Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | 0.81008106 |
| Normalized Enrichment Score (NES) | 1.9149598 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0019047157 |
| FWER p-Value | 0.017 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 47 | 4.735 | 0.0514 | Yes |
| 2 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 86 | 4.479 | 0.1002 | Yes |
| 3 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 115 | 4.296 | 0.1472 | Yes |
| 4 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 121 | 4.254 | 0.1943 | Yes |
| 5 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 136 | 4.181 | 0.2404 | Yes |
| 6 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 170 | 4.018 | 0.2842 | Yes |
| 7 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 223 | 3.792 | 0.3250 | Yes |
| 8 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 226 | 3.782 | 0.3670 | Yes |
| 9 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 229 | 3.773 | 0.4089 | Yes |
| 10 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 237 | 3.732 | 0.4502 | Yes |
| 11 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 263 | 3.632 | 0.4899 | Yes |
| 12 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 410 | 3.166 | 0.5212 | Yes |
| 13 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 481 | 2.978 | 0.5524 | Yes |
| 14 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 570 | 2.788 | 0.5810 | Yes |
| 15 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 576 | 2.771 | 0.6117 | Yes |
| 16 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 610 | 2.680 | 0.6406 | Yes |
| 17 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 998 | 2.160 | 0.6542 | Yes |
| 18 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 1047 | 2.089 | 0.6761 | Yes |
| 19 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 1159 | 1.949 | 0.6948 | Yes |
| 20 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 1720 | 1.540 | 0.6968 | Yes |
| 21 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 1776 | 1.502 | 0.7120 | Yes |
| 22 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 1794 | 1.491 | 0.7281 | Yes |
| 23 | IP6K2 | inositol hexakisphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:17313] | 1920 | 1.401 | 0.7403 | Yes |
| 24 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 2172 | 1.253 | 0.7474 | Yes |
| 25 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 2322 | 1.212 | 0.7569 | Yes |
| 26 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 2356 | 1.196 | 0.7693 | Yes |
| 27 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 2527 | 1.117 | 0.7771 | Yes |
| 28 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 2819 | 0.999 | 0.7804 | Yes |
| 29 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 3047 | 0.907 | 0.7843 | Yes |
| 30 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 3231 | 0.833 | 0.7886 | Yes |
| 31 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 3410 | 0.770 | 0.7924 | Yes |
| 32 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 3638 | 0.692 | 0.7940 | Yes |
| 33 | KPNA1 | karyopherin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] | 3898 | 0.606 | 0.7937 | Yes |
| 34 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 3981 | 0.585 | 0.7980 | Yes |
| 35 | ABCE1 | ATP binding cassette subfamily E member 1 [Source:HGNC Symbol;Acc:HGNC:69] | 4008 | 0.576 | 0.8037 | Yes |
| 36 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 4179 | 0.525 | 0.8049 | Yes |
| 37 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 4202 | 0.516 | 0.8101 | Yes |
| 38 | KPNB1 | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] | 5136 | 0.246 | 0.7876 | No |
| 39 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 5250 | 0.239 | 0.7872 | No |
| 40 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 5635 | 0.213 | 0.7792 | No |
| 41 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 5803 | 0.159 | 0.7765 | No |
| 42 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 5873 | 0.139 | 0.7761 | No |
| 43 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 6021 | 0.092 | 0.7732 | No |
| 44 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12476 | 0.000 | 0.5989 | No |
| 45 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 18247 | 0.000 | 0.4430 | No |
| 46 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 18248 | 0.000 | 0.4430 | No |
| 47 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 18250 | 0.000 | 0.4430 | No |
| 48 | IFNA17 | interferon alpha 17 [Source:HGNC Symbol;Acc:HGNC:5422] | 18252 | 0.000 | 0.4429 | No |
| 49 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 18259 | 0.000 | 0.4428 | No |
| 50 | IFNA21 | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] | 18266 | 0.000 | 0.4426 | No |
| 51 | IFNAR2 | interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] | 18530 | 0.000 | 0.4355 | No |
| 52 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18539 | 0.000 | 0.4353 | No |
| 53 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 20379 | 0.000 | 0.3856 | No |
| 54 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 20380 | 0.000 | 0.3856 | No |
| 55 | IFNA5 | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] | 21880 | 0.000 | 0.3451 | No |
| 56 | IFNA4 | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] | 21881 | 0.000 | 0.3451 | No |
| 57 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 21883 | 0.000 | 0.3451 | No |
| 58 | IFNA6 | interferon alpha 6 [Source:HGNC Symbol;Acc:HGNC:5427] | 21884 | 0.000 | 0.3451 | No |
| 59 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 21885 | 0.000 | 0.3451 | No |
| 60 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 21886 | 0.000 | 0.3451 | No |
| 61 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 21889 | 0.000 | 0.3450 | No |
| 62 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 21919 | 0.000 | 0.3442 | No |
| 63 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 24714 | 0.000 | 0.2688 | No |
| 64 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 25495 | 0.000 | 0.2477 | No |
| 65 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 26698 | 0.000 | 0.2152 | No |
| 66 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 29177 | -0.170 | 0.1502 | No |
| 67 | RNASEL | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] | 29288 | -0.195 | 0.1494 | No |
| 68 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 30450 | -0.479 | 0.1233 | No |
| 69 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 31386 | -0.729 | 0.1062 | No |
| 70 | PTPN6 | protein tyrosine phosphatase non-receptor type 6 [Source:HGNC Symbol;Acc:HGNC:9658] | 31738 | -0.816 | 0.1058 | No |
| 71 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 32152 | -0.963 | 0.1053 | No |
| 72 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 32572 | -1.108 | 0.1063 | No |
| 73 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 33385 | -1.413 | 0.1001 | No |
