Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_PANCREAS_BETA_CELLS |
| Enrichment Score (ES) | -0.6969549 |
| Normalized Enrichment Score (NES) | -1.3207868 |
| Nominal p-value | 0.059840426 |
| FDR q-value | 0.09080024 |
| FWER p-Value | 0.646 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 3037 | 0.910 | -0.0303 | No |
| 2 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 3951 | 0.592 | -0.0213 | No |
| 3 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 4855 | 0.327 | -0.0271 | No |
| 4 | SRP14 | signal recognition particle 14 [Source:HGNC Symbol;Acc:HGNC:11299] | 4899 | 0.318 | -0.0102 | No |
| 5 | VDR | vitamin D receptor [Source:HGNC Symbol;Acc:HGNC:12679] | 4916 | 0.313 | 0.0072 | No |
| 6 | SRP9 | signal recognition particle 9 [Source:HGNC Symbol;Acc:HGNC:11304] | 5290 | 0.239 | 0.0107 | No |
| 7 | SCGN | secretagogin, EF-hand calcium binding protein [Source:HGNC Symbol;Acc:HGNC:16941] | 6563 | 0.000 | -0.0236 | No |
| 8 | CHGA | chromogranin A [Source:HGNC Symbol;Acc:HGNC:1929] | 10616 | 0.000 | -0.1330 | No |
| 9 | G6PC2 | glucose-6-phosphatase catalytic subunit 2 [Source:HGNC Symbol;Acc:HGNC:28906] | 12385 | 0.000 | -0.1807 | No |
| 10 | SST | somatostatin [Source:HGNC Symbol;Acc:HGNC:11329] | 12436 | 0.000 | -0.1821 | No |
| 11 | SYT13 | synaptotagmin 13 [Source:HGNC Symbol;Acc:HGNC:14962] | 13743 | 0.000 | -0.2173 | No |
| 12 | PAX4 | paired box 4 [Source:HGNC Symbol;Acc:HGNC:8618] | 14917 | 0.000 | -0.2490 | No |
| 13 | DCX | doublecortin [Source:HGNC Symbol;Acc:HGNC:2714] | 16028 | 0.000 | -0.2789 | No |
| 14 | PCSK2 | proprotein convertase subtilisin/kexin type 2 [Source:HGNC Symbol;Acc:HGNC:8744] | 16274 | 0.000 | -0.2856 | No |
| 15 | PCSK1 | proprotein convertase subtilisin/kexin type 1 [Source:HGNC Symbol;Acc:HGNC:8743] | 16275 | 0.000 | -0.2856 | No |
| 16 | GCG | glucagon [Source:HGNC Symbol;Acc:HGNC:4191] | 16964 | 0.000 | -0.3041 | No |
| 17 | GCK | glucokinase [Source:HGNC Symbol;Acc:HGNC:4195] | 16966 | 0.000 | -0.3041 | No |
| 18 | INS | insulin [Source:HGNC Symbol;Acc:HGNC:6081] | 17804 | 0.000 | -0.3267 | No |
| 19 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 18003 | 0.000 | -0.3321 | No |
| 20 | NKX2-2 | NK2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7835] | 19303 | 0.000 | -0.3671 | No |
| 21 | IAPP | islet amyloid polypeptide [Source:HGNC Symbol;Acc:HGNC:5329] | 19356 | 0.000 | -0.3685 | No |
| 22 | NEUROD1 | neuronal differentiation 1 [Source:HGNC Symbol;Acc:HGNC:7762] | 19362 | 0.000 | -0.3687 | No |
| 23 | NEUROG3 | neurogenin 3 [Source:HGNC Symbol;Acc:HGNC:13806] | 19477 | 0.000 | -0.3718 | No |
| 24 | FOXA2 | forkhead box A2 [Source:HGNC Symbol;Acc:HGNC:5022] | 20814 | 0.000 | -0.4078 | No |
| 25 | NKX6-1 | NK6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7839] | 25378 | 0.000 | -0.5310 | No |
| 26 | PDX1 | pancreatic and duodenal homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6107] | 26266 | 0.000 | -0.5549 | No |
| 27 | INSM1 | INSM transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:6090] | 26929 | 0.000 | -0.5728 | No |
| 28 | ISL1 | ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132] | 27146 | 0.000 | -0.5786 | No |
| 29 | SLC2A2 | solute carrier family 2 member 2 [Source:HGNC Symbol;Acc:HGNC:11006] | 28491 | 0.000 | -0.6149 | No |
| 30 | ABCC8 | ATP binding cassette subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:59] | 28504 | 0.000 | -0.6152 | No |
| 31 | ELP4 | elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:1171] | 28781 | -0.067 | -0.6189 | No |
| 32 | PAK3 | p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592] | 29031 | -0.132 | -0.6181 | No |
| 33 | STXBP1 | syntaxin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11444] | 31954 | -0.898 | -0.6459 | Yes |
| 34 | HNF1A | HNF1 homeobox A [Source:HGNC Symbol;Acc:HGNC:11621] | 32012 | -0.915 | -0.5955 | Yes |
| 35 | PKLR | pyruvate kinase L/R [Source:HGNC Symbol;Acc:HGNC:9020] | 32591 | -1.116 | -0.5477 | Yes |
| 36 | MAFB | MAF bZIP transcription factor B [Source:HGNC Symbol;Acc:HGNC:6408] | 33055 | -1.276 | -0.4877 | Yes |
| 37 | AKT3 | AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] | 33851 | -1.538 | -0.4218 | Yes |
| 38 | LMO2 | LIM domain only 2 [Source:HGNC Symbol;Acc:HGNC:6642] | 35678 | -2.616 | -0.3224 | Yes |
| 39 | FOXO1 | forkhead box O1 [Source:HGNC Symbol;Acc:HGNC:3819] | 36020 | -2.950 | -0.1640 | Yes |
| 40 | PAX6 | paired box 6 [Source:HGNC Symbol;Acc:HGNC:8620] | 36408 | -3.395 | 0.0184 | Yes |
