Fig 1: Enrichment plot: HINATA_NFKB_IMMU_INF
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HINATA_NFKB_IMMU_INF |
| Enrichment Score (ES) | 0.9394445 |
| Normalized Enrichment Score (NES) | 1.6235882 |
| Nominal p-value | 0.0030395137 |
| FDR q-value | 0.05728744 |
| FWER p-Value | 0.024 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 3 | 4.998 | 0.1934 | Yes |
| 2 | CD83 | CD83 molecule [Source:HGNC Symbol;Acc:HGNC:1703] | 223 | 4.055 | 0.3445 | Yes |
| 3 | NFKB1 | nuclear factor kappa B subunit 1 [Source:HGNC Symbol;Acc:HGNC:7794] | 262 | 3.886 | 0.4939 | Yes |
| 4 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 341 | 3.647 | 0.6330 | Yes |
| 5 | NFKBIA | NFKB inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:7797] | 413 | 3.427 | 0.7637 | Yes |
| 6 | TNFAIP2 | TNF alpha induced protein 2 [Source:HGNC Symbol;Acc:HGNC:11895] | 774 | 2.696 | 0.8583 | Yes |
| 7 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 1027 | 2.270 | 0.9394 | Yes |
| 8 | PTX3 | pentraxin 3 [Source:HGNC Symbol;Acc:HGNC:9692] | 12152 | 0.000 | 0.6394 | No |
| 9 | OLR1 | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] | 16679 | 0.000 | 0.5173 | No |
| 10 | ICAM1 | intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] | 18253 | 0.000 | 0.4749 | No |
| 11 | CXCL6 | C-X-C motif chemokine ligand 6 [Source:HGNC Symbol;Acc:HGNC:10643] | 19477 | 0.000 | 0.4419 | No |
| 12 | CXCL8 | C-X-C motif chemokine ligand 8 [Source:HGNC Symbol;Acc:HGNC:6025] | 19482 | 0.000 | 0.4418 | No |
| 13 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 19493 | 0.000 | 0.4415 | No |
| 14 | CXCL2 | C-X-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:4603] | 19494 | 0.000 | 0.4415 | No |
| 15 | RELA | RELA proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] | 31274 | -0.853 | 0.1569 | No |
