Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | GOBP_MEIOTIC_CHROMOSOME_SEGREGATION |
| Enrichment Score (ES) | -0.7639683 |
| Normalized Enrichment Score (NES) | -1.5616666 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.14702336 |
| FWER p-Value | 0.967 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | EME2 | essential meiotic structure-specific endonuclease subunit 2 [Source:HGNC Symbol;Acc:HGNC:27289] | 1191 | 2.075 | -0.0141 | No |
| 2 | ACTR2 | actin related protein 2 [Source:HGNC Symbol;Acc:HGNC:169] | 1814 | 1.532 | -0.0176 | No |
| 3 | ACTR3 | actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170] | 2082 | 1.372 | -0.0129 | No |
| 4 | MUS81 | MUS81 structure-specific endonuclease subunit [Source:HGNC Symbol;Acc:HGNC:29814] | 2687 | 1.026 | -0.0203 | No |
| 5 | SLX4 | SLX4 structure-specific endonuclease subunit [Source:HGNC Symbol;Acc:HGNC:23845] | 3124 | 0.830 | -0.0248 | No |
| 6 | UBE2B | ubiquitin conjugating enzyme E2 B [Source:HGNC Symbol;Acc:HGNC:12473] | 3630 | 0.630 | -0.0330 | No |
| 7 | RNF212 | ring finger protein 212 [Source:HGNC Symbol;Acc:HGNC:27729] | 4273 | 0.473 | -0.0463 | No |
| 8 | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit [Source:HGNC Symbol;Acc:HGNC:3436] | 4910 | 0.312 | -0.0607 | No |
| 9 | HFM1 | helicase for meiosis 1 [Source:HGNC Symbol;Acc:HGNC:20193] | 7203 | 0.000 | -0.1227 | No |
| 10 | ANKRD31 | ankyrin repeat domain 31 [Source:HGNC Symbol;Acc:HGNC:26853] | 7362 | 0.000 | -0.1269 | No |
| 11 | STAG3 | stromal antigen 3 [Source:HGNC Symbol;Acc:HGNC:11356] | 7519 | 0.000 | -0.1311 | No |
| 12 | PTTG2 | pituitary tumor-transforming 2 [Source:HGNC Symbol;Acc:HGNC:9691] | 7590 | 0.000 | -0.1330 | No |
| 13 | RAD21L1 | RAD21 cohesin complex component like 1 [Source:HGNC Symbol;Acc:HGNC:16271] | 7747 | 0.000 | -0.1373 | No |
| 14 | C1orf146 | chromosome 1 open reading frame 146 [Source:HGNC Symbol;Acc:HGNC:24032] | 9855 | 0.000 | -0.1942 | No |
| 15 | SHOC1 | shortage in chiasmata 1 [Source:HGNC Symbol;Acc:HGNC:26535] | 10505 | 0.000 | -0.2117 | No |
| 16 | MEIOC | meiosis specific with coiled-coil domain [Source:HGNC Symbol;Acc:HGNC:26670] | 10524 | 0.000 | -0.2122 | No |
| 17 | RNF212B | ring finger protein 212B [Source:HGNC Symbol;Acc:HGNC:20438] | 11407 | 0.000 | -0.2361 | No |
| 18 | IHO1 | interactor of HORMAD1 1 [Source:HGNC Symbol;Acc:HGNC:27945] | 12599 | 0.000 | -0.2682 | No |
| 19 | MEIKIN | meiotic kinetochore factor [Source:HGNC Symbol;Acc:HGNC:51253] | 12663 | 0.000 | -0.2700 | No |
| 20 | TERB1 | telomere repeat binding bouquet formation protein 1 [Source:HGNC Symbol;Acc:HGNC:26675] | 12963 | 0.000 | -0.2780 | No |
| 21 | TERB2 | telomere repeat binding bouquet formation protein 2 [Source:HGNC Symbol;Acc:HGNC:28520] | 12964 | 0.000 | -0.2780 | No |
| 22 | REC8 | REC8 meiotic recombination protein [Source:HGNC Symbol;Acc:HGNC:16879] | 13542 | 0.000 | -0.2936 | No |
| 23 | TEX11 | testis expressed 11 [Source:HGNC Symbol;Acc:HGNC:11733] | 15149 | 0.000 | -0.3370 | No |
| 24 | TEX12 | testis expressed 12 [Source:HGNC Symbol;Acc:HGNC:11734] | 15150 | 0.000 | -0.3370 | No |
| 25 | TEX15 | testis expressed 15, meiosis and synapsis associated [Source:HGNC Symbol;Acc:HGNC:11738] | 15151 | 0.000 | -0.3370 | No |
| 26 | MEI4 | meiotic double-stranded break formation protein 4 [Source:HGNC Symbol;Acc:HGNC:43638] | 16327 | 0.000 | -0.3688 | No |
| 27 | DMC1 | DNA meiotic recombinase 1 [Source:HGNC Symbol;Acc:HGNC:2927] | 16854 | 0.000 | -0.3830 | No |
| 28 | SYCE3 | synaptonemal complex central element protein 3 [Source:HGNC Symbol;Acc:HGNC:35245] | 16941 | 0.000 | -0.3853 | No |
| 29 | SYCE2 | synaptonemal complex central element protein 2 [Source:HGNC Symbol;Acc:HGNC:27411] | 16942 | 0.000 | -0.3853 | No |
| 30 | SYCE1 | synaptonemal complex central element protein 1 [Source:HGNC Symbol;Acc:HGNC:28852] | 16943 | 0.000 | -0.3853 | No |
| 31 | SYCP1 | synaptonemal complex protein 1 [Source:HGNC Symbol;Acc:HGNC:11487] | 17841 | 0.000 | -0.4096 | No |
| 32 | CCNB1IP1 | cyclin B1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:19437] | 18311 | 0.000 | -0.4222 | No |
| 33 | PTTG3P | pituitary tumor-transforming 3, pseudogene [Source:HGNC Symbol;Acc:HGNC:13422] | 18498 | 0.000 | -0.4273 | No |
| 34 | P3H4 | prolyl 3-hydroxylase family member 4 (inactive) [Source:HGNC Symbol;Acc:HGNC:16946] | 18575 | 0.000 | -0.4293 | No |
| 35 | MOS | MOS proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:7199] | 19031 | 0.000 | -0.4416 | No |
| 36 | SPO11 | SPO11 initiator of meiotic double stranded breaks [Source:HGNC Symbol;Acc:HGNC:11250] | 19485 | 0.000 | -0.4539 | No |
| 37 | C14orf39 | chromosome 14 open reading frame 39 [Source:HGNC Symbol;Acc:HGNC:19849] | 19730 | 0.000 | -0.4605 | No |
| 38 | CORT | cortistatin [Source:HGNC Symbol;Acc:HGNC:2257] | 20264 | 0.000 | -0.4749 | No |
| 39 | CENPX | centromere protein X [Source:HGNC Symbol;Acc:HGNC:11422] | 21036 | 0.000 | -0.4957 | No |
| 40 | MAJIN | membrane anchored junction protein [Source:HGNC Symbol;Acc:HGNC:27441] | 21861 | 0.000 | -0.5180 | No |
| 41 | SPATA22 | spermatogenesis associated 22 [Source:HGNC Symbol;Acc:HGNC:30705] | 22008 | 0.000 | -0.5219 | No |
| 42 | FMN2 | formin 2 [Source:HGNC Symbol;Acc:HGNC:14074] | 24256 | 0.000 | -0.5826 | No |
| 43 | MAEL | maelstrom spermatogenic transposon silencer [Source:HGNC Symbol;Acc:HGNC:25929] | 24328 | 0.000 | -0.5846 | No |
| 44 | MSH4 | mutS homolog 4 [Source:HGNC Symbol;Acc:HGNC:7327] | 25676 | 0.000 | -0.6210 | No |
| 45 | HORMAD2 | HORMA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28383] | 26473 | 0.000 | -0.6425 | No |
| 46 | HORMAD1 | HORMA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25245] | 26474 | 0.000 | -0.6425 | No |
| 47 | SYCE1L | synaptonemal complex central element protein 1 like [Source:HGNC Symbol;Acc:HGNC:37236] | 27585 | 0.000 | -0.6725 | No |
| 48 | MEIOB | meiosis specific with OB-fold [Source:HGNC Symbol;Acc:HGNC:28569] | 28721 | -0.160 | -0.7018 | No |
| 49 | BAG6 | BAG cochaperone 6 [Source:HGNC Symbol;Acc:HGNC:13919] | 28966 | -0.228 | -0.7064 | No |
| 50 | CHFR | checkpoint with forkhead and ring finger domains [Source:HGNC Symbol;Acc:HGNC:20455] | 29605 | -0.389 | -0.7202 | No |
| 51 | FANCM | FA complementation group M [Source:HGNC Symbol;Acc:HGNC:23168] | 30269 | -0.545 | -0.7334 | No |
| 52 | SIRT7 | sirtuin 7 [Source:HGNC Symbol;Acc:HGNC:14935] | 31002 | -0.770 | -0.7465 | No |
| 53 | CENPC | centromere protein C [Source:HGNC Symbol;Acc:HGNC:1854] | 31024 | -0.780 | -0.7403 | No |
| 54 | MLH1 | mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] | 31867 | -1.046 | -0.7539 | Yes |
| 55 | MAPK15 | mitogen-activated protein kinase 15 [Source:HGNC Symbol;Acc:HGNC:24667] | 31991 | -1.090 | -0.7478 | Yes |
| 56 | NDC1 | NDC1 transmembrane nucleoporin [Source:HGNC Symbol;Acc:HGNC:25525] | 32592 | -1.264 | -0.7530 | Yes |
| 57 | PTTG1 | PTTG1 regulator of sister chromatid separation, securin [Source:HGNC Symbol;Acc:HGNC:9690] | 32691 | -1.316 | -0.7442 | Yes |
| 58 | SYCP2 | synaptonemal complex protein 2 [Source:HGNC Symbol;Acc:HGNC:11490] | 33048 | -1.474 | -0.7410 | Yes |
| 59 | KASH5 | KASH domain containing 5 [Source:HGNC Symbol;Acc:HGNC:26520] | 33396 | -1.622 | -0.7362 | Yes |
| 60 | ATM | ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] | 33775 | -1.796 | -0.7308 | Yes |
| 61 | EME1 | essential meiotic structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:HGNC:24965] | 34030 | -1.929 | -0.7209 | Yes |
| 62 | TOP2B | DNA topoisomerase II beta [Source:HGNC Symbol;Acc:HGNC:11990] | 34152 | -1.997 | -0.7068 | Yes |
| 63 | RMI1 | RecQ mediated genome instability 1 [Source:HGNC Symbol;Acc:HGNC:25764] | 34190 | -2.019 | -0.6902 | Yes |
| 64 | MLH3 | mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128] | 34199 | -2.026 | -0.6728 | Yes |
| 65 | PRDM9 | PR/SET domain 9 [Source:HGNC Symbol;Acc:HGNC:13994] | 34459 | -2.128 | -0.6613 | Yes |
| 66 | RAD21 | RAD21 cohesin complex component [Source:HGNC Symbol;Acc:HGNC:9811] | 34850 | -2.390 | -0.6510 | Yes |
| 67 | BRIP1 | BRCA1 interacting protein C-terminal helicase 1 [Source:HGNC Symbol;Acc:HGNC:20473] | 35005 | -2.491 | -0.6335 | Yes |
| 68 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 35087 | -2.553 | -0.6135 | Yes |
| 69 | TRIP13 | thyroid hormone receptor interactor 13 [Source:HGNC Symbol;Acc:HGNC:12307] | 35157 | -2.606 | -0.5927 | Yes |
| 70 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 35393 | -2.750 | -0.5751 | Yes |
| 71 | MRE11 | MRE11 homolog, double strand break repair nuclease [Source:HGNC Symbol;Acc:HGNC:7230] | 35408 | -2.762 | -0.5515 | Yes |
| 72 | NCAPH2 | non-SMC condensin II complex subunit H2 [Source:HGNC Symbol;Acc:HGNC:25071] | 35448 | -2.795 | -0.5282 | Yes |
| 73 | RAD51C | RAD51 paralog C [Source:HGNC Symbol;Acc:HGNC:9820] | 35677 | -3.050 | -0.5078 | Yes |
| 74 | ZCWPW1 | zinc finger CW-type and PWWP domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23486] | 35684 | -3.053 | -0.4814 | Yes |
| 75 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 36054 | -3.383 | -0.4620 | Yes |
| 76 | FANCD2 | FA complementation group D2 [Source:HGNC Symbol;Acc:HGNC:3585] | 36074 | -3.406 | -0.4328 | Yes |
| 77 | SGO2 | shugoshin 2 [Source:HGNC Symbol;Acc:HGNC:30812] | 36079 | -3.411 | -0.4033 | Yes |
| 78 | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149] | 36096 | -3.434 | -0.3738 | Yes |
| 79 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1148] | 36172 | -3.498 | -0.3454 | Yes |
| 80 | AGO4 | argonaute RISC component 4 [Source:HGNC Symbol;Acc:HGNC:18424] | 36192 | -3.524 | -0.3153 | Yes |
| 81 | SGO1 | shugoshin 1 [Source:HGNC Symbol;Acc:HGNC:25088] | 36304 | -3.637 | -0.2866 | Yes |
| 82 | PLK1 | polo like kinase 1 [Source:HGNC Symbol;Acc:HGNC:9077] | 36660 | -4.066 | -0.2608 | Yes |
| 83 | M1AP | meiosis 1 associated protein [Source:HGNC Symbol;Acc:HGNC:25183] | 36724 | -4.149 | -0.2264 | Yes |
| 84 | CCNE1 | cyclin E1 [Source:HGNC Symbol;Acc:HGNC:1589] | 36735 | -4.169 | -0.1904 | Yes |
| 85 | NUF2 | NUF2 component of NDC80 kinetochore complex [Source:HGNC Symbol;Acc:HGNC:14621] | 36883 | -4.431 | -0.1559 | Yes |
| 86 | ESPL1 | extra spindle pole bodies like 1, separase [Source:HGNC Symbol;Acc:HGNC:16856] | 36917 | -4.488 | -0.1177 | Yes |
| 87 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 36941 | -4.548 | -0.0787 | Yes |
| 88 | CCNE2 | cyclin E2 [Source:HGNC Symbol;Acc:HGNC:1590] | 36967 | -4.606 | -0.0393 | Yes |
| 89 | CENPS | centromere protein S [Source:HGNC Symbol;Acc:HGNC:23163] | 37055 | -4.900 | 0.0009 | Yes |
