Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.42963088 |
| Normalized Enrichment Score (NES) | 1.1154785 |
| Nominal p-value | 0.107913665 |
| FDR q-value | 0.24697533 |
| FWER p-Value | 0.658 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 42 | 4.786 | 0.0357 | Yes |
| 2 | SERPINB2 | serpin family B member 2 [Source:HGNC Symbol;Acc:HGNC:8584] | 74 | 4.552 | 0.0698 | Yes |
| 3 | MAFF | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] | 89 | 4.452 | 0.1037 | Yes |
| 4 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 114 | 4.297 | 0.1361 | Yes |
| 5 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 123 | 4.245 | 0.1685 | Yes |
| 6 | PDGFB | platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] | 160 | 4.087 | 0.1989 | Yes |
| 7 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 173 | 4.008 | 0.2294 | Yes |
| 8 | CFB | complement factor B [Source:HGNC Symbol;Acc:HGNC:1037] | 261 | 3.637 | 0.2550 | Yes |
| 9 | F9 | coagulation factor IX [Source:HGNC Symbol;Acc:HGNC:3551] | 293 | 3.536 | 0.2814 | Yes |
| 10 | MMP14 | matrix metallopeptidase 14 [Source:HGNC Symbol;Acc:HGNC:7160] | 527 | 2.876 | 0.2972 | Yes |
| 11 | PLEK | pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] | 604 | 2.688 | 0.3158 | Yes |
| 12 | DUSP14 | dual specificity phosphatase 14 [Source:HGNC Symbol;Acc:HGNC:17007] | 616 | 2.675 | 0.3361 | Yes |
| 13 | SERPINC1 | serpin family C member 1 [Source:HGNC Symbol;Acc:HGNC:775] | 656 | 2.675 | 0.3556 | Yes |
| 14 | MMP2 | matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] | 779 | 2.457 | 0.3712 | Yes |
| 15 | WDR1 | WD repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12754] | 898 | 2.290 | 0.3856 | Yes |
| 16 | FBN1 | fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] | 979 | 2.181 | 0.4002 | Yes |
| 17 | GNG12 | G protein subunit gamma 12 [Source:HGNC Symbol;Acc:HGNC:19663] | 1547 | 1.667 | 0.3977 | Yes |
| 18 | THBS1 | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] | 1615 | 1.618 | 0.4083 | Yes |
| 19 | ANXA1 | annexin A1 [Source:HGNC Symbol;Acc:HGNC:533] | 2080 | 1.304 | 0.4058 | Yes |
| 20 | FYN | FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] | 2342 | 1.202 | 0.4080 | Yes |
| 21 | GDA | guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212] | 2449 | 1.148 | 0.4139 | Yes |
| 22 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 2550 | 1.111 | 0.4198 | Yes |
| 23 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 2908 | 0.955 | 0.4174 | Yes |
| 24 | ADAM9 | ADAM metallopeptidase domain 9 [Source:HGNC Symbol;Acc:HGNC:216] | 2995 | 0.927 | 0.4222 | Yes |
| 25 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 3067 | 0.898 | 0.4272 | Yes |
| 26 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 3252 | 0.824 | 0.4286 | Yes |
| 27 | KLF7 | Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] | 3431 | 0.762 | 0.4296 | Yes |
| 28 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 3712 | 0.671 | 0.4272 | No |
| 29 | F10 | coagulation factor X [Source:HGNC Symbol;Acc:HGNC:3528] | 3902 | 0.605 | 0.4267 | No |
| 30 | ITIH1 | inter-alpha-trypsin inhibitor heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:6166] | 4002 | 0.577 | 0.4285 | No |
| 31 | PREP | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] | 4175 | 0.526 | 0.4279 | No |
| 32 | S100A13 | S100 calcium binding protein A13 [Source:HGNC Symbol;Acc:HGNC:10490] | 4374 | 0.471 | 0.4262 | No |
| 33 | RABIF | RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] | 4604 | 0.405 | 0.4231 | No |
| 34 | BMP1 | bone morphogenetic protein 1 [Source:HGNC Symbol;Acc:HGNC:1067] | 4700 | 0.374 | 0.4234 | No |
| 35 | CTSH | cathepsin H [Source:HGNC Symbol;Acc:HGNC:2535] | 5231 | 0.239 | 0.4109 | No |
| 36 | CPN1 | carboxypeptidase N subunit 1 [Source:HGNC Symbol;Acc:HGNC:2312] | 5517 | 0.239 | 0.4050 | No |
| 37 | GNB2 | G protein subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:4398] | 5587 | 0.229 | 0.4049 | No |
| 38 | THBD | thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] | 5644 | 0.210 | 0.4050 | No |
| 39 | SH2B2 | SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:17381] | 5750 | 0.174 | 0.4035 | No |
| 40 | ARF4 | ADP ribosylation factor 4 [Source:HGNC Symbol;Acc:HGNC:655] | 5898 | 0.131 | 0.4005 | No |
| 41 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629] | 6711 | 0.000 | 0.3785 | No |
| 42 | PLAT | plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051] | 9965 | 0.000 | 0.2905 | No |
| 43 | APOC3 | apolipoprotein C3 [Source:HGNC Symbol;Acc:HGNC:610] | 10200 | 0.000 | 0.2842 | No |
| 44 | APOC2 | apolipoprotein C2 [Source:HGNC Symbol;Acc:HGNC:609] | 10202 | 0.000 | 0.2842 | No |
| 45 | APOC1 | apolipoprotein C1 [Source:HGNC Symbol;Acc:HGNC:607] | 10203 | 0.000 | 0.2842 | No |
| 46 | F13B | coagulation factor XIII B chain [Source:HGNC Symbol;Acc:HGNC:3534] | 10948 | 0.000 | 0.2640 | No |
| 47 | KLKB1 | kallikrein B1 [Source:HGNC Symbol;Acc:HGNC:6371] | 11234 | 0.000 | 0.2563 | No |
| 48 | TMPRSS6 | transmembrane serine protease 6 [Source:HGNC Symbol;Acc:HGNC:16517] | 11657 | 0.000 | 0.2449 | No |
| 49 | PROZ | protein Z, vitamin K dependent plasma glycoprotein [Source:HGNC Symbol;Acc:HGNC:9460] | 11705 | 0.000 | 0.2436 | No |
| 50 | PROC | protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451] | 11723 | 0.000 | 0.2432 | No |
| 51 | P2RY1 | purinergic receptor P2Y1 [Source:HGNC Symbol;Acc:HGNC:8539] | 14187 | 0.000 | 0.1765 | No |
| 52 | MBL2 | mannose binding lectin 2 [Source:HGNC Symbol;Acc:HGNC:6922] | 15585 | 0.000 | 0.1387 | No |
| 53 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 15594 | 0.000 | 0.1385 | No |
| 54 | C8B | complement C8 beta chain [Source:HGNC Symbol;Acc:HGNC:1353] | 15654 | 0.000 | 0.1369 | No |
| 55 | C8A | complement C8 alpha chain [Source:HGNC Symbol;Acc:HGNC:1352] | 15655 | 0.000 | 0.1369 | No |
| 56 | C8G | complement C8 gamma chain [Source:HGNC Symbol;Acc:HGNC:1354] | 15657 | 0.000 | 0.1369 | No |
| 57 | HTRA1 | HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476] | 15681 | 0.000 | 0.1362 | No |
| 58 | CFD | complement factor D [Source:HGNC Symbol;Acc:HGNC:2771] | 15761 | 0.000 | 0.1341 | No |
| 59 | CFI | complement factor I [Source:HGNC Symbol;Acc:HGNC:5394] | 15762 | 0.000 | 0.1341 | No |
| 60 | DCT | dopachrome tautomerase [Source:HGNC Symbol;Acc:HGNC:2709] | 16026 | 0.000 | 0.1270 | No |
| 61 | C2 | complement C2 [Source:HGNC Symbol;Acc:HGNC:1248] | 16101 | 0.000 | 0.1250 | No |
| 62 | C9 | complement C9 [Source:HGNC Symbol;Acc:HGNC:1358] | 16106 | 0.000 | 0.1249 | No |
| 63 | F2 | coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535] | 16150 | 0.000 | 0.1237 | No |
| 64 | TF | transferrin [Source:HGNC Symbol;Acc:HGNC:11740] | 16270 | 0.000 | 0.1205 | No |
| 65 | F12 | coagulation factor XII [Source:HGNC Symbol;Acc:HGNC:3530] | 16471 | 0.000 | 0.1151 | No |
| 66 | F11 | coagulation factor XI [Source:HGNC Symbol;Acc:HGNC:3529] | 16472 | 0.000 | 0.1151 | No |
| 67 | FGA | fibrinogen alpha chain [Source:HGNC Symbol;Acc:HGNC:3661] | 16707 | 0.000 | 0.1088 | No |
| 68 | FGG | fibrinogen gamma chain [Source:HGNC Symbol;Acc:HGNC:3694] | 16708 | 0.000 | 0.1088 | No |
| 69 | OLR1 | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] | 16762 | 0.000 | 0.1073 | No |
| 70 | GP9 | glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] | 17164 | 0.000 | 0.0965 | No |
| 71 | TIMP3 | TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822] | 17176 | 0.000 | 0.0962 | No |
| 72 | HRG | histidine rich glycoprotein [Source:HGNC Symbol;Acc:HGNC:5181] | 17530 | 0.000 | 0.0866 | No |
| 73 | HNF4A | hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024] | 17709 | 0.000 | 0.0818 | No |
| 74 | SERPING1 | serpin family G member 1 [Source:HGNC Symbol;Acc:HGNC:1228] | 17835 | 0.000 | 0.0784 | No |
| 75 | SERPINA1 | serpin family A member 1 [Source:HGNC Symbol;Acc:HGNC:8941] | 17850 | 0.000 | 0.0780 | No |
| 76 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 18003 | 0.000 | 0.0739 | No |
| 77 | MMP7 | matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174] | 19196 | 0.000 | 0.0417 | No |
| 78 | MMP1 | matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] | 19199 | 0.000 | 0.0416 | No |
| 79 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 19203 | 0.000 | 0.0415 | No |
| 80 | MMP8 | matrix metallopeptidase 8 [Source:HGNC Symbol;Acc:HGNC:7175] | 19209 | 0.000 | 0.0414 | No |
| 81 | ACOX2 | acyl-CoA oxidase 2 [Source:HGNC Symbol;Acc:HGNC:120] | 20173 | 0.000 | 0.0153 | No |
| 82 | MEP1A | meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015] | 20362 | 0.000 | 0.0103 | No |
| 83 | GP1BA | glycoprotein Ib platelet subunit alpha [Source:HGNC Symbol;Acc:HGNC:4439] | 20427 | 0.000 | 0.0085 | No |
| 84 | CPB2 | carboxypeptidase B2 [Source:HGNC Symbol;Acc:HGNC:2300] | 20624 | 0.000 | 0.0032 | No |
| 85 | TFPI2 | tissue factor pathway inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11761] | 22173 | 0.000 | -0.0387 | No |
| 86 | PRSS23 | serine protease 23 [Source:HGNC Symbol;Acc:HGNC:14370] | 22455 | 0.000 | -0.0463 | No |
| 87 | ITGA2 | integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] | 23836 | 0.000 | -0.0836 | No |
| 88 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 24425 | 0.000 | -0.0995 | No |
| 89 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 24747 | 0.000 | -0.1082 | No |
| 90 | HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008] | 24789 | 0.000 | -0.1093 | No |
| 91 | PLG | plasminogen [Source:HGNC Symbol;Acc:HGNC:9071] | 24823 | 0.000 | -0.1102 | No |
| 92 | C1QA | complement C1q A chain [Source:HGNC Symbol;Acc:HGNC:1241] | 24880 | 0.000 | -0.1117 | No |
| 93 | LEFTY2 | left-right determination factor 2 [Source:HGNC Symbol;Acc:HGNC:3122] | 25000 | 0.000 | -0.1150 | No |
| 94 | RGN | regucalcin [Source:HGNC Symbol;Acc:HGNC:9989] | 25304 | 0.000 | -0.1232 | No |
| 95 | KLK8 | kallikrein related peptidase 8 [Source:HGNC Symbol;Acc:HGNC:6369] | 25459 | 0.000 | -0.1273 | No |
| 96 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 25703 | 0.000 | -0.1339 | No |
| 97 | MMP11 | matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157] | 25706 | 0.000 | -0.1340 | No |
| 98 | F2RL2 | coagulation factor II thrombin receptor like 2 [Source:HGNC Symbol;Acc:HGNC:3539] | 26169 | 0.000 | -0.1465 | No |
| 99 | SPARC | secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219] | 28365 | 0.000 | -0.2059 | No |
| 100 | CTSO | cathepsin O [Source:HGNC Symbol;Acc:HGNC:2542] | 28953 | -0.110 | -0.2209 | No |
| 101 | MMP15 | matrix metallopeptidase 15 [Source:HGNC Symbol;Acc:HGNC:7161] | 29244 | -0.185 | -0.2273 | No |
| 102 | PEF1 | penta-EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30009] | 29597 | -0.262 | -0.2348 | No |
| 103 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 29893 | -0.330 | -0.2403 | No |
| 104 | VWF | von Willebrand factor [Source:HGNC Symbol;Acc:HGNC:12726] | 29921 | -0.336 | -0.2384 | No |
| 105 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 29960 | -0.344 | -0.2368 | No |
| 106 | MST1 | macrophage stimulating 1 [Source:HGNC Symbol;Acc:HGNC:7380] | 30119 | -0.387 | -0.2381 | No |
| 107 | SIRT2 | sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] | 30623 | -0.519 | -0.2477 | No |
| 108 | HPN | hepsin [Source:HGNC Symbol;Acc:HGNC:5155] | 31186 | -0.670 | -0.2578 | No |
| 109 | C3 | complement C3 [Source:HGNC Symbol;Acc:HGNC:1318] | 31763 | -0.825 | -0.2670 | No |
| 110 | USP11 | ubiquitin specific peptidase 11 [Source:HGNC Symbol;Acc:HGNC:12609] | 31770 | -0.828 | -0.2608 | No |
| 111 | S100A1 | S100 calcium binding protein A1 [Source:HGNC Symbol;Acc:HGNC:10486] | 31995 | -0.911 | -0.2599 | No |
| 112 | COMP | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:HGNC:2227] | 32003 | -0.914 | -0.2530 | No |
| 113 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 32136 | -0.956 | -0.2493 | No |
| 114 | CAPN2 | calpain 2 [Source:HGNC Symbol;Acc:HGNC:1479] | 32158 | -0.965 | -0.2424 | No |
| 115 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 32657 | -1.134 | -0.2472 | No |
| 116 | FN1 | fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] | 32727 | -1.158 | -0.2401 | No |
| 117 | F3 | coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541] | 32848 | -1.199 | -0.2342 | No |
| 118 | ISCU | iron-sulfur cluster assembly enzyme [Source:HGNC Symbol;Acc:HGNC:29882] | 33366 | -1.404 | -0.2374 | No |
| 119 | MASP2 | mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 33455 | -1.448 | -0.2286 | No |
| 120 | ANG | angiogenin [Source:HGNC Symbol;Acc:HGNC:483] | 33579 | -1.451 | -0.2208 | No |
| 121 | CTSE | cathepsin E [Source:HGNC Symbol;Acc:HGNC:2530] | 33648 | -1.458 | -0.2114 | No |
| 122 | LTA4H | leukotriene A4 hydrolase [Source:HGNC Symbol;Acc:HGNC:6710] | 33822 | -1.528 | -0.2043 | No |
| 123 | CSRP1 | cysteine and glycine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2469] | 34020 | -1.630 | -0.1971 | No |
| 124 | DUSP6 | dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] | 34100 | -1.666 | -0.1865 | No |
| 125 | CFH | complement factor H [Source:HGNC Symbol;Acc:HGNC:4883] | 34353 | -1.788 | -0.1795 | No |
| 126 | CASP9 | caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511] | 34451 | -1.832 | -0.1681 | No |
| 127 | C1R | complement C1r [Source:HGNC Symbol;Acc:HGNC:1246] | 34805 | -2.052 | -0.1619 | No |
| 128 | LRP1 | LDL receptor related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692] | 34833 | -2.074 | -0.1466 | No |
| 129 | CRIP2 | cysteine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2361] | 34924 | -2.128 | -0.1327 | No |
| 130 | MSRB2 | methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061] | 35164 | -2.299 | -0.1215 | No |
| 131 | PROS1 | protein S [Source:HGNC Symbol;Acc:HGNC:9456] | 35659 | -2.608 | -0.1148 | No |
| 132 | CAPN5 | calpain 5 [Source:HGNC Symbol;Acc:HGNC:1482] | 35696 | -2.632 | -0.0955 | No |
| 133 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 35698 | -2.637 | -0.0753 | No |
| 134 | GSN | gelsolin [Source:HGNC Symbol;Acc:HGNC:4620] | 35954 | -2.875 | -0.0601 | No |
| 135 | CPQ | carboxypeptidase Q [Source:HGNC Symbol;Acc:HGNC:16910] | 36066 | -2.990 | -0.0401 | No |
| 136 | PLAU | plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] | 36751 | -3.911 | -0.0285 | No |
| 137 | F8 | coagulation factor VIII [Source:HGNC Symbol;Acc:HGNC:3546] | 37071 | -4.901 | 0.0005 | No |
