Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_GAQ_versus_KO_NA.Nof1.cls #KO_GAQ_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_GAQ_versus_KO_NA_repos |
| Upregulated in class | KO_GAQ |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.5485728 |
| Normalized Enrichment Score (NES) | 1.3986027 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.03829268 |
| FWER p-Value | 0.093 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 170 | 4.018 | 0.0353 | Yes |
| 2 | NABP1 | nucleic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:26232] | 412 | 3.162 | 0.0602 | Yes |
| 3 | WFS1 | wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762] | 677 | 2.641 | 0.0793 | Yes |
| 4 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 [Source:HGNC Symbol;Acc:HGNC:13744] | 850 | 2.342 | 0.0979 | Yes |
| 5 | SRPRA | SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307] | 928 | 2.248 | 0.1182 | Yes |
| 6 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 993 | 2.164 | 0.1380 | Yes |
| 7 | HSPA5 | heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol;Acc:HGNC:5238] | 1090 | 2.036 | 0.1556 | Yes |
| 8 | SDAD1 | SDA1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25537] | 1105 | 2.009 | 0.1752 | Yes |
| 9 | CEBPB | CCAAT enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] | 1106 | 2.008 | 0.1951 | Yes |
| 10 | TATDN2 | TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988] | 1133 | 1.969 | 0.2140 | Yes |
| 11 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16829] | 1367 | 1.850 | 0.2261 | Yes |
| 12 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol;Acc:HGNC:6968] | 1375 | 1.842 | 0.2442 | Yes |
| 13 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680] | 1470 | 1.727 | 0.2588 | Yes |
| 14 | ASNS | asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] | 1681 | 1.572 | 0.2687 | Yes |
| 15 | FUS | FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] | 1719 | 1.541 | 0.2831 | Yes |
| 16 | LSM1 | LSM1 homolog, mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:20472] | 1867 | 1.449 | 0.2935 | Yes |
| 17 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 1911 | 1.410 | 0.3063 | Yes |
| 18 | SLC1A4 | solute carrier family 1 member 4 [Source:HGNC Symbol;Acc:HGNC:10942] | 1912 | 1.409 | 0.3203 | Yes |
| 19 | DDIT4 | DNA damage inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] | 1930 | 1.394 | 0.3337 | Yes |
| 20 | NOP14 | NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] | 2319 | 1.212 | 0.3353 | Yes |
| 21 | ATF4 | activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786] | 2373 | 1.180 | 0.3456 | Yes |
| 22 | DCP1A | decapping mRNA 1A [Source:HGNC Symbol;Acc:HGNC:18714] | 2436 | 1.155 | 0.3553 | Yes |
| 23 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol;Acc:HGNC:12855] | 2467 | 1.140 | 0.3659 | Yes |
| 24 | DKC1 | dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890] | 2488 | 1.134 | 0.3766 | Yes |
| 25 | KIF5B | kinesin family member 5B [Source:HGNC Symbol;Acc:HGNC:6324] | 2533 | 1.115 | 0.3865 | Yes |
| 26 | EXOSC4 | exosome component 4 [Source:HGNC Symbol;Acc:HGNC:18189] | 2630 | 1.073 | 0.3945 | Yes |
| 27 | EIF2S1 | eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC Symbol;Acc:HGNC:3265] | 2642 | 1.066 | 0.4048 | Yes |
| 28 | SLC7A5 | solute carrier family 7 member 5 [Source:HGNC Symbol;Acc:HGNC:11063] | 2830 | 0.993 | 0.4096 | Yes |
| 29 | SERP1 | stress associated endoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:10759] | 2831 | 0.992 | 0.4195 | Yes |
| 30 | EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3288] | 2875 | 0.970 | 0.4280 | Yes |
| 31 | PAIP1 | poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] | 2886 | 0.962 | 0.4373 | Yes |
| 32 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 3037 | 0.910 | 0.4422 | Yes |
| 33 | CNOT4 | CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:7880] | 3127 | 0.868 | 0.4485 | Yes |
| 34 | TARS1 | threonyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:11572] | 3139 | 0.866 | 0.4568 | Yes |
| 35 | BAG3 | BAG cochaperone 3 [Source:HGNC Symbol;Acc:HGNC:939] | 3479 | 0.745 | 0.4550 | Yes |
| 36 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 3506 | 0.733 | 0.4616 | Yes |
| 37 | EDC4 | enhancer of mRNA decapping 4 [Source:HGNC Symbol;Acc:HGNC:17157] | 3527 | 0.724 | 0.4682 | Yes |
| 38 | HYOU1 | hypoxia up-regulated 1 [Source:HGNC Symbol;Acc:HGNC:16931] | 3593 | 0.706 | 0.4735 | Yes |
| 39 | NOLC1 | nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15608] | 3633 | 0.693 | 0.4793 | Yes |
| 40 | LSM4 | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17259] | 3696 | 0.678 | 0.4844 | Yes |
| 41 | CNOT6 | CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14099] | 3720 | 0.666 | 0.4904 | Yes |
| 42 | NOP56 | NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] | 3732 | 0.662 | 0.4967 | Yes |
| 43 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 3951 | 0.592 | 0.4966 | Yes |
| 44 | TTC37 | tetratricopeptide repeat domain 37 [Source:HGNC Symbol;Acc:HGNC:23639] | 4006 | 0.577 | 0.5009 | Yes |
| 45 | XPOT | exportin for tRNA [Source:HGNC Symbol;Acc:HGNC:12826] | 4127 | 0.543 | 0.5031 | Yes |
| 46 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434] | 4197 | 0.518 | 0.5063 | Yes |
| 47 | EIF4G1 | eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol;Acc:HGNC:3296] | 4258 | 0.500 | 0.5097 | Yes |
| 48 | BANF1 | BAF nuclear assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:17397] | 4293 | 0.491 | 0.5136 | Yes |
| 49 | NPM1 | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] | 4342 | 0.477 | 0.5171 | Yes |
| 50 | SSR1 | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] | 4393 | 0.467 | 0.5204 | Yes |
| 51 | EXOSC2 | exosome component 2 [Source:HGNC Symbol;Acc:HGNC:17097] | 4454 | 0.442 | 0.5231 | Yes |
| 52 | EXOSC1 | exosome component 1 [Source:HGNC Symbol;Acc:HGNC:17286] | 4490 | 0.434 | 0.5265 | Yes |
| 53 | YIF1A | Yip1 interacting factor homolog A, membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:16688] | 4648 | 0.391 | 0.5261 | Yes |
| 54 | EIF4A1 | eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol;Acc:HGNC:3282] | 4756 | 0.357 | 0.5268 | Yes |
| 55 | HSPA9 | heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244] | 4759 | 0.356 | 0.5303 | Yes |
| 56 | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] | 4829 | 0.338 | 0.5318 | Yes |
| 57 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 4855 | 0.327 | 0.5343 | Yes |
| 58 | CNOT2 | CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] | 4868 | 0.325 | 0.5372 | Yes |
| 59 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 4901 | 0.318 | 0.5395 | Yes |
| 60 | PREB | prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] | 4914 | 0.314 | 0.5423 | Yes |
| 61 | EXOSC10 | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] | 4992 | 0.291 | 0.5431 | Yes |
| 62 | PDIA5 | protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] | 5001 | 0.287 | 0.5458 | Yes |
| 63 | CXXC1 | CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] | 5014 | 0.283 | 0.5483 | Yes |
| 64 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 5098 | 0.258 | 0.5486 | Yes |
| 65 | NFYA | nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] | 5624 | 0.217 | 0.5365 | No |
| 66 | DDX10 | DEAD-box helicase 10 [Source:HGNC Symbol;Acc:HGNC:2735] | 5696 | 0.190 | 0.5365 | No |
| 67 | EIF4A3 | eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:HGNC:18683] | 5805 | 0.159 | 0.5352 | No |
| 68 | SPCS3 | signal peptidase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26212] | 5897 | 0.131 | 0.5340 | No |
| 69 | SHC1 | SHC adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:10840] | 6088 | 0.072 | 0.5296 | No |
| 70 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 6097 | 0.069 | 0.5300 | No |
| 71 | EIF2AK3 | eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255] | 6230 | 0.035 | 0.5268 | No |
| 72 | IGFBP1 | insulin like growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5469] | 11892 | 0.000 | 0.3737 | No |
| 73 | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] | 18594 | 0.000 | 0.1925 | No |
| 74 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 28039 | 0.000 | -0.0629 | No |
| 75 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 28559 | -0.010 | -0.0768 | No |
| 76 | TSPYL2 | TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] | 28703 | -0.048 | -0.0802 | No |
| 77 | NHP2 | NHP2 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:14377] | 28760 | -0.062 | -0.0811 | No |
| 78 | IARS1 | isoleucyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:5330] | 28933 | -0.106 | -0.0847 | No |
| 79 | GEMIN4 | gem nuclear organelle associated protein 4 [Source:HGNC Symbol;Acc:HGNC:15717] | 29030 | -0.132 | -0.0860 | No |
| 80 | PDIA6 | protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168] | 29167 | -0.167 | -0.0880 | No |
| 81 | VEGFA | vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] | 29178 | -0.170 | -0.0866 | No |
| 82 | ARFGAP1 | ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:15852] | 29223 | -0.179 | -0.0860 | No |
| 83 | MTREX | Mtr4 exosome RNA helicase [Source:HGNC Symbol;Acc:HGNC:18734] | 29413 | -0.219 | -0.0889 | No |
| 84 | ZBTB17 | zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936] | 29447 | -0.227 | -0.0876 | No |
| 85 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 29534 | -0.248 | -0.0874 | No |
| 86 | ATP6V0D1 | ATPase H+ transporting V0 subunit d1 [Source:HGNC Symbol;Acc:HGNC:13724] | 29646 | -0.276 | -0.0877 | No |
| 87 | CEBPG | CCAAT enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] | 29662 | -0.281 | -0.0853 | No |
| 88 | DCTN1 | dynactin subunit 1 [Source:HGNC Symbol;Acc:HGNC:2711] | 29714 | -0.294 | -0.0838 | No |
| 89 | EXOSC9 | exosome component 9 [Source:HGNC Symbol;Acc:HGNC:9137] | 29721 | -0.295 | -0.0810 | No |
| 90 | XBP1 | X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801] | 29889 | -0.329 | -0.0822 | No |
| 91 | ALDH18A1 | aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol;Acc:HGNC:9722] | 29896 | -0.331 | -0.0791 | No |
| 92 | EXOC2 | exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] | 30153 | -0.396 | -0.0821 | No |
| 93 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 30223 | -0.414 | -0.0799 | No |
| 94 | KHSRP | KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] | 30492 | -0.481 | -0.0823 | No |
| 95 | RPS14 | ribosomal protein S14 [Source:HGNC Symbol;Acc:HGNC:10387] | 30548 | -0.497 | -0.0789 | No |
| 96 | ATF6 | activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] | 30682 | -0.533 | -0.0772 | No |
| 97 | PARN | poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] | 30715 | -0.543 | -0.0726 | No |
| 98 | EEF2 | eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214] | 30896 | -0.589 | -0.0717 | No |
| 99 | PSAT1 | phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129] | 31099 | -0.645 | -0.0707 | No |
| 100 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 31156 | -0.662 | -0.0657 | No |
| 101 | IMP3 | IMP U3 small nucleolar ribonucleoprotein 3 [Source:HGNC Symbol;Acc:HGNC:14497] | 31769 | -0.827 | -0.0740 | No |
| 102 | KDELR3 | KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol;Acc:HGNC:6306] | 31822 | -0.846 | -0.0670 | No |
| 103 | ERN1 | endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] | 32189 | -0.980 | -0.0671 | No |
| 104 | STC2 | stanniocalcin 2 [Source:HGNC Symbol;Acc:HGNC:11374] | 32549 | -1.100 | -0.0659 | No |
| 105 | EXOSC5 | exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] | 33039 | -1.269 | -0.0665 | No |
| 106 | POP4 | POP4 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30081] | 33044 | -1.273 | -0.0540 | No |
| 107 | SLC30A5 | solute carrier family 30 member 5 [Source:HGNC Symbol;Acc:HGNC:19089] | 33078 | -1.283 | -0.0421 | No |
| 108 | TUBB2A | tubulin beta 2A class IIa [Source:HGNC Symbol;Acc:HGNC:12412] | 33750 | -1.494 | -0.0454 | No |
| 109 | ERO1A | endoplasmic reticulum oxidoreductase 1 alpha [Source:HGNC Symbol;Acc:HGNC:13280] | 34880 | -2.099 | -0.0551 | No |
| 110 | EDEM1 | ER degradation enhancing alpha-mannosidase like protein 1 [Source:HGNC Symbol;Acc:HGNC:18967] | 34945 | -2.139 | -0.0356 | No |
| 111 | FKBP14 | FKBP prolyl isomerase 14 [Source:HGNC Symbol;Acc:HGNC:18625] | 35339 | -2.338 | -0.0230 | No |
| 112 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 35814 | -2.749 | -0.0085 | No |
| 113 | WIPI1 | WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] | 36934 | -4.326 | 0.0042 | No |
