Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_CHOLESTEROL_HOMEOSTASIS |
| Enrichment Score (ES) | -0.554432 |
| Normalized Enrichment Score (NES) | -1.1331184 |
| Nominal p-value | 0.21052632 |
| FDR q-value | 0.41876677 |
| FWER p-Value | 0.998 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ERRFI1 | ERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185] | 456 | 3.066 | 0.0172 | No |
| 2 | ACTG1 | actin gamma 1 [Source:HGNC Symbol;Acc:HGNC:144] | 516 | 2.906 | 0.0436 | No |
| 3 | CHKA | choline kinase alpha [Source:HGNC Symbol;Acc:HGNC:1937] | 814 | 2.394 | 0.0586 | No |
| 4 | S100A11 | S100 calcium binding protein A11 [Source:HGNC Symbol;Acc:HGNC:10488] | 988 | 2.174 | 0.0749 | No |
| 5 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 993 | 2.164 | 0.0956 | No |
| 6 | ATF5 | activating transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:790] | 995 | 2.163 | 0.1164 | No |
| 7 | HSD17B7 | hydroxysteroid 17-beta dehydrogenase 7 [Source:HGNC Symbol;Acc:HGNC:5215] | 1286 | 1.876 | 0.1267 | No |
| 8 | ALCAM | activated leukocyte cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:400] | 1484 | 1.717 | 0.1379 | No |
| 9 | CXCL16 | C-X-C motif chemokine ligand 16 [Source:HGNC Symbol;Acc:HGNC:16642] | 1843 | 1.468 | 0.1423 | No |
| 10 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] | 2206 | 1.234 | 0.1445 | No |
| 11 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 2550 | 1.111 | 0.1459 | No |
| 12 | TRIB3 | tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] | 2730 | 1.037 | 0.1510 | No |
| 13 | ANTXR2 | ANTXR cell adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:21732] | 2869 | 0.973 | 0.1567 | No |
| 14 | LPL | lipoprotein lipase [Source:HGNC Symbol;Acc:HGNC:6677] | 3198 | 0.844 | 0.1560 | No |
| 15 | ANXA5 | annexin A5 [Source:HGNC Symbol;Acc:HGNC:543] | 3216 | 0.838 | 0.1636 | No |
| 16 | TMEM97 | transmembrane protein 97 [Source:HGNC Symbol;Acc:HGNC:28106] | 3516 | 0.729 | 0.1625 | No |
| 17 | CTNNB1 | catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] | 3688 | 0.680 | 0.1644 | No |
| 18 | GNAI1 | G protein subunit alpha i1 [Source:HGNC Symbol;Acc:HGNC:4384] | 4098 | 0.550 | 0.1587 | No |
| 19 | GUSB | glucuronidase beta [Source:HGNC Symbol;Acc:HGNC:4696] | 4223 | 0.512 | 0.1603 | No |
| 20 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 4257 | 0.500 | 0.1642 | No |
| 21 | FASN | fatty acid synthase [Source:HGNC Symbol;Acc:HGNC:3594] | 4296 | 0.489 | 0.1679 | No |
| 22 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 4522 | 0.425 | 0.1659 | No |
| 23 | GLDC | glycine decarboxylase [Source:HGNC Symbol;Acc:HGNC:4313] | 4635 | 0.396 | 0.1667 | No |
| 24 | NFIL3 | nuclear factor, interleukin 3 regulated [Source:HGNC Symbol;Acc:HGNC:7787] | 4959 | 0.302 | 0.1609 | No |
| 25 | FABP5 | fatty acid binding protein 5 [Source:HGNC Symbol;Acc:HGNC:3560] | 4965 | 0.301 | 0.1636 | No |
| 26 | LDLR | low density lipoprotein receptor [Source:HGNC Symbol;Acc:HGNC:6547] | 5866 | 0.140 | 0.1407 | No |
| 27 | FBXO6 | F-box protein 6 [Source:HGNC Symbol;Acc:HGNC:13585] | 6866 | 0.000 | 0.1137 | No |
| 28 | PLSCR1 | phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092] | 9312 | 0.000 | 0.0476 | No |
| 29 | GPX8 | glutathione peroxidase 8 (putative) [Source:HGNC Symbol;Acc:HGNC:33100] | 9521 | 0.000 | 0.0420 | No |
| 30 | GSTM2 | glutathione S-transferase mu 2 [Source:HGNC Symbol;Acc:HGNC:4634] | 9703 | 0.000 | 0.0371 | No |
| 31 | ADH4 | alcohol dehydrogenase 4 (class II), pi polypeptide [Source:HGNC Symbol;Acc:HGNC:252] | 11208 | 0.000 | -0.0035 | No |
| 32 | ANXA13 | annexin A13 [Source:HGNC Symbol;Acc:HGNC:536] | 14380 | 0.000 | -0.0892 | No |
| 33 | AVPR1A | arginine vasopressin receptor 1A [Source:HGNC Symbol;Acc:HGNC:895] | 16652 | 0.000 | -0.1505 | No |
| 34 | SEMA3B | semaphorin 3B [Source:HGNC Symbol;Acc:HGNC:10724] | 17925 | 0.000 | -0.1849 | No |
| 35 | PLAUR | plasminogen activator, urokinase receptor [Source:HGNC Symbol;Acc:HGNC:9053] | 23036 | 0.000 | -0.3229 | No |
| 36 | MAL2 | mal, T cell differentiation protein 2 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:13634] | 28337 | 0.000 | -0.4661 | No |
| 37 | EBP | EBP cholestenol delta-isomerase [Source:HGNC Symbol;Acc:HGNC:3133] | 28607 | -0.024 | -0.4732 | No |
| 38 | CYP51A1 | cytochrome P450 family 51 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2649] | 28739 | -0.057 | -0.4761 | No |
| 39 | CPEB2 | cytoplasmic polyadenylation element binding protein 2 [Source:HGNC Symbol;Acc:HGNC:21745] | 29902 | -0.332 | -0.5043 | No |
| 40 | STX5 | syntaxin 5 [Source:HGNC Symbol;Acc:HGNC:11440] | 30265 | -0.423 | -0.5101 | No |
| 41 | LSS | lanosterol synthase [Source:HGNC Symbol;Acc:HGNC:6708] | 30779 | -0.562 | -0.5185 | No |
| 42 | HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:HGNC Symbol;Acc:HGNC:5007] | 32110 | -0.946 | -0.5453 | Yes |
| 43 | ATXN2 | ataxin 2 [Source:HGNC Symbol;Acc:HGNC:10555] | 32290 | -1.021 | -0.5403 | Yes |
| 44 | SQLE | squalene epoxidase [Source:HGNC Symbol;Acc:HGNC:11279] | 32348 | -1.026 | -0.5320 | Yes |
| 45 | SREBF2 | sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11290] | 32504 | -1.086 | -0.5257 | Yes |
| 46 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 32657 | -1.134 | -0.5189 | Yes |
| 47 | MVK | mevalonate kinase [Source:HGNC Symbol;Acc:HGNC:7530] | 32664 | -1.137 | -0.5081 | Yes |
| 48 | NIBAN1 | niban apoptosis regulator 1 [Source:HGNC Symbol;Acc:HGNC:16784] | 32927 | -1.232 | -0.5033 | Yes |
| 49 | FDFT1 | farnesyl-diphosphate farnesyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:3629] | 33208 | -1.335 | -0.4980 | Yes |
| 50 | PMVK | phosphomevalonate kinase [Source:HGNC Symbol;Acc:HGNC:9141] | 33733 | -1.487 | -0.4979 | Yes |
| 51 | STARD4 | StAR related lipid transfer domain containing 4 [Source:HGNC Symbol;Acc:HGNC:18058] | 33777 | -1.508 | -0.4845 | Yes |
| 52 | LGALS3 | galectin 3 [Source:HGNC Symbol;Acc:HGNC:6563] | 34060 | -1.646 | -0.4763 | Yes |
| 53 | SC5D | sterol-C5-desaturase [Source:HGNC Symbol;Acc:HGNC:10547] | 34067 | -1.648 | -0.4605 | Yes |
| 54 | FDPS | farnesyl diphosphate synthase [Source:HGNC Symbol;Acc:HGNC:3631] | 34122 | -1.673 | -0.4459 | Yes |
| 55 | NSDHL | NAD(P) dependent steroid dehydrogenase-like [Source:HGNC Symbol;Acc:HGNC:13398] | 34408 | -1.811 | -0.4361 | Yes |
| 56 | JAG1 | jagged canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:6188] | 34686 | -1.954 | -0.4248 | Yes |
| 57 | ACAT2 | acetyl-CoA acetyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:94] | 34736 | -1.996 | -0.4069 | Yes |
| 58 | PDK3 | pyruvate dehydrogenase kinase 3 [Source:HGNC Symbol;Acc:HGNC:8811] | 34786 | -2.036 | -0.3886 | Yes |
| 59 | PNRC1 | proline rich nuclear receptor coactivator 1 [Source:HGNC Symbol;Acc:HGNC:17278] | 34792 | -2.046 | -0.3691 | Yes |
| 60 | ALDOC | aldolase, fructose-bisphosphate C [Source:HGNC Symbol;Acc:HGNC:418] | 35047 | -2.208 | -0.3546 | Yes |
| 61 | DHCR7 | 7-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2860] | 35132 | -2.271 | -0.3350 | Yes |
| 62 | PPARG | peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] | 35221 | -2.316 | -0.3151 | Yes |
| 63 | PCYT2 | phosphate cytidylyltransferase 2, ethanolamine [Source:HGNC Symbol;Acc:HGNC:8756] | 35430 | -2.416 | -0.2975 | Yes |
| 64 | MVD | mevalonate diphosphate decarboxylase [Source:HGNC Symbol;Acc:HGNC:7529] | 35492 | -2.469 | -0.2753 | Yes |
| 65 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 35698 | -2.637 | -0.2555 | Yes |
| 66 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 35715 | -2.654 | -0.2303 | Yes |
| 67 | TM7SF2 | transmembrane 7 superfamily member 2 [Source:HGNC Symbol;Acc:HGNC:11863] | 36035 | -2.966 | -0.2104 | Yes |
| 68 | TP53INP1 | tumor protein p53 inducible nuclear protein 1 [Source:HGNC Symbol;Acc:HGNC:18022] | 36046 | -2.975 | -0.1820 | Yes |
| 69 | ECH1 | enoyl-CoA hydratase 1 [Source:HGNC Symbol;Acc:HGNC:3149] | 36133 | -3.086 | -0.1546 | Yes |
| 70 | CBS | cystathionine beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550] | 36305 | -3.246 | -0.1280 | Yes |
| 71 | ETHE1 | ETHE1 persulfide dioxygenase [Source:HGNC Symbol;Acc:HGNC:23287] | 36530 | -3.547 | -0.0999 | Yes |
| 72 | SCD | stearoyl-CoA desaturase [Source:HGNC Symbol;Acc:HGNC:10571] | 36674 | -3.768 | -0.0675 | Yes |
| 73 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 36770 | -3.946 | -0.0320 | Yes |
| 74 | ACSS2 | acyl-CoA synthetase short chain family member 2 [Source:HGNC Symbol;Acc:HGNC:15814] | 36894 | -4.219 | 0.0053 | Yes |
