Fig 1: Enrichment plot: HALLMARK_PEROXISOME
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_PEROXISOME |
| Enrichment Score (ES) | -0.6343711 |
| Normalized Enrichment Score (NES) | -1.3583055 |
| Nominal p-value | 0.018757327 |
| FDR q-value | 0.08641082 |
| FWER p-Value | 0.464 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ATXN1 | ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] | 313 | 3.487 | 0.0184 | No |
| 2 | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit [Source:HGNC Symbol;Acc:HGNC:3433] | 343 | 3.403 | 0.0439 | No |
| 3 | SOD2 | superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180] | 497 | 2.945 | 0.0624 | No |
| 4 | ACSL4 | acyl-CoA synthetase long chain family member 4 [Source:HGNC Symbol;Acc:HGNC:3571] | 907 | 2.278 | 0.0689 | No |
| 5 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 1748 | 1.521 | 0.0579 | No |
| 6 | CDK7 | cyclin dependent kinase 7 [Source:HGNC Symbol;Acc:HGNC:1778] | 1857 | 1.456 | 0.0662 | No |
| 7 | SLC25A19 | solute carrier family 25 member 19 [Source:HGNC Symbol;Acc:HGNC:14409] | 2333 | 1.208 | 0.0627 | No |
| 8 | CNBP | CCHC-type zinc finger nucleic acid binding protein [Source:HGNC Symbol;Acc:HGNC:13164] | 2335 | 1.207 | 0.0720 | No |
| 9 | PRDX1 | peroxiredoxin 1 [Source:HGNC Symbol;Acc:HGNC:9352] | 2441 | 1.151 | 0.0780 | No |
| 10 | CRABP2 | cellular retinoic acid binding protein 2 [Source:HGNC Symbol;Acc:HGNC:2339] | 2455 | 1.145 | 0.0865 | No |
| 11 | YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [Source:HGNC Symbol;Acc:HGNC:12853] | 2848 | 0.986 | 0.0835 | No |
| 12 | ACOX1 | acyl-CoA oxidase 1 [Source:HGNC Symbol;Acc:HGNC:119] | 3038 | 0.910 | 0.0854 | No |
| 13 | DHRS3 | dehydrogenase/reductase 3 [Source:HGNC Symbol;Acc:HGNC:17693] | 3140 | 0.865 | 0.0893 | No |
| 14 | VPS4B | vacuolar protein sorting 4 homolog B [Source:HGNC Symbol;Acc:HGNC:10895] | 3558 | 0.715 | 0.0836 | No |
| 15 | BCL10 | BCL10 immune signaling adaptor [Source:HGNC Symbol;Acc:HGNC:989] | 4071 | 0.559 | 0.0740 | No |
| 16 | TSPO | translocator protein [Source:HGNC Symbol;Acc:HGNC:1158] | 4187 | 0.523 | 0.0749 | No |
| 17 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 4257 | 0.500 | 0.0769 | No |
| 18 | HRAS | HRas proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:5173] | 4677 | 0.380 | 0.0685 | No |
| 19 | PEX5 | peroxisomal biogenesis factor 5 [Source:HGNC Symbol;Acc:HGNC:9719] | 4792 | 0.346 | 0.0681 | No |
| 20 | PEX11A | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] | 4807 | 0.343 | 0.0704 | No |
| 21 | SEMA3C | semaphorin 3C [Source:HGNC Symbol;Acc:HGNC:10725] | 4878 | 0.322 | 0.0710 | No |
| 22 | PABPC1 | poly(A) binding protein cytoplasmic 1 [Source:HGNC Symbol;Acc:HGNC:8554] | 4972 | 0.298 | 0.0708 | No |
| 23 | NUDT19 | nudix hydrolase 19 [Source:HGNC Symbol;Acc:HGNC:32036] | 5412 | 0.239 | 0.0607 | No |
| 24 | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 8025 | 0.000 | -0.0099 | No |
| 25 | EHHADH | enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [Source:HGNC Symbol;Acc:HGNC:3247] | 8043 | 0.000 | -0.0103 | No |
| 26 | GSTK1 | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] | 9690 | 0.000 | -0.0549 | No |
| 27 | SLC27A2 | solute carrier family 27 member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 11001 | 0.000 | -0.0903 | No |
| 28 | ESR2 | estrogen receptor 2 [Source:HGNC Symbol;Acc:HGNC:3468] | 12086 | 0.000 | -0.1196 | No |
| 29 | STS | steroid sulfatase [Source:HGNC Symbol;Acc:HGNC:11425] | 12445 | 0.000 | -0.1293 | No |
| 30 | TTR | transthyretin [Source:HGNC Symbol;Acc:HGNC:12405] | 12716 | 0.000 | -0.1366 | No |
| 31 | HSD11B2 | hydroxysteroid 11-beta dehydrogenase 2 [Source:HGNC Symbol;Acc:HGNC:5209] | 14478 | 0.000 | -0.1842 | No |
| 32 | CEL | carboxyl ester lipase [Source:HGNC Symbol;Acc:HGNC:1848] | 15752 | 0.000 | -0.2186 | No |
| 33 | DIO1 | iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883] | 15815 | 0.000 | -0.2203 | No |
| 34 | SERPINA6 | serpin family A member 6 [Source:HGNC Symbol;Acc:HGNC:1540] | 17854 | 0.000 | -0.2754 | No |
| 35 | UGT2B17 | UDP glucuronosyltransferase family 2 member B17 [Source:HGNC Symbol;Acc:HGNC:12547] | 18254 | 0.000 | -0.2861 | No |
| 36 | NR1I2 | nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] | 20072 | 0.000 | -0.3353 | No |
| 37 | SULT2B1 | sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] | 20900 | 0.000 | -0.3576 | No |
| 38 | CRABP1 | cellular retinoic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2338] | 21191 | 0.000 | -0.3655 | No |
| 39 | SCGB1A1 | secretoglobin family 1A member 1 [Source:HGNC Symbol;Acc:HGNC:12523] | 21385 | 0.000 | -0.3707 | No |
| 40 | HAO2 | hydroxyacid oxidase 2 [Source:HGNC Symbol;Acc:HGNC:4810] | 22083 | 0.000 | -0.3895 | No |
| 41 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] | 23042 | 0.000 | -0.4154 | No |
| 42 | FABP6 | fatty acid binding protein 6 [Source:HGNC Symbol;Acc:HGNC:3561] | 24292 | 0.000 | -0.4492 | No |
| 43 | ALB | albumin [Source:HGNC Symbol;Acc:HGNC:399] | 24712 | 0.000 | -0.4605 | No |
| 44 | ABCC8 | ATP binding cassette subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:59] | 28504 | 0.000 | -0.5630 | No |
| 45 | CTBP1 | C-terminal binding protein 1 [Source:HGNC Symbol;Acc:HGNC:2494] | 28563 | -0.011 | -0.5645 | No |
| 46 | PEX13 | peroxisomal biogenesis factor 13 [Source:HGNC Symbol;Acc:HGNC:8855] | 28893 | -0.095 | -0.5727 | No |
| 47 | SIAH1 | siah E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:10857] | 28894 | -0.095 | -0.5719 | No |
| 48 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 29201 | -0.176 | -0.5789 | No |
| 49 | PEX14 | peroxisomal biogenesis factor 14 [Source:HGNC Symbol;Acc:HGNC:8856] | 29367 | -0.215 | -0.5817 | No |
| 50 | ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3435] | 29708 | -0.292 | -0.5886 | No |
| 51 | PEX2 | peroxisomal biogenesis factor 2 [Source:HGNC Symbol;Acc:HGNC:9717] | 29788 | -0.312 | -0.5883 | No |
| 52 | FIS1 | fission, mitochondrial 1 [Source:HGNC Symbol;Acc:HGNC:21689] | 30056 | -0.367 | -0.5927 | No |
| 53 | CLN8 | CLN8 transmembrane ER and ERGIC protein [Source:HGNC Symbol;Acc:HGNC:2079] | 30160 | -0.398 | -0.5924 | No |
| 54 | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 [Source:HGNC Symbol;Acc:HGNC:11104] | 30288 | -0.430 | -0.5926 | No |
| 55 | PEX6 | peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:HGNC:8859] | 30314 | -0.436 | -0.5899 | No |
| 56 | ISOC1 | isochorismatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24254] | 30351 | -0.448 | -0.5874 | No |
| 57 | MVP | major vault protein [Source:HGNC Symbol;Acc:HGNC:7531] | 30391 | -0.460 | -0.5849 | No |
| 58 | RXRG | retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] | 30479 | -0.479 | -0.5836 | No |
| 59 | ACOT8 | acyl-CoA thioesterase 8 [Source:HGNC Symbol;Acc:HGNC:15919] | 31013 | -0.618 | -0.5932 | No |
| 60 | ITGB1BP1 | integrin subunit beta 1 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:23927] | 31218 | -0.677 | -0.5935 | No |
| 61 | ECI2 | enoyl-CoA delta isomerase 2 [Source:HGNC Symbol;Acc:HGNC:14601] | 32730 | -1.159 | -0.6254 | Yes |
| 62 | SLC23A2 | solute carrier family 23 member 2 [Source:HGNC Symbol;Acc:HGNC:10973] | 32756 | -1.167 | -0.6171 | Yes |
| 63 | SLC25A17 | solute carrier family 25 member 17 [Source:HGNC Symbol;Acc:HGNC:10987] | 32786 | -1.177 | -0.6088 | Yes |
| 64 | ACSL5 | acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526] | 32809 | -1.185 | -0.6003 | Yes |
| 65 | IDE | insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381] | 33086 | -1.287 | -0.5978 | Yes |
| 66 | SLC25A4 | solute carrier family 25 member 4 [Source:HGNC Symbol;Acc:HGNC:10990] | 33238 | -1.352 | -0.5915 | Yes |
| 67 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 33434 | -1.438 | -0.5857 | Yes |
| 68 | HMGCL | 3-hydroxy-3-methylglutaryl-CoA lyase [Source:HGNC Symbol;Acc:HGNC:5005] | 33609 | -1.451 | -0.5792 | Yes |
| 69 | LONP2 | lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] | 33655 | -1.459 | -0.5692 | Yes |
| 70 | RDH11 | retinol dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:17964] | 33736 | -1.488 | -0.5599 | Yes |
| 71 | ABCB9 | ATP binding cassette subfamily B member 9 [Source:HGNC Symbol;Acc:HGNC:50] | 33919 | -1.573 | -0.5527 | Yes |
| 72 | RETSAT | retinol saturase [Source:HGNC Symbol;Acc:HGNC:25991] | 34084 | -1.659 | -0.5443 | Yes |
| 73 | FDPS | farnesyl diphosphate synthase [Source:HGNC Symbol;Acc:HGNC:3631] | 34122 | -1.673 | -0.5324 | Yes |
| 74 | ABCB1 | ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40] | 34154 | -1.690 | -0.5202 | Yes |
| 75 | ABCD3 | ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] | 34258 | -1.746 | -0.5096 | Yes |
| 76 | CTPS1 | CTP synthase 1 [Source:HGNC Symbol;Acc:HGNC:2519] | 34397 | -1.805 | -0.4994 | Yes |
| 77 | DLG4 | discs large MAGUK scaffold protein 4 [Source:HGNC Symbol;Acc:HGNC:2903] | 34410 | -1.812 | -0.4858 | Yes |
| 78 | CRAT | carnitine O-acetyltransferase [Source:HGNC Symbol;Acc:HGNC:2342] | 34598 | -1.922 | -0.4760 | Yes |
| 79 | MLYCD | malonyl-CoA decarboxylase [Source:HGNC Symbol;Acc:HGNC:7150] | 34614 | -1.931 | -0.4615 | Yes |
| 80 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 34662 | -1.944 | -0.4478 | Yes |
| 81 | GNPAT | glyceronephosphate O-acyltransferase [Source:HGNC Symbol;Acc:HGNC:4416] | 34950 | -2.142 | -0.4391 | Yes |
| 82 | CAT | catalase [Source:HGNC Symbol;Acc:HGNC:1516] | 35041 | -2.202 | -0.4245 | Yes |
| 83 | CADM1 | cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5951] | 35328 | -2.329 | -0.4143 | Yes |
| 84 | SCP2 | sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] | 35337 | -2.336 | -0.3965 | Yes |
| 85 | ACSL1 | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] | 35348 | -2.344 | -0.3787 | Yes |
| 86 | ABCC5 | ATP binding cassette subfamily C member 5 [Source:HGNC Symbol;Acc:HGNC:56] | 35445 | -2.426 | -0.3626 | Yes |
| 87 | ALDH9A1 | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] | 35485 | -2.466 | -0.3447 | Yes |
| 88 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 35489 | -2.468 | -0.3257 | Yes |
| 89 | ABCB4 | ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45] | 35490 | -2.469 | -0.3067 | Yes |
| 90 | PEX11B | peroxisomal biogenesis factor 11 beta [Source:HGNC Symbol;Acc:HGNC:8853] | 35509 | -2.483 | -0.2881 | Yes |
| 91 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383] | 35532 | -2.509 | -0.2693 | Yes |
| 92 | CACNA1B | calcium voltage-gated channel subunit alpha1 B [Source:HGNC Symbol;Acc:HGNC:1389] | 35647 | -2.608 | -0.2523 | Yes |
| 93 | HSD17B4 | hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] | 35691 | -2.624 | -0.2332 | Yes |
| 94 | ELOVL5 | ELOVL fatty acid elongase 5 [Source:HGNC Symbol;Acc:HGNC:21308] | 35734 | -2.663 | -0.2139 | Yes |
| 95 | FADS1 | fatty acid desaturase 1 [Source:HGNC Symbol;Acc:HGNC:3574] | 35774 | -2.709 | -0.1940 | Yes |
| 96 | ACAA1 | acetyl-CoA acyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:82] | 35784 | -2.718 | -0.1733 | Yes |
| 97 | HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol;Acc:HGNC:18324] | 35892 | -2.842 | -0.1543 | Yes |
| 98 | ABCD1 | ATP binding cassette subfamily D member 1 [Source:HGNC Symbol;Acc:HGNC:61] | 36067 | -2.991 | -0.1360 | Yes |
| 99 | ECH1 | enoyl-CoA hydratase 1 [Source:HGNC Symbol;Acc:HGNC:3149] | 36133 | -3.086 | -0.1140 | Yes |
| 100 | DHCR24 | 24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859] | 36192 | -3.161 | -0.0912 | Yes |
| 101 | ABCD2 | ATP binding cassette subfamily D member 2 [Source:HGNC Symbol;Acc:HGNC:66] | 36487 | -3.470 | -0.0724 | Yes |
| 102 | MSH2 | mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] | 36701 | -3.805 | -0.0488 | Yes |
| 103 | CLN6 | CLN6 transmembrane ER protein [Source:HGNC Symbol;Acc:HGNC:2077] | 36709 | -3.830 | -0.0195 | Yes |
| 104 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] | 36725 | -3.859 | 0.0099 | Yes |
