:3129] | 14850 | 0.000 | 0.4342 | No |
| 53 | IL17RB | interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] | 14903 | 0.000 | 0.4328 | No |
| 54 | IL18R1 | interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] | 15252 | 0.000 | 0.4234 | No |
| 55 | IL2RA | interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] | 15548 | 0.000 | 0.4155 | No |
| 56 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15821 | 0.000 | 0.4081 | No |
| 57 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15822 | 0.000 | 0.4081 | No |
| 58 | IL3RA | interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] | 16448 | 0.000 | 0.3912 | No |
| 59 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18401 | 0.000 | 0.3385 | No |
| 60 | CXCL13 | C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] | 18806 | 0.000 | 0.3276 | No |
| 61 | OSMR | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] | 18928 | 0.000 | 0.3243 | No |
| 62 | CXCL9 | C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] | 19368 | 0.000 | 0.3124 | No |
| 63 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19380 | 0.000 | 0.3121 | No |
| 64 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 19382 | 0.000 | 0.3121 | No |
| 65 | IL12RB1 | interleukin 12 receptor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:5971] | 19545 | 0.000 | 0.3077 | No |
| 66 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 19916 | 0.000 | 0.2977 | No |
| 67 | IFNGR1 | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] | 20441 | 0.000 | 0.2836 | No |
| 68 | IFNGR2 | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] | 20443 | 0.000 | 0.2835 | No |
| 69 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 22828 | 0.000 | 0.2191 | No |
| 70 | CD38 | CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667] | 22925 | 0.000 | 0.2165 | No |
| 71 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 24383 | 0.000 | 0.1771 | No |
| 72 | REG1A | regenerating family member 1 alpha [Source:HGNC Symbol;Acc:HGNC:9951] | 26247 | 0.000 | 0.1268 | No |
| 73 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 26857 | 0.000 | 0.1103 | No |
| 74 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 27785 | -0.075 | 0.0861 | No |
| 75 | PTPN2 | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] | 28239 | -0.141 | 0.0753 | No |
| 76 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 28584 | -0.187 | 0.0679 | No |
| 77 | IL17RA | interleukin 17 receptor A [Source:HGNC Symbol;Acc:HGNC:5985] | 29814 | -0.370 | 0.0385 | No |
| 78 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 29919 | -0.385 | 0.0397 | No |
| 79 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 30460 | -0.469 | 0.0300 | No |
| 80 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] | 30739 | -0.516 | 0.0278 | No |
| 81 | INHBE | inhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029] | 31890 | -0.728 | 0.0043 | No |
| 82 | ACVRL1 | activin A receptor like type 1 [Source:HGNC Symbol;Acc:HGNC:175] | 33752 | -1.283 | -0.0327 | No |
| 83 | ACVR1B | activin A receptor type 1B [Source:HGNC Symbol;Acc:HGNC:172] | 33877 | -1.329 | -0.0223 | No |
| 84 | CSF2RB | colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] | 34526 | -1.573 | -0.0235 | No |
| 85 | IL6ST | interleukin 6 signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] | 36147 | -2.703 | -0.0393 | No |
| 86 | CSF3R | colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] | 36194 | -2.747 | -0.0121 | No |
| 87 | ITGA4 | integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] | 36743 | -3.505 | 0.0094 | No |
