Fig 1: Enrichment plot: REACTOME_DEFENSINS
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | REACTOME_DEFENSINS |
| Enrichment Score (ES) | 0.96293193 |
| Normalized Enrichment Score (NES) | 2.217469 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | CCR2 | C-C motif chemokine receptor 2 [Source:HGNC Symbol;Acc:HGNC:1603] | 320 | 3.725 | 0.4531 | Yes |
| 2 | TLR1 | toll like receptor 1 [Source:HGNC Symbol;Acc:HGNC:11847] | 952 | 2.396 | 0.7330 | Yes |
| 3 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1375 | 1.947 | 0.9629 | Yes |
| 4 | DEFB4A | defensin beta 4A [Source:HGNC Symbol;Acc:HGNC:2767] | 6857 | 0.000 | 0.8150 | No |
| 5 | DEFB4B | defensin beta 4B [Source:HGNC Symbol;Acc:HGNC:30193] | 6858 | 0.000 | 0.8150 | No |
| 6 | ART1 | ADP-ribosyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:723] | 7138 | 0.000 | 0.8074 | No |
| 7 | DEFB129 | defensin beta 129 [Source:HGNC Symbol;Acc:HGNC:16218] | 7172 | 0.000 | 0.8065 | No |
| 8 | DEFB128 | defensin beta 128 [Source:HGNC Symbol;Acc:HGNC:18106] | 7173 | 0.000 | 0.8065 | No |
| 9 | DEFB127 | defensin beta 127 [Source:HGNC Symbol;Acc:HGNC:16206] | 7174 | 0.000 | 0.8065 | No |
| 10 | DEFB126 | defensin beta 126 [Source:HGNC Symbol;Acc:HGNC:15900] | 7175 | 0.000 | 0.8065 | No |
| 11 | DEFB125 | defensin beta 125 [Source:HGNC Symbol;Acc:HGNC:18105] | 7176 | 0.000 | 0.8065 | No |
| 12 | DEFB124 | defensin beta 124 [Source:HGNC Symbol;Acc:HGNC:18104] | 7177 | 0.000 | 0.8065 | No |
| 13 | DEFB123 | defensin beta 123 [Source:HGNC Symbol;Acc:HGNC:18103] | 7178 | 0.000 | 0.8065 | No |
| 14 | DEFB121 | defensin beta 121 [Source:HGNC Symbol;Acc:HGNC:18101] | 7180 | 0.000 | 0.8065 | No |
| 15 | DEFB136 | defensin beta 136 [Source:HGNC Symbol;Acc:HGNC:34433] | 7185 | 0.000 | 0.8064 | No |
| 16 | DEFB135 | defensin beta 135 [Source:HGNC Symbol;Acc:HGNC:32400] | 7186 | 0.000 | 0.8064 | No |
| 17 | DEFB134 | defensin beta 134 [Source:HGNC Symbol;Acc:HGNC:32399] | 7187 | 0.000 | 0.8064 | No |
| 18 | DEFB133 | defensin beta 133 [Source:HGNC Symbol;Acc:HGNC:31331] | 7188 | 0.000 | 0.8064 | No |
| 19 | DEFB132 | defensin beta 132 [Source:HGNC Symbol;Acc:HGNC:33806] | 7189 | 0.000 | 0.8064 | No |
| 20 | DEFB119 | defensin beta 119 [Source:HGNC Symbol;Acc:HGNC:18099] | 7376 | 0.000 | 0.8014 | No |
| 21 | DEFB118 | defensin beta 118 [Source:HGNC Symbol;Acc:HGNC:16196] | 7377 | 0.000 | 0.8014 | No |
| 22 | DEFB116 | defensin beta 116 [Source:HGNC Symbol;Acc:HGNC:18097] | 7380 | 0.000 | 0.8013 | No |
| 23 | DEFB115 | defensin beta 115 [Source:HGNC Symbol;Acc:HGNC:18096] | 7383 | 0.000 | 0.8013 | No |
| 24 | DEFB114 | defensin beta 114 [Source:HGNC Symbol;Acc:HGNC:18095] | 7385 | 0.000 | 0.8012 | No |
| 25 | DEFB113 | defensin beta 113 [Source:HGNC Symbol;Acc:HGNC:18094] | 7386 | 0.000 | 0.8012 | No |
| 26 | DEFB112 | defensin beta 112 [Source:HGNC Symbol;Acc:HGNC:18093] | 7387 | 0.000 | 0.8012 | No |
| 27 | DEFB110 | defensin beta 110 [Source:HGNC Symbol;Acc:HGNC:18091] | 7389 | 0.000 | 0.8012 | No |
| 28 | DEFA1B | defensin alpha 1B [Source:HGNC Symbol;Acc:HGNC:33596] | 8490 | 0.000 | 0.7715 | No |
| 29 | CD4 | CD4 molecule [Source:HGNC Symbol;Acc:HGNC:1678] | 15652 | 0.000 | 0.5782 | No |
| 30 | DEFB1 | defensin beta 1 [Source:HGNC Symbol;Acc:HGNC:2766] | 20363 | 0.000 | 0.4510 | No |
| 31 | DEFA6 | defensin alpha 6 [Source:HGNC Symbol;Acc:HGNC:2765] | 20415 | 0.000 | 0.4496 | No |
| 32 | DEFA4 | defensin alpha 4 [Source:HGNC Symbol;Acc:HGNC:2763] | 20420 | 0.000 | 0.4495 | No |
| 33 | DEFA5 | defensin alpha 5 [Source:HGNC Symbol;Acc:HGNC:2764] | 20422 | 0.000 | 0.4495 | No |
| 34 | DEFA3 | defensin alpha 3 [Source:HGNC Symbol;Acc:HGNC:2762] | 20425 | 0.000 | 0.4495 | No |
| 35 | DEFA1 | defensin alpha 1 [Source:HGNC Symbol;Acc:HGNC:2761] | 20427 | 0.000 | 0.4494 | No |
| 36 | PRSS3 | serine protease 3 [Source:HGNC Symbol;Acc:HGNC:9486] | 22386 | 0.000 | 0.3966 | No |
| 37 | DEFB130A | defensin beta 130A [Source:HGNC Symbol;Acc:HGNC:18107] | 26856 | 0.000 | 0.2759 | No |
| 38 | DEFB130B | defensin beta 130B [Source:HGNC Symbol;Acc:HGNC:39814] | 26858 | 0.000 | 0.2759 | No |
| 39 | DEFB131A | defensin beta 131A [Source:HGNC Symbol;Acc:HGNC:18108] | 26859 | 0.000 | 0.2759 | No |
| 40 | DEFB103A | defensin beta 103A [Source:HGNC Symbol;Acc:HGNC:15967] | 27877 | 0.000 | 0.2484 | No |
| 41 | DEFB103B | defensin beta 103B [Source:HGNC Symbol;Acc:HGNC:31702] | 27880 | 0.000 | 0.2484 | No |
| 42 | DEFB104B | defensin beta 104B [Source:HGNC Symbol;Acc:HGNC:26165] | 27898 | 0.000 | 0.2479 | No |
| 43 | DEFB104A | defensin beta 104A [Source:HGNC Symbol;Acc:HGNC:18115] | 27901 | 0.000 | 0.2479 | No |
| 44 | DEFB105A | defensin beta 105A [Source:HGNC Symbol;Acc:HGNC:18087] | 27915 | 0.000 | 0.2475 | No |
| 45 | DEFB105B | defensin beta 105B [Source:HGNC Symbol;Acc:HGNC:29930] | 27916 | 0.000 | 0.2475 | No |
| 46 | CCR6 | C-C motif chemokine receptor 6 [Source:HGNC Symbol;Acc:HGNC:1607] | 27929 | 0.000 | 0.2472 | No |
| 47 | DEFB106B | defensin beta 106B [Source:HGNC Symbol;Acc:HGNC:28879] | 27938 | 0.000 | 0.2470 | No |
| 48 | DEFB106A | defensin beta 106A [Source:HGNC Symbol;Acc:HGNC:18088] | 27946 | 0.000 | 0.2468 | No |
| 49 | DEFB107A | defensin beta 107A [Source:HGNC Symbol;Acc:HGNC:18086] | 27967 | 0.000 | 0.2462 | No |
| 50 | DEFB107B | defensin beta 107B [Source:HGNC Symbol;Acc:HGNC:31918] | 27969 | 0.000 | 0.2462 | No |
| 51 | DEFB108B | defensin beta 108B [Source:HGNC Symbol;Acc:HGNC:29966] | 27999 | 0.000 | 0.2454 | No |
