Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.6807006 |
| Normalized Enrichment Score (NES) | -1.4466957 |
| Nominal p-value | 0.004672897 |
| FDR q-value | 0.049703952 |
| FWER p-Value | 0.13 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 148 | 4.135 | 0.0252 | No |
| 2 | ATXN1 | ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] | 313 | 3.487 | 0.0454 | No |
| 3 | AQP9 | aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] | 521 | 2.887 | 0.0602 | No |
| 4 | HAO1 | hydroxyacid oxidase 1 [Source:HGNC Symbol;Acc:HGNC:4809] | 698 | 2.607 | 0.0739 | No |
| 5 | BCAR3 | BCAR3 adaptor protein, NSP family member [Source:HGNC Symbol;Acc:HGNC:973] | 953 | 2.212 | 0.0826 | No |
| 6 | GCLM | glutamate-cysteine ligase modifier subunit [Source:HGNC Symbol;Acc:HGNC:4312] | 1359 | 1.862 | 0.0848 | No |
| 7 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 1748 | 1.521 | 0.0851 | No |
| 8 | PEX12 | peroxisomal biogenesis factor 12 [Source:HGNC Symbol;Acc:HGNC:8854] | 2258 | 1.227 | 0.0800 | No |
| 9 | TFCP2L1 | transcription factor CP2 like 1 [Source:HGNC Symbol;Acc:HGNC:17925] | 2296 | 1.225 | 0.0877 | No |
| 10 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 2908 | 0.955 | 0.0779 | No |
| 11 | CH25H | cholesterol 25-hydroxylase [Source:HGNC Symbol;Acc:HGNC:1907] | 2973 | 0.939 | 0.0828 | No |
| 12 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 3684 | 0.681 | 0.0684 | No |
| 13 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 4257 | 0.500 | 0.0565 | No |
| 14 | PEX11A | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] | 4807 | 0.343 | 0.0440 | No |
| 15 | PECR | peroxisomal trans-2-enoyl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:18281] | 5371 | 0.239 | 0.0305 | No |
| 16 | SOAT2 | sterol O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:11178] | 5540 | 0.239 | 0.0276 | No |
| 17 | PEX19 | peroxisomal biogenesis factor 19 [Source:HGNC Symbol;Acc:HGNC:9713] | 5754 | 0.173 | 0.0231 | No |
| 18 | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 8025 | 0.000 | -0.0383 | No |
| 19 | ALDH8A1 | aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471] | 8736 | 0.000 | -0.0575 | No |
| 20 | GSTK1 | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] | 9690 | 0.000 | -0.0833 | No |
| 21 | SLC23A1 | solute carrier family 23 member 1 [Source:HGNC Symbol;Acc:HGNC:10974] | 9892 | 0.000 | -0.0887 | No |
| 22 | NEDD4 | NEDD4 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727] | 10541 | 0.000 | -0.1062 | No |
| 23 | SLC27A2 | solute carrier family 27 member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 11001 | 0.000 | -0.1186 | No |
| 24 | SLC27A5 | solute carrier family 27 member 5 [Source:HGNC Symbol;Acc:HGNC:10999] | 11002 | 0.000 | -0.1186 | No |
| 25 | AKR1D1 | aldo-keto reductase family 1 member D1 [Source:HGNC Symbol;Acc:HGNC:388] | 11660 | 0.000 | -0.1364 | No |
| 26 | AGXT | alanine--glyoxylate and serine--pyruvate aminotransferase [Source:HGNC Symbol;Acc:HGNC:341] | 12299 | 0.000 | -0.1536 | No |
| 27 | CYP39A1 | cytochrome P450 family 39 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:17449] | 12454 | 0.000 | -0.1578 | No |
| 28 | HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5217] | 12592 | 0.000 | -0.1615 | No |
| 29 | TTR | transthyretin [Source:HGNC Symbol;Acc:HGNC:12405] | 12716 | 0.000 | -0.1648 | No |
| 30 | RBP1 | retinol binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9919] | 12878 | 0.000 | -0.1692 | No |
| 31 | DIO1 | iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883] | 15815 | 0.000 | -0.2486 | No |
| 32 | DIO2 | iodothyronine deiodinase 2 [Source:HGNC Symbol;Acc:HGNC:2884] | 15816 | 0.000 | -0.2486 | No |
| 33 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16176 | 0.000 | -0.2583 | No |
| 34 | SERPINA6 | serpin family A member 6 [Source:HGNC Symbol;Acc:HGNC:1540] | 17854 | 0.000 | -0.3036 | No |
| 35 | OPTN | optineurin [Source:HGNC Symbol;Acc:HGNC:17142] | 18103 | 0.000 | -0.3104 | No |
| 36 | BMP6 | bone morphogenetic protein 6 [Source:HGNC Symbol;Acc:HGNC:1073] | 19166 | 0.000 | -0.3391 | No |
| 37 | HSD17B6 | hydroxysteroid 17-beta dehydrogenase 6 [Source:HGNC Symbol;Acc:HGNC:23316] | 19885 | 0.000 | -0.3585 | No |
| 38 | NR1I2 | nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] | 20072 | 0.000 | -0.3635 | No |
| 39 | NR1H4 | nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967] | 20098 | 0.000 | -0.3642 | No |
| 40 | SULT2B1 | sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] | 20900 | 0.000 | -0.3859 | No |
| 41 | SULT1B1 | sulfotransferase family 1B member 1 [Source:HGNC Symbol;Acc:HGNC:17845] | 21214 | 0.000 | -0.3943 | No |
| 42 | PIPOX | pipecolic acid and sarcosine oxidase [Source:HGNC Symbol;Acc:HGNC:17804] | 22140 | 0.000 | -0.4193 | No |
| 43 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] | 23042 | 0.000 | -0.4437 | No |
| 44 | CYP46A1 | cytochrome P450 family 46 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2641] | 23294 | 0.000 | -0.4505 | No |
| 45 | ABCA6 | ATP binding cassette subfamily A member 6 [Source:HGNC Symbol;Acc:HGNC:36] | 24262 | 0.000 | -0.4766 | No |
| 46 | ABCA4 | ATP binding cassette subfamily A member 4 [Source:HGNC Symbol;Acc:HGNC:34] | 24265 | 0.000 | -0.4767 | No |
| 47 | ABCA9 | ATP binding cassette subfamily A member 9 [Source:HGNC Symbol;Acc:HGNC:39] | 24266 | 0.000 | -0.4767 | No |
| 48 | ABCA8 | ATP binding cassette subfamily A member 8 [Source:HGNC Symbol;Acc:HGNC:38] | 24267 | 0.000 | -0.4767 | No |
| 49 | SLCO1A2 | solute carrier organic anion transporter family member 1A2 [Source:HGNC Symbol;Acc:HGNC:10956] | 24316 | 0.000 | -0.4780 | No |
| 50 | KLF1 | Kruppel like factor 1 [Source:HGNC Symbol;Acc:HGNC:6345] | 25433 | 0.000 | -0.5082 | No |
| 51 | BBOX1 | gamma-butyrobetaine hydroxylase 1 [Source:HGNC Symbol;Acc:HGNC:964] | 25722 | 0.000 | -0.5160 | No |
| 52 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2653] | 25788 | 0.000 | -0.5177 | No |
| 53 | CYP7B1 | cytochrome P450 family 7 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2652] | 26117 | 0.000 | -0.5266 | No |
| 54 | CYP7A1 | cytochrome P450 family 7 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2651] | 26140 | 0.000 | -0.5272 | No |
| 55 | GNMT | glycine N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4415] | 27561 | 0.000 | -0.5656 | No |
| 56 | ABCG8 | ATP binding cassette subfamily G member 8 [Source:HGNC Symbol;Acc:HGNC:13887] | 28473 | 0.000 | -0.5902 | No |
| 57 | LIPE | lipase E, hormone sensitive type [Source:HGNC Symbol;Acc:HGNC:6621] | 28688 | -0.044 | -0.5957 | No |
| 58 | PEX13 | peroxisomal biogenesis factor 13 [Source:HGNC Symbol;Acc:HGNC:8855] | 28893 | -0.095 | -0.6005 | No |
| 59 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 29201 | -0.176 | -0.6076 | No |
| 60 | PNPLA8 | patatin like phospholipase domain containing 8 [Source:HGNC Symbol;Acc:HGNC:28900] | 29423 | -0.221 | -0.6120 | No |
| 61 | AR | androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] | 29880 | -0.328 | -0.6220 | No |
| 62 | PEX6 | peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:HGNC:8859] | 30314 | -0.436 | -0.6306 | No |
| 63 | ISOC1 | isochorismatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24254] | 30351 | -0.448 | -0.6285 | No |
| 64 | RXRG | retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] | 30479 | -0.479 | -0.6285 | No |
| 65 | PHYH | phytanoyl-CoA 2-hydroxylase [Source:HGNC Symbol;Acc:HGNC:8940] | 32410 | -1.048 | -0.6733 | Yes |
| 66 | PEX7 | peroxisomal biogenesis factor 7 [Source:HGNC Symbol;Acc:HGNC:8860] | 32516 | -1.090 | -0.6684 | Yes |
| 67 | SLC23A2 | solute carrier family 23 member 2 [Source:HGNC Symbol;Acc:HGNC:10973] | 32756 | -1.167 | -0.6667 | Yes |
| 68 | ACSL5 | acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526] | 32809 | -1.185 | -0.6597 | Yes |
| 69 | NR0B2 | nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961] | 32935 | -1.234 | -0.6543 | Yes |
| 70 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 33434 | -1.438 | -0.6577 | Yes |
| 71 | AMACR | alpha-methylacyl-CoA racemase [Source:HGNC Symbol;Acc:HGNC:451] | 33438 | -1.440 | -0.6476 | Yes |
| 72 | LONP2 | lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] | 33655 | -1.459 | -0.6431 | Yes |
| 73 | FDXR | ferredoxin reductase [Source:HGNC Symbol;Acc:HGNC:3642] | 33816 | -1.525 | -0.6366 | Yes |
| 74 | PEX16 | peroxisomal biogenesis factor 16 [Source:HGNC Symbol;Acc:HGNC:8857] | 34011 | -1.623 | -0.6304 | Yes |
| 75 | NPC1 | NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897] | 34065 | -1.648 | -0.6202 | Yes |
| 76 | RETSAT | retinol saturase [Source:HGNC Symbol;Acc:HGNC:25991] | 34084 | -1.659 | -0.6090 | Yes |
| 77 | PXMP2 | peroxisomal membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:9716] | 34127 | -1.674 | -0.5983 | Yes |
| 78 | ABCD3 | ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] | 34258 | -1.746 | -0.5895 | Yes |
| 79 | PEX11G | peroxisomal biogenesis factor 11 gamma [Source:HGNC Symbol;Acc:HGNC:20208] | 34306 | -1.765 | -0.5783 | Yes |
| 80 | RXRA | retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] | 34454 | -1.834 | -0.5693 | Yes |
| 81 | MLYCD | malonyl-CoA decarboxylase [Source:HGNC Symbol;Acc:HGNC:7150] | 34614 | -1.931 | -0.5599 | Yes |
| 82 | SLC22A18 | solute carrier family 22 member 18 [Source:HGNC Symbol;Acc:HGNC:10964] | 34716 | -1.979 | -0.5487 | Yes |
| 83 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 34748 | -2.002 | -0.5354 | Yes |
| 84 | PEX1 | peroxisomal biogenesis factor 1 [Source:HGNC Symbol;Acc:HGNC:8850] | 34920 | -2.126 | -0.5250 | Yes |
| 85 | GNPAT | glyceronephosphate O-acyltransferase [Source:HGNC Symbol;Acc:HGNC:4416] | 34950 | -2.142 | -0.5106 | Yes |
| 86 | ABCA5 | ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35] | 34970 | -2.150 | -0.4960 | Yes |
| 87 | NUDT12 | nudix hydrolase 12 [Source:HGNC Symbol;Acc:HGNC:18826] | 34996 | -2.167 | -0.4813 | Yes |
| 88 | CAT | catalase [Source:HGNC Symbol;Acc:HGNC:1516] | 35041 | -2.202 | -0.4670 | Yes |
| 89 | SCP2 | sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] | 35337 | -2.336 | -0.4584 | Yes |
| 90 | ACSL1 | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] | 35348 | -2.344 | -0.4421 | Yes |
| 91 | ABCA3 | ATP binding cassette subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:33] | 35361 | -2.356 | -0.4258 | Yes |
| 92 | ALDH9A1 | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] | 35485 | -2.466 | -0.4117 | Yes |
| 93 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 35489 | -2.468 | -0.3944 | Yes |
| 94 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383] | 35532 | -2.509 | -0.3778 | Yes |
| 95 | PEX26 | peroxisomal biogenesis factor 26 [Source:HGNC Symbol;Acc:HGNC:22965] | 35662 | -2.608 | -0.3628 | Yes |
| 96 | EFHC1 | EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16406] | 35676 | -2.615 | -0.3447 | Yes |
| 97 | HSD17B4 | hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] | 35691 | -2.624 | -0.3265 | Yes |
| 98 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 35715 | -2.654 | -0.3084 | Yes |
| 99 | FADS1 | fatty acid desaturase 1 [Source:HGNC Symbol;Acc:HGNC:3574] | 35774 | -2.709 | -0.2909 | Yes |
| 100 | HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol;Acc:HGNC:18324] | 35892 | -2.842 | -0.2739 | Yes |
| 101 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) [Source:HGNC Symbol;Acc:HGNC:11003] | 35972 | -2.894 | -0.2556 | Yes |
| 102 | ABCD1 | ATP binding cassette subfamily D member 1 [Source:HGNC Symbol;Acc:HGNC:61] | 36067 | -2.991 | -0.2370 | Yes |
| 103 | DHCR24 | 24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859] | 36192 | -3.161 | -0.2181 | Yes |
| 104 | CROT | carnitine O-octanoyltransferase [Source:HGNC Symbol;Acc:HGNC:2366] | 36345 | -3.311 | -0.1988 | Yes |
| 105 | ABCD2 | ATP binding cassette subfamily D member 2 [Source:HGNC Symbol;Acc:HGNC:66] | 36487 | -3.470 | -0.1781 | Yes |
| 106 | ABCG4 | ATP binding cassette subfamily G member 4 [Source:HGNC Symbol;Acc:HGNC:13884] | 36491 | -3.479 | -0.1536 | Yes |
| 107 | HACL1 | 2-hydroxyacyl-CoA lyase 1 [Source:HGNC Symbol;Acc:HGNC:17856] | 36582 | -3.618 | -0.1304 | Yes |
| 108 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] | 36725 | -3.859 | -0.1070 | Yes |
| 109 | CYP27A1 | cytochrome P450 family 27 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2605] | 36764 | -3.931 | -0.0803 | Yes |
| 110 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 36770 | -3.946 | -0.0525 | Yes |
| 111 | PFKM | phosphofructokinase, muscle [Source:HGNC Symbol;Acc:HGNC:8877] | 36918 | -4.287 | -0.0262 | Yes |
| 112 | PAOX | polyamine oxidase [Source:HGNC Symbol;Acc:HGNC:20837] | 36952 | -4.365 | 0.0037 | Yes |
