Fig 1: Enrichment plot: MORI_IMMATURE_B_LYMPHOCYTE_DN
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | MORI_IMMATURE_B_LYMPHOCYTE_DN |
| Enrichment Score (ES) | -0.82005155 |
| Normalized Enrichment Score (NES) | -1.688128 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0011744855 |
| FWER p-Value | 0.018 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | CDKN1A | cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] | 1552 | 1.761 | -0.0338 | No |
| 2 | TXN | thioredoxin [Source:HGNC Symbol;Acc:HGNC:12435] | 2153 | 1.328 | -0.0439 | No |
| 3 | HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B [Source:HGNC Symbol;Acc:HGNC:5034] | 3364 | 0.733 | -0.0733 | No |
| 4 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434] | 3377 | 0.727 | -0.0702 | No |
| 5 | DCK | deoxycytidine kinase [Source:HGNC Symbol;Acc:HGNC:2704] | 3798 | 0.562 | -0.0790 | No |
| 6 | CBX1 | chromobox 1 [Source:HGNC Symbol;Acc:HGNC:1551] | 4848 | 0.333 | -0.1058 | No |
| 7 | PREP | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] | 5134 | 0.234 | -0.1124 | No |
| 8 | SLBP | stem-loop binding protein [Source:HGNC Symbol;Acc:HGNC:10904] | 5676 | 0.088 | -0.1266 | No |
| 9 | RAG1 | recombination activating 1 [Source:HGNC Symbol;Acc:HGNC:9831] | 12341 | 0.000 | -0.3067 | No |
| 10 | CDCA5 | cell division cycle associated 5 [Source:HGNC Symbol;Acc:HGNC:14626] | 16663 | 0.000 | -0.4235 | No |
| 11 | IGLL1 | immunoglobulin lambda like polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:5870] | 18444 | 0.000 | -0.4716 | No |
| 12 | CENPA | centromere protein A [Source:HGNC Symbol;Acc:HGNC:1851] | 21014 | 0.000 | -0.5411 | No |
| 13 | ENPEP | glutamyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:3355] | 24244 | 0.000 | -0.6283 | No |
| 14 | RAMP1 | receptor activity modifying protein 1 [Source:HGNC Symbol;Acc:HGNC:9843] | 25044 | 0.000 | -0.6499 | No |
| 15 | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 [Source:HGNC Symbol;Acc:HGNC:11101] | 28164 | -0.014 | -0.7342 | No |
| 16 | HMGN2 | high mobility group nucleosomal binding domain 2 [Source:HGNC Symbol;Acc:HGNC:4986] | 28663 | -0.147 | -0.7470 | No |
| 17 | HAUS3 | HAUS augmin like complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:28719] | 29927 | -0.477 | -0.7789 | No |
| 18 | ANP32E | acidic nuclear phosphoprotein 32 family member E [Source:HGNC Symbol;Acc:HGNC:16673] | 30436 | -0.597 | -0.7899 | No |
| 19 | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [Source:HGNC Symbol;Acc:HGNC:11100] | 30659 | -0.672 | -0.7928 | No |
| 20 | ACTN4 | actinin alpha 4 [Source:HGNC Symbol;Acc:HGNC:166] | 31041 | -0.783 | -0.7995 | No |
| 21 | PRDX4 | peroxiredoxin 4 [Source:HGNC Symbol;Acc:HGNC:17169] | 31333 | -0.870 | -0.8033 | No |
| 22 | UCK2 | uridine-cytidine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12562] | 31782 | -1.019 | -0.8107 | No |
| 23 | HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 [Source:HGNC Symbol;Acc:HGNC:24941] | 32128 | -1.148 | -0.8148 | Yes |
| 24 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 32234 | -1.194 | -0.8121 | Yes |
| 25 | LGALS1 | galectin 1 [Source:HGNC Symbol;Acc:HGNC:6561] | 32308 | -1.226 | -0.8084 | Yes |
| 26 | PCK2 | phosphoenolpyruvate carboxykinase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:8725] | 32634 | -1.286 | -0.8113 | Yes |
| 27 | RBBP4 | RB binding protein 4, chromatin remodeling factor [Source:HGNC Symbol;Acc:HGNC:9887] | 32686 | -1.314 | -0.8066 | Yes |
| 28 | HJURP | Holliday junction recognition protein [Source:HGNC Symbol;Acc:HGNC:25444] | 32737 | -1.335 | -0.8018 | Yes |
| 29 | CDC45 | cell division cycle 45 [Source:HGNC Symbol;Acc:HGNC:1739] | 32822 | -1.363 | -0.7978 | Yes |
| 30 | XRCC6 | X-ray repair cross complementing 6 [Source:HGNC Symbol;Acc:HGNC:4055] | 33004 | -1.453 | -0.7960 | Yes |
| 31 | SLC16A1 | solute carrier family 16 member 1 [Source:HGNC Symbol;Acc:HGNC:10922] | 33206 | -1.537 | -0.7943 | Yes |
| 32 | LMNB1 | lamin B1 [Source:HGNC Symbol;Acc:HGNC:6637] | 33291 | -1.571 | -0.7894 | Yes |
| 33 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 33303 | -1.578 | -0.7824 | Yes |
| 34 | HMGB1 | high mobility group box 1 [Source:HGNC Symbol;Acc:HGNC:4983] | 33349 | -1.593 | -0.7763 | Yes |
| 35 | TUBB4B | tubulin beta 4B class IVb [Source:HGNC Symbol;Acc:HGNC:20771] | 33365 | -1.603 | -0.7693 | Yes |
| 36 | KPNA2 | karyopherin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6395] | 33683 | -1.743 | -0.7698 | Yes |
| 37 | CKAP5 | cytoskeleton associated protein 5 [Source:HGNC Symbol;Acc:HGNC:28959] | 34140 | -1.987 | -0.7730 | Yes |
| 38 | HMGB2 | high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000] | 34287 | -2.069 | -0.7674 | Yes |
| 39 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 34580 | -2.221 | -0.7650 | Yes |
| 40 | H2AC4 | H2A clustered histone 4 [Source:HGNC Symbol;Acc:HGNC:4734] | 34680 | -2.278 | -0.7572 | Yes |
| 41 | MCM10 | minichromosome maintenance 10 replication initiation factor [Source:HGNC Symbol;Acc:HGNC:18043] | 34813 | -2.360 | -0.7499 | Yes |
| 42 | RAD51 | RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817] | 34863 | -2.398 | -0.7402 | Yes |
| 43 | TUBA1A | tubulin alpha 1a [Source:HGNC Symbol;Acc:HGNC:20766] | 34888 | -2.411 | -0.7297 | Yes |
| 44 | PRIM1 | DNA primase subunit 1 [Source:HGNC Symbol;Acc:HGNC:9369] | 35069 | -2.538 | -0.7229 | Yes |
| 45 | TUBA1B | tubulin alpha 1b [Source:HGNC Symbol;Acc:HGNC:18809] | 35072 | -2.540 | -0.7112 | Yes |
| 46 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35087 | -2.553 | -0.6999 | Yes |
| 47 | MCM3 | minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] | 35150 | -2.598 | -0.6896 | Yes |
| 48 | RRM1 | ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451] | 35160 | -2.606 | -0.6778 | Yes |
| 49 | CENPL | centromere protein L [Source:HGNC Symbol;Acc:HGNC:17879] | 35293 | -2.681 | -0.6690 | Yes |
| 50 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3527] | 35361 | -2.726 | -0.6583 | Yes |
| 51 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 35393 | -2.750 | -0.6464 | Yes |
| 52 | TUBB | tubulin beta class I [Source:HGNC Symbol;Acc:HGNC:20778] | 35477 | -2.816 | -0.6357 | Yes |
| 53 | CHEK1 | checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] | 35483 | -2.821 | -0.6228 | Yes |
| 54 | DLGAP5 | DLG associated protein 5 [Source:HGNC Symbol;Acc:HGNC:16864] | 35546 | -2.882 | -0.6112 | Yes |
| 55 | MCM2 | minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] | 35740 | -3.078 | -0.6022 | Yes |
| 56 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 35783 | -3.122 | -0.5890 | Yes |
| 57 | UBE2C | ubiquitin conjugating enzyme E2 C [Source:HGNC Symbol;Acc:HGNC:15937] | 35837 | -3.176 | -0.5758 | Yes |
| 58 | IQGAP3 | IQ motif containing GTPase activating protein 3 [Source:HGNC Symbol;Acc:HGNC:20669] | 35851 | -3.186 | -0.5615 | Yes |
| 59 | RAD54L | RAD54 like [Source:HGNC Symbol;Acc:HGNC:9826] | 36017 | -3.355 | -0.5505 | Yes |
| 60 | CCNB1 | cyclin B1 [Source:HGNC Symbol;Acc:HGNC:1579] | 36019 | -3.358 | -0.5350 | Yes |
| 61 | MCM7 | minichromosome maintenance complex component 7 [Source:HGNC Symbol;Acc:HGNC:6950] | 36039 | -3.372 | -0.5200 | Yes |
| 62 | GSN | gelsolin [Source:HGNC Symbol;Acc:HGNC:4620] | 36048 | -3.379 | -0.5046 | Yes |
| 63 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 36054 | -3.383 | -0.4892 | Yes |
| 64 | CDCA7 | cell division cycle associated 7 [Source:HGNC Symbol;Acc:HGNC:14628] | 36057 | -3.385 | -0.4736 | Yes |
| 65 | KIFC1 | kinesin family member C1 [Source:HGNC Symbol;Acc:HGNC:6389] | 36060 | -3.389 | -0.4581 | Yes |
| 66 | DTL | denticleless E3 ubiquitin protein ligase homolog [Source:HGNC Symbol;Acc:HGNC:30288] | 36080 | -3.411 | -0.4429 | Yes |
| 67 | TMPO | thymopoietin [Source:HGNC Symbol;Acc:HGNC:11875] | 36086 | -3.421 | -0.4272 | Yes |
| 68 | STMN1 | stathmin 1 [Source:HGNC Symbol;Acc:HGNC:6510] | 36157 | -3.491 | -0.4130 | Yes |
| 69 | LIG1 | DNA ligase 1 [Source:HGNC Symbol;Acc:HGNC:6598] | 36371 | -3.711 | -0.4017 | Yes |
| 70 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) [Source:HGNC Symbol;Acc:HGNC:11003] | 36379 | -3.721 | -0.3847 | Yes |
| 71 | CDKN3 | cyclin dependent kinase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:1791] | 36393 | -3.744 | -0.3678 | Yes |
| 72 | CDC20 | cell division cycle 20 [Source:HGNC Symbol;Acc:HGNC:1723] | 36488 | -3.857 | -0.3526 | Yes |
| 73 | NEK2 | NIMA related kinase 2 [Source:HGNC Symbol;Acc:HGNC:7745] | 36508 | -3.891 | -0.3352 | Yes |
| 74 | NCAPH | non-SMC condensin I complex subunit H [Source:HGNC Symbol;Acc:HGNC:1112] | 36519 | -3.907 | -0.3174 | Yes |
| 75 | PTGR1 | prostaglandin reductase 1 [Source:HGNC Symbol;Acc:HGNC:18429] | 36537 | -3.921 | -0.2998 | Yes |
| 76 | DNMT1 | DNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:2976] | 36553 | -3.943 | -0.2821 | Yes |
| 77 | NUSAP1 | nucleolar and spindle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18538] | 36576 | -3.975 | -0.2643 | Yes |
| 78 | PRC1 | protein regulator of cytokinesis 1 [Source:HGNC Symbol;Acc:HGNC:9341] | 36590 | -3.998 | -0.2463 | Yes |
| 79 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36591 | -3.999 | -0.2278 | Yes |
| 80 | CDKN2C | cyclin dependent kinase inhibitor 2C [Source:HGNC Symbol;Acc:HGNC:1789] | 36685 | -4.099 | -0.2115 | Yes |
| 81 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 36709 | -4.137 | -0.1930 | Yes |
| 82 | H2AZ2 | H2A.Z variant histone 2 [Source:HGNC Symbol;Acc:HGNC:20664] | 36713 | -4.143 | -0.1740 | Yes |
| 83 | RRM2 | ribonucleotide reductase regulatory subunit M2 [Source:HGNC Symbol;Acc:HGNC:10452] | 36786 | -4.241 | -0.1564 | Yes |
| 84 | MELK | maternal embryonic leucine zipper kinase [Source:HGNC Symbol;Acc:HGNC:16870] | 36795 | -4.256 | -0.1370 | Yes |
| 85 | HMGB3 | high mobility group box 3 [Source:HGNC Symbol;Acc:HGNC:5004] | 36819 | -4.299 | -0.1178 | Yes |
| 86 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 36838 | -4.351 | -0.0982 | Yes |
| 87 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 36851 | -4.372 | -0.0784 | Yes |
| 88 | E2F8 | E2F transcription factor 8 [Source:HGNC Symbol;Acc:HGNC:24727] | 36887 | -4.439 | -0.0589 | Yes |
| 89 | CDCA3 | cell division cycle associated 3 [Source:HGNC Symbol;Acc:HGNC:14624] | 36915 | -4.481 | -0.0390 | Yes |
| 90 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 36941 | -4.548 | -0.0187 | Yes |
| 91 | MKI67 | marker of proliferation Ki-67 [Source:HGNC Symbol;Acc:HGNC:7107] | 37062 | -4.928 | 0.0008 | Yes |
