Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | SANA_TNF_SIGNALING_UP |
| Enrichment Score (ES) | 0.8165919 |
| Normalized Enrichment Score (NES) | 2.031403 |
| Nominal p-value | 0.0 |
| FDR q-value | 2.5586633E-4 |
| FWER p-Value | 0.002 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 49 | 4.852 | 0.0296 | Yes |
| 2 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 55 | 4.827 | 0.0602 | Yes |
| 3 | PARP14 | poly(ADP-ribose) polymerase family member 14 [Source:HGNC Symbol;Acc:HGNC:29232] | 57 | 4.823 | 0.0909 | Yes |
| 4 | GBP1 | guanylate binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4182] | 59 | 4.819 | 0.1216 | Yes |
| 5 | CMPK2 | cytidine/uridine monophosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:27015] | 60 | 4.819 | 0.1524 | Yes |
| 6 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 66 | 4.776 | 0.1827 | Yes |
| 7 | PLA1A | phospholipase A1 member A [Source:HGNC Symbol;Acc:HGNC:17661] | 67 | 4.766 | 0.2130 | Yes |
| 8 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 78 | 4.727 | 0.2429 | Yes |
| 9 | SLC15A3 | solute carrier family 15 member 3 [Source:HGNC Symbol;Acc:HGNC:18068] | 100 | 4.618 | 0.2718 | Yes |
| 10 | IFIH1 | interferon induced with helicase C domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] | 126 | 4.446 | 0.2994 | Yes |
| 11 | LGALS9 | galectin 9 [Source:HGNC Symbol;Acc:HGNC:6570] | 145 | 4.356 | 0.3267 | Yes |
| 12 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 243 | 3.976 | 0.3494 | Yes |
| 13 | SAMD9L | sterile alpha motif domain containing 9 like [Source:HGNC Symbol;Acc:HGNC:1349] | 257 | 3.933 | 0.3742 | Yes |
| 14 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 283 | 3.829 | 0.3979 | Yes |
| 15 | DDX60 | DExD/H-box helicase 60 [Source:HGNC Symbol;Acc:HGNC:25942] | 298 | 3.789 | 0.4217 | Yes |
| 16 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 307 | 3.781 | 0.4456 | Yes |
| 17 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 349 | 3.605 | 0.4674 | Yes |
| 18 | TNFAIP3 | TNF alpha induced protein 3 [Source:HGNC Symbol;Acc:HGNC:11896] | 375 | 3.557 | 0.4894 | Yes |
| 19 | ITGAV | integrin subunit alpha V [Source:HGNC Symbol;Acc:HGNC:6150] | 398 | 3.471 | 0.5110 | Yes |
| 20 | NFKBIA | NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797] | 413 | 3.427 | 0.5324 | Yes |
| 21 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 419 | 3.394 | 0.5539 | Yes |
| 22 | SOD2 | superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180] | 427 | 3.359 | 0.5751 | Yes |
| 23 | TNIP1 | TNFAIP3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16903] | 488 | 3.246 | 0.5942 | Yes |
| 24 | LGALS3BP | galectin 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6564] | 556 | 3.095 | 0.6121 | Yes |
| 25 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 637 | 2.896 | 0.6284 | Yes |
| 26 | TNFAIP2 | TNF alpha induced protein 2 [Source:HGNC Symbol;Acc:HGNC:11895] | 774 | 2.696 | 0.6419 | Yes |
| 27 | TAPBP | TAP binding protein [Source:HGNC Symbol;Acc:HGNC:11566] | 786 | 2.676 | 0.6587 | Yes |
| 28 | LIPG | lipase G, endothelial type [Source:HGNC Symbol;Acc:HGNC:6623] | 848 | 2.568 | 0.6734 | Yes |
| 29 | RIPK2 | receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] | 920 | 2.458 | 0.6872 | Yes |
| 30 | DNAJA1 | DnaJ heat shock protein family (Hsp40) member A1 [Source:HGNC Symbol;Acc:HGNC:5229] | 931 | 2.436 | 0.7024 | Yes |
| 31 | SAT1 | spermidine/spermine N1-acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10540] | 1296 | 2.040 | 0.7056 | Yes |
| 32 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1375 | 1.947 | 0.7159 | Yes |
| 33 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 1399 | 1.916 | 0.7275 | Yes |
| 34 | IL7R | interleukin 7 receptor [Source:HGNC Symbol;Acc:HGNC:6024] | 1411 | 1.896 | 0.7393 | Yes |
| 35 | CASP1 | caspase 1 [Source:HGNC Symbol;Acc:HGNC:1499] | 1452 | 1.852 | 0.7500 | Yes |
| 36 | INHBA | inhibin subunit beta A [Source:HGNC Symbol;Acc:HGNC:6066] | 1587 | 1.726 | 0.7574 | Yes |
| 37 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 1667 | 1.673 | 0.7659 | Yes |
| 38 | FTH1 | ferritin heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:3976] | 1717 | 1.621 | 0.7749 | Yes |
| 39 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 1893 | 1.470 | 0.7795 | Yes |
| 40 | IFI44L | interferon induced protein 44 like [Source:HGNC Symbol;Acc:HGNC:17817] | 1912 | 1.458 | 0.7883 | Yes |
| 41 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 2011 | 1.422 | 0.7948 | Yes |
| 42 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 2022 | 1.414 | 0.8035 | Yes |
| 43 | DENND11 | DENN domain containing 11 [Source:HGNC Symbol;Acc:HGNC:29472] | 2039 | 1.404 | 0.8120 | Yes |
| 44 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 2180 | 1.310 | 0.8166 | Yes |
| 45 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 2761 | 0.998 | 0.8073 | No |
| 46 | RABL3 | RAB, member of RAS oncogene family like 3 [Source:HGNC Symbol;Acc:HGNC:18072] | 2906 | 0.924 | 0.8093 | No |
| 47 | SPAG9 | sperm associated antigen 9 [Source:HGNC Symbol;Acc:HGNC:14524] | 2966 | 0.898 | 0.8134 | No |
| 48 | PDGFRL | platelet derived growth factor receptor like [Source:HGNC Symbol;Acc:HGNC:8805] | 3974 | 0.499 | 0.7894 | No |
| 49 | BIRC3 | baculoviral IAP repeat containing 3 [Source:HGNC Symbol;Acc:HGNC:591] | 4726 | 0.369 | 0.7714 | No |
| 50 | CCL11 | C-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10610] | 5998 | 0.000 | 0.7371 | No |
| 51 | CCL20 | C-C motif chemokine ligand 20 [Source:HGNC Symbol;Acc:HGNC:10619] | 6032 | 0.000 | 0.7362 | No |
| 52 | APOL1 | apolipoprotein L1 [Source:HGNC Symbol;Acc:HGNC:618] | 9802 | 0.000 | 0.6344 | No |
| 53 | APOL3 | apolipoprotein L3 [Source:HGNC Symbol;Acc:HGNC:14868] | 9804 | 0.000 | 0.6343 | No |
| 54 | CX3CL1 | C-X3-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:10647] | 10488 | 0.000 | 0.6159 | No |
| 55 | ACKR3 | atypical chemokine receptor 3 [Source:HGNC Symbol;Acc:HGNC:23692] | 10858 | 0.000 | 0.6059 | No |
| 56 | ICOSLG | inducible T cell costimulator ligand [Source:HGNC Symbol;Acc:HGNC:17087] | 10970 | 0.000 | 0.6029 | No |
| 57 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12283 | 0.000 | 0.5674 | No |
| 58 | UBD | ubiquitin D [Source:HGNC Symbol;Acc:HGNC:18795] | 12616 | 0.000 | 0.5585 | No |
| 59 | IL32 | interleukin 32 [Source:HGNC Symbol;Acc:HGNC:16830] | 13676 | 0.000 | 0.5299 | No |
| 60 | VCAM1 | vascular cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:12663] | 13734 | 0.000 | 0.5283 | No |
| 61 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 15514 | 0.000 | 0.4803 | No |
| 62 | ICAM1 | intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] | 18253 | 0.000 | 0.4063 | No |
| 63 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18934 | 0.000 | 0.3879 | No |
| 64 | CTHRC1 | collagen triple helix repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:18831] | 18961 | 0.000 | 0.3872 | No |
| 65 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 19132 | 0.000 | 0.3826 | No |
| 66 | CXCL6 | C-X-C motif chemokine ligand 6 [Source:HGNC Symbol;Acc:HGNC:10643] | 19477 | 0.000 | 0.3733 | No |
| 67 | CXCL8 | C-X-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025] | 19482 | 0.000 | 0.3732 | No |
| 68 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 19493 | 0.000 | 0.3729 | No |
| 69 | CXCL2 | C-X-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:4603] | 19494 | 0.000 | 0.3729 | No |
| 70 | LAMB3 | laminin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6490] | 20641 | 0.000 | 0.3420 | No |
| 71 | ANO9 | anoctamin 9 [Source:HGNC Symbol;Acc:HGNC:20679] | 22042 | 0.000 | 0.3041 | No |
| 72 | C1QTNF1 | C1q and TNF related 1 [Source:HGNC Symbol;Acc:HGNC:14324] | 23678 | 0.000 | 0.2599 | No |
| 73 | SSPN | sarcospan [Source:HGNC Symbol;Acc:HGNC:11322] | 24252 | 0.000 | 0.2445 | No |
| 74 | CCL8 | C-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:10635] | 27821 | 0.000 | 0.1481 | No |
| 75 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 27823 | 0.000 | 0.1480 | No |
| 76 | ATP13A3 | ATPase 13A3 [Source:HGNC Symbol;Acc:HGNC:24113] | 30519 | -0.628 | 0.0792 | No |
| 77 | OXR1 | oxidation resistance 1 [Source:HGNC Symbol;Acc:HGNC:15822] | 32657 | -1.297 | 0.0297 | No |
| 78 | BPGM | bisphosphoglycerate mutase [Source:HGNC Symbol;Acc:HGNC:1093] | 33552 | -1.693 | 0.0164 | No |
| 79 | DRAM1 | DNA damage regulated autophagy modulator 1 [Source:HGNC Symbol;Acc:HGNC:25645] | 34026 | -1.928 | 0.0159 | No |
| 80 | NCEH1 | neutral cholesterol ester hydrolase 1 [Source:HGNC Symbol;Acc:HGNC:29260] | 34533 | -2.186 | 0.0161 | No |
| 81 | RHOB | ras homolog family member B [Source:HGNC Symbol;Acc:HGNC:668] | 34573 | -2.217 | 0.0292 | No |
| 82 | RAC3 | Rac family small GTPase 3 [Source:HGNC Symbol;Acc:HGNC:9803] | 35423 | -2.774 | 0.0240 | No |
| 83 | SMAD3 | SMAD family member 3 [Source:HGNC Symbol;Acc:HGNC:6769] | 35941 | -3.304 | 0.0310 | No |
