Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HECKER_IFNB1_TARGETS |
| Enrichment Score (ES) | 0.8311957 |
| Normalized Enrichment Score (NES) | 2.0409667 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.7718852E-4 |
| FWER p-Value | 0.002 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 17 | 4.971 | 0.0291 | Yes |
| 2 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 35 | 4.928 | 0.0579 | Yes |
| 3 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 49 | 4.852 | 0.0863 | Yes |
| 4 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 55 | 4.827 | 0.1148 | Yes |
| 5 | GBP1 | guanylate binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4182] | 59 | 4.819 | 0.1434 | Yes |
| 6 | CMPK2 | cytidine/uridine monophosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:27015] | 60 | 4.819 | 0.1720 | Yes |
| 7 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 66 | 4.776 | 0.2002 | Yes |
| 8 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 71 | 4.757 | 0.2284 | Yes |
| 9 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 78 | 4.727 | 0.2563 | Yes |
| 10 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 85 | 4.682 | 0.2839 | Yes |
| 11 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 101 | 4.617 | 0.3109 | Yes |
| 12 | HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 [Source:HGNC Symbol;Acc:HGNC:26072] | 106 | 4.605 | 0.3382 | Yes |
| 13 | IFI44 | interferon induced protein 44 [Source:HGNC Symbol;Acc:HGNC:16938] | 119 | 4.515 | 0.3646 | Yes |
| 14 | DHX58 | DExH-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:29517] | 180 | 4.220 | 0.3881 | Yes |
| 15 | SIGLEC1 | sialic acid binding Ig like lectin 1 [Source:HGNC Symbol;Acc:HGNC:11127] | 195 | 4.142 | 0.4123 | Yes |
| 16 | EIF2AK2 | eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437] | 228 | 4.036 | 0.4354 | Yes |
| 17 | DDX58 | DExD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102] | 237 | 4.005 | 0.4590 | Yes |
| 18 | SAMD9L | sterile alpha motif domain containing 9 like [Source:HGNC Symbol;Acc:HGNC:1349] | 257 | 3.933 | 0.4818 | Yes |
| 19 | SAMD9 | sterile alpha motif domain containing 9 [Source:HGNC Symbol;Acc:HGNC:1348] | 264 | 3.882 | 0.5047 | Yes |
| 20 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 271 | 3.864 | 0.5275 | Yes |
| 21 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 281 | 3.833 | 0.5500 | Yes |
| 22 | C3AR1 | complement C3a receptor 1 [Source:HGNC Symbol;Acc:HGNC:1319] | 290 | 3.811 | 0.5724 | Yes |
| 23 | PARP12 | poly(ADP-ribose) polymerase family member 12 [Source:HGNC Symbol;Acc:HGNC:21919] | 291 | 3.808 | 0.5950 | Yes |
| 24 | DDX60 | DExD/H-box helicase 60 [Source:HGNC Symbol;Acc:HGNC:25942] | 298 | 3.789 | 0.6174 | Yes |
| 25 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 307 | 3.781 | 0.6396 | Yes |
| 26 | STAP1 | signal transducing adaptor family member 1 [Source:HGNC Symbol;Acc:HGNC:24133] | 324 | 3.708 | 0.6612 | Yes |
| 27 | MGAM | maltase-glucoamylase [Source:HGNC Symbol;Acc:HGNC:7043] | 347 | 3.608 | 0.6820 | Yes |
| 28 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 349 | 3.605 | 0.7034 | Yes |
| 29 | EPSTI1 | epithelial stromal interaction 1 [Source:HGNC Symbol;Acc:HGNC:16465] | 374 | 3.557 | 0.7239 | Yes |
| 30 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 419 | 3.394 | 0.7428 | Yes |
| 31 | LGALS3BP | galectin 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6564] | 556 | 3.095 | 0.7575 | Yes |
| 32 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 580 | 3.035 | 0.7749 | Yes |
| 33 | PNPT1 | polyribonucleotide nucleotidyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:23166] | 594 | 2.998 | 0.7924 | Yes |
| 34 | DTX3L | deltex E3 ubiquitin ligase 3L [Source:HGNC Symbol;Acc:HGNC:30323] | 918 | 2.459 | 0.7983 | Yes |
| 35 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 1025 | 2.276 | 0.8089 | Yes |
| 36 | HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 [Source:HGNC Symbol;Acc:HGNC:24368] | 1562 | 1.752 | 0.8048 | Yes |
| 37 | IFI44L | interferon induced protein 44 like [Source:HGNC Symbol;Acc:HGNC:17817] | 1912 | 1.458 | 0.8040 | Yes |
| 38 | PLSCR1 | phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092] | 2072 | 1.379 | 0.8079 | Yes |
| 39 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 2180 | 1.310 | 0.8128 | Yes |
| 40 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 2290 | 1.253 | 0.8173 | Yes |
| 41 | PDZK1IP1 | PDZK1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16887] | 2294 | 1.252 | 0.8247 | Yes |
| 42 | SH3BGRL2 | SH3 domain binding glutamate rich protein like 2 [Source:HGNC Symbol;Acc:HGNC:15567] | 2324 | 1.231 | 0.8312 | Yes |
| 43 | LAP3 | leucine aminopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:18449] | 2936 | 0.913 | 0.8201 | No |
| 44 | MYL9 | myosin light chain 9 [Source:HGNC Symbol;Acc:HGNC:15754] | 3545 | 0.665 | 0.8076 | No |
| 45 | TMEM140 | transmembrane protein 140 [Source:HGNC Symbol;Acc:HGNC:21870] | 4036 | 0.475 | 0.7972 | No |
| 46 | SCO2 | synthesis of cytochrome C oxidase 2 [Source:HGNC Symbol;Acc:HGNC:10604] | 4420 | 0.466 | 0.7896 | No |
| 47 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 5211 | 0.211 | 0.7695 | No |
| 48 | RPS23 | ribosomal protein S23 [Source:HGNC Symbol;Acc:HGNC:10410] | 5898 | 0.019 | 0.7511 | No |
| 49 | HES4 | hes family bHLH transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:24149] | 6874 | 0.000 | 0.7247 | No |
| 50 | ARG1 | arginase 1 [Source:HGNC Symbol;Acc:HGNC:663] | 6975 | 0.000 | 0.7220 | No |
| 51 | CD163 | CD163 molecule [Source:HGNC Symbol;Acc:HGNC:1631] | 7418 | 0.000 | 0.7101 | No |
| 52 | LY6E | lymphocyte antigen 6 family member E [Source:HGNC Symbol;Acc:HGNC:6727] | 8934 | 0.000 | 0.6691 | No |
| 53 | FCER1A | Fc fragment of IgE receptor Ia [Source:HGNC Symbol;Acc:HGNC:3609] | 9611 | 0.000 | 0.6509 | No |
| 54 | TYMP | thymidine phosphorylase [Source:HGNC Symbol;Acc:HGNC:3148] | 9953 | 0.000 | 0.6417 | No |
| 55 | RTP4 | receptor transporter protein 4 [Source:HGNC Symbol;Acc:HGNC:23992] | 10255 | 0.000 | 0.6335 | No |
| 56 | GZMB | granzyme B [Source:HGNC Symbol;Acc:HGNC:4709] | 11975 | 0.000 | 0.5871 | No |
| 57 | APOBEC3A | apolipoprotein B mRNA editing enzyme catalytic subunit 3A [Source:HGNC Symbol;Acc:HGNC:17343] | 12291 | 0.000 | 0.5785 | No |
| 58 | APOBEC3B | apolipoprotein B mRNA editing enzyme catalytic subunit 3B [Source:HGNC Symbol;Acc:HGNC:17352] | 12293 | 0.000 | 0.5785 | No |
| 59 | TCL1A | T cell leukemia/lymphoma 1A [Source:HGNC Symbol;Acc:HGNC:11648] | 12903 | 0.000 | 0.5621 | No |
| 60 | TNFAIP6 | TNF alpha induced protein 6 [Source:HGNC Symbol;Acc:HGNC:11898] | 15369 | 0.000 | 0.4954 | No |
| 61 | G0S2 | G0/G1 switch 2 [Source:HGNC Symbol;Acc:HGNC:30229] | 15720 | 0.000 | 0.4860 | No |
| 62 | GP9 | glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] | 17083 | 0.000 | 0.4492 | No |
| 63 | SERPING1 | serpin family G member 1 [Source:HGNC Symbol;Acc:HGNC:1228] | 17756 | 0.000 | 0.4310 | No |
| 64 | SPON2 | spondin 2 [Source:HGNC Symbol;Acc:HGNC:11253] | 18971 | 0.000 | 0.3982 | No |
| 65 | CXCL8 | C-X-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025] | 19482 | 0.000 | 0.3844 | No |
| 66 | CHI3L1 | chitinase 3 like 1 [Source:HGNC Symbol;Acc:HGNC:1932] | 19896 | 0.000 | 0.3732 | No |
| 67 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 20142 | 0.000 | 0.3666 | No |
| 68 | KCNJ15 | potassium inwardly rectifying channel subfamily J member 15 [Source:HGNC Symbol;Acc:HGNC:6261] | 20790 | 0.000 | 0.3491 | No |
| 69 | KLRD1 | killer cell lectin like receptor D1 [Source:HGNC Symbol;Acc:HGNC:6378] | 20873 | 0.000 | 0.3469 | No |
| 70 | LAMP3 | lysosomal associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:14582] | 21464 | 0.000 | 0.3310 | No |
| 71 | CABP5 | calcium binding protein 5 [Source:HGNC Symbol;Acc:HGNC:13714] | 21738 | 0.000 | 0.3236 | No |
| 72 | ZBP1 | Z-DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:16176] | 23002 | 0.000 | 0.2895 | No |
| 73 | MS4A4A | membrane spanning 4-domains A4A [Source:HGNC Symbol;Acc:HGNC:13371] | 23133 | 0.000 | 0.2859 | No |
| 74 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 24418 | 0.000 | 0.2512 | No |
| 75 | C1QB | complement C1q B chain [Source:HGNC Symbol;Acc:HGNC:1242] | 24812 | 0.000 | 0.2406 | No |
| 76 | C1QA | complement C1q A chain [Source:HGNC Symbol;Acc:HGNC:1241] | 24813 | 0.000 | 0.2406 | No |
| 77 | C1QC | complement C1q C chain [Source:HGNC Symbol;Acc:HGNC:1245] | 24831 | 0.000 | 0.2402 | No |
| 78 | FFAR2 | free fatty acid receptor 2 [Source:HGNC Symbol;Acc:HGNC:4501] | 25412 | 0.000 | 0.2245 | No |
| 79 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 25426 | 0.000 | 0.2241 | No |
| 80 | MMP25 | matrix metallopeptidase 25 [Source:HGNC Symbol;Acc:HGNC:14246] | 25622 | 0.000 | 0.2189 | No |
| 81 | CMTM5 | CKLF like MARVEL transmembrane domain containing 5 [Source:HGNC Symbol;Acc:HGNC:19176] | 26922 | 0.000 | 0.1837 | No |
| 82 | CMTM2 | CKLF like MARVEL transmembrane domain containing 2 [Source:HGNC Symbol;Acc:HGNC:19173] | 26936 | 0.000 | 0.1834 | No |
| 83 | TRBV27 | T cell receptor beta variable 27 [Source:HGNC Symbol;Acc:HGNC:12208] | 27573 | 0.000 | 0.1662 | No |
| 84 | CCL8 | C-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:10635] | 27821 | 0.000 | 0.1595 | No |
| 85 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 29900 | -0.469 | 0.1061 | No |
| 86 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 32096 | -1.134 | 0.0536 | No |
| 87 | ITGA2B | integrin subunit alpha 2b [Source:HGNC Symbol;Acc:HGNC:6138] | 32507 | -1.233 | 0.0498 | No |
| 88 | EGR2 | early growth response 2 [Source:HGNC Symbol;Acc:HGNC:3239] | 33049 | -1.475 | 0.0439 | No |
| 89 | TREML1 | triggering receptor expressed on myeloid cells like 1 [Source:HGNC Symbol;Acc:HGNC:20434] | 34291 | -2.071 | 0.0227 | No |
| 90 | CYP4F3 | cytochrome P450 family 4 subfamily F member 3 [Source:HGNC Symbol;Acc:HGNC:2646] | 34550 | -2.196 | 0.0288 | No |
| 91 | PROS1 | protein S [Source:HGNC Symbol;Acc:HGNC:9456] | 35411 | -2.765 | 0.0219 | No |
| 92 | JUP | junction plakoglobin [Source:HGNC Symbol;Acc:HGNC:6207] | 36556 | -3.946 | 0.0144 | No |
