Fig 1: Enrichment plot: HALLMARK_INTERFERON_ALPHA_RESPONSE
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_INTERFERON_ALPHA_RESPONSE |
| Enrichment Score (ES) | 0.7287308 |
| Normalized Enrichment Score (NES) | 1.8200173 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0016285714 |
| FWER p-Value | 0.002 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | GBP4 | guanylate binding protein 4 [Source:HGNC Symbol;Acc:HGNC:20480] | 79 | 4.519 | 0.0248 | Yes |
| 2 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 86 | 4.479 | 0.0513 | Yes |
| 3 | PARP14 | poly(ADP-ribose) polymerase family member 14 [Source:HGNC Symbol;Acc:HGNC:29232] | 87 | 4.461 | 0.0779 | Yes |
| 4 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 115 | 4.296 | 0.1028 | Yes |
| 5 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 121 | 4.254 | 0.1280 | Yes |
| 6 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 136 | 4.181 | 0.1526 | Yes |
| 7 | IFI44 | interferon induced protein 44 [Source:HGNC Symbol;Acc:HGNC:16938] | 150 | 4.127 | 0.1768 | Yes |
| 8 | HELZ2 | helicase with zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:30021] | 203 | 3.862 | 0.1984 | Yes |
| 9 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 226 | 3.782 | 0.2204 | Yes |
| 10 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 237 | 3.732 | 0.2424 | Yes |
| 11 | IFIH1 | interferon induced with helicase C domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] | 246 | 3.685 | 0.2641 | Yes |
| 12 | PROCR | protein C receptor [Source:HGNC Symbol;Acc:HGNC:9452] | 259 | 3.667 | 0.2857 | Yes |
| 13 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 263 | 3.632 | 0.3072 | Yes |
| 14 | DHX58 | DExH-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:29517] | 282 | 3.562 | 0.3280 | Yes |
| 15 | EIF2AK2 | eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437] | 288 | 3.554 | 0.3490 | Yes |
| 16 | CMPK2 | cytidine/uridine monophosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:27015] | 319 | 3.463 | 0.3689 | Yes |
| 17 | TRIM21 | tripartite motif containing 21 [Source:HGNC Symbol;Acc:HGNC:11312] | 378 | 3.266 | 0.3868 | Yes |
| 18 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 410 | 3.166 | 0.4048 | Yes |
| 19 | HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 [Source:HGNC Symbol;Acc:HGNC:26072] | 443 | 3.135 | 0.4226 | Yes |
| 20 | DDX60 | DExD/H-box helicase 60 [Source:HGNC Symbol;Acc:HGNC:25942] | 583 | 2.755 | 0.4353 | Yes |
| 21 | SAMD9 | sterile alpha motif domain containing 9 [Source:HGNC Symbol;Acc:HGNC:1348] | 603 | 2.689 | 0.4508 | Yes |
| 22 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 610 | 2.680 | 0.4666 | Yes |
| 23 | PARP12 | poly(ADP-ribose) polymerase family member 12 [Source:HGNC Symbol;Acc:HGNC:21919] | 695 | 2.612 | 0.4799 | Yes |
| 24 | TRAFD1 | TRAF-type zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24808] | 719 | 2.581 | 0.4947 | Yes |
| 25 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 722 | 2.579 | 0.5100 | Yes |
| 26 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 783 | 2.453 | 0.5230 | Yes |
| 27 | SAMD9L | sterile alpha motif domain containing 9 like [Source:HGNC Symbol;Acc:HGNC:1349] | 785 | 2.443 | 0.5375 | Yes |
| 28 | TRIM25 | tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932] | 836 | 2.354 | 0.5502 | Yes |
| 29 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 998 | 2.160 | 0.5587 | Yes |
| 30 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 1047 | 2.089 | 0.5699 | Yes |
| 31 | RIPK2 | receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] | 1078 | 2.054 | 0.5813 | Yes |
| 32 | PNPT1 | polyribonucleotide nucleotidyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:23166] | 1080 | 2.049 | 0.5935 | Yes |
| 33 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 1159 | 1.949 | 0.6030 | Yes |
| 34 | EPSTI1 | epithelial stromal interaction 1 [Source:HGNC Symbol;Acc:HGNC:16465] | 1162 | 1.942 | 0.6145 | Yes |
| 35 | LGALS3BP | galectin 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6564] | 1410 | 1.788 | 0.6185 | Yes |
| 36 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 1439 | 1.753 | 0.6282 | Yes |
| 37 | UBE2L6 | ubiquitin conjugating enzyme E2 L6 [Source:HGNC Symbol;Acc:HGNC:12490] | 1495 | 1.714 | 0.6369 | Yes |
| 38 | CASP8 | caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509] | 1498 | 1.711 | 0.6471 | Yes |
| 39 | BATF2 | basic leucine zipper ATF-like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:25163] | 1634 | 1.605 | 0.6530 | Yes |
| 40 | TRIM14 | tripartite motif containing 14 [Source:HGNC Symbol;Acc:HGNC:16283] | 1686 | 1.571 | 0.6610 | Yes |
| 41 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 1720 | 1.540 | 0.6693 | Yes |
| 42 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 1776 | 1.502 | 0.6768 | Yes |
| 43 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 1794 | 1.491 | 0.6852 | Yes |
| 44 | UBA7 | ubiquitin like modifier activating enzyme 7 [Source:HGNC Symbol;Acc:HGNC:12471] | 1799 | 1.487 | 0.6939 | Yes |
| 45 | WARS1 | tryptophanyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12729] | 2008 | 1.349 | 0.6964 | Yes |
| 46 | CD47 | CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] | 2116 | 1.286 | 0.7011 | Yes |
| 47 | PSME2 | proteasome activator subunit 2 [Source:HGNC Symbol;Acc:HGNC:9569] | 2315 | 1.215 | 0.7030 | Yes |
| 48 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 2363 | 1.188 | 0.7088 | Yes |
| 49 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 2527 | 1.117 | 0.7111 | Yes |
| 50 | CMTR1 | cap methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:21077] | 2538 | 1.113 | 0.7174 | Yes |
| 51 | MOV10 | Mov10 RISC complex RNA helicase [Source:HGNC Symbol;Acc:HGNC:7200] | 2569 | 1.101 | 0.7232 | Yes |
| 52 | TRIM5 | tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276] | 2758 | 1.022 | 0.7242 | Yes |
| 53 | TENT5A | terminal nucleotidyltransferase 5A [Source:HGNC Symbol;Acc:HGNC:18345] | 2967 | 0.944 | 0.7242 | Yes |
| 54 | OGFR | opioid growth factor receptor [Source:HGNC Symbol;Acc:HGNC:15768] | 3004 | 0.923 | 0.7287 | Yes |
| 55 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 3231 | 0.833 | 0.7276 | No |
| 56 | TDRD7 | tudor domain containing 7 [Source:HGNC Symbol;Acc:HGNC:30831] | 3541 | 0.721 | 0.7235 | No |
| 57 | NMI | N-myc and STAT interactor [Source:HGNC Symbol;Acc:HGNC:7854] | 4135 | 0.539 | 0.7107 | No |
| 58 | RNF31 | ring finger protein 31 [Source:HGNC Symbol;Acc:HGNC:16031] | 4475 | 0.437 | 0.7042 | No |
| 59 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 4532 | 0.421 | 0.7052 | No |
| 60 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 5250 | 0.239 | 0.6872 | No |
| 61 | TRIM26 | tripartite motif containing 26 [Source:HGNC Symbol;Acc:HGNC:12962] | 5663 | 0.200 | 0.6773 | No |
| 62 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 6021 | 0.092 | 0.6682 | No |
| 63 | SP110 | SP110 nuclear body protein [Source:HGNC Symbol;Acc:HGNC:5401] | 6524 | 0.000 | 0.6546 | No |
| 64 | SELL | selectin L [Source:HGNC Symbol;Acc:HGNC:10720] | 7228 | 0.000 | 0.6356 | No |
| 65 | CCRL2 | C-C motif chemokine receptor like 2 [Source:HGNC Symbol;Acc:HGNC:1612] | 8858 | 0.000 | 0.5915 | No |
| 66 | PLSCR1 | phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092] | 9312 | 0.000 | 0.5793 | No |
| 67 | LY6E | lymphocyte antigen 6 family member E [Source:HGNC Symbol;Acc:HGNC:6727] | 9342 | 0.000 | 0.5785 | No |
| 68 | RTP4 | receptor transporter protein 4 [Source:HGNC Symbol;Acc:HGNC:23992] | 10584 | 0.000 | 0.5450 | No |
| 69 | IFI30 | IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398] | 11610 | 0.000 | 0.5173 | No |
| 70 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12476 | 0.000 | 0.4939 | No |
| 71 | TMEM140 | transmembrane protein 140 [Source:HGNC Symbol;Acc:HGNC:21870] | 13490 | 0.000 | 0.4665 | No |
| 72 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 13912 | 0.000 | 0.4551 | No |
| 73 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 15594 | 0.000 | 0.4097 | No |
| 74 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 17777 | 0.000 | 0.3507 | No |
| 75 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 19000 | 0.000 | 0.3177 | No |
| 76 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 20380 | 0.000 | 0.2804 | No |
| 77 | IFI44L | interferon induced protein 44 like [Source:HGNC Symbol;Acc:HGNC:17817] | 20820 | 0.000 | 0.2685 | No |
| 78 | LAMP3 | lysosomal associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:14582] | 21708 | 0.000 | 0.2445 | No |
| 79 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 30450 | -0.479 | 0.0111 | No |
| 80 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 30775 | -0.560 | 0.0057 | No |
| 81 | NCOA7 | nuclear receptor coactivator 7 [Source:HGNC Symbol;Acc:HGNC:21081] | 30819 | -0.572 | 0.0079 | No |
| 82 | LAP3 | leucine aminopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:18449] | 31053 | -0.630 | 0.0054 | No |
| 83 | SLC25A28 | solute carrier family 25 member 28 [Source:HGNC Symbol;Acc:HGNC:23472] | 32192 | -0.982 | -0.0195 | No |
| 84 | LPAR6 | lysophosphatidic acid receptor 6 [Source:HGNC Symbol;Acc:HGNC:15520] | 32433 | -1.057 | -0.0197 | No |
| 85 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 32572 | -1.108 | -0.0168 | No |
| 86 | IL15 | interleukin 15 [Source:HGNC Symbol;Acc:HGNC:5977] | 32892 | -1.216 | -0.0182 | No |
| 87 | CASP1 | caspase 1 [Source:HGNC Symbol;Acc:HGNC:1499] | 33129 | -1.302 | -0.0168 | No |
| 88 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 33385 | -1.413 | -0.0153 | No |
| 89 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 33602 | -1.451 | -0.0125 | No |
| 90 | ELF1 | E74 like ETS transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3316] | 33756 | -1.496 | -0.0077 | No |
| 91 | NUB1 | negative regulator of ubiquitin like proteins 1 [Source:HGNC Symbol;Acc:HGNC:17623] | 33880 | -1.549 | -0.0018 | No |
| 92 | CD74 | CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] | 34181 | -1.707 | 0.0003 | No |
| 93 | MVB12A | multivesicular body subunit 12A [Source:HGNC Symbol;Acc:HGNC:25153] | 34441 | -1.826 | 0.0042 | No |
| 94 | CNP | 2',3'-cyclic nucleotide 3' phosphodiesterase [Source:HGNC Symbol;Acc:HGNC:2158] | 35333 | -2.333 | -0.0060 | No |
| 95 | TXNIP | thioredoxin interacting protein [Source:HGNC Symbol;Acc:HGNC:16952] | 35449 | -2.436 | 0.0054 | No |
| 96 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 35660 | -2.608 | 0.0153 | No |
| 97 | GMPR | guanosine monophosphate reductase [Source:HGNC Symbol;Acc:HGNC:4376] | 36757 | -3.918 | 0.0090 | No |
