Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | 0.86558425 |
| Normalized Enrichment Score (NES) | 2.1148632 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 17 | 4.971 | 0.0405 | Yes |
| 2 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 35 | 4.928 | 0.0807 | Yes |
| 3 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 46 | 4.877 | 0.1206 | Yes |
| 4 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 49 | 4.852 | 0.1606 | Yes |
| 5 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 55 | 4.827 | 0.2002 | Yes |
| 6 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 66 | 4.776 | 0.2393 | Yes |
| 7 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 85 | 4.682 | 0.2774 | Yes |
| 8 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 97 | 4.635 | 0.3153 | Yes |
| 9 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 101 | 4.617 | 0.3533 | Yes |
| 10 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 135 | 4.408 | 0.3888 | Yes |
| 11 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 154 | 4.328 | 0.4240 | Yes |
| 12 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 249 | 3.962 | 0.4541 | Yes |
| 13 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 271 | 3.864 | 0.4854 | Yes |
| 14 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 281 | 3.833 | 0.5167 | Yes |
| 15 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 307 | 3.781 | 0.5472 | Yes |
| 16 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 331 | 3.693 | 0.5771 | Yes |
| 17 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 349 | 3.605 | 0.6063 | Yes |
| 18 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 419 | 3.394 | 0.6324 | Yes |
| 19 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 637 | 2.896 | 0.6504 | Yes |
| 20 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 841 | 2.586 | 0.6663 | Yes |
| 21 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 842 | 2.584 | 0.6876 | Yes |
| 22 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 944 | 2.415 | 0.7048 | Yes |
| 23 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 1025 | 2.276 | 0.7214 | Yes |
| 24 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 1027 | 2.270 | 0.7400 | Yes |
| 25 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 1154 | 2.093 | 0.7539 | Yes |
| 26 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 1283 | 2.058 | 0.7674 | Yes |
| 27 | IP6K2 | inositol hexakisphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:17313] | 1312 | 2.016 | 0.7833 | Yes |
| 28 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 1399 | 1.916 | 0.7967 | Yes |
| 29 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 1576 | 1.741 | 0.8063 | Yes |
| 30 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 1829 | 1.524 | 0.8121 | Yes |
| 31 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 1919 | 1.455 | 0.8217 | Yes |
| 32 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 2011 | 1.422 | 0.8309 | Yes |
| 33 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 2022 | 1.414 | 0.8423 | Yes |
| 34 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 2094 | 1.365 | 0.8517 | Yes |
| 35 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 2290 | 1.253 | 0.8567 | Yes |
| 36 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 2337 | 1.225 | 0.8656 | Yes |
| 37 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 2761 | 0.998 | 0.8624 | No |
| 38 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 3281 | 0.766 | 0.8547 | No |
| 39 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 3624 | 0.631 | 0.8506 | No |
| 40 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 4792 | 0.350 | 0.8220 | No |
| 41 | ABCE1 | ATP binding cassette subfamily E member 1 [Source:HGNC Symbol;Acc:HGNC:69] | 4834 | 0.338 | 0.8237 | No |
| 42 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 4990 | 0.283 | 0.8218 | No |
| 43 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 5211 | 0.211 | 0.8176 | No |
| 44 | KPNA1 | karyopherin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] | 5279 | 0.193 | 0.8174 | No |
| 45 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 5317 | 0.181 | 0.8179 | No |
| 46 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12283 | 0.000 | 0.6297 | No |
| 47 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 18175 | 0.000 | 0.4706 | No |
| 48 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 18176 | 0.000 | 0.4706 | No |
| 49 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 18178 | 0.000 | 0.4706 | No |
| 50 | IFNA17 | interferon alpha 17 [Source:HGNC Symbol;Acc:HGNC:5422] | 18180 | 0.000 | 0.4706 | No |
| 51 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 18187 | 0.000 | 0.4704 | No |
| 52 | IFNA21 | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] | 18195 | 0.000 | 0.4702 | No |
| 53 | IFNAR2 | interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] | 18462 | 0.000 | 0.4630 | No |
| 54 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18471 | 0.000 | 0.4628 | No |
| 55 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 20142 | 0.000 | 0.4177 | No |
| 56 | IFNA5 | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] | 21637 | 0.000 | 0.3773 | No |
| 57 | IFNA4 | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] | 21638 | 0.000 | 0.3773 | No |
| 58 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 21640 | 0.000 | 0.3773 | No |
| 59 | IFNA6 | interferon alpha 6 [Source:HGNC Symbol;Acc:HGNC:5427] | 21641 | 0.000 | 0.3773 | No |
| 60 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 21642 | 0.000 | 0.3773 | No |
| 61 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 21643 | 0.000 | 0.3773 | No |
| 62 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 21646 | 0.000 | 0.3773 | No |
| 63 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 21676 | 0.000 | 0.3765 | No |
| 64 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 24418 | 0.000 | 0.3024 | No |
| 65 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 25426 | 0.000 | 0.2752 | No |
| 66 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 26497 | 0.000 | 0.2463 | No |
| 67 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 28615 | -0.137 | 0.1903 | No |
| 68 | RNASEL | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] | 28841 | -0.195 | 0.1858 | No |
| 69 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 29900 | -0.469 | 0.1611 | No |
| 70 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 30264 | -0.543 | 0.1557 | No |
| 71 | KPNB1 | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] | 30365 | -0.575 | 0.1578 | No |
| 72 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 32464 | -1.232 | 0.1113 | No |
| 73 | PTPN6 | protein tyrosine phosphatase non-receptor type 6 [Source:HGNC Symbol;Acc:HGNC:9658] | 33487 | -1.660 | 0.0973 | No |
