Fig 1: Enrichment plot: GOMF_SEROTONIN_RECEPTOR_ACTIVITY
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | GOMF_SEROTONIN_RECEPTOR_ACTIVITY |
| Enrichment Score (ES) | -0.8800717 |
| Normalized Enrichment Score (NES) | -1.6137499 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.08282946 |
| FWER p-Value | 0.698 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | OR6T1 | olfactory receptor family 6 subfamily T member 1 [Source:HGNC Symbol;Acc:HGNC:14848] | 14463 | 0.000 | -0.3903 | No |
| 2 | OR5T3 | olfactory receptor family 5 subfamily T member 3 [Source:HGNC Symbol;Acc:HGNC:15297] | 14940 | 0.000 | -0.4031 | No |
| 3 | OR5T2 | olfactory receptor family 5 subfamily T member 2 [Source:HGNC Symbol;Acc:HGNC:15296] | 14942 | 0.000 | -0.4032 | No |
| 4 | HTR4 | 5-hydroxytryptamine receptor 4 [Source:HGNC Symbol;Acc:HGNC:5299] | 15502 | 0.000 | -0.4182 | No |
| 5 | HTR6 | 5-hydroxytryptamine receptor 6 [Source:HGNC Symbol;Acc:HGNC:5301] | 15504 | 0.000 | -0.4183 | No |
| 6 | HTR7 | 5-hydroxytryptamine receptor 7 [Source:HGNC Symbol;Acc:HGNC:5302] | 15505 | 0.000 | -0.4183 | No |
| 7 | HTR1E | 5-hydroxytryptamine receptor 1E [Source:HGNC Symbol;Acc:HGNC:5291] | 15570 | 0.000 | -0.4200 | No |
| 8 | HTR1F | 5-hydroxytryptamine receptor 1F [Source:HGNC Symbol;Acc:HGNC:5292] | 15572 | 0.000 | -0.4200 | No |
| 9 | HTR1D | 5-hydroxytryptamine receptor 1D [Source:HGNC Symbol;Acc:HGNC:5289] | 15573 | 0.000 | -0.4200 | No |
| 10 | HTR1A | 5-hydroxytryptamine receptor 1A [Source:HGNC Symbol;Acc:HGNC:5286] | 15574 | 0.000 | -0.4200 | No |
| 11 | HTR2B | 5-hydroxytryptamine receptor 2B [Source:HGNC Symbol;Acc:HGNC:5294] | 15581 | 0.000 | -0.4202 | No |
| 12 | HTR2C | 5-hydroxytryptamine receptor 2C [Source:HGNC Symbol;Acc:HGNC:5295] | 15582 | 0.000 | -0.4202 | No |
| 13 | HTR2A | 5-hydroxytryptamine receptor 2A [Source:HGNC Symbol;Acc:HGNC:5293] | 15583 | 0.000 | -0.4202 | No |
| 14 | HTR5A | 5-hydroxytryptamine receptor 5A [Source:HGNC Symbol;Acc:HGNC:5300] | 15602 | 0.000 | -0.4207 | No |
| 15 | CHRM2 | cholinergic receptor muscarinic 2 [Source:HGNC Symbol;Acc:HGNC:1951] | 17889 | 0.000 | -0.4824 | No |
| 16 | CHRM3 | cholinergic receptor muscarinic 3 [Source:HGNC Symbol;Acc:HGNC:1952] | 17891 | 0.000 | -0.4824 | No |
| 17 | CHRM1 | cholinergic receptor muscarinic 1 [Source:HGNC Symbol;Acc:HGNC:1950] | 17892 | 0.000 | -0.4824 | No |
| 18 | CHRM5 | cholinergic receptor muscarinic 5 [Source:HGNC Symbol;Acc:HGNC:1954] | 17893 | 0.000 | -0.4824 | No |
| 19 | DRD4 | dopamine receptor D4 [Source:HGNC Symbol;Acc:HGNC:3025] | 18552 | 0.000 | -0.5001 | No |
| 20 | OR10J5 | olfactory receptor family 10 subfamily J member 5 [Source:HGNC Symbol;Acc:HGNC:14993] | 23127 | 0.000 | -0.6236 | No |
| 21 | OR10H1 | olfactory receptor family 10 subfamily H member 1 [Source:HGNC Symbol;Acc:HGNC:8172] | 23153 | 0.000 | -0.6243 | No |
| 22 | OR10H3 | olfactory receptor family 10 subfamily H member 3 [Source:HGNC Symbol;Acc:HGNC:8174] | 23154 | 0.000 | -0.6243 | No |
| 23 | OR10H2 | olfactory receptor family 10 subfamily H member 2 [Source:HGNC Symbol;Acc:HGNC:8173] | 23155 | 0.000 | -0.6243 | No |
| 24 | OR10H5 | olfactory receptor family 10 subfamily H member 5 [Source:HGNC Symbol;Acc:HGNC:15389] | 23156 | 0.000 | -0.6243 | No |
| 25 | OR10H4 | olfactory receptor family 10 subfamily H member 4 [Source:HGNC Symbol;Acc:HGNC:15388] | 23157 | 0.000 | -0.6243 | No |
| 26 | OR11H4 | olfactory receptor family 11 subfamily H member 4 [Source:HGNC Symbol;Acc:HGNC:15347] | 23390 | 0.000 | -0.6305 | No |
| 27 | OR11H7 | olfactory receptor family 11 subfamily H member 7 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:15350] | 23399 | 0.000 | -0.6307 | No |
| 28 | HRH1 | histamine receptor H1 [Source:HGNC Symbol;Acc:HGNC:5182] | 24200 | 0.000 | -0.6523 | No |
| 29 | HRH3 | histamine receptor H3 [Source:HGNC Symbol;Acc:HGNC:5184] | 24203 | 0.000 | -0.6524 | No |
| 30 | HRH2 | histamine receptor H2 [Source:HGNC Symbol;Acc:HGNC:5183] | 24205 | 0.000 | -0.6524 | No |
| 31 | HRH4 | histamine receptor H4 [Source:HGNC Symbol;Acc:HGNC:17383] | 24208 | 0.000 | -0.6525 | No |
| 32 | OR10J6P | olfactory receptor family 10 subfamily J member 6 pseudogene [Source:HGNC Symbol;Acc:HGNC:14994] | 24525 | 0.000 | -0.6610 | No |
| 33 | CHRM4 | cholinergic receptor muscarinic 4 [Source:HGNC Symbol;Acc:HGNC:1953] | 30691 | -0.534 | -0.7133 | Yes |
| 34 | HTR1B | 5-hydroxytryptamine receptor 1B [Source:HGNC Symbol;Acc:HGNC:5287] | 36871 | -4.151 | 0.0059 | Yes |
