Fig 1: Enrichment plot: MODULE_210
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | MODULE_210 |
| Enrichment Score (ES) | 0.7637258 |
| Normalized Enrichment Score (NES) | 1.5410974 |
| Nominal p-value | 0.03557312 |
| FDR q-value | 0.22455086 |
| FWER p-Value | 0.884 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 71 | 4.757 | 0.1325 | Yes |
| 2 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 73 | 4.750 | 0.2666 | Yes |
| 3 | MMP13 | matrix metallopeptidase 13 [Source:HGNC Symbol;Acc:HGNC:7159] | 105 | 4.607 | 0.3959 | Yes |
| 4 | TRAF1 | TNF receptor associated factor 1 [Source:HGNC Symbol;Acc:HGNC:12031] | 141 | 4.379 | 0.5187 | Yes |
| 5 | MMP14 | matrix metallopeptidase 14 [Source:HGNC Symbol;Acc:HGNC:7160] | 598 | 2.990 | 0.5909 | Yes |
| 6 | MMP2 | matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] | 643 | 2.885 | 0.6712 | Yes |
| 7 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 1667 | 1.673 | 0.6909 | Yes |
| 8 | AEBP1 | AE binding protein 1 [Source:HGNC Symbol;Acc:HGNC:303] | 1765 | 1.570 | 0.7326 | Yes |
| 9 | BMP1 | bone morphogenetic protein 1 [Source:HGNC Symbol;Acc:HGNC:1067] | 2062 | 1.385 | 0.7637 | Yes |
| 10 | TRAF2 | TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] | 3326 | 0.751 | 0.7509 | No |
| 11 | MMP12 | matrix metallopeptidase 12 [Source:HGNC Symbol;Acc:HGNC:7158] | 3951 | 0.507 | 0.7484 | No |
| 12 | ADAM9 | ADAM metallopeptidase domain 9 [Source:HGNC Symbol;Acc:HGNC:216] | 4724 | 0.369 | 0.7379 | No |
| 13 | APC2 | APC regulator of WNT signaling pathway 2 [Source:HGNC Symbol;Acc:HGNC:24036] | 6313 | 0.000 | 0.6951 | No |
| 14 | MMP23A | matrix metallopeptidase 23A (pseudogene) [Source:HGNC Symbol;Acc:HGNC:7170] | 8739 | 0.000 | 0.6297 | No |
| 15 | ADAM23 | ADAM metallopeptidase domain 23 [Source:HGNC Symbol;Acc:HGNC:202] | 9437 | 0.000 | 0.6109 | No |
| 16 | ADAM11 | ADAM metallopeptidase domain 11 [Source:HGNC Symbol;Acc:HGNC:189] | 9651 | 0.000 | 0.6051 | No |
| 17 | ADAM12 | ADAM metallopeptidase domain 12 [Source:HGNC Symbol;Acc:HGNC:190] | 9655 | 0.000 | 0.6050 | No |
| 18 | KEL | Kell metallo-endopeptidase (Kell blood group) [Source:HGNC Symbol;Acc:HGNC:6308] | 18263 | 0.000 | 0.3728 | No |
| 19 | MMP7 | matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174] | 19125 | 0.000 | 0.3496 | No |
| 20 | MMP1 | matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] | 19128 | 0.000 | 0.3495 | No |
| 21 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 19132 | 0.000 | 0.3494 | No |
| 22 | CPB2 | carboxypeptidase B2 [Source:HGNC Symbol;Acc:HGNC:2300] | 20386 | 0.000 | 0.3156 | No |
| 23 | ACE | angiotensin I converting enzyme [Source:HGNC Symbol;Acc:HGNC:2707] | 24249 | 0.000 | 0.2114 | No |
| 24 | MMP11 | matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157] | 25636 | 0.000 | 0.1740 | No |
| 25 | ADAM15 | ADAM metallopeptidase domain 15 [Source:HGNC Symbol;Acc:HGNC:193] | 31181 | -0.819 | 0.0476 | No |
| 26 | GGH | gamma-glutamyl hydrolase [Source:HGNC Symbol;Acc:HGNC:4248] | 31978 | -1.085 | 0.0568 | No |
| 27 | ANPEP | alanyl aminopeptidase, membrane [Source:HGNC Symbol;Acc:HGNC:500] | 32562 | -1.252 | 0.0764 | No |
| 28 | ADAM10 | ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:HGNC:188] | 33394 | -1.620 | 0.0997 | No |
