Datasetgreenberg_collapsed_to_symbols.Nof1.cls
#KO_LPS_versus_KO_NA.Nof1.cls
#KO_LPS_versus_KO_NA_repos
PhenotypeNof1.cls#KO_LPS_versus_KO_NA_repos
Upregulated in classKO_LPS
GeneSetHALLMARK_APOPTOSIS
Enrichment Score (ES)0.43739116
Normalized Enrichment Score (NES)1.1585146
Nominal p-value0.078125
FDR q-value0.16053626
FWER p-Value0.427
Table: GSEA Results Summary



Fig 1: Enrichment plot: HALLMARK_APOPTOSIS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

SYMBOLTITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1IL1Binterleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992]34.9980.0189Yes
2IL1Ainterleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991]284.9480.0371Yes
3ISG20interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130]464.8770.0552Yes
4TIMP1TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820]734.7500.0726Yes
5TNFtumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892]1274.4450.0881Yes
6GADD45Bgrowth arrest and DNA damage inducible beta [Source:HGNC Symbol;Acc:HGNC:4096]1524.3320.1039Yes
7BCL2L1BCL2 like 1 [Source:HGNC Symbol;Acc:HGNC:992]2044.1040.1182Yes
8GADD45Agrowth arrest and DNA damage inducible alpha [Source:HGNC Symbol;Acc:HGNC:4095]2254.0520.1330Yes
9IER3immediate early response 3 [Source:HGNC Symbol;Acc:HGNC:5392]2593.8970.1470Yes
10TAP1transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43]2673.8740.1615Yes
11GCH1GTP cyclohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:4193]2723.8600.1761Yes
12CFLARCASP8 and FADD like apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:1876]3223.7140.1889Yes
13IL6interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018]3413.6470.2023Yes
14CCND2cyclin D2 [Source:HGNC Symbol;Acc:HGNC:1583]3933.4960.2142Yes
15SOD2superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180]4273.3590.2261Yes
16FASFas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920]4703.2870.2375Yes
17BCL2L11BCL2 like 11 [Source:HGNC Symbol;Acc:HGNC:994]4863.2520.2495Yes
18SQSTM1sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280]5083.2060.2611Yes
19SMAD7SMAD family member 7 [Source:HGNC Symbol;Acc:HGNC:6773]5183.1850.2730Yes
20PDGFRBplatelet derived growth factor receptor beta [Source:HGNC Symbol;Acc:HGNC:8804]5353.1400.2845Yes
21CD14CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628]5363.1380.2965Yes
22CD44CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681]5433.1300.3082Yes
23MMP2matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166]6432.8850.3165Yes
24BTG2BTG anti-proliferation factor 2 [Source:HGNC Symbol;Acc:HGNC:1131]7682.7020.3234Yes
25CASP8caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509]8162.6230.3322Yes
26PEA15proliferation and apoptosis adaptor protein 15 [Source:HGNC Symbol;Acc:HGNC:8822]9012.4870.3393Yes
27DNAJA1DnaJ heat shock protein family (Hsp40) member A1 [Source:HGNC Symbol;Acc:HGNC:5229]9312.4360.3478Yes
28IFITM3interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414]9442.4150.3567Yes
29ATF3activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785]9472.4110.3658Yes
30BTG3BTG anti-proliferation factor 3 [Source:HGNC Symbol;Acc:HGNC:1132]9952.3170.3734Yes
31IRF1interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116]10272.2700.3812Yes
32SAT1spermidine/spermine N1-acetyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10540]12962.0400.3817Yes
33ETF1eukaryotic translation termination factor 1 [Source:HGNC Symbol;Acc:HGNC:3477]14241.8810.3854Yes
34HGFhepatocyte growth factor [Source:HGNC Symbol;Acc:HGNC:4893]14431.8610.3920Yes
35CASP1caspase 1 [Source:HGNC Symbol;Acc:HGNC:1499]14521.8520.3988Yes
36CTHcystathionine gamma-lyase [Source:HGNC Symbol;Acc:HGNC:2501]14801.8290.4051Yes
37ANXA1annexin A1 [Source:HGNC Symbol;Acc:HGNC:533]14921.8200.4117Yes
38DDIT3DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726]15131.7920.4180Yes
39CDKN1Acyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784]15521.7610.4236Yes
40CREBBPCREB binding protein [Source:HGNC Symbol;Acc:HGNC:2348]17071.6320.4257Yes
41CASP7caspase 7 [Source:HGNC Symbol;Acc:HGNC:1508]17431.5910.4308Yes
42XIAPX-linked inhibitor of apoptosis [Source:HGNC Symbol;Acc:HGNC:592]18271.5260.4343Yes
43TSPOtranslocator protein [Source:HGNC Symbol;Acc:HGNC:1158]19201.4550.4374Yes
44SLC20A1solute carrier family 20 member 1 [Source:HGNC Symbol;Acc:HGNC:10946]24101.1840.4287No
45TGFB2transforming growth factor beta 2 [Source:HGNC Symbol;Acc:HGNC:11768]25341.1210.4296No
46HMOX1heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013]26591.0390.4302No
47ROCK1Rho associated coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251]26811.0290.4335No
48TNFRSF12ATNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152]27980.9810.4341No
49BCL10BCL10 immune signaling adaptor [Source:HGNC Symbol;Acc:HGNC:989]30530.8540.4305No
50PSEN1presenilin 1 [Source:HGNC Symbol;Acc:HGNC:9508]30780.8490.4331No
51MCL1MCL1 apoptosis regulator, BCL2 family member [Source:HGNC Symbol;Acc:HGNC:6943]32670.7710.4309No
52PTK2protein tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:9611]35320.6690.4263No
53DNAJC3DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439]36120.6350.4266No
54CTNNB1catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514]45310.4300.4034No
55BIRC3baculoviral IAP repeat containing 3 [Source:HGNC Symbol;Acc:HGNC:591]47260.3690.3995No
56PPP2R5Bprotein phosphatase 2 regulatory subunit B'beta [Source:HGNC Symbol;Acc:HGNC:9310]52030.2120.3874No
57APPamyloid beta precursor protein [Source:HGNC Symbol;Acc:HGNC:620]52530.2000.3869No
58ANKHANKH inorganic pyrophosphate transport regulator [Source:HGNC Symbol;Acc:HGNC:15492]55470.1230.3794No
59BCL2L2BCL2 like 2 [Source:HGNC Symbol;Acc:HGNC:995]55710.1170.3792No
60BCL2L10BCL2 like 10 [Source:HGNC Symbol;Acc:HGNC:993]70390.0000.3395No
61CCNA1cyclin A1 [Source:HGNC Symbol;Acc:HGNC:1577]72410.0000.3341No
62PLPPR4phospholipid phosphatase related 4 [Source:HGNC Symbol;Acc:HGNC:23496]73320.0000.3316No
63GUCY2Dguanylate cyclase 2D, retinal [Source:HGNC Symbol;Acc:HGNC:4689]80940.0000.3110No
64FEZ1fasciculation and elongation protein zeta 1 [Source:HGNC Symbol;Acc:HGNC:3659]88850.0000.2896No
65GPX3glutathione peroxidase 3 [Source:HGNC Symbol;Acc:HGNC:4555]91950.0000.2813No
66NEFHneurofilament heavy [Source:HGNC Symbol;Acc:HGNC:7737]94000.0000.2757No
67PLATplasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051]96410.0000.2693No
68LEF1lymphoid enhancer binding factor 1 [Source:HGNC Symbol;Acc:HGNC:6551]110820.0000.2303No
69PRF1perforin 1 [Source:HGNC Symbol;Acc:HGNC:9360]112780.0000.2250No
70EREGepiregulin [Source:HGNC Symbol;Acc:HGNC:3443]112880.0000.2247No
71IGFBP6insulin like growth factor binding protein 6 [Source:HGNC Symbol;Acc:HGNC:5475]115730.0000.2170No
72ERBB2erb-b2 receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:3430]118020.0000.2109No
73TNFSF10TNF superfamily member 10 [Source:HGNC Symbol;Acc:HGNC:11925]122540.0000.1987No
74IL18interleukin 18 [Source:HGNC Symbol;Acc:HGNC:5986]136390.0000.1612No
75BGNbiglycan [Source:HGNC Symbol;Acc:HGNC:1044]154500.0000.1122No
76BIKBCL2 interacting killer [Source:HGNC Symbol;Acc:HGNC:1051]154590.0000.1120No
77CD2CD2 molecule [Source:HGNC Symbol;Acc:HGNC:1639]156510.0000.1068No
78DCNdecorin [Source:HGNC Symbol;Acc:HGNC:2705]159370.0000.0991No
79F2coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535]160650.0000.0956No
80F2Rcoagulation factor II thrombin receptor [Source:HGNC Symbol;Acc:HGNC:3537]164240.0000.0859No
81AVPR1Aarginine vasopressin receptor 1A [Source:HGNC Symbol;Acc:HGNC:895]165710.0000.0820No
82TIMP3TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822]170940.0000.0678No
83DPYDdihydropyrimidine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:3012]181160.0000.0402No
84LUMlumican [Source:HGNC Symbol;Acc:HGNC:6724]187750.0000.0224No
85AIFM3apoptosis inducing factor mitochondria associated 3 [Source:HGNC Symbol;Acc:HGNC:26398]199830.000-0.0103No
86IFNB1interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434]216760.000-0.0561No
87PMAIP1phorbol-12-myristate-13-acetate-induced protein 1 [Source:HGNC Symbol;Acc:HGNC:9108]227120.000-0.0841No
88CASP4caspase 4 [Source:HGNC Symbol;Acc:HGNC:1505]239190.000-0.1168No
89FASLGFas ligand [Source:HGNC Symbol;Acc:HGNC:11936]249670.000-0.1452No
90IFNGR1interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439]252170.000-0.1519No
91SATB1SATB homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10541]263660.000-0.1830No
92KRT18keratin 18 [Source:HGNC Symbol;Acc:HGNC:6430]268280.000-0.1955No
93CD38CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667]279270.000-0.2252No
94CD69CD69 molecule [Source:HGNC Symbol;Acc:HGNC:1694]280110.000-0.2274No
95TGFBR3transforming growth factor beta receptor 3 [Source:HGNC Symbol;Acc:HGNC:11774]280980.000-0.2298No
96NEDD9neural precursor cell expressed, developmentally down-regulated 9 [Source:HGNC Symbol;Acc:HGNC:7733]28177-0.017-0.2318No
97ERBB3erb-b2 receptor tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3431]28276-0.047-0.2343No
98DIABLOdiablo IAP-binding mitochondrial protein [Source:HGNC Symbol;Acc:HGNC:21528]28526-0.111-0.2406No
99PPP3R1protein phosphatase 3 regulatory subunit B, alpha [Source:HGNC Symbol;Acc:HGNC:9317]28756-0.171-0.2462No
100RNASELribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050]28841-0.195-0.2477No
101VDAC2voltage dependent anion channel 2 [Source:HGNC Symbol;Acc:HGNC:12672]29212-0.287-0.2566No
102SOD1superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179]29239-0.295-0.2562No
103GSRglutathione-disulfide reductase [Source:HGNC Symbol;Acc:HGNC:4623]29781-0.436-0.2692No
104BCAP31B cell receptor associated protein 31 [Source:HGNC Symbol;Acc:HGNC:16695]30132-0.535-0.2766No
105MADDMAP kinase activating death domain [Source:HGNC Symbol;Acc:HGNC:6766]30305-0.556-0.2792No
106GSTM1glutathione S-transferase mu 1 [Source:HGNC Symbol;Acc:HGNC:4632]30763-0.698-0.2889No
107DNM1Ldynamin 1 like [Source:HGNC Symbol;Acc:HGNC:2973]30816-0.714-0.2876No
108JUNJun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204]30852-0.729-0.2858No
109DFFADNA fragmentation factor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2772]30868-0.733-0.2834No
110EBPEBP cholestenol delta-isomerase [Source:HGNC Symbol;Acc:HGNC:3133]31120-0.796-0.2871No
111SPTAN1spectrin alpha, non-erythrocytic 1 [Source:HGNC Symbol;Acc:HGNC:11273]31243-0.843-0.2872No
112RELARELA proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955]31274-0.853-0.2848No
113RHOT2ras homolog family member T2 [Source:HGNC Symbol;Acc:HGNC:21169]31287-0.857-0.2819No
114PSEN2presenilin 2 [Source:HGNC Symbol;Acc:HGNC:9509]31689-0.987-0.2890No
115IGF2Rinsulin like growth factor 2 receptor [Source:HGNC Symbol;Acc:HGNC:5467]31694-0.989-0.2853No
116BAXBCL2 associated X, apoptosis regulator [Source:HGNC Symbol;Acc:HGNC:959]31717-0.999-0.2821No
117EGR3early growth response 3 [Source:HGNC Symbol;Acc:HGNC:3240]32005-1.096-0.2857No
118DAP3death associated protein 3 [Source:HGNC Symbol;Acc:HGNC:2673]32024-1.102-0.2820No
119PLCB2phospholipase C beta 2 [Source:HGNC Symbol;Acc:HGNC:9055]32067-1.120-0.2789No
120CLUclusterin [Source:HGNC Symbol;Acc:HGNC:2095]32096-1.134-0.2753No
121CYLDCYLD lysine 63 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:2584]32189-1.171-0.2733No
122ADD1adducin 1 [Source:HGNC Symbol;Acc:HGNC:243]32300-1.222-0.2717No
123LMNAlamin A/C [Source:HGNC Symbol;Acc:HGNC:6636]32700-1.320-0.2775No
124CAV1caveolin 1 [Source:HGNC Symbol;Acc:HGNC:1527]33208-1.538-0.2853No
125HSPB1heat shock protein family B (small) member 1 [Source:HGNC Symbol;Acc:HGNC:5246]33439-1.636-0.2853No
126SC5Dsterol-C5-desaturase [Source:HGNC Symbol;Acc:HGNC:10547]33472-1.651-0.2799No
127PAK1p21 (RAC1) activated kinase 1 [Source:HGNC Symbol;Acc:HGNC:8590]33557-1.697-0.2757No
128CASP2caspase 2 [Source:HGNC Symbol;Acc:HGNC:1503]33578-1.707-0.2698No
129LGALS3galectin 3 [Source:HGNC Symbol;Acc:HGNC:6563]33581-1.709-0.2633No
130RARAretinoic acid receptor alpha [Source:HGNC Symbol;Acc:HGNC:9864]33908-1.871-0.2650No
131GNA15G protein subunit alpha 15 [Source:HGNC Symbol;Acc:HGNC:4383]33978-1.901-0.2597No
132TIMP2TIMP metallopeptidase inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11821]33986-1.905-0.2526No
133CASP9caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511]34215-2.033-0.2510No
134HMGB2high mobility group box 2 [Source:HGNC Symbol;Acc:HGNC:5000]34287-2.069-0.2451No
135PPT1palmitoyl-protein thioesterase 1 [Source:HGNC Symbol;Acc:HGNC:9325]34340-2.111-0.2385No
136BIDBH3 interacting domain death agonist [Source:HGNC Symbol;Acc:HGNC:1050]34423-2.127-0.2326No
137CDKN1Bcyclin dependent kinase inhibitor 1B [Source:HGNC Symbol;Acc:HGNC:1785]34467-2.131-0.2256No
138CCND1cyclin D1 [Source:HGNC Symbol;Acc:HGNC:1582]34510-2.164-0.2185No
139RHOBras homolog family member B [Source:HGNC Symbol;Acc:HGNC:668]34573-2.217-0.2118No
140BRCA1BRCA1 DNA repair associated [Source:HGNC Symbol;Acc:HGNC:1100]34852-2.390-0.2102No
141EMP1epithelial membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:3333]34883-2.408-0.2019No
142FDXRferredoxin reductase [Source:HGNC Symbol;Acc:HGNC:3642]34934-2.434-0.1939No
143CDK2cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771]34953-2.448-0.1851No
144RETSATretinol saturase [Source:HGNC Symbol;Acc:HGNC:25991]35106-2.563-0.1795No
145TXNIPthioredoxin interacting protein [Source:HGNC Symbol;Acc:HGNC:16952]35184-2.627-0.1716No
146ENO2enolase 2 [Source:HGNC Symbol;Acc:HGNC:3353]35365-2.729-0.1660No
147DAPdeath associated protein [Source:HGNC Symbol;Acc:HGNC:2672]35501-2.844-0.1589No
148GPX1glutathione peroxidase 1 [Source:HGNC Symbol;Acc:HGNC:4553]36023-3.360-0.1602No
149MGMTO-6-methylguanine-DNA methyltransferase [Source:HGNC Symbol;Acc:HGNC:7059]36030-3.368-0.1475No
150GSNgelsolin [Source:HGNC Symbol;Acc:HGNC:4620]36048-3.379-0.1351No
151TOP2ADNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989]36054-3.383-0.1224No
152BMP2bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:HGNC:1069]36066-3.397-0.1098No
153BNIP3LBCL2 interacting protein 3 like [Source:HGNC Symbol;Acc:HGNC:1085]36313-3.642-0.1026No
154GPX4glutathione peroxidase 4 [Source:HGNC Symbol;Acc:HGNC:4556]36315-3.646-0.0887No
155H1-0H1.0 linker histone [Source:HGNC Symbol;Acc:HGNC:4714]36463-3.820-0.0782No
156CASP3caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504]36525-3.917-0.0649No
157CDC25Bcell division cycle 25B [Source:HGNC Symbol;Acc:HGNC:1726]36562-3.957-0.0508No
158WEE1WEE1 G2 checkpoint kinase [Source:HGNC Symbol;Acc:HGNC:12761]36574-3.975-0.0360No
159CASP6caspase 6 [Source:HGNC Symbol;Acc:HGNC:1507]36617-4.029-0.0218No
160PDCD4programmed cell death 4 [Source:HGNC Symbol;Acc:HGNC:8763]36707-4.134-0.0085No
161BMFBcl2 modifying factor [Source:HGNC Symbol;Acc:HGNC:24132]37068-4.9410.0006No
Table: GSEA details [plain text format]



Fig 2: HALLMARK_APOPTOSIS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HALLMARK_APOPTOSIS: Random ES distribution   
Gene set null distribution of ES for HALLMARK_APOPTOSIS