Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.6791609 |
| Normalized Enrichment Score (NES) | 1.6664083 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0030219045 |
| FWER p-Value | 0.005 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 3 | 4.996 | 0.0523 | Yes |
| 2 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 46 | 4.743 | 0.1009 | Yes |
| 3 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 47 | 4.735 | 0.1506 | Yes |
| 4 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 128 | 4.232 | 0.1928 | Yes |
| 5 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 229 | 3.773 | 0.2297 | Yes |
| 6 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] | 268 | 3.618 | 0.2666 | Yes |
| 7 | PIK3R5 | phosphoinositide-3-kinase regulatory subunit 5 [Source:HGNC Symbol;Acc:HGNC:30035] | 532 | 2.862 | 0.2895 | Yes |
| 8 | CD36 | CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] | 551 | 2.820 | 0.3185 | Yes |
| 9 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 576 | 2.771 | 0.3470 | Yes |
| 10 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] | 596 | 2.705 | 0.3748 | Yes |
| 11 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 688 | 2.622 | 0.3999 | Yes |
| 12 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 715 | 2.584 | 0.4262 | Yes |
| 13 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 722 | 2.579 | 0.4531 | Yes |
| 14 | CD14 | CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] | 845 | 2.351 | 0.4745 | Yes |
| 15 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 883 | 2.317 | 0.4978 | Yes |
| 16 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 1030 | 2.110 | 0.5160 | Yes |
| 17 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 1047 | 2.089 | 0.5374 | Yes |
| 18 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 1177 | 1.926 | 0.5542 | Yes |
| 19 | FAS | Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] | 1320 | 1.876 | 0.5700 | Yes |
| 20 | HAX1 | HCLS1 associated protein X-1 [Source:HGNC Symbol;Acc:HGNC:16915] | 1541 | 1.674 | 0.5816 | Yes |
| 21 | ACVR1B | activin A receptor type 1B [Source:HGNC Symbol;Acc:HGNC:172] | 1553 | 1.664 | 0.5987 | Yes |
| 22 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 1720 | 1.540 | 0.6104 | Yes |
| 23 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1942 | 1.389 | 0.6190 | Yes |
| 24 | HMOX1 | heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] | 2096 | 1.297 | 0.6285 | Yes |
| 25 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 2101 | 1.295 | 0.6419 | Yes |
| 26 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 2172 | 1.253 | 0.6532 | Yes |
| 27 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 2550 | 1.111 | 0.6547 | Yes |
| 28 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 2897 | 0.958 | 0.6554 | Yes |
| 29 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 3047 | 0.907 | 0.6608 | Yes |
| 30 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 3252 | 0.824 | 0.6640 | Yes |
| 31 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] | 3320 | 0.793 | 0.6705 | Yes |
| 32 | IL17RA | interleukin 17 receptor A [Source:HGNC Symbol;Acc:HGNC:5985] | 3490 | 0.740 | 0.6737 | Yes |
| 33 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 3564 | 0.713 | 0.6792 | Yes |
| 34 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 3931 | 0.597 | 0.6755 | No |
| 35 | BAK1 | BCL2 antagonist/killer 1 [Source:HGNC Symbol;Acc:HGNC:949] | 4466 | 0.438 | 0.6657 | No |
| 36 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 4522 | 0.425 | 0.6687 | No |
| 37 | CSF2RB | colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] | 5141 | 0.243 | 0.6545 | No |
| 38 | CBL | Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541] | 6338 | 0.005 | 0.6222 | No |
| 39 | LTBR | lymphotoxin beta receptor [Source:HGNC Symbol;Acc:HGNC:6718] | 8061 | 0.000 | 0.5757 | No |
| 40 | TNFRSF21 | TNF receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] | 9386 | 0.000 | 0.5399 | No |
| 41 | CRLF2 | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | 10994 | 0.000 | 0.4965 | No |
| 42 | LEPR | leptin receptor [Source:HGNC Symbol;Acc:HGNC:6554] | 11529 | 0.000 | 0.4821 | No |
| 43 | PLA2G2A | phospholipase A2 group IIA [Source:HGNC Symbol;Acc:HGNC:9031] | 11770 | 0.000 | 0.4756 | No |
| 44 | CSF2RA | colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] | 12074 | 0.000 | 0.4674 | No |
| 45 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13583 | 0.000 | 0.4266 | No |
| 46 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 13912 | 0.000 | 0.4178 | No |
| 47 | IL9R | interleukin 9 receptor [Source:HGNC Symbol;Acc:HGNC:6030] | 13985 | 0.000 | 0.4158 | No |
| 48 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14230 | 0.000 | 0.4092 | No |
| 49 | EBI3 | Epstein-Barr virus induced 3 [Source:HGNC Symbol;Acc:HGNC:3129] | 15119 | 0.000 | 0.3852 | No |
| 50 | IL17RB | interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] | 15175 | 0.000 | 0.3837 | No |
| 51 | IL2RA | interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] | 15603 | 0.000 | 0.3722 | No |
| 52 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15885 | 0.000 | 0.3646 | No |
| 53 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15886 | 0.000 | 0.3646 | No |
| 54 | IL3RA | interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] | 16542 | 0.000 | 0.3469 | No |
| 55 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 17775 | 0.000 | 0.3136 | No |
| 56 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 17777 | 0.000 | 0.3136 | No |
| 57 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18539 | 0.000 | 0.2930 | No |
| 58 | CXCL13 | C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] | 18962 | 0.000 | 0.2816 | No |
| 59 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 19000 | 0.000 | 0.2806 | No |
| 60 | OSMR | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] | 19090 | 0.000 | 0.2782 | No |
| 61 | CXCL9 | C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] | 19550 | 0.000 | 0.2658 | No |
| 62 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19562 | 0.000 | 0.2655 | No |
| 63 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 19564 | 0.000 | 0.2655 | No |
| 64 | IL12RB1 | interleukin 12 receptor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:5971] | 19729 | 0.000 | 0.2611 | No |
| 65 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 21697 | 0.000 | 0.2079 | No |
| 66 | REG1A | regenerating family member 1 alpha [Source:HGNC Symbol;Acc:HGNC:9951] | 23787 | 0.000 | 0.1514 | No |
| 67 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 24425 | 0.000 | 0.1342 | No |
| 68 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 24747 | 0.000 | 0.1256 | No |
| 69 | IFNGR1 | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] | 25284 | 0.000 | 0.1111 | No |
| 70 | IFNGR2 | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] | 25286 | 0.000 | 0.1110 | No |
| 71 | IL18R1 | interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] | 25800 | 0.000 | 0.0972 | No |
| 72 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 28030 | 0.000 | 0.0369 | No |
| 73 | CD38 | CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667] | 28137 | 0.000 | 0.0341 | No |
| 74 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 29177 | -0.170 | 0.0078 | No |
| 75 | PTPN2 | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] | 29681 | -0.284 | -0.0028 | No |
| 76 | ACVRL1 | activin A receptor like type 1 [Source:HGNC Symbol;Acc:HGNC:175] | 29908 | -0.333 | -0.0054 | No |
| 77 | CNTFR | ciliary neurotrophic factor receptor [Source:HGNC Symbol;Acc:HGNC:2170] | 31947 | -0.894 | -0.0511 | No |
| 78 | IL13RA1 | interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] | 32199 | -0.987 | -0.0476 | No |
| 79 | INHBE | inhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029] | 32758 | -1.167 | -0.0504 | No |
| 80 | DNTT | DNA nucleotidylexotransferase [Source:HGNC Symbol;Acc:HGNC:2983] | 33154 | -1.312 | -0.0473 | No |
| 81 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 33385 | -1.413 | -0.0387 | No |
| 82 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 33602 | -1.451 | -0.0293 | No |
| 83 | CSF3R | colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] | 34273 | -1.753 | -0.0291 | No |
| 84 | IL6ST | interleukin 6 signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] | 34565 | -1.904 | -0.0170 | No |
| 85 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 34570 | -1.905 | 0.0029 | No |
| 86 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 34718 | -1.982 | 0.0197 | No |
| 87 | ITGA4 | integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] | 36900 | -4.231 | 0.0051 | No |
