Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_PI3K_AKT_MTOR_SIGNALING |
| Enrichment Score (ES) | 0.34103042 |
| Normalized Enrichment Score (NES) | 0.86278784 |
| Nominal p-value | 0.9702381 |
| FDR q-value | 0.9463503 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SQSTM1 | sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280] | 338 | 3.434 | 0.0221 | Yes |
| 2 | ADCY2 | adenylate cyclase 2 [Source:HGNC Symbol;Acc:HGNC:233] | 530 | 2.864 | 0.0430 | Yes |
| 3 | MAP2K3 | mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843] | 746 | 2.532 | 0.0602 | Yes |
| 4 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 883 | 2.317 | 0.0776 | Yes |
| 5 | NFKBIB | NFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798] | 926 | 2.249 | 0.0970 | Yes |
| 6 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 1047 | 2.089 | 0.1127 | Yes |
| 7 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 1177 | 1.926 | 0.1268 | Yes |
| 8 | MAPK10 | mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872] | 1220 | 1.877 | 0.1427 | Yes |
| 9 | ACTR3 | actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170] | 1557 | 1.663 | 0.1488 | Yes |
| 10 | CDKN1A | cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] | 1774 | 1.506 | 0.1566 | Yes |
| 11 | PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988] | 1846 | 1.467 | 0.1681 | Yes |
| 12 | PFN1 | profilin 1 [Source:HGNC Symbol;Acc:HGNC:8881] | 1873 | 1.447 | 0.1805 | Yes |
| 13 | PAK4 | p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059] | 1947 | 1.385 | 0.1912 | Yes |
| 14 | UBE2D3 | ubiquitin conjugating enzyme E2 D3 [Source:HGNC Symbol;Acc:HGNC:12476] | 2009 | 1.349 | 0.2018 | Yes |
| 15 | CFL1 | cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874] | 2015 | 1.346 | 0.2139 | Yes |
| 16 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 2101 | 1.295 | 0.2234 | Yes |
| 17 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 2172 | 1.253 | 0.2329 | Yes |
| 18 | RIT1 | Ras like without CAAX 1 [Source:HGNC Symbol;Acc:HGNC:10023] | 2193 | 1.241 | 0.2436 | Yes |
| 19 | TRAF2 | TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] | 2602 | 1.085 | 0.2425 | Yes |
| 20 | ACTR2 | actin related protein 2 [Source:HGNC Symbol;Acc:HGNC:169] | 2625 | 1.076 | 0.2517 | Yes |
| 21 | TRIB3 | tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] | 2730 | 1.037 | 0.2583 | Yes |
| 22 | SLC2A1 | solute carrier family 2 member 1 [Source:HGNC Symbol;Acc:HGNC:11005] | 2841 | 0.989 | 0.2643 | Yes |
| 23 | PPP2R1B | protein phosphatase 2 scaffold subunit Abeta [Source:HGNC Symbol;Acc:HGNC:9303] | 2873 | 0.970 | 0.2723 | Yes |
| 24 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 2897 | 0.958 | 0.2804 | Yes |
| 25 | UBE2N | ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492] | 3236 | 0.830 | 0.2788 | Yes |
| 26 | AKT1S1 | AKT1 substrate 1 [Source:HGNC Symbol;Acc:HGNC:28426] | 3456 | 0.752 | 0.2798 | Yes |
| 27 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 3506 | 0.733 | 0.2851 | Yes |
| 28 | RPTOR | regulatory associated protein of MTOR complex 1 [Source:HGNC Symbol;Acc:HGNC:30287] | 3584 | 0.708 | 0.2895 | Yes |
| 29 | CAB39 | calcium binding protein 39 [Source:HGNC Symbol;Acc:HGNC:20292] | 3629 | 0.695 | 0.2946 | Yes |
| 30 | TIAM1 | TIAM Rac1 associated GEF 1 [Source:HGNC Symbol;Acc:HGNC:11805] | 3643 | 0.691 | 0.3005 | Yes |
| 31 | NCK1 | NCK adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:7664] | 3675 | 0.686 | 0.3059 | Yes |
| 32 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 3684 | 0.681 | 0.3119 | Yes |
| 33 | ATF1 | activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783] | 3744 | 0.659 | 0.3163 | Yes |
| 34 | TBK1 | TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] | 3745 | 0.659 | 0.3223 | Yes |
| 35 | YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Source:HGNC Symbol;Acc:HGNC:12849] | 3774 | 0.652 | 0.3275 | Yes |
| 36 | CAB39L | calcium binding protein 39 like [Source:HGNC Symbol;Acc:HGNC:20290] | 3872 | 0.615 | 0.3305 | Yes |
| 37 | AP2M1 | adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564] | 4081 | 0.556 | 0.3299 | Yes |
| 38 | ARPC3 | actin related protein 2/3 complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:706] | 4100 | 0.549 | 0.3344 | Yes |
| 39 | GSK3B | glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617] | 4114 | 0.544 | 0.3390 | Yes |
| 40 | ARF1 | ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652] | 4247 | 0.502 | 0.3400 | Yes |
| 41 | HRAS | HRas proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:5173] | 4677 | 0.380 | 0.3319 | Yes |
| 42 | PPP1CA | protein phosphatase 1 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9281] | 4752 | 0.358 | 0.3331 | Yes |
| 43 | SMAD2 | SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] | 4808 | 0.343 | 0.3348 | Yes |
| 44 | CLTC | clathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092] | 4886 | 0.320 | 0.3356 | Yes |
| 45 | DDIT3 | DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] | 4897 | 0.318 | 0.3382 | Yes |
| 46 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 4901 | 0.318 | 0.3410 | Yes |
| 47 | RIPK1 | receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019] | 5010 | 0.284 | 0.3407 | No |
| 48 | NOD1 | nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390] | 5532 | 0.239 | 0.3288 | No |
| 49 | ARHGDIA | Rho GDP dissociation inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:678] | 5636 | 0.213 | 0.3279 | No |
| 50 | CSNK2B | casein kinase 2 beta [Source:HGNC Symbol;Acc:HGNC:2460] | 5683 | 0.195 | 0.3285 | No |
| 51 | PRKAA2 | protein kinase AMP-activated catalytic subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:9377] | 6833 | 0.000 | 0.2974 | No |
| 52 | FGF22 | fibroblast growth factor 22 [Source:HGNC Symbol;Acc:HGNC:3679] | 6953 | 0.000 | 0.2942 | No |
| 53 | FGF17 | fibroblast growth factor 17 [Source:HGNC Symbol;Acc:HGNC:3673] | 6956 | 0.000 | 0.2941 | No |
| 54 | PRKCB | protein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395] | 6990 | 0.000 | 0.2932 | No |
| 55 | PITX2 | paired like homeodomain 2 [Source:HGNC Symbol;Acc:HGNC:9005] | 7420 | 0.000 | 0.2816 | No |
| 56 | CAMK4 | calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464] | 9192 | 0.000 | 0.2338 | No |
| 57 | GNGT1 | G protein subunit gamma transducin 1 [Source:HGNC Symbol;Acc:HGNC:4411] | 16283 | 0.000 | 0.0421 | No |
| 58 | IL4 | interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014] | 17773 | 0.000 | 0.0018 | No |
| 59 | NGF | nerve growth factor [Source:HGNC Symbol;Acc:HGNC:7808] | 19386 | 0.000 | -0.0418 | No |
| 60 | FGF6 | fibroblast growth factor 6 [Source:HGNC Symbol;Acc:HGNC:3684] | 22755 | 0.000 | -0.1328 | No |
| 61 | PLCB1 | phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917] | 23446 | 0.000 | -0.1515 | No |
| 62 | GNA14 | G protein subunit alpha 14 [Source:HGNC Symbol;Acc:HGNC:4382] | 24225 | 0.000 | -0.1725 | No |
| 63 | FASLG | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] | 25034 | 0.000 | -0.1944 | No |
| 64 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 27201 | 0.000 | -0.2529 | No |
| 65 | THEM4 | thioesterase superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:17947] | 27968 | 0.000 | -0.2737 | No |
| 66 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 28955 | -0.111 | -0.2993 | No |
| 67 | MAPK1 | mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] | 29008 | -0.126 | -0.2996 | No |
| 68 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859] | 29056 | -0.139 | -0.2996 | No |
| 69 | MAPK8 | mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] | 29333 | -0.205 | -0.3052 | No |
| 70 | RALB | RAS like proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:9840] | 29372 | -0.215 | -0.3042 | No |
| 71 | AKT1 | AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] | 29526 | -0.246 | -0.3061 | No |
| 72 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 29534 | -0.248 | -0.3041 | No |
| 73 | MKNK1 | MAPK interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:7110] | 29609 | -0.265 | -0.3036 | No |
| 74 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 29893 | -0.330 | -0.3083 | No |
| 75 | PRKAG1 | protein kinase AMP-activated non-catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:9385] | 30006 | -0.357 | -0.3081 | No |
| 76 | RPS6KA3 | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] | 30142 | -0.393 | -0.3081 | No |
| 77 | RPS6KA1 | ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430] | 30373 | -0.454 | -0.3102 | No |
| 78 | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:9829] | 30645 | -0.525 | -0.3128 | No |
| 79 | MAPKAP1 | MAPK associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18752] | 30927 | -0.596 | -0.3150 | No |
| 80 | PTEN | phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588] | 31674 | -0.792 | -0.3279 | No |
| 81 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol;Acc:HGNC:9391] | 31771 | -0.828 | -0.3230 | No |
| 82 | MAPK9 | mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886] | 31811 | -0.843 | -0.3164 | No |
| 83 | GRK2 | G protein-coupled receptor kinase 2 [Source:HGNC Symbol;Acc:HGNC:289] | 32076 | -0.933 | -0.3150 | No |
| 84 | PIKFYVE | phosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785] | 32215 | -0.991 | -0.3097 | No |
| 85 | DUSP3 | dual specificity phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:3069] | 32229 | -0.997 | -0.3010 | No |
| 86 | ACACA | acetyl-CoA carboxylase alpha [Source:HGNC Symbol;Acc:HGNC:84] | 32380 | -1.035 | -0.2956 | No |
| 87 | TSC2 | TSC complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:12363] | 32471 | -1.070 | -0.2883 | No |
| 88 | IRAK4 | interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] | 32736 | -1.160 | -0.2849 | No |
| 89 | CDK4 | cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] | 33017 | -1.262 | -0.2810 | No |
| 90 | SFN | stratifin [Source:HGNC Symbol;Acc:HGNC:10773] | 33200 | -1.332 | -0.2738 | No |
| 91 | SLA | Src like adaptor [Source:HGNC Symbol;Acc:HGNC:10902] | 33357 | -1.400 | -0.2653 | No |
| 92 | ECSIT | ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548] | 33720 | -1.484 | -0.2615 | No |
| 93 | MKNK2 | MAPK interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:7111] | 34138 | -1.683 | -0.2575 | No |
| 94 | DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [Source:HGNC Symbol;Acc:HGNC:16500] | 34416 | -1.814 | -0.2485 | No |
| 95 | CDK2 | cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] | 34482 | -1.849 | -0.2334 | No |
| 96 | CDKN1B | cyclin dependent kinase inhibitor 1B [Source:HGNC Symbol;Acc:HGNC:1785] | 35125 | -2.268 | -0.2301 | No |
| 97 | CXCR4 | C-X-C motif chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:2561] | 35166 | -2.299 | -0.2103 | No |
| 98 | ITPR2 | inositol 1,4,5-trisphosphate receptor type 2 [Source:HGNC Symbol;Acc:HGNC:6181] | 35968 | -2.888 | -0.2057 | No |
| 99 | VAV3 | vav guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:12659] | 35974 | -2.895 | -0.1795 | No |
| 100 | E2F1 | E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] | 36193 | -3.164 | -0.1566 | No |
| 101 | PLCG1 | phospholipase C gamma 1 [Source:HGNC Symbol;Acc:HGNC:9065] | 36490 | -3.473 | -0.1330 | No |
| 102 | MAP2K6 | mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846] | 36776 | -3.954 | -0.1047 | No |
| 103 | PIK3R3 | phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981] | 36789 | -3.979 | -0.0688 | No |
| 104 | PDK1 | pyruvate dehydrogenase kinase 1 [Source:HGNC Symbol;Acc:HGNC:8809] | 36835 | -4.060 | -0.0331 | No |
| 105 | PLA2G12A | phospholipase A2 group XIIA [Source:HGNC Symbol;Acc:HGNC:18554] | 36958 | -4.387 | 0.0036 | No |
