Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.45792624 |
| Normalized Enrichment Score (NES) | 1.215702 |
| Nominal p-value | 0.03846154 |
| FDR q-value | 0.123282626 |
| FWER p-Value | 0.287 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 17 | 4.863 | 0.0494 | Yes |
| 2 | HSPA5 | heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol;Acc:HGNC:5238] | 473 | 2.422 | 0.0619 | Yes |
| 3 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 520 | 2.310 | 0.0843 | Yes |
| 4 | SRPRA | SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307] | 592 | 2.149 | 0.1044 | Yes |
| 5 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 642 | 2.069 | 0.1243 | Yes |
| 6 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 [Source:HGNC Symbol;Acc:HGNC:13744] | 651 | 2.040 | 0.1450 | Yes |
| 7 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680] | 666 | 2.015 | 0.1652 | Yes |
| 8 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16829] | 699 | 1.960 | 0.1845 | Yes |
| 9 | CEBPB | CCAAT enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] | 727 | 1.931 | 0.2035 | Yes |
| 10 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol;Acc:HGNC:12855] | 763 | 1.870 | 0.2217 | Yes |
| 11 | ASNS | asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] | 812 | 1.797 | 0.2388 | Yes |
| 12 | NABP1 | nucleic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:26232] | 852 | 1.756 | 0.2558 | Yes |
| 13 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol;Acc:HGNC:6968] | 983 | 1.594 | 0.2686 | Yes |
| 14 | ATF4 | activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786] | 1218 | 1.377 | 0.2764 | Yes |
| 15 | FUS | FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] | 1228 | 1.369 | 0.2901 | Yes |
| 16 | SDAD1 | SDA1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25537] | 1300 | 1.313 | 0.3017 | Yes |
| 17 | CNOT4 | CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:7880] | 1443 | 1.222 | 0.3104 | Yes |
| 18 | SLC1A4 | solute carrier family 1 member 4 [Source:HGNC Symbol;Acc:HGNC:10942] | 1481 | 1.200 | 0.3217 | Yes |
| 19 | EIF2S1 | eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC Symbol;Acc:HGNC:3265] | 1582 | 1.153 | 0.3308 | Yes |
| 20 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 1667 | 1.109 | 0.3399 | Yes |
| 21 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 1688 | 1.098 | 0.3506 | Yes |
| 22 | DCP1A | decapping mRNA 1A [Source:HGNC Symbol;Acc:HGNC:18714] | 1726 | 1.074 | 0.3606 | Yes |
| 23 | HYOU1 | hypoxia up-regulated 1 [Source:HGNC Symbol;Acc:HGNC:16931] | 1905 | 0.993 | 0.3659 | Yes |
| 24 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434] | 1963 | 0.962 | 0.3742 | Yes |
| 25 | SLC7A5 | solute carrier family 7 member 5 [Source:HGNC Symbol;Acc:HGNC:11063] | 1989 | 0.949 | 0.3833 | Yes |
| 26 | KIF5B | kinesin family member 5B [Source:HGNC Symbol;Acc:HGNC:6324] | 2057 | 0.918 | 0.3909 | Yes |
| 27 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 2116 | 0.892 | 0.3985 | Yes |
| 28 | LSM1 | LSM1 homolog, mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:20472] | 2136 | 0.881 | 0.4070 | Yes |
| 29 | ARFGAP1 | ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:15852] | 2213 | 0.851 | 0.4136 | Yes |
| 30 | TARS1 | threonyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:11572] | 2238 | 0.842 | 0.4216 | Yes |
| 31 | NOP14 | NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] | 2261 | 0.833 | 0.4296 | Yes |
| 32 | TSPYL2 | TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] | 2653 | 0.689 | 0.4260 | Yes |
| 33 | IARS1 | isoleucyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:5330] | 2721 | 0.670 | 0.4311 | Yes |
| 34 | SERP1 | stress associated endoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:10759] | 2872 | 0.630 | 0.4335 | Yes |
| 35 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 2894 | 0.625 | 0.4393 | Yes |
| 36 | EXOSC1 | exosome component 1 [Source:HGNC Symbol;Acc:HGNC:17286] | 2912 | 0.622 | 0.4453 | Yes |
| 37 | LSM4 | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17259] | 3115 | 0.573 | 0.4457 | Yes |
| 38 | BAG3 | BAG cochaperone 3 [Source:HGNC Symbol;Acc:HGNC:939] | 3313 | 0.525 | 0.4457 | Yes |
| 39 | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] | 3499 | 0.481 | 0.4456 | Yes |
| 40 | EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3288] | 3541 | 0.471 | 0.4494 | Yes |
| 41 | EIF4A1 | eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol;Acc:HGNC:3282] | 3687 | 0.441 | 0.4500 | Yes |
| 42 | EXOSC4 | exosome component 4 [Source:HGNC Symbol;Acc:HGNC:18189] | 3744 | 0.432 | 0.4529 | Yes |
| 43 | DKC1 | dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890] | 3806 | 0.420 | 0.4555 | Yes |
| 44 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 3872 | 0.407 | 0.4579 | Yes |
| 45 | EIF4G1 | eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol;Acc:HGNC:3296] | 4186 | 0.342 | 0.4530 | No |
| 46 | TTC37 | tetratricopeptide repeat domain 37 [Source:HGNC Symbol;Acc:HGNC:23639] | 4313 | 0.315 | 0.4528 | No |
| 47 | NPM1 | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] | 4396 | 0.296 | 0.4536 | No |
| 48 | DDIT4 | DNA damage inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] | 4510 | 0.277 | 0.4534 | No |
| 49 | PDIA6 | protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168] | 4761 | 0.228 | 0.4490 | No |
| 50 | PDIA5 | protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] | 4784 | 0.223 | 0.4506 | No |
| 51 | SSR1 | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] | 4885 | 0.203 | 0.4500 | No |
| 52 | NOLC1 | nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15608] | 4988 | 0.180 | 0.4491 | No |
| 53 | XBP1 | X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801] | 5038 | 0.171 | 0.4495 | No |
| 54 | EXOSC2 | exosome component 2 [Source:HGNC Symbol;Acc:HGNC:17097] | 5041 | 0.170 | 0.4512 | No |
| 55 | NOP56 | NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] | 5045 | 0.169 | 0.4529 | No |
| 56 | HSPA9 | heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244] | 5275 | 0.134 | 0.4481 | No |
| 57 | ZBTB17 | zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936] | 5304 | 0.129 | 0.4486 | No |
| 58 | VEGFA | vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] | 5362 | 0.117 | 0.4483 | No |
| 59 | POP4 | POP4 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30081] | 5437 | 0.103 | 0.4473 | No |
| 60 | YIF1A | Yip1 interacting factor homolog A, membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:16688] | 5497 | 0.093 | 0.4467 | No |
| 61 | SPCS3 | signal peptidase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26212] | 5659 | 0.059 | 0.4430 | No |
| 62 | TATDN2 | TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988] | 5683 | 0.055 | 0.4429 | No |
| 63 | PAIP1 | poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] | 5724 | 0.049 | 0.4423 | No |
| 64 | CNOT6 | CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14099] | 5772 | 0.039 | 0.4415 | No |
| 65 | EDC4 | enhancer of mRNA decapping 4 [Source:HGNC Symbol;Acc:HGNC:17157] | 5777 | 0.037 | 0.4417 | No |
| 66 | EIF4A3 | eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:HGNC:18683] | 5798 | 0.032 | 0.4415 | No |
| 67 | BANF1 | BAF nuclear assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:17397] | 5896 | 0.012 | 0.4390 | No |
| 68 | CNOT2 | CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] | 5942 | 0.004 | 0.4378 | No |
| 69 | IGFBP1 | insulin like growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5469] | 11480 | 0.000 | 0.2881 | No |
| 70 | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] | 18453 | 0.000 | 0.0996 | No |
| 71 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 22836 | 0.000 | -0.0189 | No |
| 72 | CXXC1 | CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] | 27486 | -0.023 | -0.1444 | No |
| 73 | DDX10 | DEAD-box helicase 10 [Source:HGNC Symbol;Acc:HGNC:2735] | 27573 | -0.038 | -0.1464 | No |
| 74 | WFS1 | wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762] | 28002 | -0.103 | -0.1569 | No |
| 75 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 28092 | -0.118 | -0.1581 | No |
| 76 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 28164 | -0.130 | -0.1587 | No |
| 77 | NFYA | nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] | 28196 | -0.134 | -0.1581 | No |
| 78 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 28467 | -0.173 | -0.1637 | No |
| 79 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 28606 | -0.189 | -0.1655 | No |
| 80 | PSAT1 | phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129] | 28687 | -0.200 | -0.1656 | No |
| 81 | XPOT | exportin for tRNA [Source:HGNC Symbol;Acc:HGNC:12826] | 29073 | -0.261 | -0.1733 | No |
| 82 | MTREX | Mtr4 exosome RNA helicase [Source:HGNC Symbol;Acc:HGNC:18734] | 29203 | -0.281 | -0.1739 | No |
| 83 | PREB | prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] | 29300 | -0.296 | -0.1735 | No |
| 84 | EXOSC10 | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] | 29315 | -0.299 | -0.1708 | No |
| 85 | KDELR3 | KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol;Acc:HGNC:6306] | 29565 | -0.336 | -0.1741 | No |
| 86 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 30284 | -0.444 | -0.1889 | No |
| 87 | ALDH18A1 | aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol;Acc:HGNC:9722] | 30450 | -0.467 | -0.1886 | No |
| 88 | RPS14 | ribosomal protein S14 [Source:HGNC Symbol;Acc:HGNC:10387] | 30622 | -0.499 | -0.1881 | No |
| 89 | ATF6 | activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] | 31022 | -0.562 | -0.1932 | No |
| 90 | NHP2 | NHP2 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:14377] | 31026 | -0.563 | -0.1875 | No |
| 91 | EXOC2 | exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] | 31235 | -0.599 | -0.1870 | No |
| 92 | SHC1 | SHC adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:10840] | 31299 | -0.610 | -0.1824 | No |
| 93 | EEF2 | eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214] | 31435 | -0.639 | -0.1795 | No |
| 94 | STC2 | stanniocalcin 2 [Source:HGNC Symbol;Acc:HGNC:11374] | 31586 | -0.668 | -0.1767 | No |
| 95 | GEMIN4 | gem nuclear organelle associated protein 4 [Source:HGNC Symbol;Acc:HGNC:15717] | 31944 | -0.741 | -0.1788 | No |
| 96 | PARN | poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] | 32070 | -0.773 | -0.1743 | No |
| 97 | EXOSC9 | exosome component 9 [Source:HGNC Symbol;Acc:HGNC:9137] | 32301 | -0.840 | -0.1719 | No |
| 98 | CEBPG | CCAAT enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] | 32619 | -0.922 | -0.1710 | No |
| 99 | DCTN1 | dynactin subunit 1 [Source:HGNC Symbol;Acc:HGNC:2711] | 32662 | -0.933 | -0.1626 | No |
| 100 | SLC30A5 | solute carrier family 30 member 5 [Source:HGNC Symbol;Acc:HGNC:19089] | 33021 | -1.041 | -0.1616 | No |
| 101 | FKBP14 | FKBP prolyl isomerase 14 [Source:HGNC Symbol;Acc:HGNC:18625] | 33382 | -1.154 | -0.1595 | No |
| 102 | IMP3 | IMP U3 small nucleolar ribonucleoprotein 3 [Source:HGNC Symbol;Acc:HGNC:14497] | 33555 | -1.213 | -0.1517 | No |
| 103 | KHSRP | KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] | 33704 | -1.265 | -0.1428 | No |
| 104 | ATP6V0D1 | ATPase H+ transporting V0 subunit d1 [Source:HGNC Symbol;Acc:HGNC:13724] | 33779 | -1.294 | -0.1315 | No |
| 105 | TUBB2A | tubulin beta 2A class IIa [Source:HGNC Symbol;Acc:HGNC:12412] | 34362 | -1.510 | -0.1318 | No |
| 106 | EDEM1 | ER degradation enhancing alpha-mannosidase like protein 1 [Source:HGNC Symbol;Acc:HGNC:18967] | 35344 | -2.022 | -0.1376 | No |
| 107 | EIF2AK3 | eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255] | 35377 | -2.047 | -0.1175 | No |
| 108 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 35407 | -2.067 | -0.0971 | No |
| 109 | ERN1 | endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] | 35492 | -2.119 | -0.0777 | No |
| 110 | ERO1A | endoplasmic reticulum oxidoreductase 1 alpha [Source:HGNC Symbol;Acc:HGNC:13280] | 35593 | -2.193 | -0.0579 | No |
| 111 | EXOSC5 | exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] | 35600 | -2.199 | -0.0355 | No |
| 112 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36457 | -3.057 | -0.0273 | No |
| 113 | WIPI1 | WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] | 37021 | -4.337 | 0.0019 | No |
