Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION |
| Enrichment Score (ES) | 0.7669233 |
| Normalized Enrichment Score (NES) | 1.9785957 |
| Nominal p-value | 0.0 |
| FDR q-value | 4.2207565E-4 |
| FWER p-Value | 0.005 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 267 | 3.874 | 0.0263 | Yes |
| 2 | LY96 | lymphocyte antigen 96 [Source:HGNC Symbol;Acc:HGNC:17156] | 301 | 3.789 | 0.0581 | Yes |
| 3 | ITGAV | integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] | 398 | 3.471 | 0.0855 | Yes |
| 4 | PSMB10 | proteasome 20S subunit beta 10 [Source:HGNC Symbol;Acc:HGNC:9538] | 492 | 3.237 | 0.1109 | Yes |
| 5 | CD36 | CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] | 525 | 3.162 | 0.1374 | Yes |
| 6 | CD14 | CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] | 536 | 3.138 | 0.1642 | Yes |
| 7 | PSMA6 | proteasome 20S subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:9535] | 656 | 2.853 | 0.1857 | Yes |
| 8 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 662 | 2.848 | 0.2101 | Yes |
| 9 | PSME2 | proteasome activator subunit 2 [Source:HGNC Symbol;Acc:HGNC:9569] | 745 | 2.754 | 0.2317 | Yes |
| 10 | VAMP3 | vesicle associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:12644] | 775 | 2.693 | 0.2542 | Yes |
| 11 | TAPBP | TAP binding protein [Source:HGNC Symbol;Acc:HGNC:11566] | 786 | 2.676 | 0.2771 | Yes |
| 12 | LNPEP | leucyl and cystinyl aminopeptidase [Source:HGNC Symbol;Acc:HGNC:6656] | 938 | 2.426 | 0.2939 | Yes |
| 13 | TLR1 | toll like receptor 1 [Source:HGNC Symbol;Acc:HGNC:11847] | 952 | 2.396 | 0.3143 | Yes |
| 14 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 1010 | 2.308 | 0.3327 | Yes |
| 15 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 1109 | 2.155 | 0.3487 | Yes |
| 16 | TLR6 | toll like receptor 6 [Source:HGNC Symbol;Acc:HGNC:16711] | 1114 | 2.149 | 0.3671 | Yes |
| 17 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 1154 | 2.093 | 0.3841 | Yes |
| 18 | TAP2 | transporter 2, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:44] | 1182 | 2.075 | 0.4013 | Yes |
| 19 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 1283 | 2.058 | 0.4164 | Yes |
| 20 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1375 | 1.947 | 0.4308 | Yes |
| 21 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 1399 | 1.916 | 0.4467 | Yes |
| 22 | PSMA4 | proteasome 20S subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:9533] | 1573 | 1.744 | 0.4571 | Yes |
| 23 | TIRAP | TIR domain containing adaptor protein [Source:HGNC Symbol;Acc:HGNC:17192] | 1724 | 1.614 | 0.4670 | Yes |
| 24 | IKBKG | inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [Source:HGNC Symbol;Acc:HGNC:5961] | 1779 | 1.562 | 0.4790 | Yes |
| 25 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 1793 | 1.552 | 0.4921 | Yes |
| 26 | PSMD11 | proteasome 26S subunit, non-ATPase 11 [Source:HGNC Symbol;Acc:HGNC:9556] | 1906 | 1.461 | 0.5017 | Yes |
| 27 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 1929 | 1.449 | 0.5136 | Yes |
| 28 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 2011 | 1.422 | 0.5237 | Yes |
| 29 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 2022 | 1.414 | 0.5356 | Yes |
| 30 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 2094 | 1.365 | 0.5455 | Yes |
| 31 | PSMC1 | proteasome 26S subunit, ATPase 1 [Source:HGNC Symbol;Acc:HGNC:9547] | 2095 | 1.364 | 0.5573 | Yes |
| 32 | PSMC2 | proteasome 26S subunit, ATPase 2 [Source:HGNC Symbol;Acc:HGNC:9548] | 2105 | 1.357 | 0.5688 | Yes |
| 33 | PSMC5 | proteasome 26S subunit, ATPase 5 [Source:HGNC Symbol;Acc:HGNC:9552] | 2122 | 1.346 | 0.5800 | Yes |
| 34 | IKBKB | inhibitor of nuclear factor kappa B kinase subunit beta [Source:HGNC Symbol;Acc:HGNC:5960] | 2149 | 1.330 | 0.5908 | Yes |
| 35 | PSMA5 | proteasome 20S subunit alpha 5 [Source:HGNC Symbol;Acc:HGNC:9534] | 2214 | 1.291 | 0.6002 | Yes |
| 36 | PSMD12 | proteasome 26S subunit, non-ATPase 12 [Source:HGNC Symbol;Acc:HGNC:9557] | 2467 | 1.163 | 0.6034 | Yes |
| 37 | PSMD14 | proteasome 26S subunit, non-ATPase 14 [Source:HGNC Symbol;Acc:HGNC:16889] | 2576 | 1.092 | 0.6099 | Yes |
| 38 | PSMB6 | proteasome 20S subunit beta 6 [Source:HGNC Symbol;Acc:HGNC:9543] | 2633 | 1.058 | 0.6176 | Yes |
| 39 | PSMD3 | proteasome 26S subunit, non-ATPase 3 [Source:HGNC Symbol;Acc:HGNC:9560] | 2654 | 1.043 | 0.6260 | Yes |
| 40 | PSMD7 | proteasome 26S subunit, non-ATPase 7 [Source:HGNC Symbol;Acc:HGNC:9565] | 2664 | 1.037 | 0.6348 | Yes |
| 41 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 2761 | 0.998 | 0.6408 | Yes |
| 42 | NCF2 | neutrophil cytosolic factor 2 [Source:HGNC Symbol;Acc:HGNC:7661] | 2887 | 0.932 | 0.6455 | Yes |
| 43 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 2959 | 0.901 | 0.6513 | Yes |
| 44 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 2979 | 0.894 | 0.6585 | Yes |
| 45 | CYBB | cytochrome b-245 beta chain [Source:HGNC Symbol;Acc:HGNC:2578] | 2980 | 0.892 | 0.6663 | Yes |
| 46 | PSMD6 | proteasome 26S subunit, non-ATPase 6 [Source:HGNC Symbol;Acc:HGNC:9564] | 3004 | 0.883 | 0.6733 | Yes |
| 47 | SEC22B | SEC22 homolog B, vesicle trafficking protein (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:10700] | 3014 | 0.877 | 0.6806 | Yes |
| 48 | PSMB4 | proteasome 20S subunit beta 4 [Source:HGNC Symbol;Acc:HGNC:9541] | 3049 | 0.858 | 0.6871 | Yes |
| 49 | PSME4 | proteasome activator subunit 4 [Source:HGNC Symbol;Acc:HGNC:20635] | 3142 | 0.820 | 0.6917 | Yes |
| 50 | PSMA7 | proteasome 20S subunit alpha 7 [Source:HGNC Symbol;Acc:HGNC:9536] | 3160 | 0.810 | 0.6982 | Yes |
| 51 | VAMP8 | vesicle associated membrane protein 8 [Source:HGNC Symbol;Acc:HGNC:12647] | 3212 | 0.791 | 0.7037 | Yes |
| 52 | PSMB5 | proteasome 20S subunit beta 5 [Source:HGNC Symbol;Acc:HGNC:9542] | 3304 | 0.762 | 0.7078 | Yes |
| 53 | PSMA2 | proteasome 20S subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:9531] | 3356 | 0.738 | 0.7128 | Yes |
| 54 | UBB | ubiquitin B [Source:HGNC Symbol;Acc:HGNC:12463] | 3452 | 0.700 | 0.7163 | Yes |
| 55 | SEM1 | SEM1 26S proteasome complex subunit [Source:HGNC Symbol;Acc:HGNC:10845] | 3571 | 0.651 | 0.7187 | Yes |
| 56 | PSMC6 | proteasome 26S subunit, ATPase 6 [Source:HGNC Symbol;Acc:HGNC:9553] | 3628 | 0.630 | 0.7226 | Yes |
| 57 | PSMB7 | proteasome 20S subunit beta 7 [Source:HGNC Symbol;Acc:HGNC:9544] | 3674 | 0.607 | 0.7267 | Yes |
| 58 | PSMD1 | proteasome 26S subunit, non-ATPase 1 [Source:HGNC Symbol;Acc:HGNC:9554] | 3719 | 0.592 | 0.7306 | Yes |
| 59 | PSMD2 | proteasome 26S subunit, non-ATPase 2 [Source:HGNC Symbol;Acc:HGNC:9559] | 3755 | 0.580 | 0.7347 | Yes |
| 60 | CYBA | cytochrome b-245 alpha chain [Source:HGNC Symbol;Acc:HGNC:2577] | 3813 | 0.558 | 0.7379 | Yes |
| 61 | CTSS | cathepsin S [Source:HGNC Symbol;Acc:HGNC:2545] | 4445 | 0.459 | 0.7248 | Yes |
| 62 | PSMC4 | proteasome 26S subunit, ATPase 4 [Source:HGNC Symbol;Acc:HGNC:9551] | 4452 | 0.456 | 0.7286 | Yes |
| 63 | PSMD8 | proteasome 26S subunit, non-ATPase 8 [Source:HGNC Symbol;Acc:HGNC:9566] | 4463 | 0.453 | 0.7323 | Yes |
| 64 | PSMB11 | proteasome subunit beta 11 [Source:HGNC Symbol;Acc:HGNC:31963] | 4478 | 0.449 | 0.7358 | Yes |
| 65 | PSMC3 | proteasome 26S subunit, ATPase 3 [Source:HGNC Symbol;Acc:HGNC:9549] | 4480 | 0.449 | 0.7396 | Yes |
| 66 | PSMD13 | proteasome 26S subunit, non-ATPase 13 [Source:HGNC Symbol;Acc:HGNC:9558] | 4488 | 0.448 | 0.7433 | Yes |
| 67 | PDIA3 | protein disulfide isomerase family A member 3 [Source:HGNC Symbol;Acc:HGNC:4606] | 4513 | 0.438 | 0.7464 | Yes |
| 68 | SEC61A2 | SEC61 translocon subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:17702] | 4525 | 0.431 | 0.7499 | Yes |
| 69 | PSMD10 | proteasome 26S subunit, non-ATPase 10 [Source:HGNC Symbol;Acc:HGNC:9555] | 4538 | 0.426 | 0.7532 | Yes |
| 70 | SEC61A1 | SEC61 translocon subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:18276] | 4567 | 0.419 | 0.7561 | Yes |
| 71 | PSMB3 | proteasome 20S subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:9540] | 4610 | 0.404 | 0.7584 | Yes |
| 72 | BTK | Bruton tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1133] | 4656 | 0.388 | 0.7606 | Yes |
| 73 | PSMD4 | proteasome 26S subunit, non-ATPase 4 [Source:HGNC Symbol;Acc:HGNC:9561] | 4758 | 0.359 | 0.7610 | Yes |
| 74 | SEC61G | SEC61 translocon subunit gamma [Source:HGNC Symbol;Acc:HGNC:18277] | 4853 | 0.331 | 0.7613 | Yes |
| 75 | CHUK | component of inhibitor of nuclear factor kappa B kinase complex [Source:HGNC Symbol;Acc:HGNC:1974] | 4884 | 0.322 | 0.7632 | Yes |
| 76 | PSMF1 | proteasome inhibitor subunit 1 [Source:HGNC Symbol;Acc:HGNC:9571] | 4975 | 0.289 | 0.7633 | Yes |
| 77 | PSMA1 | proteasome 20S subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:9530] | 4980 | 0.289 | 0.7657 | Yes |
| 78 | NCF4 | neutrophil cytosolic factor 4 [Source:HGNC Symbol;Acc:HGNC:7662] | 5022 | 0.270 | 0.7669 | Yes |
| 79 | PSME3 | proteasome activator subunit 3 [Source:HGNC Symbol;Acc:HGNC:9570] | 5307 | 0.184 | 0.7608 | No |
| 80 | PSMB1 | proteasome 20S subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:9537] | 5620 | 0.104 | 0.7533 | No |
| 81 | PSMD9 | proteasome 26S subunit, non-ATPase 9 [Source:HGNC Symbol;Acc:HGNC:9567] | 5854 | 0.027 | 0.7472 | No |
| 82 | CD207 | CD207 molecule [Source:HGNC Symbol;Acc:HGNC:17935] | 7829 | 0.000 | 0.6939 | No |
| 83 | S100A9 | S100 calcium binding protein A9 [Source:HGNC Symbol;Acc:HGNC:10499] | 8248 | 0.000 | 0.6826 | No |
| 84 | S100A8 | S100 calcium binding protein A8 [Source:HGNC Symbol;Acc:HGNC:10498] | 8251 | 0.000 | 0.6825 | No |
| 85 | FCGR1A | Fc fragment of IgG receptor Ia [Source:HGNC Symbol;Acc:HGNC:3613] | 11262 | 0.000 | 0.6011 | No |
| 86 | FCGR1B | Fc fragment of IgG receptor Ib [Source:HGNC Symbol;Acc:HGNC:3614] | 11264 | 0.000 | 0.6011 | No |
| 87 | FGB | fibrinogen beta chain [Source:HGNC Symbol;Acc:HGNC:3662] | 16625 | 0.000 | 0.4562 | No |
| 88 | FGA | fibrinogen alpha chain [Source:HGNC Symbol;Acc:HGNC:3661] | 16626 | 0.000 | 0.4562 | No |
| 89 | FGG | fibrinogen gamma chain [Source:HGNC Symbol;Acc:HGNC:3694] | 16627 | 0.000 | 0.4562 | No |
| 90 | CTSL | cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537] | 22035 | 0.000 | 0.3100 | No |
| 91 | MRC2 | mannose receptor C type 2 [Source:HGNC Symbol;Acc:HGNC:16875] | 25186 | 0.000 | 0.2248 | No |
| 92 | MRC1 | mannose receptor C-type 1 [Source:HGNC Symbol;Acc:HGNC:7228] | 25200 | 0.000 | 0.2245 | No |
| 93 | SEC61B | SEC61 translocon subunit beta [Source:HGNC Symbol;Acc:HGNC:16993] | 28292 | -0.053 | 0.1413 | No |
| 94 | PSMB2 | proteasome 20S subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:9539] | 28494 | -0.102 | 0.1368 | No |
| 95 | UBC | ubiquitin C [Source:HGNC Symbol;Acc:HGNC:12468] | 28528 | -0.112 | 0.1369 | No |
| 96 | SNAP23 | synaptosome associated protein 23 [Source:HGNC Symbol;Acc:HGNC:11131] | 28607 | -0.135 | 0.1359 | No |
| 97 | RPS27A | ribosomal protein S27a [Source:HGNC Symbol;Acc:HGNC:10417] | 28678 | -0.151 | 0.1353 | No |
| 98 | PSMD5 | proteasome 26S subunit, non-ATPase 5 [Source:HGNC Symbol;Acc:HGNC:9563] | 28920 | -0.211 | 0.1306 | No |
| 99 | UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 [Source:HGNC Symbol;Acc:HGNC:12458] | 29607 | -0.390 | 0.1155 | No |
| 100 | STX4 | syntaxin 4 [Source:HGNC Symbol;Acc:HGNC:11439] | 30720 | -0.689 | 0.0914 | No |
| 101 | S100A1 | S100 calcium binding protein A1 [Source:HGNC Symbol;Acc:HGNC:10486] | 30778 | -0.703 | 0.0959 | No |
| 102 | PSMA8 | proteasome 20S subunit alpha 8 [Source:HGNC Symbol;Acc:HGNC:22985] | 31928 | -1.067 | 0.0741 | No |
| 103 | NCF1 | neutrophil cytosolic factor 1 [Source:HGNC Symbol;Acc:HGNC:7660] | 31935 | -1.070 | 0.0831 | No |
| 104 | TLR4 | toll like receptor 4 [Source:HGNC Symbol;Acc:HGNC:11850] | 32202 | -1.176 | 0.0861 | No |
| 105 | HMGB1 | high mobility group box 1 [Source:HGNC Symbol;Acc:HGNC:4983] | 33349 | -1.593 | 0.0689 | No |
| 106 | ITGB5 | integrin subunit beta 5 [Source:HGNC Symbol;Acc:HGNC:6160] | 36387 | -3.731 | 0.0190 | No |
