Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | GOCC_LYSOSOMAL_LUMEN |
| Enrichment Score (ES) | -0.75529313 |
| Normalized Enrichment Score (NES) | -1.5915883 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.13011573 |
| FWER p-Value | 0.916 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | PLD3 | phospholipase D family member 3 [Source:HGNC Symbol;Acc:HGNC:17158] | 1678 | 1.573 | -0.0311 | No |
| 2 | HSP90AA1 | heat shock protein 90 alpha family class A member 1 [Source:HGNC Symbol;Acc:HGNC:5253] | 2743 | 1.028 | -0.0505 | No |
| 3 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 3067 | 0.898 | -0.0511 | No |
| 4 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 3712 | 0.671 | -0.0624 | No |
| 5 | CTSD | cathepsin D [Source:HGNC Symbol;Acc:HGNC:2529] | 3719 | 0.666 | -0.0565 | No |
| 6 | AGRN | agrin [Source:HGNC Symbol;Acc:HGNC:329] | 4038 | 0.570 | -0.0599 | No |
| 7 | GUSB | glucuronidase beta [Source:HGNC Symbol;Acc:HGNC:4696] | 4223 | 0.512 | -0.0602 | No |
| 8 | SDC4 | syndecan 4 [Source:HGNC Symbol;Acc:HGNC:10661] | 4670 | 0.381 | -0.0688 | No |
| 9 | CSPG4 | chondroitin sulfate proteoglycan 4 [Source:HGNC Symbol;Acc:HGNC:2466] | 5987 | 0.104 | -0.1035 | No |
| 10 | ACP2 | acid phosphatase 2, lysosomal [Source:HGNC Symbol;Acc:HGNC:123] | 6041 | 0.087 | -0.1041 | No |
| 11 | EPDR1 | ependymin related 1 [Source:HGNC Symbol;Acc:HGNC:17572] | 6567 | 0.000 | -0.1183 | No |
| 12 | RNASET2 | ribonuclease T2 [Source:HGNC Symbol;Acc:HGNC:21686] | 6804 | 0.000 | -0.1247 | No |
| 13 | SDC2 | syndecan 2 [Source:HGNC Symbol;Acc:HGNC:10659] | 6877 | 0.000 | -0.1266 | No |
| 14 | APOB | apolipoprotein B [Source:HGNC Symbol;Acc:HGNC:603] | 6883 | 0.000 | -0.1268 | No |
| 15 | NEU4 | neuraminidase 4 [Source:HGNC Symbol;Acc:HGNC:21328] | 9916 | 0.000 | -0.2087 | No |
| 16 | HSPG2 | heparan sulfate proteoglycan 2 [Source:HGNC Symbol;Acc:HGNC:5273] | 10381 | 0.000 | -0.2212 | No |
| 17 | ACAN | aggrecan [Source:HGNC Symbol;Acc:HGNC:319] | 10899 | 0.000 | -0.2352 | No |
| 18 | IFI30 | IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398] | 11610 | 0.000 | -0.2544 | No |
| 19 | CBLIF | cobalamin binding intrinsic factor [Source:HGNC Symbol;Acc:HGNC:4268] | 13446 | 0.000 | -0.3040 | No |
| 20 | BGN | biglycan [Source:HGNC Symbol;Acc:HGNC:1044] | 15529 | 0.000 | -0.3603 | No |
| 21 | BCAN | brevican [Source:HGNC Symbol;Acc:HGNC:23059] | 15753 | 0.000 | -0.3663 | No |
| 22 | DCN | decorin [Source:HGNC Symbol;Acc:HGNC:2705] | 16022 | 0.000 | -0.3736 | No |
| 23 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16176 | 0.000 | -0.3777 | No |
| 24 | KERA | keratocan [Source:HGNC Symbol;Acc:HGNC:6309] | 18531 | 0.000 | -0.4413 | No |
| 25 | LUM | lumican [Source:HGNC Symbol;Acc:HGNC:6724] | 18842 | 0.000 | -0.4497 | No |
| 26 | OGN | osteoglycin [Source:HGNC Symbol;Acc:HGNC:8126] | 19784 | 0.000 | -0.4751 | No |
| 27 | OMD | osteomodulin [Source:HGNC Symbol;Acc:HGNC:8134] | 19854 | 0.000 | -0.4770 | No |
| 28 | PRELP | proline and arginine rich end leucine rich repeat protein [Source:HGNC Symbol;Acc:HGNC:9357] | 21140 | 0.000 | -0.5117 | No |
| 29 | SPACA7 | sperm acrosome associated 7 [Source:HGNC Symbol;Acc:HGNC:29575] | 21356 | 0.000 | -0.5175 | No |
| 30 | CTSL | cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537] | 22264 | 0.000 | -0.5421 | No |
| 31 | CUBN | cubilin [Source:HGNC Symbol;Acc:HGNC:2548] | 22397 | 0.000 | -0.5456 | No |
| 32 | HPSE | heparanase [Source:HGNC Symbol;Acc:HGNC:5164] | 23817 | 0.000 | -0.5840 | No |
| 33 | FMOD | fibromodulin [Source:HGNC Symbol;Acc:HGNC:3774] | 24606 | 0.000 | -0.6053 | No |
| 34 | FASLG | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] | 25034 | 0.000 | -0.6168 | No |
| 35 | NCAN | neurocan [Source:HGNC Symbol;Acc:HGNC:2465] | 27878 | 0.000 | -0.6937 | No |
| 36 | SERPINB13 | serpin family B member 13 [Source:HGNC Symbol;Acc:HGNC:8944] | 27907 | 0.000 | -0.6944 | No |
| 37 | CD1E | CD1e molecule [Source:HGNC Symbol;Acc:HGNC:1638] | 28092 | 0.000 | -0.6994 | No |
| 38 | GPC3 | glypican 3 [Source:HGNC Symbol;Acc:HGNC:4451] | 28191 | 0.000 | -0.7020 | No |
| 39 | GPC2 | glypican 2 [Source:HGNC Symbol;Acc:HGNC:4450] | 28193 | 0.000 | -0.7021 | No |
| 40 | GPC5 | glypican 5 [Source:HGNC Symbol;Acc:HGNC:4453] | 28195 | 0.000 | -0.7021 | No |
| 41 | GPC4 | glypican 4 [Source:HGNC Symbol;Acc:HGNC:4452] | 28197 | 0.000 | -0.7021 | No |
| 42 | GPC6 | glypican 6 [Source:HGNC Symbol;Acc:HGNC:4454] | 28199 | 0.000 | -0.7022 | No |
| 43 | CHID1 | chitinase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28474] | 29362 | -0.213 | -0.7316 | No |
| 44 | NPC2 | NPC intracellular cholesterol transporter 2 [Source:HGNC Symbol;Acc:HGNC:14537] | 29490 | -0.239 | -0.7329 | No |
| 45 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 29960 | -0.344 | -0.7424 | No |
| 46 | PDGFRB | platelet derived growth factor receptor beta [Source:HGNC Symbol;Acc:HGNC:8804] | 30141 | -0.392 | -0.7437 | No |
| 47 | GBA | glucosylceramidase beta [Source:HGNC Symbol;Acc:HGNC:4177] | 30331 | -0.441 | -0.7449 | No |
| 48 | SMPD1 | sphingomyelin phosphodiesterase 1 [Source:HGNC Symbol;Acc:HGNC:11120] | 30387 | -0.458 | -0.7422 | No |
| 49 | PPT2 | palmitoyl-protein thioesterase 2 [Source:HGNC Symbol;Acc:HGNC:9326] | 30554 | -0.498 | -0.7421 | No |
| 50 | ASAH1 | N-acylsphingosine amidohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:735] | 30898 | -0.590 | -0.7461 | No |
| 51 | GALNS | galactosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4122] | 30926 | -0.596 | -0.7414 | No |
| 52 | PLBD2 | phospholipase B domain containing 2 [Source:HGNC Symbol;Acc:HGNC:27283] | 31442 | -0.746 | -0.7485 | Yes |
| 53 | TXNDC5 | thioredoxin domain containing 5 [Source:HGNC Symbol;Acc:HGNC:21073] | 31657 | -0.785 | -0.7472 | Yes |
| 54 | CTSS | cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545] | 31759 | -0.823 | -0.7424 | Yes |
| 55 | GNS | glucosamine (N-acetyl)-6-sulfatase [Source:HGNC Symbol;Acc:HGNC:4422] | 31789 | -0.834 | -0.7356 | Yes |
| 56 | GPC1 | glypican 1 [Source:HGNC Symbol;Acc:HGNC:4449] | 31932 | -0.890 | -0.7314 | Yes |
| 57 | HSPA8 | heat shock protein family A (Hsp70) member 8 [Source:HGNC Symbol;Acc:HGNC:5241] | 32047 | -0.925 | -0.7261 | Yes |
| 58 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 32136 | -0.956 | -0.7198 | Yes |
| 59 | MANBA | mannosidase beta [Source:HGNC Symbol;Acc:HGNC:6831] | 32436 | -1.059 | -0.7182 | Yes |
| 60 | GLA | galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] | 33275 | -1.365 | -0.7285 | Yes |
| 61 | MAN2B2 | mannosidase alpha class 2B member 2 [Source:HGNC Symbol;Acc:HGNC:29623] | 33629 | -1.451 | -0.7248 | Yes |
| 62 | SDC1 | syndecan 1 [Source:HGNC Symbol;Acc:HGNC:10658] | 33793 | -1.515 | -0.7155 | Yes |
| 63 | NEU1 | neuraminidase 1 [Source:HGNC Symbol;Acc:HGNC:7758] | 33821 | -1.528 | -0.7023 | Yes |
| 64 | LIPA | lipase A, lysosomal acid type [Source:HGNC Symbol;Acc:HGNC:6617] | 33918 | -1.573 | -0.6907 | Yes |
| 65 | CD74 | CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] | 34181 | -1.707 | -0.6822 | Yes |
| 66 | GAA | glucosidase alpha, acid [Source:HGNC Symbol;Acc:HGNC:4065] | 34225 | -1.730 | -0.6677 | Yes |
| 67 | CTSA | cathepsin A [Source:HGNC Symbol;Acc:HGNC:9251] | 34731 | -1.992 | -0.6632 | Yes |
| 68 | PPT1 | palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325] | 34732 | -1.993 | -0.6451 | Yes |
| 69 | GALC | galactosylceramidase [Source:HGNC Symbol;Acc:HGNC:4115] | 34886 | -2.103 | -0.6302 | Yes |
| 70 | VCAN | versican [Source:HGNC Symbol;Acc:HGNC:2464] | 34958 | -2.145 | -0.6126 | Yes |
| 71 | HEXA | hexosaminidase subunit alpha [Source:HGNC Symbol;Acc:HGNC:4878] | 34980 | -2.161 | -0.5936 | Yes |
| 72 | FUCA1 | alpha-L-fucosidase 1 [Source:HGNC Symbol;Acc:HGNC:4006] | 35070 | -2.222 | -0.5758 | Yes |
| 73 | IDUA | alpha-L-iduronidase [Source:HGNC Symbol;Acc:HGNC:5391] | 35146 | -2.280 | -0.5571 | Yes |
| 74 | CSPG5 | chondroitin sulfate proteoglycan 5 [Source:HGNC Symbol;Acc:HGNC:2467] | 35194 | -2.312 | -0.5374 | Yes |
| 75 | TPP1 | tripeptidyl peptidase 1 [Source:HGNC Symbol;Acc:HGNC:2073] | 35347 | -2.343 | -0.5202 | Yes |
| 76 | TCN2 | transcobalamin 2 [Source:HGNC Symbol;Acc:HGNC:11653] | 35429 | -2.416 | -0.5005 | Yes |
| 77 | SCARB2 | scavenger receptor class B member 2 [Source:HGNC Symbol;Acc:HGNC:1665] | 35625 | -2.586 | -0.4823 | Yes |
| 78 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 35698 | -2.637 | -0.4603 | Yes |
| 79 | IDS | iduronate 2-sulfatase [Source:HGNC Symbol;Acc:HGNC:5389] | 35714 | -2.654 | -0.4366 | Yes |
| 80 | MAN2B1 | mannosidase alpha class 2B member 1 [Source:HGNC Symbol;Acc:HGNC:6826] | 35769 | -2.703 | -0.4135 | Yes |
| 81 | ARSB | arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] | 35777 | -2.711 | -0.3891 | Yes |
| 82 | GLB1 | galactosidase beta 1 [Source:HGNC Symbol;Acc:HGNC:4298] | 35857 | -2.789 | -0.3659 | Yes |
| 83 | CTSF | cathepsin F [Source:HGNC Symbol;Acc:HGNC:2531] | 35934 | -2.848 | -0.3420 | Yes |
| 84 | SDC3 | syndecan 3 [Source:HGNC Symbol;Acc:HGNC:10660] | 36087 | -3.014 | -0.3188 | Yes |
| 85 | PSAP | prosaposin [Source:HGNC Symbol;Acc:HGNC:9498] | 36108 | -3.050 | -0.2916 | Yes |
| 86 | NAGLU | N-acetyl-alpha-glucosaminidase [Source:HGNC Symbol;Acc:HGNC:7632] | 36176 | -3.139 | -0.2649 | Yes |
| 87 | ATP13A2 | ATPase cation transporting 13A2 [Source:HGNC Symbol;Acc:HGNC:30213] | 36364 | -3.337 | -0.2397 | Yes |
| 88 | ARSA | arylsulfatase A [Source:HGNC Symbol;Acc:HGNC:713] | 36443 | -3.442 | -0.2105 | Yes |
| 89 | HEXB | hexosaminidase subunit beta [Source:HGNC Symbol;Acc:HGNC:4879] | 36616 | -3.660 | -0.1819 | Yes |
| 90 | SGSH | N-sulfoglucosamine sulfohydrolase [Source:HGNC Symbol;Acc:HGNC:10818] | 36726 | -3.861 | -0.1498 | Yes |
| 91 | GYG1 | glycogenin 1 [Source:HGNC Symbol;Acc:HGNC:4699] | 36791 | -3.983 | -0.1154 | Yes |
| 92 | NAAA | N-acylethanolamine acid amidase [Source:HGNC Symbol;Acc:HGNC:736] | 36873 | -4.160 | -0.0798 | Yes |
| 93 | GM2A | GM2 ganglioside activator [Source:HGNC Symbol;Acc:HGNC:4367] | 37004 | -4.580 | -0.0417 | Yes |
| 94 | HYAL1 | hyaluronidase 1 [Source:HGNC Symbol;Acc:HGNC:5320] | 37061 | -4.847 | 0.0008 | Yes |
