Fig 1: Enrichment plot: GNF2_TTK
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | GNF2_TTK |
| Enrichment Score (ES) | -0.84343547 |
| Normalized Enrichment Score (NES) | -1.596903 |
| Nominal p-value | 0.0014025245 |
| FDR q-value | 0.008141085 |
| FWER p-Value | 0.156 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | CKS2 | CDC28 protein kinase regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:2000] | 2837 | 0.990 | -0.0622 | No |
| 2 | CCT2 | chaperonin containing TCP1 subunit 2 [Source:HGNC Symbol;Acc:HGNC:1615] | 4858 | 0.327 | -0.1120 | No |
| 3 | ZWINT | ZW10 interacting kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13195] | 23551 | 0.000 | -0.6165 | No |
| 4 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 28955 | -0.111 | -0.7607 | No |
| 5 | TYMS | thymidylate synthetase [Source:HGNC Symbol;Acc:HGNC:12441] | 32001 | -0.913 | -0.8296 | Yes |
| 6 | FEN1 | flap structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:HGNC:3650] | 32513 | -1.089 | -0.8276 | Yes |
| 7 | CENPU | centromere protein U [Source:HGNC Symbol;Acc:HGNC:21348] | 32530 | -1.094 | -0.8122 | Yes |
| 8 | TPX2 | TPX2 microtubule nucleation factor [Source:HGNC Symbol;Acc:HGNC:1249] | 32541 | -1.098 | -0.7966 | Yes |
| 9 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 32582 | -1.110 | -0.7816 | Yes |
| 10 | HJURP | Holliday junction recognition protein [Source:HGNC Symbol;Acc:HGNC:25444] | 33207 | -1.335 | -0.7790 | Yes |
| 11 | FANCI | FA complementation group I [Source:HGNC Symbol;Acc:HGNC:25568] | 33326 | -1.384 | -0.7622 | Yes |
| 12 | GINS2 | GINS complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:24575] | 33419 | -1.430 | -0.7439 | Yes |
| 13 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 33442 | -1.442 | -0.7236 | Yes |
| 14 | DBF4 | DBF4 zinc finger [Source:HGNC Symbol;Acc:HGNC:17364] | 33637 | -1.452 | -0.7078 | Yes |
| 15 | CDC20 | cell division cycle 20 [Source:HGNC Symbol;Acc:HGNC:1723] | 33722 | -1.484 | -0.6885 | Yes |
| 16 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 33797 | -1.517 | -0.6685 | Yes |
| 17 | PLK4 | polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397] | 34155 | -1.691 | -0.6536 | Yes |
| 18 | KIF18B | kinesin family member 18B [Source:HGNC Symbol;Acc:HGNC:27102] | 34182 | -1.707 | -0.6296 | Yes |
| 19 | KIF2C | kinesin family member 2C [Source:HGNC Symbol;Acc:HGNC:6393] | 34210 | -1.718 | -0.6054 | Yes |
| 20 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 34487 | -1.852 | -0.5860 | Yes |
| 21 | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149] | 34488 | -1.854 | -0.5591 | Yes |
| 22 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 34662 | -1.944 | -0.5356 | Yes |
| 23 | HMMR | hyaluronan mediated motility receptor [Source:HGNC Symbol;Acc:HGNC:5012] | 34669 | -1.947 | -0.5075 | Yes |
| 24 | KIF11 | kinesin family member 11 [Source:HGNC Symbol;Acc:HGNC:6388] | 34689 | -1.957 | -0.4797 | Yes |
| 25 | RRM1 | ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451] | 34774 | -2.027 | -0.4526 | Yes |
| 26 | PRC1 | protein regulator of cytokinesis 1 [Source:HGNC Symbol;Acc:HGNC:9341] | 34782 | -2.033 | -0.4233 | Yes |
| 27 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 34879 | -2.099 | -0.3954 | Yes |
| 28 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 34919 | -2.126 | -0.3657 | Yes |
| 29 | NUSAP1 | nucleolar and spindle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18538] | 35078 | -2.229 | -0.3376 | Yes |
| 30 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 35185 | -2.308 | -0.3070 | Yes |
| 31 | FOXM1 | forkhead box M1 [Source:HGNC Symbol;Acc:HGNC:3818] | 35329 | -2.329 | -0.2771 | Yes |
| 32 | MELK | maternal embryonic leucine zipper kinase [Source:HGNC Symbol;Acc:HGNC:16870] | 35444 | -2.426 | -0.2450 | Yes |
| 33 | MCM2 | minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] | 35567 | -2.531 | -0.2116 | Yes |
| 34 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 35581 | -2.547 | -0.1750 | Yes |
| 35 | ASPM | assembly factor for spindle microtubules [Source:HGNC Symbol;Acc:HGNC:19048] | 35708 | -2.647 | -0.1400 | Yes |
| 36 | RACGAP1 | Rac GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:9804] | 35725 | -2.658 | -0.1019 | Yes |
| 37 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 35850 | -2.788 | -0.0649 | Yes |
| 38 | CENPF | centromere protein F [Source:HGNC Symbol;Acc:HGNC:1857] | 35994 | -2.919 | -0.0264 | Yes |
| 39 | GMNN | geminin DNA replication inhibitor [Source:HGNC Symbol;Acc:HGNC:17493] | 36724 | -3.858 | 0.0099 | Yes |
