Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.62115914 |
| Normalized Enrichment Score (NES) | -1.2852112 |
| Nominal p-value | 0.043093923 |
| FDR q-value | 0.15847662 |
| FWER p-Value | 0.814 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 187 | 4.198 | 0.0220 | No |
| 2 | HAO1 | hydroxyacid oxidase 1 [Source:HGNC Symbol;Acc:HGNC:4809] | 387 | 3.527 | 0.0393 | No |
| 3 | ATXN1 | ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] | 523 | 3.168 | 0.0561 | No |
| 4 | BCAR3 | BCAR3 adaptor protein, NSP family member [Source:HGNC Symbol;Acc:HGNC:973] | 630 | 2.913 | 0.0720 | No |
| 5 | AQP9 | aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] | 654 | 2.858 | 0.0898 | No |
| 6 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 889 | 2.512 | 0.0996 | No |
| 7 | PEX11A | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] | 985 | 2.347 | 0.1122 | No |
| 8 | TFCP2L1 | transcription factor CP2 like 1 [Source:HGNC Symbol;Acc:HGNC:17925] | 1449 | 1.855 | 0.1116 | No |
| 9 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 1694 | 1.650 | 0.1157 | No |
| 10 | GCLM | glutamate-cysteine ligase modifier subunit [Source:HGNC Symbol;Acc:HGNC:4312] | 1865 | 1.496 | 0.1207 | No |
| 11 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 1893 | 1.470 | 0.1295 | No |
| 12 | PEX12 | peroxisomal biogenesis factor 12 [Source:HGNC Symbol;Acc:HGNC:8854] | 2265 | 1.265 | 0.1276 | No |
| 13 | PEX19 | peroxisomal biogenesis factor 19 [Source:HGNC Symbol;Acc:HGNC:9713] | 3041 | 0.864 | 0.1122 | No |
| 14 | CH25H | cholesterol 25-hydroxylase [Source:HGNC Symbol;Acc:HGNC:1907] | 3793 | 0.564 | 0.0955 | No |
| 15 | PXMP2 | peroxisomal membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:9716] | 4047 | 0.474 | 0.0917 | No |
| 16 | SLC27A2 | solute carrier family 27 member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 4412 | 0.468 | 0.0849 | No |
| 17 | ISOC1 | isochorismatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24254] | 4651 | 0.391 | 0.0810 | No |
| 18 | LIPE | lipase E, hormone sensitive type [Source:HGNC Symbol;Acc:HGNC:6621] | 5153 | 0.230 | 0.0689 | No |
| 19 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 5754 | 0.064 | 0.0531 | No |
| 20 | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 7622 | 0.000 | 0.0026 | No |
| 21 | ALDH8A1 | aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471] | 8328 | 0.000 | -0.0165 | No |
| 22 | GSTK1 | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] | 9366 | 0.000 | -0.0445 | No |
| 23 | SLC23A1 | solute carrier family 23 member 1 [Source:HGNC Symbol;Acc:HGNC:10974] | 9567 | 0.000 | -0.0499 | No |
| 24 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 9859 | 0.000 | -0.0578 | No |
| 25 | NEDD4 | NEDD4 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727] | 10212 | 0.000 | -0.0673 | No |
| 26 | SLC27A5 | solute carrier family 27 member 5 [Source:HGNC Symbol;Acc:HGNC:10999] | 10673 | 0.000 | -0.0797 | No |
| 27 | AKR1D1 | aldo-keto reductase family 1 member D1 [Source:HGNC Symbol;Acc:HGNC:388] | 11330 | 0.000 | -0.0975 | No |
| 28 | AGXT | alanine--glyoxylate and serine--pyruvate aminotransferase [Source:HGNC Symbol;Acc:HGNC:341] | 11961 | 0.000 | -0.1145 | No |
| 29 | CYP39A1 | cytochrome P450 family 39 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:17449] | 12262 | 0.000 | -0.1226 | No |
| 30 | HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5217] | 12398 | 0.000 | -0.1263 | No |
| 31 | TTR | transthyretin [Source:HGNC Symbol;Acc:HGNC:12405] | 12521 | 0.000 | -0.1296 | No |
| 32 | RBP1 | retinol binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9919] | 12680 | 0.000 | -0.1339 | No |
| 33 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2653] | 15318 | 0.000 | -0.2052 | No |
| 34 | DIO1 | iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883] | 15731 | 0.000 | -0.2163 | No |
| 35 | DIO2 | iodothyronine deiodinase 2 [Source:HGNC Symbol;Acc:HGNC:2884] | 15732 | 0.000 | -0.2163 | No |
| 36 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16091 | 0.000 | -0.2260 | No |
| 37 | SERPINA6 | serpin family A member 6 [Source:HGNC Symbol;Acc:HGNC:1540] | 17774 | 0.000 | -0.2715 | No |
| 38 | OPTN | optineurin [Source:HGNC Symbol;Acc:HGNC:17142] | 18030 | 0.000 | -0.2784 | No |
| 39 | BMP6 | bone morphogenetic protein 6 [Source:HGNC Symbol;Acc:HGNC:1073] | 19095 | 0.000 | -0.3071 | No |
| 40 | HSD17B6 | hydroxysteroid 17-beta dehydrogenase 6 [Source:HGNC Symbol;Acc:HGNC:23316] | 19814 | 0.000 | -0.3266 | No |
| 41 | NR1I2 | nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] | 20003 | 0.000 | -0.3316 | No |
| 42 | SULT2B1 | sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] | 20655 | 0.000 | -0.3492 | No |
| 43 | SULT1B1 | sulfotransferase family 1B member 1 [Source:HGNC Symbol;Acc:HGNC:17845] | 20969 | 0.000 | -0.3577 | No |
| 44 | PIPOX | pipecolic acid and sarcosine oxidase [Source:HGNC Symbol;Acc:HGNC:17804] | 21908 | 0.000 | -0.3831 | No |
| 45 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] | 22737 | 0.000 | -0.4055 | No |
| 46 | CYP46A1 | cytochrome P450 family 46 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2641] | 22990 | 0.000 | -0.4123 | No |
| 47 | ABCA6 | ATP binding cassette subfamily A member 6 [Source:HGNC Symbol;Acc:HGNC:36] | 23966 | 0.000 | -0.4387 | No |
| 48 | ABCA4 | ATP binding cassette subfamily A member 4 [Source:HGNC Symbol;Acc:HGNC:34] | 23969 | 0.000 | -0.4387 | No |
| 49 | ABCA9 | ATP binding cassette subfamily A member 9 [Source:HGNC Symbol;Acc:HGNC:39] | 23970 | 0.000 | -0.4387 | No |
| 50 | ABCA8 | ATP binding cassette subfamily A member 8 [Source:HGNC Symbol;Acc:HGNC:38] | 23971 | 0.000 | -0.4387 | No |
| 51 | SLCO1A2 | solute carrier organic anion transporter family member 1A2 [Source:HGNC Symbol;Acc:HGNC:10956] | 24020 | 0.000 | -0.4400 | No |
| 52 | ABCG8 | ATP binding cassette subfamily G member 8 [Source:HGNC Symbol;Acc:HGNC:13887] | 24611 | 0.000 | -0.4560 | No |
| 53 | NR1H4 | nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967] | 24665 | 0.000 | -0.4574 | No |
| 54 | KLF1 | Kruppel like factor 1 [Source:HGNC Symbol;Acc:HGNC:6345] | 25366 | 0.000 | -0.4763 | No |
| 55 | BBOX1 | gamma-butyrobetaine hydroxylase 1 [Source:HGNC Symbol;Acc:HGNC:964] | 25652 | 0.000 | -0.4840 | No |
| 56 | CYP7B1 | cytochrome P450 family 7 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2652] | 25916 | 0.000 | -0.4911 | No |
| 57 | CYP7A1 | cytochrome P450 family 7 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2651] | 25939 | 0.000 | -0.4917 | No |
| 58 | GNMT | glycine N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4415] | 27359 | 0.000 | -0.5301 | No |
| 59 | PEX13 | peroxisomal biogenesis factor 13 [Source:HGNC Symbol;Acc:HGNC:8855] | 28308 | -0.057 | -0.5554 | No |
| 60 | MLYCD | malonyl-CoA decarboxylase [Source:HGNC Symbol;Acc:HGNC:7150] | 28388 | -0.081 | -0.5570 | No |
| 61 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 29239 | -0.295 | -0.5781 | No |
| 62 | AR | androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] | 29355 | -0.328 | -0.5791 | No |
| 63 | PNPLA8 | patatin like phospholipase domain containing 8 [Source:HGNC Symbol;Acc:HGNC:28900] | 29683 | -0.412 | -0.5853 | No |
| 64 | PEX11G | peroxisomal biogenesis factor 11 gamma [Source:HGNC Symbol;Acc:HGNC:20208] | 30248 | -0.538 | -0.5970 | No |
| 65 | SLC23A2 | solute carrier family 23 member 2 [Source:HGNC Symbol;Acc:HGNC:10973] | 30315 | -0.560 | -0.5952 | No |
| 66 | ABCA5 | ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35] | 30700 | -0.685 | -0.6012 | No |
| 67 | AMACR | alpha-methylacyl-CoA racemase [Source:HGNC Symbol;Acc:HGNC:451] | 31043 | -0.783 | -0.6054 | No |
| 68 | PEX6 | peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:HGNC:8859] | 31627 | -0.966 | -0.6149 | Yes |
| 69 | ACSL1 | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] | 31786 | -1.020 | -0.6126 | Yes |
| 70 | NPC1 | NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897] | 31967 | -1.081 | -0.6105 | Yes |
| 71 | SOAT2 | sterol O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:11178] | 32032 | -1.106 | -0.6051 | Yes |
| 72 | LONP2 | lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] | 32216 | -1.184 | -0.6025 | Yes |
| 73 | ACSL5 | acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526] | 32288 | -1.215 | -0.5966 | Yes |
| 74 | NR0B2 | nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961] | 32514 | -1.234 | -0.5947 | Yes |
| 75 | PEX1 | peroxisomal biogenesis factor 1 [Source:HGNC Symbol;Acc:HGNC:8850] | 33239 | -1.549 | -0.6043 | Yes |
| 76 | PEX7 | peroxisomal biogenesis factor 7 [Source:HGNC Symbol;Acc:HGNC:8860] | 33309 | -1.580 | -0.5960 | Yes |
| 77 | PHYH | phytanoyl-CoA 2-hydroxylase [Source:HGNC Symbol;Acc:HGNC:8940] | 33345 | -1.592 | -0.5867 | Yes |
| 78 | RXRG | retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] | 33936 | -1.880 | -0.5905 | Yes |
| 79 | PEX16 | peroxisomal biogenesis factor 16 [Source:HGNC Symbol;Acc:HGNC:8857] | 33993 | -1.910 | -0.5797 | Yes |
| 80 | ABCD3 | ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] | 34018 | -1.925 | -0.5679 | Yes |
| 81 | SLC22A18 | solute carrier family 22 member 18 [Source:HGNC Symbol;Acc:HGNC:10964] | 34119 | -1.979 | -0.5579 | Yes |
| 82 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 34161 | -2.002 | -0.5461 | Yes |
| 83 | ABCG4 | ATP binding cassette subfamily G member 4 [Source:HGNC Symbol;Acc:HGNC:13884] | 34517 | -2.172 | -0.5417 | Yes |
| 84 | PECR | peroxisomal trans-2-enoyl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:18281] | 34643 | -2.257 | -0.5306 | Yes |
| 85 | NUDT12 | nudix hydrolase 12 [Source:HGNC Symbol;Acc:HGNC:18826] | 34660 | -2.265 | -0.5164 | Yes |
| 86 | SCP2 | sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] | 34707 | -2.292 | -0.5029 | Yes |
| 87 | FDXR | ferredoxin reductase [Source:HGNC Symbol;Acc:HGNC:3642] | 34934 | -2.434 | -0.4933 | Yes |
| 88 | HSD17B4 | hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] | 34969 | -2.461 | -0.4784 | Yes |
| 89 | RETSAT | retinol saturase [Source:HGNC Symbol;Acc:HGNC:25991] | 35106 | -2.563 | -0.4655 | Yes |
| 90 | CAT | catalase [Source:HGNC Symbol;Acc:HGNC:1516] | 35119 | -2.573 | -0.4493 | Yes |
| 91 | EFHC1 | EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16406] | 35170 | -2.615 | -0.4338 | Yes |
| 92 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383] | 35196 | -2.643 | -0.4174 | Yes |
| 93 | HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol;Acc:HGNC:18324] | 35236 | -2.675 | -0.4012 | Yes |
| 94 | GNPAT | glyceronephosphate O-acyltransferase [Source:HGNC Symbol;Acc:HGNC:4416] | 35335 | -2.708 | -0.3864 | Yes |
| 95 | ABCA3 | ATP binding cassette subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:33] | 35606 | -2.956 | -0.3747 | Yes |
| 96 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 35624 | -2.974 | -0.3560 | Yes |
| 97 | ALDH9A1 | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] | 35743 | -3.081 | -0.3393 | Yes |
| 98 | PEX26 | peroxisomal biogenesis factor 26 [Source:HGNC Symbol;Acc:HGNC:22965] | 35869 | -3.208 | -0.3220 | Yes |
| 99 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 35928 | -3.289 | -0.3024 | Yes |
| 100 | RXRA | retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] | 36067 | -3.397 | -0.2843 | Yes |
| 101 | FADS1 | fatty acid desaturase 1 [Source:HGNC Symbol;Acc:HGNC:3574] | 36100 | -3.438 | -0.2630 | Yes |
| 102 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 36140 | -3.471 | -0.2417 | Yes |
| 103 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) [Source:HGNC Symbol;Acc:HGNC:11003] | 36379 | -3.721 | -0.2241 | Yes |
| 104 | ABCD1 | ATP binding cassette subfamily D member 1 [Source:HGNC Symbol;Acc:HGNC:61] | 36470 | -3.832 | -0.2019 | Yes |
| 105 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] | 36479 | -3.842 | -0.1773 | Yes |
| 106 | PAOX | polyamine oxidase [Source:HGNC Symbol;Acc:HGNC:20837] | 36513 | -3.898 | -0.1531 | Yes |
| 107 | CROT | carnitine O-octanoyltransferase [Source:HGNC Symbol;Acc:HGNC:2366] | 36628 | -4.035 | -0.1302 | Yes |
| 108 | PFKM | phosphofructokinase, muscle [Source:HGNC Symbol;Acc:HGNC:8877] | 36771 | -4.215 | -0.1069 | Yes |
| 109 | DHCR24 | 24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859] | 36824 | -4.316 | -0.0805 | Yes |
| 110 | HACL1 | 2-hydroxyacyl-CoA lyase 1 [Source:HGNC Symbol;Acc:HGNC:17856] | 36850 | -4.371 | -0.0530 | Yes |
| 111 | ABCD2 | ATP binding cassette subfamily D member 2 [Source:HGNC Symbol;Acc:HGNC:66] | 36913 | -4.479 | -0.0258 | Yes |
| 112 | CYP27A1 | cytochrome P450 family 27 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2605] | 37020 | -4.744 | 0.0019 | Yes |
