Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_SPERMATOGENESIS |
| Enrichment Score (ES) | -0.62719864 |
| Normalized Enrichment Score (NES) | -1.3650513 |
| Nominal p-value | 0.0057537397 |
| FDR q-value | 0.09781132 |
| FWER p-Value | 0.432 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ELOVL3 | ELOVL fatty acid elongase 3 [Source:HGNC Symbol;Acc:HGNC:18047] | 184 | 3.980 | 0.0334 | No |
| 2 | IL13RA2 | interleukin 13 receptor subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:5975] | 305 | 3.508 | 0.0640 | No |
| 3 | TLE4 | TLE family member 4, transcriptional corepressor [Source:HGNC Symbol;Acc:HGNC:11840] | 1864 | 1.452 | 0.0359 | No |
| 4 | RPL39L | ribosomal protein L39 like [Source:HGNC Symbol;Acc:HGNC:17094] | 1945 | 1.387 | 0.0471 | No |
| 5 | DPEP3 | dipeptidase 3 [Source:HGNC Symbol;Acc:HGNC:23029] | 2094 | 1.297 | 0.0556 | No |
| 6 | PGS1 | phosphatidylglycerophosphate synthase 1 [Source:HGNC Symbol;Acc:HGNC:30029] | 2528 | 1.116 | 0.0547 | No |
| 7 | CCT6B | chaperonin containing TCP1 subunit 6B [Source:HGNC Symbol;Acc:HGNC:1621] | 2621 | 1.079 | 0.0626 | No |
| 8 | PAPOLB | poly(A) polymerase beta [Source:HGNC Symbol;Acc:HGNC:15970] | 2786 | 1.013 | 0.0679 | No |
| 9 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 3564 | 0.713 | 0.0538 | No |
| 10 | TEKT2 | tektin 2 [Source:HGNC Symbol;Acc:HGNC:11725] | 3804 | 0.641 | 0.0535 | No |
| 11 | AGFG1 | ArfGAP with FG repeats 1 [Source:HGNC Symbol;Acc:HGNC:5175] | 4320 | 0.482 | 0.0442 | No |
| 12 | PACRG | parkin coregulated [Source:HGNC Symbol;Acc:HGNC:19152] | 4516 | 0.426 | 0.0430 | No |
| 13 | TSN | translin [Source:HGNC Symbol;Acc:HGNC:12379] | 4780 | 0.350 | 0.0393 | No |
| 14 | ARL4A | ADP ribosylation factor like GTPase 4A [Source:HGNC Symbol;Acc:HGNC:695] | 4803 | 0.343 | 0.0420 | No |
| 15 | PIAS2 | protein inhibitor of activated STAT 2 [Source:HGNC Symbol;Acc:HGNC:17311] | 4810 | 0.342 | 0.0452 | No |
| 16 | RAD17 | RAD17 checkpoint clamp loader component [Source:HGNC Symbol;Acc:HGNC:9807] | 4912 | 0.314 | 0.0455 | No |
| 17 | ZPBP | zona pellucida binding protein [Source:HGNC Symbol;Acc:HGNC:15662] | 5202 | 0.239 | 0.0399 | No |
| 18 | NAA11 | N-alpha-acetyltransferase 11, NatA catalytic subunit [Source:HGNC Symbol;Acc:HGNC:28125] | 5646 | 0.206 | 0.0299 | No |
| 19 | CSNK2A2 | casein kinase 2 alpha 2 [Source:HGNC Symbol;Acc:HGNC:2459] | 5732 | 0.181 | 0.0294 | No |
| 20 | PSMG1 | proteasome assembly chaperone 1 [Source:HGNC Symbol;Acc:HGNC:3043] | 6223 | 0.037 | 0.0165 | No |
| 21 | SCG5 | secretogranin V [Source:HGNC Symbol;Acc:HGNC:10816] | 6577 | 0.000 | 0.0069 | No |
| 22 | SCG3 | secretogranin III [Source:HGNC Symbol;Acc:HGNC:13707] | 6579 | 0.000 | 0.0069 | No |
| 23 | ADCYAP1 | adenylate cyclase activating polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:241] | 7425 | 0.000 | -0.0159 | No |
| 24 | ART3 | ADP-ribosyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:725] | 7534 | 0.000 | -0.0189 | No |
| 25 | CCNA1 | cyclin A1 [Source:HGNC Symbol;Acc:HGNC:1577] | 7640 | 0.000 | -0.0217 | No |
| 26 | ZC2HC1C | zinc finger C2HC-type containing 1C [Source:HGNC Symbol;Acc:HGNC:20354] | 8361 | 0.000 | -0.0412 | No |
| 27 | HOXB1 | homeobox B1 [Source:HGNC Symbol;Acc:HGNC:5111] | 8936 | 0.000 | -0.0567 | No |
| 28 | ADAM2 | ADAM metallopeptidase domain 2 [Source:HGNC Symbol;Acc:HGNC:198] | 9015 | 0.000 | -0.0588 | No |
| 29 | ADAD1 | adenosine deaminase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30713] | 9170 | 0.000 | -0.0630 | No |
| 30 | CAMK4 | calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464] | 9192 | 0.000 | -0.0636 | No |
| 31 | CRISP2 | cysteine rich secretory protein 2 [Source:HGNC Symbol;Acc:HGNC:12024] | 9233 | 0.000 | -0.0647 | No |
| 32 | NPY5R | neuropeptide Y receptor Y5 [Source:HGNC Symbol;Acc:HGNC:7958] | 9240 | 0.000 | -0.0648 | No |
| 33 | DMRT1 | doublesex and mab-3 related transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:2934] | 9608 | 0.000 | -0.0747 | No |
| 34 | NEFH | neurofilament heavy [Source:HGNC Symbol;Acc:HGNC:7737] | 9725 | 0.000 | -0.0779 | No |
| 35 | GRM8 | glutamate metabotropic receptor 8 [Source:HGNC Symbol;Acc:HGNC:4600] | 10017 | 0.000 | -0.0858 | No |
| 36 | TULP2 | TUB like protein 2 [Source:HGNC Symbol;Acc:HGNC:12424] | 10193 | 0.000 | -0.0905 | No |
| 37 | CFTR | CF transmembrane conductance regulator [Source:HGNC Symbol;Acc:HGNC:1884] | 10229 | 0.000 | -0.0914 | No |
| 38 | LDHC | lactate dehydrogenase C [Source:HGNC Symbol;Acc:HGNC:6544] | 11207 | 0.000 | -0.1179 | No |
| 39 | CLGN | calmegin [Source:HGNC Symbol;Acc:HGNC:2060] | 11681 | 0.000 | -0.1307 | No |
| 40 | PRM2 | protamine 2 [Source:HGNC Symbol;Acc:HGNC:9448] | 11687 | 0.000 | -0.1308 | No |
| 41 | SEPTIN4 | septin 4 [Source:HGNC Symbol;Acc:HGNC:9165] | 11869 | 0.000 | -0.1357 | No |
| 42 | JAM3 | junctional adhesion molecule 3 [Source:HGNC Symbol;Acc:HGNC:15532] | 12236 | 0.000 | -0.1456 | No |
| 43 | GAD1 | glutamate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:4092] | 12517 | 0.000 | -0.1532 | No |
| 44 | THEG | theg spermatid protein [Source:HGNC Symbol;Acc:HGNC:13706] | 12737 | 0.000 | -0.1591 | No |
| 45 | ALOX15 | arachidonate 15-lipoxygenase [Source:HGNC Symbol;Acc:HGNC:433] | 12809 | 0.000 | -0.1610 | No |
| 46 | TCP11 | t-complex 11 [Source:HGNC Symbol;Acc:HGNC:11658] | 14536 | 0.000 | -0.2077 | No |
| 47 | TNP2 | transition protein 2 [Source:HGNC Symbol;Acc:HGNC:11952] | 15072 | 0.000 | -0.2222 | No |
| 48 | TNP1 | transition protein 1 [Source:HGNC Symbol;Acc:HGNC:11951] | 15074 | 0.000 | -0.2222 | No |
| 49 | HTR5A | 5-hydroxytryptamine receptor 5A [Source:HGNC Symbol;Acc:HGNC:5300] | 15602 | 0.000 | -0.2365 | No |
| 50 | CLVS1 | clavesin 1 [Source:HGNC Symbol;Acc:HGNC:23139] | 15730 | 0.000 | -0.2399 | No |
| 51 | MTNR1A | melatonin receptor 1A [Source:HGNC Symbol;Acc:HGNC:7463] | 15818 | 0.000 | -0.2423 | No |
| 52 | DCC | DCC netrin 1 receptor [Source:HGNC Symbol;Acc:HGNC:2701] | 16017 | 0.000 | -0.2477 | No |
| 53 | ACTL7B | actin like 7B [Source:HGNC Symbol;Acc:HGNC:162] | 16097 | 0.000 | -0.2498 | No |
| 54 | GPR182 | G protein-coupled receptor 182 [Source:HGNC Symbol;Acc:HGNC:13708] | 16405 | 0.000 | -0.2581 | No |
| 55 | GAPDHS | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [Source:HGNC Symbol;Acc:HGNC:24864] | 16511 | 0.000 | -0.2609 | No |
| 56 | AKAP4 | A-kinase anchoring protein 4 [Source:HGNC Symbol;Acc:HGNC:374] | 16667 | 0.000 | -0.2651 | No |
| 57 | DMC1 | DNA meiotic recombinase 1 [Source:HGNC Symbol;Acc:HGNC:2927] | 16936 | 0.000 | -0.2724 | No |
| 58 | TKTL1 | transketolase like 1 [Source:HGNC Symbol;Acc:HGNC:11835] | 17271 | 0.000 | -0.2814 | No |
| 59 | HBZ | hemoglobin subunit zeta [Source:HGNC Symbol;Acc:HGNC:4835] | 17319 | 0.000 | -0.2827 | No |
| 60 | SYCP1 | synaptonemal complex protein 1 [Source:HGNC Symbol;Acc:HGNC:11487] | 17917 | 0.000 | -0.2989 | No |
| 61 | DNAJB8 | DnaJ heat shock protein family (Hsp40) member B8 [Source:HGNC Symbol;Acc:HGNC:23699] | 18586 | 0.000 | -0.3169 | No |
| 62 | IL12RB2 | interleukin 12 receptor subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:5972] | 19732 | 0.000 | -0.3479 | No |
| 63 | MEP1B | meprin A subunit beta [Source:HGNC Symbol;Acc:HGNC:7020] | 20361 | 0.000 | -0.3649 | No |
| 64 | ACRV1 | acrosomal vesicle protein 1 [Source:HGNC Symbol;Acc:HGNC:127] | 20568 | 0.000 | -0.3705 | No |
| 65 | TSSK2 | testis specific serine kinase 2 [Source:HGNC Symbol;Acc:HGNC:11401] | 21739 | 0.000 | -0.4021 | No |
| 66 | SNAP91 | synaptosome associated protein 91 [Source:HGNC Symbol;Acc:HGNC:14986] | 21873 | 0.000 | -0.4057 | No |
| 67 | CST8 | cystatin 8 [Source:HGNC Symbol;Acc:HGNC:2480] | 21911 | 0.000 | -0.4067 | No |
| 68 | OAZ3 | ornithine decarboxylase antizyme 3 [Source:HGNC Symbol;Acc:HGNC:8097] | 23089 | 0.000 | -0.4386 | No |
| 69 | ODF1 | outer dense fiber of sperm tails 1 [Source:HGNC Symbol;Acc:HGNC:8113] | 23809 | 0.000 | -0.4580 | No |
| 70 | ZNRF4 | zinc and ring finger 4 [Source:HGNC Symbol;Acc:HGNC:17726] | 23851 | 0.000 | -0.4592 | No |
| 71 | DDX4 | DEAD-box helicase 4 [Source:HGNC Symbol;Acc:HGNC:18700] | 23927 | 0.000 | -0.4612 | No |
| 72 | ACE | angiotensin I converting enzyme [Source:HGNC Symbol;Acc:HGNC:2707] | 24547 | 0.000 | -0.4779 | No |
| 73 | PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor [Source:HGNC Symbol;Acc:HGNC:17301] | 25563 | 0.000 | -0.5054 | No |
| 74 | SHE | Src homology 2 domain containing E [Source:HGNC Symbol;Acc:HGNC:27004] | 25690 | 0.000 | -0.5088 | No |
| 75 | H1-6 | H1.6 linker histone, cluster member [Source:HGNC Symbol;Acc:HGNC:4720] | 27872 | 0.000 | -0.5678 | No |
| 76 | DDX25 | DEAD-box helicase 25 [Source:HGNC Symbol;Acc:HGNC:18698] | 28260 | 0.000 | -0.5783 | No |
| 77 | MAP7 | microtubule associated protein 7 [Source:HGNC Symbol;Acc:HGNC:6869] | 28407 | 0.000 | -0.5822 | No |
| 78 | SLC2A5 | solute carrier family 2 member 5 [Source:HGNC Symbol;Acc:HGNC:11010] | 28492 | 0.000 | -0.5845 | No |
| 79 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 28955 | -0.111 | -0.5959 | No |
| 80 | PHKG2 | phosphorylase kinase catalytic subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:8931] | 29074 | -0.144 | -0.5978 | No |
| 81 | PEBP1 | phosphatidylethanolamine binding protein 1 [Source:HGNC Symbol;Acc:HGNC:8630] | 29110 | -0.150 | -0.5973 | No |
| 82 | TUBA3C | tubulin alpha 3c [Source:HGNC Symbol;Acc:HGNC:12408] | 29130 | -0.156 | -0.5963 | No |
| 83 | YBX2 | Y-box binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17948] | 29187 | -0.173 | -0.5961 | No |
| 84 | TALDO1 | transaldolase 1 [Source:HGNC Symbol;Acc:HGNC:11559] | 29663 | -0.281 | -0.6063 | No |
| 85 | IP6K1 | inositol hexakisphosphate kinase 1 [Source:HGNC Symbol;Acc:HGNC:18360] | 29682 | -0.285 | -0.6040 | No |
| 86 | MTOR | mechanistic target of rapamycin kinase [Source:HGNC Symbol;Acc:HGNC:3942] | 29701 | -0.291 | -0.6017 | No |
| 87 | VDAC3 | voltage dependent anion channel 3 [Source:HGNC Symbol;Acc:HGNC:12674] | 30497 | -0.481 | -0.6185 | No |
| 88 | CHRM4 | cholinergic receptor muscarinic 4 [Source:HGNC Symbol;Acc:HGNC:1953] | 30691 | -0.534 | -0.6186 | No |
| 89 | CNIH2 | cornichon family AMPA receptor auxiliary protein 2 [Source:HGNC Symbol;Acc:HGNC:28744] | 30785 | -0.563 | -0.6157 | No |
| 90 | CLPB | caseinolytic mitochondrial matrix peptidase chaperone subunit B [Source:HGNC Symbol;Acc:HGNC:30664] | 30804 | -0.568 | -0.6107 | No |
| 91 | COIL | coilin [Source:HGNC Symbol;Acc:HGNC:2184] | 31309 | -0.705 | -0.6175 | No |
| 92 | GFI1 | growth factor independent 1 transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:4237] | 31667 | -0.790 | -0.6196 | Yes |
| 93 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol;Acc:HGNC:9391] | 31771 | -0.828 | -0.6144 | Yes |
| 94 | SIRT1 | sirtuin 1 [Source:HGNC Symbol;Acc:HGNC:14929] | 31772 | -0.829 | -0.6064 | Yes |
| 95 | BRAF | B-Raf proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1097] | 31894 | -0.874 | -0.6012 | Yes |
| 96 | NOS1 | nitric oxide synthase 1 [Source:HGNC Symbol;Acc:HGNC:7872] | 32024 | -0.920 | -0.5958 | Yes |
| 97 | HSPA1L | heat shock protein family A (Hsp70) member 1 like [Source:HGNC Symbol;Acc:HGNC:5234] | 32105 | -0.945 | -0.5889 | Yes |
| 98 | SLC12A2 | solute carrier family 12 member 2 [Source:HGNC Symbol;Acc:HGNC:10911] | 32393 | -1.039 | -0.5866 | Yes |
| 99 | IFT88 | intraflagellar transport 88 [Source:HGNC Symbol;Acc:HGNC:20606] | 32548 | -1.100 | -0.5802 | Yes |
| 100 | CHFR | checkpoint with forkhead and ring finger domains [Source:HGNC Symbol;Acc:HGNC:20455] | 32804 | -1.183 | -0.5757 | Yes |
| 101 | MLF1 | myeloid leukemia factor 1 [Source:HGNC Symbol;Acc:HGNC:7125] | 32812 | -1.186 | -0.5644 | Yes |
| 102 | GSTM3 | glutathione S-transferase mu 3 [Source:HGNC Symbol;Acc:HGNC:4635] | 32903 | -1.222 | -0.5550 | Yes |
| 103 | MAST2 | microtubule associated serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:19035] | 32947 | -1.240 | -0.5442 | Yes |
| 104 | AURKA | aurora kinase A [Source:HGNC Symbol;Acc:HGNC:11393] | 33083 | -1.285 | -0.5355 | Yes |
| 105 | IDE | insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381] | 33086 | -1.287 | -0.5231 | Yes |
| 106 | PGK2 | phosphoglycerate kinase 2 [Source:HGNC Symbol;Acc:HGNC:8898] | 33089 | -1.289 | -0.5107 | Yes |
| 107 | GSG1 | germ cell associated 1 [Source:HGNC Symbol;Acc:HGNC:19716] | 33296 | -1.374 | -0.5031 | Yes |
| 108 | DBF4 | DBF4 zinc finger [Source:HGNC Symbol;Acc:HGNC:17364] | 33637 | -1.452 | -0.4983 | Yes |
| 109 | TNNI3 | troponin I3, cardiac type [Source:HGNC Symbol;Acc:HGNC:11947] | 33702 | -1.476 | -0.4857 | Yes |
| 110 | PARP2 | poly(ADP-ribose) polymerase 2 [Source:HGNC Symbol;Acc:HGNC:272] | 33847 | -1.537 | -0.4748 | Yes |
| 111 | CDKN3 | cyclin dependent kinase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:1791] | 33991 | -1.612 | -0.4631 | Yes |
| 112 | PHF7 | PHD finger protein 7 [Source:HGNC Symbol;Acc:HGNC:18458] | 34015 | -1.627 | -0.4480 | Yes |
| 113 | NF2 | neurofibromin 2 [Source:HGNC Symbol;Acc:HGNC:7773] | 34038 | -1.638 | -0.4328 | Yes |
| 114 | POMC | proopiomelanocortin [Source:HGNC Symbol;Acc:HGNC:9201] | 34192 | -1.713 | -0.4204 | Yes |
| 115 | HSPA2 | heat shock protein family A (Hsp70) member 2 [Source:HGNC Symbol;Acc:HGNC:5235] | 34200 | -1.716 | -0.4041 | Yes |
| 116 | KIF2C | kinesin family member 2C [Source:HGNC Symbol;Acc:HGNC:6393] | 34210 | -1.718 | -0.3877 | Yes |
| 117 | ZC3H14 | zinc finger CCCH-type containing 14 [Source:HGNC Symbol;Acc:HGNC:20509] | 34262 | -1.747 | -0.3723 | Yes |
| 118 | MLLT10 | MLLT10 histone lysine methyltransferase DOT1L cofactor [Source:HGNC Symbol;Acc:HGNC:16063] | 34296 | -1.762 | -0.3562 | Yes |
| 119 | SPATA6 | spermatogenesis associated 6 [Source:HGNC Symbol;Acc:HGNC:18309] | 34484 | -1.850 | -0.3434 | Yes |
| 120 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] | 34602 | -1.924 | -0.3280 | Yes |
| 121 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 34919 | -2.126 | -0.3160 | Yes |
| 122 | NPHP1 | nephrocystin 1 [Source:HGNC Symbol;Acc:HGNC:7905] | 35087 | -2.237 | -0.2989 | Yes |
| 123 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 35185 | -2.308 | -0.2793 | Yes |
| 124 | NCAPH | non-SMC condensin I complex subunit H [Source:HGNC Symbol;Acc:HGNC:1112] | 35378 | -2.378 | -0.2615 | Yes |
| 125 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1148] | 35570 | -2.532 | -0.2423 | Yes |
| 126 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 35581 | -2.547 | -0.2180 | Yes |
| 127 | GMCL1 | germ cell-less 1, spermatogenesis associated [Source:HGNC Symbol;Acc:HGNC:23843] | 35602 | -2.565 | -0.1938 | Yes |
| 128 | TOPBP1 | DNA topoisomerase II binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17008] | 35740 | -2.675 | -0.1717 | Yes |
| 129 | NEK2 | NIMA related kinase 2 [Source:HGNC Symbol;Acc:HGNC:7745] | 35837 | -2.768 | -0.1475 | Yes |
| 130 | PDHA2 | pyruvate dehydrogenase E1 subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:8807] | 35840 | -2.770 | -0.1209 | Yes |
| 131 | STRBP | spermatid perinuclear RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16462] | 35953 | -2.875 | -0.0962 | Yes |
| 132 | HSPA4L | heat shock protein family A (Hsp70) member 4 like [Source:HGNC Symbol;Acc:HGNC:17041] | 36045 | -2.975 | -0.0699 | Yes |
| 133 | PCSK4 | proprotein convertase subtilisin/kexin type 4 [Source:HGNC Symbol;Acc:HGNC:8746] | 36226 | -3.195 | -0.0440 | Yes |
| 134 | ACRBP | acrosin binding protein [Source:HGNC Symbol;Acc:HGNC:17195] | 36318 | -3.261 | -0.0149 | Yes |
| 135 | LPIN1 | lipin 1 [Source:HGNC Symbol;Acc:HGNC:13345] | 36644 | -3.711 | 0.0121 | Yes |
