Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_PROTEIN_SECRETION |
| Enrichment Score (ES) | -0.45671847 |
| Normalized Enrichment Score (NES) | -0.93713874 |
| Nominal p-value | 0.61810154 |
| FDR q-value | 0.99963146 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 474 | 2.422 | 0.0186 | No |
| 2 | CTSC | cathepsin C [Source:HGNC Symbol;Acc:HGNC:2528] | 753 | 1.886 | 0.0355 | No |
| 3 | M6PR | mannose-6-phosphate receptor, cation dependent [Source:HGNC Symbol;Acc:HGNC:6752] | 894 | 1.698 | 0.0537 | No |
| 4 | ATP6V1H | ATPase H+ transporting V1 subunit H [Source:HGNC Symbol;Acc:HGNC:18303] | 1049 | 1.520 | 0.0692 | No |
| 5 | DST | dystonin [Source:HGNC Symbol;Acc:HGNC:1090] | 1250 | 1.348 | 0.0812 | No |
| 6 | YKT6 | YKT6 v-SNARE homolog [Source:HGNC Symbol;Acc:HGNC:16959] | 1357 | 1.273 | 0.0948 | No |
| 7 | ATP6V1B1 | ATPase H+ transporting V1 subunit B1 [Source:HGNC Symbol;Acc:HGNC:853] | 1795 | 1.037 | 0.0965 | No |
| 8 | RAB5A | RAB5A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9783] | 1801 | 1.033 | 0.1097 | No |
| 9 | USO1 | USO1 vesicle transport factor [Source:HGNC Symbol;Acc:HGNC:30904] | 1990 | 0.948 | 0.1169 | No |
| 10 | AP1G1 | adaptor related protein complex 1 subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:555] | 2002 | 0.942 | 0.1288 | No |
| 11 | STX12 | syntaxin 12 [Source:HGNC Symbol;Acc:HGNC:11430] | 2222 | 0.848 | 0.1338 | No |
| 12 | ATP7A | ATPase copper transporting alpha [Source:HGNC Symbol;Acc:HGNC:869] | 2400 | 0.778 | 0.1391 | No |
| 13 | VPS4B | vacuolar protein sorting 4 homolog B [Source:HGNC Symbol;Acc:HGNC:10895] | 2501 | 0.740 | 0.1460 | No |
| 14 | VAMP3 | vesicle associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:12644] | 2547 | 0.729 | 0.1542 | No |
| 15 | RAB22A | RAB22A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9764] | 2599 | 0.708 | 0.1620 | No |
| 16 | ARF1 | ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652] | 2686 | 0.679 | 0.1685 | No |
| 17 | RAB2A | RAB2A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9763] | 2821 | 0.644 | 0.1732 | No |
| 18 | CLN5 | CLN5 intracellular trafficking protein [Source:HGNC Symbol;Acc:HGNC:2076] | 2853 | 0.635 | 0.1806 | No |
| 19 | AP2B1 | adaptor related protein complex 2 subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:563] | 3388 | 0.509 | 0.1727 | No |
| 20 | TMX1 | thioredoxin related transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:15487] | 3527 | 0.474 | 0.1752 | No |
| 21 | ARCN1 | archain 1 [Source:HGNC Symbol;Acc:HGNC:649] | 3942 | 0.390 | 0.1690 | No |
| 22 | TSG101 | tumor susceptibility 101 [Source:HGNC Symbol;Acc:HGNC:15971] | 4001 | 0.373 | 0.1723 | No |
| 23 | AP2M1 | adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564] | 4111 | 0.357 | 0.1739 | No |
| 24 | ARFGAP3 | ADP ribosylation factor GTPase activating protein 3 [Source:HGNC Symbol;Acc:HGNC:661] | 4410 | 0.292 | 0.1697 | No |
| 25 | SEC22B | SEC22 homolog B, vesicle trafficking protein (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:10700] | 4502 | 0.278 | 0.1708 | No |
| 26 | ARFGEF1 | ADP ribosylation factor guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:15772] | 4693 | 0.238 | 0.1688 | No |
| 27 | RAB14 | RAB14, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:16524] | 4757 | 0.229 | 0.1700 | No |
| 28 | SH3GL2 | SH3 domain containing GRB2 like 2, endophilin A1 [Source:HGNC Symbol;Acc:HGNC:10831] | 4842 | 0.212 | 0.1705 | No |
| 29 | CLTC | clathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092] | 4917 | 0.196 | 0.1710 | No |
| 30 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 4947 | 0.189 | 0.1727 | No |
| 31 | YIPF6 | Yip1 domain family member 6 [Source:HGNC Symbol;Acc:HGNC:28304] | 5223 | 0.146 | 0.1672 | No |
| 32 | COG2 | component of oligomeric golgi complex 2 [Source:HGNC Symbol;Acc:HGNC:6546] | 5484 | 0.097 | 0.1614 | No |
| 33 | SNX2 | sorting nexin 2 [Source:HGNC Symbol;Acc:HGNC:11173] | 5679 | 0.056 | 0.1569 | No |
| 34 | COPB2 | COPI coat complex subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:2232] | 5686 | 0.055 | 0.1574 | No |
| 35 | RER1 | retention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309] | 5709 | 0.054 | 0.1575 | No |
| 36 | LMAN1 | lectin, mannose binding 1 [Source:HGNC Symbol;Acc:HGNC:6631] | 5743 | 0.045 | 0.1572 | No |
| 37 | AP3S1 | adaptor related protein complex 3 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:2013] | 5800 | 0.031 | 0.1561 | No |
| 38 | TSPAN8 | tetraspanin 8 [Source:HGNC Symbol;Acc:HGNC:11855] | 11220 | 0.000 | 0.0096 | No |
| 39 | SCRN1 | secernin 1 [Source:HGNC Symbol;Acc:HGNC:22192] | 13926 | 0.000 | -0.0635 | No |
| 40 | KRT18 | keratin 18 [Source:HGNC Symbol;Acc:HGNC:6430] | 21876 | 0.000 | -0.2784 | No |
| 41 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 22045 | 0.000 | -0.2829 | No |
| 42 | SSPN | sarcospan [Source:HGNC Symbol;Acc:HGNC:11322] | 26975 | 0.000 | -0.4161 | No |
| 43 | ARFIP1 | ADP ribosylation factor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:21496] | 27400 | -0.005 | -0.4275 | No |
| 44 | TMED2 | transmembrane p24 trafficking protein 2 [Source:HGNC Symbol;Acc:HGNC:16996] | 27445 | -0.013 | -0.4286 | No |
| 45 | BET1 | Bet1 golgi vesicular membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:14562] | 27723 | -0.066 | -0.4352 | No |
| 46 | GBF1 | golgi brefeldin A resistant guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:4181] | 28052 | -0.112 | -0.4426 | No |
| 47 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 28092 | -0.118 | -0.4421 | No |
| 48 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 28164 | -0.130 | -0.4424 | No |
| 49 | DOP1A | DOP1 leucine zipper like protein A [Source:HGNC Symbol;Acc:HGNC:21194] | 28437 | -0.169 | -0.4475 | No |
| 50 | STX16 | syntaxin 16 [Source:HGNC Symbol;Acc:HGNC:11431] | 28612 | -0.190 | -0.4498 | No |
| 51 | MON2 | MON2 homolog, regulator of endosome-to-Golgi trafficking [Source:HGNC Symbol;Acc:HGNC:29177] | 28870 | -0.230 | -0.4537 | Yes |
| 52 | COPB1 | COPI coat complex subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:2231] | 28936 | -0.239 | -0.4524 | Yes |
| 53 | IGF2R | insulin like growth factor 2 receptor [Source:HGNC Symbol;Acc:HGNC:5467] | 29053 | -0.258 | -0.4522 | Yes |
| 54 | RPS6KA3 | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] | 29063 | -0.259 | -0.4491 | Yes |
| 55 | CD63 | CD63 molecule [Source:HGNC Symbol;Acc:HGNC:1692] | 29156 | -0.272 | -0.4481 | Yes |
| 56 | VAMP7 | vesicle associated membrane protein 7 [Source:HGNC Symbol;Acc:HGNC:11486] | 29307 | -0.297 | -0.4483 | Yes |
| 57 | ATP1A1 | ATPase Na+/K+ transporting subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:799] | 29317 | -0.299 | -0.4446 | Yes |
| 58 | STAM | signal transducing adaptor molecule [Source:HGNC Symbol;Acc:HGNC:11357] | 29386 | -0.310 | -0.4425 | Yes |
| 59 | AP3B1 | adaptor related protein complex 3 subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:566] | 29492 | -0.325 | -0.4411 | Yes |
| 60 | ANP32E | acidic nuclear phosphoprotein 32 family member E [Source:HGNC Symbol;Acc:HGNC:16673] | 29854 | -0.377 | -0.4460 | Yes |
| 61 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 30037 | -0.403 | -0.4457 | Yes |
| 62 | GOLGA4 | golgin A4 [Source:HGNC Symbol;Acc:HGNC:4427] | 30320 | -0.448 | -0.4475 | Yes |
| 63 | MAPK1 | mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] | 30523 | -0.481 | -0.4467 | Yes |
| 64 | ARFGEF2 | ADP ribosylation factor guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:15853] | 30748 | -0.517 | -0.4461 | Yes |
| 65 | KIF1B | kinesin family member 1B [Source:HGNC Symbol;Acc:HGNC:16636] | 30776 | -0.522 | -0.4401 | Yes |
| 66 | SCAMP3 | secretory carrier membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:10565] | 30907 | -0.543 | -0.4365 | Yes |
| 67 | NAPG | NSF attachment protein gamma [Source:HGNC Symbol;Acc:HGNC:7642] | 31057 | -0.569 | -0.4332 | Yes |
| 68 | OCRL | OCRL inositol polyphosphate-5-phosphatase [Source:HGNC Symbol;Acc:HGNC:8108] | 31262 | -0.604 | -0.4309 | Yes |
| 69 | TMED10 | transmembrane p24 trafficking protein 10 [Source:HGNC Symbol;Acc:HGNC:16998] | 31897 | -0.730 | -0.4386 | Yes |
| 70 | NAPA | NSF attachment protein alpha [Source:HGNC Symbol;Acc:HGNC:7641] | 31947 | -0.742 | -0.4303 | Yes |
| 71 | AP2S1 | adaptor related protein complex 2 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:565] | 31974 | -0.748 | -0.4213 | Yes |
| 72 | STX7 | syntaxin 7 [Source:HGNC Symbol;Acc:HGNC:11442] | 32055 | -0.769 | -0.4135 | Yes |
| 73 | SNAP23 | synaptosome associated protein 23 [Source:HGNC Symbol;Acc:HGNC:11131] | 32295 | -0.838 | -0.4091 | Yes |
| 74 | ERGIC3 | ERGIC and golgi 3 [Source:HGNC Symbol;Acc:HGNC:15927] | 32296 | -0.838 | -0.3983 | Yes |
| 75 | SEC24D | SEC24 homolog D, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:10706] | 32429 | -0.872 | -0.3906 | Yes |
| 76 | CLTA | clathrin light chain A [Source:HGNC Symbol;Acc:HGNC:2090] | 32673 | -0.936 | -0.3850 | Yes |
| 77 | RAB9A | RAB9A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9792] | 32782 | -0.967 | -0.3754 | Yes |
| 78 | DNM1L | dynamin 1 like [Source:HGNC Symbol;Acc:HGNC:2973] | 32877 | -0.999 | -0.3650 | Yes |
| 79 | TPD52 | tumor protein D52 [Source:HGNC Symbol;Acc:HGNC:12005] | 32940 | -1.020 | -0.3535 | Yes |
| 80 | COPE | COPI coat complex subunit epsilon [Source:HGNC Symbol;Acc:HGNC:2234] | 32960 | -1.026 | -0.3407 | Yes |
| 81 | GNAS | GNAS complex locus [Source:HGNC Symbol;Acc:HGNC:4392] | 33246 | -1.111 | -0.3340 | Yes |
| 82 | SCAMP1 | secretory carrier membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:10563] | 33747 | -1.282 | -0.3310 | Yes |
| 83 | ZW10 | zw10 kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13194] | 33796 | -1.299 | -0.3154 | Yes |
| 84 | VPS45 | vacuolar protein sorting 45 homolog [Source:HGNC Symbol;Acc:HGNC:14579] | 33837 | -1.316 | -0.2995 | Yes |
| 85 | PAM | peptidylglycine alpha-amidating monooxygenase [Source:HGNC Symbol;Acc:HGNC:8596] | 33852 | -1.320 | -0.2828 | Yes |
| 86 | GLA | galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] | 34042 | -1.383 | -0.2700 | Yes |
| 87 | ADAM10 | ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:HGNC:188] | 34696 | -1.648 | -0.2663 | Yes |
| 88 | CLCN3 | chloride voltage-gated channel 3 [Source:HGNC Symbol;Acc:HGNC:2021] | 34962 | -1.781 | -0.2504 | Yes |
| 89 | SGMS1 | sphingomyelin synthase 1 [Source:HGNC Symbol;Acc:HGNC:29799] | 35149 | -1.896 | -0.2308 | Yes |
| 90 | PPT1 | palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325] | 35447 | -2.096 | -0.2117 | Yes |
| 91 | VAMP4 | vesicle associated membrane protein 4 [Source:HGNC Symbol;Acc:HGNC:12645] | 35739 | -2.319 | -0.1896 | Yes |
| 92 | TOM1L1 | target of myb1 like 1 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11983] | 36010 | -2.562 | -0.1637 | Yes |
| 93 | ICA1 | islet cell autoantigen 1 [Source:HGNC Symbol;Acc:HGNC:5343] | 36280 | -2.827 | -0.1344 | Yes |
| 94 | GALC | galactosylceramidase [Source:HGNC Symbol;Acc:HGNC:4115] | 36775 | -3.571 | -0.1015 | Yes |
| 95 | CAV2 | caveolin 2 [Source:HGNC Symbol;Acc:HGNC:1528] | 36970 | -4.093 | -0.0537 | Yes |
| 96 | BNIP3 | BCL2 interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:1084] | 37034 | -4.399 | 0.0015 | Yes |
