Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | IRF2_01 |
| Enrichment Score (ES) | 0.498421 |
| Normalized Enrichment Score (NES) | 1.2767572 |
| Nominal p-value | 0.012987013 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | LIF | LIF interleukin 6 family cytokine [Source:HGNC Symbol;Acc:HGNC:6596] | 16 | 4.972 | 0.0308 | Yes |
| 2 | IL27 | interleukin 27 [Source:HGNC Symbol;Acc:HGNC:19157] | 25 | 4.955 | 0.0618 | Yes |
| 3 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 78 | 4.727 | 0.0901 | Yes |
| 4 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 97 | 4.635 | 0.1188 | Yes |
| 5 | PGM5 | phosphoglucomutase 5 [Source:HGNC Symbol;Acc:HGNC:8908] | 112 | 4.552 | 0.1471 | Yes |
| 6 | SYNE2 | spectrin repeat containing nuclear envelope protein 2 [Source:HGNC Symbol;Acc:HGNC:17084] | 211 | 4.076 | 0.1700 | Yes |
| 7 | DDX58 | DExD/H-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:19102] | 237 | 4.005 | 0.1946 | Yes |
| 8 | NT5C3A | 5'-nucleotidase, cytosolic IIIA [Source:HGNC Symbol;Acc:HGNC:17820] | 251 | 3.952 | 0.2191 | Yes |
| 9 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 267 | 3.874 | 0.2430 | Yes |
| 10 | GSDMD | gasdermin D [Source:HGNC Symbol;Acc:HGNC:25697] | 269 | 3.871 | 0.2674 | Yes |
| 11 | REL | REL proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9954] | 340 | 3.655 | 0.2885 | Yes |
| 12 | OSM | oncostatin M [Source:HGNC Symbol;Acc:HGNC:8506] | 425 | 3.363 | 0.3074 | Yes |
| 13 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 580 | 3.035 | 0.3223 | Yes |
| 14 | TAPBP | TAP binding protein [Source:HGNC Symbol;Acc:HGNC:11566] | 786 | 2.676 | 0.3336 | Yes |
| 15 | PIGV | phosphatidylinositol glycan anchor biosynthesis class V [Source:HGNC Symbol;Acc:HGNC:26031] | 794 | 2.658 | 0.3501 | Yes |
| 16 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 889 | 2.512 | 0.3634 | Yes |
| 17 | DTX3L | deltex E3 ubiquitin ligase 3L [Source:HGNC Symbol;Acc:HGNC:30323] | 918 | 2.459 | 0.3781 | Yes |
| 18 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 947 | 2.411 | 0.3925 | Yes |
| 19 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 1010 | 2.308 | 0.4053 | Yes |
| 20 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 1109 | 2.155 | 0.4162 | Yes |
| 21 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 1154 | 2.093 | 0.4282 | Yes |
| 22 | LRATD2 | LRAT domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24166] | 1302 | 2.027 | 0.4370 | Yes |
| 23 | TCIRG1 | T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [Source:HGNC Symbol;Acc:HGNC:11647] | 1583 | 1.731 | 0.4403 | Yes |
| 24 | RAPGEF6 | Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655] | 1747 | 1.588 | 0.4459 | Yes |
| 25 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 1793 | 1.552 | 0.4544 | Yes |
| 26 | DNASE1L3 | deoxyribonuclease 1 like 3 [Source:HGNC Symbol;Acc:HGNC:2959] | 1826 | 1.526 | 0.4632 | Yes |
| 27 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 1929 | 1.449 | 0.4695 | Yes |
| 28 | MAP3K11 | mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol;Acc:HGNC:6850] | 2183 | 1.308 | 0.4709 | Yes |
| 29 | MED13 | mediator complex subunit 13 [Source:HGNC Symbol;Acc:HGNC:22474] | 2500 | 1.143 | 0.4695 | Yes |
| 30 | SLC38A2 | solute carrier family 38 member 2 [Source:HGNC Symbol;Acc:HGNC:13448] | 2515 | 1.129 | 0.4763 | Yes |
| 31 | ROCK1 | Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251] | 2681 | 1.029 | 0.4783 | Yes |
| 32 | E2F3 | E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] | 2747 | 1.006 | 0.4828 | Yes |
| 33 | DUSP10 | dual specificity phosphatase 10 [Source:HGNC Symbol;Acc:HGNC:3065] | 2772 | 0.992 | 0.4884 | Yes |
| 34 | ME3 | malic enzyme 3 [Source:HGNC Symbol;Acc:HGNC:6985] | 2956 | 0.902 | 0.4891 | Yes |
| 35 | UPF2 | UPF2 regulator of nonsense mediated mRNA decay [Source:HGNC Symbol;Acc:HGNC:17854] | 3379 | 0.726 | 0.4823 | Yes |
| 36 | IKZF2 | IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177] | 3441 | 0.703 | 0.4851 | Yes |
| 37 | PRKD3 | protein kinase D3 [Source:HGNC Symbol;Acc:HGNC:9408] | 3457 | 0.698 | 0.4891 | Yes |
| 38 | TBX1 | T-box transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:11592] | 3573 | 0.650 | 0.4900 | Yes |
| 39 | CASZ1 | castor zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:26002] | 3649 | 0.621 | 0.4919 | Yes |
| 40 | PCGF5 | polycomb group ring finger 5 [Source:HGNC Symbol;Acc:HGNC:28264] | 3696 | 0.598 | 0.4944 | Yes |
| 41 | CDK6 | cyclin dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] | 3811 | 0.559 | 0.4949 | Yes |
| 42 | CSAD | cysteine sulfinic acid decarboxylase [Source:HGNC Symbol;Acc:HGNC:18966] | 3854 | 0.543 | 0.4971 | Yes |
| 43 | LSM6 | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17017] | 3927 | 0.513 | 0.4984 | Yes |
| 44 | KCNE4 | potassium voltage-gated channel subfamily E regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:6244] | 4982 | 0.287 | 0.4717 | No |
| 45 | SREK1 | splicing regulatory glutamic acid and lysine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:17882] | 5145 | 0.232 | 0.4688 | No |
| 46 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 5482 | 0.136 | 0.4606 | No |
| 47 | FXYD5 | FXYD domain containing ion transport regulator 5 [Source:HGNC Symbol;Acc:HGNC:4029] | 5760 | 0.061 | 0.4534 | No |
| 48 | PRDM16 | PR/SET domain 16 [Source:HGNC Symbol;Acc:HGNC:14000] | 6610 | 0.000 | 0.4305 | No |
| 49 | ASPA | aspartoacylase [Source:HGNC Symbol;Acc:HGNC:756] | 7462 | 0.000 | 0.4075 | No |
| 50 | BHLHE22 | basic helix-loop-helix family member e22 [Source:HGNC Symbol;Acc:HGNC:11963] | 7897 | 0.000 | 0.3957 | No |
| 51 | PROX1 | prospero homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9459] | 8091 | 0.000 | 0.3905 | No |
| 52 | HOXA6 | homeobox A6 [Source:HGNC Symbol;Acc:HGNC:5107] | 8504 | 0.000 | 0.3793 | No |
| 53 | H4C7 | H4 clustered histone 7 [Source:HGNC Symbol;Acc:HGNC:4792] | 9922 | 0.000 | 0.3410 | No |
| 54 | RTL9 | retrotransposon Gag like 9 [Source:HGNC Symbol;Acc:HGNC:29245] | 10216 | 0.000 | 0.3331 | No |
| 55 | LDB2 | LIM domain binding 2 [Source:HGNC Symbol;Acc:HGNC:6533] | 10828 | 0.000 | 0.3166 | No |
| 56 | TMPRSS5 | transmembrane serine protease 5 [Source:HGNC Symbol;Acc:HGNC:14908] | 11326 | 0.000 | 0.3031 | No |
| 57 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12283 | 0.000 | 0.2772 | No |
| 58 | MSX1 | msh homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7391] | 12321 | 0.000 | 0.2762 | No |
| 59 | UBD | ubiquitin D [Source:HGNC Symbol;Acc:HGNC:18795] | 12616 | 0.000 | 0.2683 | No |
| 60 | GLRA1 | glycine receptor alpha 1 [Source:HGNC Symbol;Acc:HGNC:4326] | 12758 | 0.000 | 0.2645 | No |
| 61 | TMEM108 | transmembrane protein 108 [Source:HGNC Symbol;Acc:HGNC:28451] | 13339 | 0.000 | 0.2488 | No |
| 62 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13382 | 0.000 | 0.2477 | No |
| 63 | IL11 | interleukin 11 [Source:HGNC Symbol;Acc:HGNC:5966] | 13631 | 0.000 | 0.2409 | No |
| 64 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14026 | 0.000 | 0.2303 | No |
| 65 | FLT3LG | fms related receptor tyrosine kinase 3 ligand [Source:HGNC Symbol;Acc:HGNC:3766] | 14040 | 0.000 | 0.2299 | No |
| 66 | RFX4 | regulatory factor X4 [Source:HGNC Symbol;Acc:HGNC:9985] | 14267 | 0.000 | 0.2238 | No |
| 67 | BLK | BLK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:1057] | 15476 | 0.000 | 0.1911 | No |
| 68 | DLX1 | distal-less homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2914] | 16722 | 0.000 | 0.1575 | No |
| 69 | DLX4 | distal-less homeobox 4 [Source:HGNC Symbol;Acc:HGNC:2917] | 16725 | 0.000 | 0.1574 | No |
| 70 | NDN | necdin, MAGE family member [Source:HGNC Symbol;Acc:HGNC:7675] | 19291 | 0.000 | 0.0880 | No |
| 71 | BNC2 | basonuclin 2 [Source:HGNC Symbol;Acc:HGNC:30988] | 19298 | 0.000 | 0.0878 | No |
| 72 | NPR3 | natriuretic peptide receptor 3 [Source:HGNC Symbol;Acc:HGNC:7945] | 20596 | 0.000 | 0.0528 | No |
| 73 | EGFL6 | EGF like domain multiple 6 [Source:HGNC Symbol;Acc:HGNC:3235] | 20880 | 0.000 | 0.0451 | No |
| 74 | CCDC68 | coiled-coil domain containing 68 [Source:HGNC Symbol;Acc:HGNC:24350] | 21566 | 0.000 | 0.0266 | No |
| 75 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 21676 | 0.000 | 0.0236 | No |
| 76 | IFNL2 | interferon lambda 2 [Source:HGNC Symbol;Acc:HGNC:18364] | 21788 | 0.000 | 0.0206 | No |
| 77 | IFNL3 | interferon lambda 3 [Source:HGNC Symbol;Acc:HGNC:18365] | 21800 | 0.000 | 0.0203 | No |
| 78 | KCNMB3 | potassium calcium-activated channel subfamily M regulatory beta subunit 3 [Source:HGNC Symbol;Acc:HGNC:6287] | 21847 | 0.000 | 0.0191 | No |
| 79 | RIMS2 | regulating synaptic membrane exocytosis 2 [Source:HGNC Symbol;Acc:HGNC:17283] | 22448 | 0.000 | 0.0028 | No |
| 80 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 24418 | 0.000 | -0.0504 | No |
| 81 | TRMT112 | tRNA methyltransferase subunit 11-2 [Source:HGNC Symbol;Acc:HGNC:26940] | 24904 | 0.000 | -0.0635 | No |
| 82 | AGBL2 | ATP/GTP binding protein like 2 [Source:HGNC Symbol;Acc:HGNC:26296] | 25281 | 0.000 | -0.0737 | No |
| 83 | BCL11A | BAF chromatin remodeling complex subunit BCL11A [Source:HGNC Symbol;Acc:HGNC:13221] | 25396 | 0.000 | -0.0768 | No |
| 84 | PIGR | polymeric immunoglobulin receptor [Source:HGNC Symbol;Acc:HGNC:8968] | 27673 | 0.000 | -0.1384 | No |
| 85 | ASH1L | ASH1 like histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:19088] | 28159 | -0.012 | -0.1514 | No |
| 86 | CUL2 | cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552] | 28173 | -0.017 | -0.1517 | No |
| 87 | TRMT6 | tRNA methyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:20900] | 28504 | -0.106 | -0.1599 | No |
| 88 | TRPM3 | transient receptor potential cation channel subfamily M member 3 [Source:HGNC Symbol;Acc:HGNC:17992] | 28752 | -0.170 | -0.1655 | No |
| 89 | CAPRIN1 | cell cycle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:6743] | 28882 | -0.201 | -0.1678 | No |
| 90 | MITF | melanocyte inducing transcription factor [Source:HGNC Symbol;Acc:HGNC:7105] | 29243 | -0.296 | -0.1756 | No |
| 91 | KARS1 | lysyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:6215] | 29753 | -0.430 | -0.1867 | No |
| 92 | MAPK6 | mitogen-activated protein kinase 6 [Source:HGNC Symbol;Acc:HGNC:6879] | 29846 | -0.454 | -0.1863 | No |
| 93 | ABHD16A | abhydrolase domain containing 16A, phospholipase [Source:HGNC Symbol;Acc:HGNC:13921] | 30105 | -0.528 | -0.1900 | No |
| 94 | TNFSF13B | TNF superfamily member 13b [Source:HGNC Symbol;Acc:HGNC:11929] | 30153 | -0.537 | -0.1879 | No |
| 95 | HPCAL1 | hippocalcin like 1 [Source:HGNC Symbol;Acc:HGNC:5145] | 30352 | -0.570 | -0.1897 | No |
| 96 | DLG1 | discs large MAGUK scaffold protein 1 [Source:HGNC Symbol;Acc:HGNC:2900] | 30548 | -0.636 | -0.1909 | No |
| 97 | TMEM229B | transmembrane protein 229B [Source:HGNC Symbol;Acc:HGNC:20130] | 30558 | -0.639 | -0.1872 | No |
| 98 | NABP2 | nucleic acid binding protein 2 [Source:HGNC Symbol;Acc:HGNC:28412] | 30735 | -0.695 | -0.1875 | No |
| 99 | GPR52 | G protein-coupled receptor 52 [Source:HGNC Symbol;Acc:HGNC:4508] | 30943 | -0.750 | -0.1884 | No |
| 100 | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing [Source:HGNC Symbol;Acc:HGNC:29289] | 31151 | -0.808 | -0.1889 | No |
| 101 | OTX1 | orthodenticle homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8521] | 31313 | -0.865 | -0.1879 | No |
| 102 | HDAC4 | histone deacetylase 4 [Source:HGNC Symbol;Acc:HGNC:14063] | 31687 | -0.987 | -0.1917 | No |
| 103 | CCDC6 | coiled-coil domain containing 6 [Source:HGNC Symbol;Acc:HGNC:18782] | 31695 | -0.990 | -0.1857 | No |
| 104 | TERF2IP | TERF2 interacting protein [Source:HGNC Symbol;Acc:HGNC:19246] | 31994 | -1.091 | -0.1869 | No |
| 105 | DAP3 | death associated protein 3 [Source:HGNC Symbol;Acc:HGNC:2673] | 32024 | -1.102 | -0.1808 | No |
| 106 | USP5 | ubiquitin specific peptidase 5 [Source:HGNC Symbol;Acc:HGNC:12628] | 32139 | -1.154 | -0.1766 | No |
| 107 | RNF220 | ring finger protein 220 [Source:HGNC Symbol;Acc:HGNC:25552] | 32722 | -1.330 | -0.1840 | No |
| 108 | KDM3A | lysine demethylase 3A [Source:HGNC Symbol;Acc:HGNC:20815] | 32952 | -1.424 | -0.1812 | No |
| 109 | DEPDC7 | DEP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:29899] | 33262 | -1.559 | -0.1797 | No |
| 110 | PLXNC1 | plexin C1 [Source:HGNC Symbol;Acc:HGNC:9106] | 33438 | -1.636 | -0.1742 | No |
| 111 | DDX17 | DEAD-box helicase 17 [Source:HGNC Symbol;Acc:HGNC:2740] | 33504 | -1.666 | -0.1655 | No |
| 112 | USF1 | upstream transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:12593] | 33603 | -1.723 | -0.1573 | No |
| 113 | ARHGAP5 | Rho GTPase activating protein 5 [Source:HGNC Symbol;Acc:HGNC:675] | 33865 | -1.847 | -0.1527 | No |
| 114 | TMBIM4 | transmembrane BAX inhibitor motif containing 4 [Source:HGNC Symbol;Acc:HGNC:24257] | 33888 | -1.859 | -0.1416 | No |
| 115 | BBX | BBX high mobility group box domain containing [Source:HGNC Symbol;Acc:HGNC:14422] | 34019 | -1.925 | -0.1330 | No |
| 116 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 34161 | -2.002 | -0.1242 | No |
| 117 | YY1AP1 | YY1 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:30935] | 34166 | -2.005 | -0.1117 | No |
| 118 | AMER1 | APC membrane recruitment protein 1 [Source:HGNC Symbol;Acc:HGNC:26837] | 34311 | -2.086 | -0.1025 | No |
| 119 | TGFB3 | transforming growth factor beta 3 [Source:HGNC Symbol;Acc:HGNC:11769] | 34331 | -2.104 | -0.0898 | No |
| 120 | PRKD2 | protein kinase D2 [Source:HGNC Symbol;Acc:HGNC:17293] | 34491 | -2.150 | -0.0806 | No |
| 121 | VGLL4 | vestigial like family member 4 [Source:HGNC Symbol;Acc:HGNC:28966] | 34823 | -2.370 | -0.0746 | No |
| 122 | MCM8 | minichromosome maintenance 8 homologous recombination repair factor [Source:HGNC Symbol;Acc:HGNC:16147] | 35317 | -2.692 | -0.0710 | No |
| 123 | SIPA1 | signal-induced proliferation-associated 1 [Source:HGNC Symbol;Acc:HGNC:10885] | 35405 | -2.759 | -0.0560 | No |
| 124 | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:685] | 35468 | -2.807 | -0.0400 | No |
| 125 | FAM13C | family with sequence similarity 13 member C [Source:HGNC Symbol;Acc:HGNC:19371] | 36546 | -3.929 | -0.0444 | No |
| 126 | ESR1 | estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] | 36949 | -4.562 | -0.0266 | No |
| 127 | SORBS1 | sorbin and SH3 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14565] | 37039 | -4.834 | 0.0014 | No |
