Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | SEKI_INFLAMMATORY_RESPONSE_LPS_UP |
| Enrichment Score (ES) | 0.80397785 |
| Normalized Enrichment Score (NES) | 1.9424579 |
| Nominal p-value | 0.0 |
| FDR q-value | 7.310469E-4 |
| FWER p-Value | 0.005 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | LIF | LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] | 25 | 4.883 | 0.0328 | Yes |
| 2 | FOSL1 | FOS like 1, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:13718] | 34 | 4.841 | 0.0657 | Yes |
| 3 | NFKBIZ | NFKB inhibitor zeta [Source:HGNC Symbol;Acc:HGNC:29805] | 45 | 4.752 | 0.0979 | Yes |
| 4 | GBP4 | guanylate binding protein 4 [Source:HGNC Symbol;Acc:HGNC:20480] | 79 | 4.519 | 0.1280 | Yes |
| 5 | RND1 | Rho family GTPase 1 [Source:HGNC Symbol;Acc:HGNC:18314] | 84 | 4.488 | 0.1586 | Yes |
| 6 | MAFF | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] | 89 | 4.452 | 0.1890 | Yes |
| 7 | SLC15A3 | solute carrier family 15 member 3 [Source:HGNC Symbol;Acc:HGNC:18068] | 93 | 4.429 | 0.2192 | Yes |
| 8 | GADD45B | growth arrest and DNA damage inducible beta [Source:HGNC Symbol;Acc:HGNC:4096] | 122 | 4.250 | 0.2476 | Yes |
| 9 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 136 | 4.181 | 0.2758 | Yes |
| 10 | ZC3H12A | zinc finger CCCH-type containing 12A [Source:HGNC Symbol;Acc:HGNC:26259] | 149 | 4.130 | 0.3038 | Yes |
| 11 | CD40 | CD40 molecule [Source:HGNC Symbol;Acc:HGNC:11919] | 153 | 4.122 | 0.3319 | Yes |
| 12 | GBP6 | guanylate binding protein family member 6 [Source:HGNC Symbol;Acc:HGNC:25395] | 188 | 3.930 | 0.3579 | Yes |
| 13 | TNIP1 | TNFAIP3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16903] | 273 | 3.595 | 0.3803 | Yes |
| 14 | IER3 | immediate early response 3 [Source:HGNC Symbol;Acc:HGNC:5392] | 337 | 3.435 | 0.4021 | Yes |
| 15 | NFKBIA | NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797] | 357 | 3.333 | 0.4244 | Yes |
| 16 | REL | REL proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9954] | 368 | 3.297 | 0.4467 | Yes |
| 17 | PLK2 | polo like kinase 2 [Source:HGNC Symbol;Acc:HGNC:19699] | 381 | 3.254 | 0.4686 | Yes |
| 18 | GCH1 | GTP cyclohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:4193] | 390 | 3.237 | 0.4906 | Yes |
| 19 | ZMYND15 | zinc finger MYND-type containing 15 [Source:HGNC Symbol;Acc:HGNC:20997] | 401 | 3.202 | 0.5122 | Yes |
| 20 | SLC4A7 | solute carrier family 4 member 7 [Source:HGNC Symbol;Acc:HGNC:11033] | 444 | 3.132 | 0.5326 | Yes |
| 21 | SH3PXD2B | SH3 and PX domains 2B [Source:HGNC Symbol;Acc:HGNC:29242] | 446 | 3.125 | 0.5539 | Yes |
| 22 | SOD2 | superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180] | 497 | 2.945 | 0.5727 | Yes |
| 23 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 715 | 2.584 | 0.5846 | Yes |
| 24 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 722 | 2.579 | 0.6021 | Yes |
| 25 | SLC11A2 | solute carrier family 11 member 2 [Source:HGNC Symbol;Acc:HGNC:10908] | 738 | 2.545 | 0.6191 | Yes |
| 26 | NFKB2 | nuclear factor kappa B subunit 2 [Source:HGNC Symbol;Acc:HGNC:7795] | 759 | 2.511 | 0.6357 | Yes |
| 27 | STX11 | syntaxin 11 [Source:HGNC Symbol;Acc:HGNC:11429] | 786 | 2.439 | 0.6517 | Yes |
| 28 | TNFAIP3 | TNF alpha induced protein 3 [Source:HGNC Symbol;Acc:HGNC:11896] | 793 | 2.431 | 0.6682 | Yes |
| 29 | EGR3 | early growth response 3 [Source:HGNC Symbol;Acc:HGNC:3240] | 807 | 2.403 | 0.6843 | Yes |
| 30 | TNFAIP2 | TNF alpha induced protein 2 [Source:HGNC Symbol;Acc:HGNC:11895] | 838 | 2.353 | 0.6996 | Yes |
| 31 | EXOC3L4 | exocyst complex component 3 like 4 [Source:HGNC Symbol;Acc:HGNC:20120] | 855 | 2.334 | 0.7152 | Yes |
| 32 | RAB20 | RAB20, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:18260] | 890 | 2.298 | 0.7300 | Yes |
| 33 | RIPK2 | receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] | 1078 | 2.054 | 0.7390 | Yes |
| 34 | JDP2 | Jun dimerization protein 2 [Source:HGNC Symbol;Acc:HGNC:17546] | 1204 | 1.890 | 0.7485 | Yes |
| 35 | FAS | Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] | 1320 | 1.876 | 0.7583 | Yes |
| 36 | PTPRE | protein tyrosine phosphatase receptor type E [Source:HGNC Symbol;Acc:HGNC:9669] | 1502 | 1.710 | 0.7651 | Yes |
| 37 | BTG1 | BTG anti-proliferation factor 1 [Source:HGNC Symbol;Acc:HGNC:1130] | 1703 | 1.554 | 0.7703 | Yes |
| 38 | GSAP | gamma-secretase activating protein [Source:HGNC Symbol;Acc:HGNC:28042] | 1789 | 1.495 | 0.7783 | Yes |
| 39 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 1794 | 1.491 | 0.7884 | Yes |
| 40 | CXCL16 | C-X-C motif chemokine ligand 16 [Source:HGNC Symbol;Acc:HGNC:16642] | 1843 | 1.468 | 0.7971 | Yes |
| 41 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1942 | 1.389 | 0.8040 | Yes |
| 42 | NEURL3 | neuralized E3 ubiquitin protein ligase 3 [Source:HGNC Symbol;Acc:HGNC:25162] | 3180 | 0.851 | 0.7764 | No |
| 43 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 4179 | 0.525 | 0.7530 | No |
| 44 | CEMIP2 | cell migration inducing hyaluronidase 2 [Source:HGNC Symbol;Acc:HGNC:11869] | 4508 | 0.428 | 0.7471 | No |
| 45 | SELE | selectin E [Source:HGNC Symbol;Acc:HGNC:10718] | 7226 | 0.000 | 0.6737 | No |
| 46 | PRRX1 | paired related homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9142] | 8721 | 0.000 | 0.6333 | No |
| 47 | CCRL2 | C-C motif chemokine receptor like 2 [Source:HGNC Symbol;Acc:HGNC:1612] | 8858 | 0.000 | 0.6296 | No |
| 48 | NGFR | nerve growth factor receptor [Source:HGNC Symbol;Acc:HGNC:7809] | 10397 | 0.000 | 0.5881 | No |
| 49 | ICOSLG | inducible T cell costimulator ligand [Source:HGNC Symbol;Acc:HGNC:17087] | 11298 | 0.000 | 0.5638 | No |
| 50 | EREG | epiregulin [Source:HGNC Symbol;Acc:HGNC:3443] | 11617 | 0.000 | 0.5552 | No |
| 51 | VCAM1 | vascular cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:12663] | 13937 | 0.000 | 0.4925 | No |
| 52 | SERPINA3 | serpin family A member 3 [Source:HGNC Symbol;Acc:HGNC:16] | 17848 | 0.000 | 0.3869 | No |
| 53 | LRATD1 | LRAT domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20743] | 18097 | 0.000 | 0.3802 | No |
| 54 | ICAM1 | intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] | 18323 | 0.000 | 0.3741 | No |
| 55 | OSMR | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] | 19090 | 0.000 | 0.3534 | No |
| 56 | CXCL6 | C-X-C motif chemokine ligand 6 [Source:HGNC Symbol;Acc:HGNC:10643] | 19548 | 0.000 | 0.3411 | No |
| 57 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19562 | 0.000 | 0.3407 | No |
| 58 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 19564 | 0.000 | 0.3407 | No |
| 59 | SCHIP1 | schwannomin interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:15678] | 20685 | 0.000 | 0.3104 | No |
| 60 | CASP4 | caspase 4 [Source:HGNC Symbol;Acc:HGNC:1505] | 24216 | 0.000 | 0.2151 | No |
| 61 | ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif 7 [Source:HGNC Symbol;Acc:HGNC:223] | 24798 | 0.000 | 0.1994 | No |
| 62 | TSLP | thymic stromal lymphopoietin [Source:HGNC Symbol;Acc:HGNC:30743] | 27166 | 0.000 | 0.1354 | No |
| 63 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 27201 | 0.000 | 0.1345 | No |
| 64 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 28030 | 0.000 | 0.1121 | No |
| 65 | CCL3 | C-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:10627] | 28037 | 0.000 | 0.1120 | No |
| 66 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 28039 | 0.000 | 0.1119 | No |
| 67 | GPR68 | G protein-coupled receptor 68 [Source:HGNC Symbol;Acc:HGNC:4519] | 29743 | -0.301 | 0.0680 | No |
| 68 | TCIM | transcriptional and immune response regulator [Source:HGNC Symbol;Acc:HGNC:1357] | 30293 | -0.431 | 0.0561 | No |
| 69 | BIRC3 | baculoviral IAP repeat containing 3 [Source:HGNC Symbol;Acc:HGNC:591] | 30579 | -0.507 | 0.0519 | No |
| 70 | NFKBIE | NFKB inhibitor epsilon [Source:HGNC Symbol;Acc:HGNC:7799] | 31535 | -0.768 | 0.0313 | No |
| 71 | BIRC2 | baculoviral IAP repeat containing 2 [Source:HGNC Symbol;Acc:HGNC:590] | 33399 | -1.421 | -0.0093 | No |
| 72 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 33602 | -1.451 | -0.0048 | No |
| 73 | ABCB1 | ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40] | 34154 | -1.690 | -0.0081 | No |
| 74 | EGR2 | early growth response 2 [Source:HGNC Symbol;Acc:HGNC:3239] | 34668 | -1.946 | -0.0087 | No |
| 75 | SLCO4A1 | solute carrier organic anion transporter family member 4A1 [Source:HGNC Symbol;Acc:HGNC:10953] | 35051 | -2.211 | -0.0038 | No |
| 76 | RFX5 | regulatory factor X5 [Source:HGNC Symbol;Acc:HGNC:9986] | 35563 | -2.528 | -0.0003 | No |
| 77 | TJP2 | tight junction protein 2 [Source:HGNC Symbol;Acc:HGNC:11828] | 35583 | -2.548 | 0.0166 | No |
| 78 | BMP2 | bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:HGNC:1069] | 36518 | -3.520 | 0.0155 | No |
