Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.4360135 |
| Normalized Enrichment Score (NES) | 1.1597668 |
| Nominal p-value | 0.055555556 |
| FDR q-value | 0.17267816 |
| FWER p-Value | 0.426 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SERPINB2 | serpin family B member 2 [Source:HGNC Symbol;Acc:HGNC:8584] | 52 | 4.845 | 0.0328 | Yes |
| 2 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 71 | 4.757 | 0.0659 | Yes |
| 3 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 73 | 4.750 | 0.0995 | Yes |
| 4 | CFB | complement factor B [Source:HGNC Symbol;Acc:HGNC:1037] | 75 | 4.745 | 0.1329 | Yes |
| 5 | MAFF | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] | 168 | 4.259 | 0.1605 | Yes |
| 6 | PDGFB | platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] | 171 | 4.251 | 0.1905 | Yes |
| 7 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 208 | 4.084 | 0.2184 | Yes |
| 8 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 243 | 3.976 | 0.2455 | Yes |
| 9 | F9 | coagulation factor IX [Source:HGNC Symbol;Acc:HGNC:3551] | 263 | 3.885 | 0.2725 | Yes |
| 10 | DUSP14 | dual specificity phosphatase 14 [Source:HGNC Symbol;Acc:HGNC:17007] | 299 | 3.789 | 0.2983 | Yes |
| 11 | FBN1 | fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] | 390 | 3.514 | 0.3207 | Yes |
| 12 | MMP14 | matrix metallopeptidase 14 [Source:HGNC Symbol;Acc:HGNC:7160] | 598 | 2.990 | 0.3362 | Yes |
| 13 | SERPINC1 | serpin family C member 1 [Source:HGNC Symbol;Acc:HGNC:775] | 623 | 2.946 | 0.3563 | Yes |
| 14 | MMP2 | matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] | 643 | 2.885 | 0.3762 | Yes |
| 15 | PLEK | pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] | 760 | 2.725 | 0.3923 | Yes |
| 16 | ITIH1 | inter-alpha-trypsin inhibitor heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:6166] | 1289 | 2.050 | 0.3925 | Yes |
| 17 | WDR1 | WD repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12754] | 1354 | 1.971 | 0.4047 | Yes |
| 18 | ANXA1 | annexin A1 [Source:HGNC Symbol;Acc:HGNC:533] | 1492 | 1.820 | 0.4138 | Yes |
| 19 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 1667 | 1.673 | 0.4209 | Yes |
| 20 | GNG12 | G protein subunit gamma 12 [Source:HGNC Symbol;Acc:HGNC:19663] | 1756 | 1.580 | 0.4297 | Yes |
| 21 | BMP1 | bone morphogenetic protein 1 [Source:HGNC Symbol;Acc:HGNC:1067] | 2062 | 1.385 | 0.4312 | Yes |
| 22 | FYN | FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] | 2469 | 1.162 | 0.4285 | Yes |
| 23 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 2531 | 1.123 | 0.4348 | Yes |
| 24 | S100A13 | S100 calcium binding protein A13 [Source:HGNC Symbol;Acc:HGNC:10490] | 2940 | 0.910 | 0.4301 | Yes |
| 25 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 2959 | 0.901 | 0.4360 | Yes |
| 26 | ARF4 | ADP ribosylation factor 4 [Source:HGNC Symbol;Acc:HGNC:655] | 3357 | 0.737 | 0.4305 | No |
| 27 | GDA | guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212] | 3773 | 0.572 | 0.4233 | No |
| 28 | KLF7 | Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] | 4588 | 0.412 | 0.4042 | No |
| 29 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 4677 | 0.382 | 0.4045 | No |
| 30 | ADAM9 | ADAM metallopeptidase domain 9 [Source:HGNC Symbol;Acc:HGNC:216] | 4724 | 0.369 | 0.4058 | No |
| 31 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 4748 | 0.362 | 0.4078 | No |
| 32 | MST1 | macrophage stimulating 1 [Source:HGNC Symbol;Acc:HGNC:7380] | 5045 | 0.260 | 0.4016 | No |
| 33 | PREP | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] | 5134 | 0.234 | 0.4009 | No |
| 34 | C3 | complement C3 [Source:HGNC Symbol;Acc:HGNC:1318] | 5495 | 0.135 | 0.3921 | No |
| 35 | PEF1 | penta-EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30009] | 5554 | 0.121 | 0.3914 | No |
| 36 | MASP2 | mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 5877 | 0.019 | 0.3828 | No |
| 37 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629] | 6319 | 0.000 | 0.3709 | No |
| 38 | PLAT | plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051] | 9641 | 0.000 | 0.2810 | No |
| 39 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 9859 | 0.000 | 0.2751 | No |
| 40 | APOC3 | apolipoprotein C3 [Source:HGNC Symbol;Acc:HGNC:610] | 9875 | 0.000 | 0.2747 | No |
| 41 | APOC2 | apolipoprotein C2 [Source:HGNC Symbol;Acc:HGNC:609] | 9877 | 0.000 | 0.2747 | No |
| 42 | APOC1 | apolipoprotein C1 [Source:HGNC Symbol;Acc:HGNC:607] | 9878 | 0.000 | 0.2747 | No |
| 43 | F13B | coagulation factor XIII B chain [Source:HGNC Symbol;Acc:HGNC:3534] | 10619 | 0.000 | 0.2547 | No |
| 44 | KLKB1 | kallikrein B1 [Source:HGNC Symbol;Acc:HGNC:6371] | 10906 | 0.000 | 0.2469 | No |
| 45 | TMPRSS6 | transmembrane serine protease 6 [Source:HGNC Symbol;Acc:HGNC:16517] | 11327 | 0.000 | 0.2356 | No |
| 46 | PROZ | protein Z, vitamin K dependent plasma glycoprotein [Source:HGNC Symbol;Acc:HGNC:9460] | 11374 | 0.000 | 0.2343 | No |
| 47 | PROC | protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451] | 11392 | 0.000 | 0.2339 | No |
| 48 | ACOX2 | acyl-CoA oxidase 2 [Source:HGNC Symbol;Acc:HGNC:120] | 12122 | 0.000 | 0.2141 | No |
| 49 | THBD | thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] | 12508 | 0.000 | 0.2037 | No |
| 50 | P2RY1 | purinergic receptor P2Y1 [Source:HGNC Symbol;Acc:HGNC:8539] | 13984 | 0.000 | 0.1638 | No |
| 51 | MBL2 | mannose binding lectin 2 [Source:HGNC Symbol;Acc:HGNC:6922] | 15505 | 0.000 | 0.1227 | No |
| 52 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 15514 | 0.000 | 0.1225 | No |
| 53 | C8B | complement C8 beta chain [Source:HGNC Symbol;Acc:HGNC:1353] | 15575 | 0.000 | 0.1208 | No |
| 54 | C8A | complement C8 alpha chain [Source:HGNC Symbol;Acc:HGNC:1352] | 15576 | 0.000 | 0.1208 | No |
| 55 | C8G | complement C8 gamma chain [Source:HGNC Symbol;Acc:HGNC:1354] | 15578 | 0.000 | 0.1208 | No |
| 56 | HTRA1 | HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476] | 15599 | 0.000 | 0.1203 | No |
| 57 | CFD | complement factor D [Source:HGNC Symbol;Acc:HGNC:2771] | 15677 | 0.000 | 0.1182 | No |
| 58 | CFI | complement factor I [Source:HGNC Symbol;Acc:HGNC:5394] | 15678 | 0.000 | 0.1182 | No |
| 59 | DCT | dopachrome tautomerase [Source:HGNC Symbol;Acc:HGNC:2709] | 15941 | 0.000 | 0.1111 | No |
| 60 | C2 | complement C2 [Source:HGNC Symbol;Acc:HGNC:1248] | 16016 | 0.000 | 0.1091 | No |
| 61 | C9 | complement C9 [Source:HGNC Symbol;Acc:HGNC:1358] | 16021 | 0.000 | 0.1090 | No |
| 62 | F2 | coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535] | 16065 | 0.000 | 0.1078 | No |
| 63 | TF | transferrin [Source:HGNC Symbol;Acc:HGNC:11740] | 16184 | 0.000 | 0.1046 | No |
| 64 | F10 | coagulation factor X [Source:HGNC Symbol;Acc:HGNC:3528] | 16387 | 0.000 | 0.0992 | No |
| 65 | F12 | coagulation factor XII [Source:HGNC Symbol;Acc:HGNC:3530] | 16388 | 0.000 | 0.0992 | No |
| 66 | F11 | coagulation factor XI [Source:HGNC Symbol;Acc:HGNC:3529] | 16389 | 0.000 | 0.0992 | No |
| 67 | FGA | fibrinogen alpha chain [Source:HGNC Symbol;Acc:HGNC:3661] | 16626 | 0.000 | 0.0928 | No |
| 68 | FGG | fibrinogen gamma chain [Source:HGNC Symbol;Acc:HGNC:3694] | 16627 | 0.000 | 0.0928 | No |
| 69 | OLR1 | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] | 16679 | 0.000 | 0.0914 | No |
| 70 | GP9 | glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] | 17083 | 0.000 | 0.0805 | No |
| 71 | TIMP3 | TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822] | 17094 | 0.000 | 0.0802 | No |
| 72 | HRG | histidine rich glycoprotein [Source:HGNC Symbol;Acc:HGNC:5181] | 17448 | 0.000 | 0.0707 | No |
| 73 | HNF4A | hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024] | 17628 | 0.000 | 0.0658 | No |
| 74 | SERPING1 | serpin family G member 1 [Source:HGNC Symbol;Acc:HGNC:1228] | 17756 | 0.000 | 0.0624 | No |
| 75 | SERPINA1 | serpin family A member 1 [Source:HGNC Symbol;Acc:HGNC:8941] | 17770 | 0.000 | 0.0620 | No |
| 76 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 17929 | 0.000 | 0.0578 | No |
| 77 | MMP7 | matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174] | 19125 | 0.000 | 0.0254 | No |
| 78 | MMP1 | matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] | 19128 | 0.000 | 0.0254 | No |
| 79 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 19132 | 0.000 | 0.0253 | No |
| 80 | MMP8 | matrix metallopeptidase 8 [Source:HGNC Symbol;Acc:HGNC:7175] | 19138 | 0.000 | 0.0251 | No |
| 81 | MEP1A | meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015] | 20125 | 0.000 | -0.0015 | No |
| 82 | GP1BA | glycoprotein Ib platelet subunit alpha [Source:HGNC Symbol;Acc:HGNC:4439] | 20190 | 0.000 | -0.0033 | No |
| 83 | CPB2 | carboxypeptidase B2 [Source:HGNC Symbol;Acc:HGNC:2300] | 20386 | 0.000 | -0.0085 | No |
| 84 | TFPI2 | tissue factor pathway inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11761] | 21941 | 0.000 | -0.0506 | No |
| 85 | PRSS23 | serine protease 23 [Source:HGNC Symbol;Acc:HGNC:14370] | 22231 | 0.000 | -0.0584 | No |
| 86 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 23524 | 0.000 | -0.0934 | No |
| 87 | ITGA2 | integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] | 23538 | 0.000 | -0.0937 | No |
| 88 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 24131 | 0.000 | -0.1098 | No |
| 89 | SPARC | secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219] | 24504 | 0.000 | -0.1198 | No |
| 90 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 24679 | 0.000 | -0.1245 | No |
| 91 | HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008] | 24722 | 0.000 | -0.1257 | No |
| 92 | PLG | plasminogen [Source:HGNC Symbol;Acc:HGNC:9071] | 24756 | 0.000 | -0.1266 | No |
| 93 | C1QA | complement C1q A chain [Source:HGNC Symbol;Acc:HGNC:1241] | 24813 | 0.000 | -0.1281 | No |
| 94 | LEFTY2 | left-right determination factor 2 [Source:HGNC Symbol;Acc:HGNC:3122] | 24931 | 0.000 | -0.1312 | No |
| 95 | RGN | regucalcin [Source:HGNC Symbol;Acc:HGNC:9989] | 25237 | 0.000 | -0.1395 | No |
| 96 | KLK8 | kallikrein related peptidase 8 [Source:HGNC Symbol;Acc:HGNC:6369] | 25391 | 0.000 | -0.1436 | No |
| 97 | MMP11 | matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157] | 25636 | 0.000 | -0.1502 | No |
| 98 | F2RL2 | coagulation factor II thrombin receptor like 2 [Source:HGNC Symbol;Acc:HGNC:3539] | 25968 | 0.000 | -0.1592 | No |
| 99 | RABIF | RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] | 28356 | -0.069 | -0.2233 | No |
| 100 | GNB2 | G protein subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:4398] | 28556 | -0.120 | -0.2278 | No |
| 101 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 28771 | -0.176 | -0.2324 | No |
| 102 | MMP15 | matrix metallopeptidase 15 [Source:HGNC Symbol;Acc:HGNC:7161] | 28808 | -0.185 | -0.2321 | No |
| 103 | CPN1 | carboxypeptidase N subunit 1 [Source:HGNC Symbol;Acc:HGNC:2312] | 29748 | -0.429 | -0.2544 | No |
| 104 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 30021 | -0.505 | -0.2582 | No |
| 105 | MSRB2 | methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061] | 30061 | -0.515 | -0.2556 | No |
| 106 | C1R | complement C1r [Source:HGNC Symbol;Acc:HGNC:1246] | 30546 | -0.634 | -0.2643 | No |
| 107 | SIRT2 | sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] | 30599 | -0.650 | -0.2611 | No |
| 108 | HPN | hepsin [Source:HGNC Symbol;Acc:HGNC:5155] | 30653 | -0.670 | -0.2578 | No |
| 109 | S100A1 | S100 calcium binding protein A1 [Source:HGNC Symbol;Acc:HGNC:10486] | 30778 | -0.703 | -0.2562 | No |
| 110 | ISCU | iron-sulfur cluster assembly enzyme [Source:HGNC Symbol;Acc:HGNC:29882] | 30996 | -0.769 | -0.2566 | No |
| 111 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 32096 | -1.134 | -0.2783 | No |
| 112 | DUSP6 | dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] | 32194 | -1.173 | -0.2727 | No |
| 113 | VWF | von Willebrand factor [Source:HGNC Symbol;Acc:HGNC:12726] | 32327 | -1.232 | -0.2675 | No |
| 114 | F3 | coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541] | 32447 | -1.232 | -0.2621 | No |
| 115 | CAPN2 | calpain 2 [Source:HGNC Symbol;Acc:HGNC:1479] | 32531 | -1.239 | -0.2556 | No |
| 116 | CTSO | cathepsin O [Source:HGNC Symbol;Acc:HGNC:2542] | 32743 | -1.336 | -0.2518 | No |
| 117 | FN1 | fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] | 32818 | -1.362 | -0.2442 | No |
| 118 | CTSE | cathepsin E [Source:HGNC Symbol;Acc:HGNC:2530] | 32925 | -1.413 | -0.2371 | No |
| 119 | CSRP1 | cysteine and glycine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2469] | 33700 | -1.752 | -0.2457 | No |
| 120 | CTSH | cathepsin H [Source:HGNC Symbol;Acc:HGNC:2535] | 33818 | -1.820 | -0.2360 | No |
| 121 | LRP1 | LDL receptor related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692] | 34022 | -1.926 | -0.2279 | No |
| 122 | CAPN5 | calpain 5 [Source:HGNC Symbol;Acc:HGNC:1482] | 34080 | -1.955 | -0.2156 | No |
| 123 | CASP9 | caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511] | 34215 | -2.033 | -0.2049 | No |
| 124 | COMP | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:HGNC:2227] | 34454 | -2.128 | -0.1963 | No |
| 125 | CRIP2 | cysteine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2361] | 34455 | -2.128 | -0.1813 | No |
| 126 | LTA4H | leukotriene A4 hydrolase [Source:HGNC Symbol;Acc:HGNC:6710] | 34496 | -2.153 | -0.1671 | No |
| 127 | CPQ | carboxypeptidase Q [Source:HGNC Symbol;Acc:HGNC:16910] | 34525 | -2.180 | -0.1525 | No |
| 128 | USP11 | ubiquitin specific peptidase 11 [Source:HGNC Symbol;Acc:HGNC:12609] | 34622 | -2.246 | -0.1392 | No |
| 129 | THBS1 | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] | 34746 | -2.313 | -0.1262 | No |
| 130 | SH2B2 | SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:17381] | 35175 | -2.620 | -0.1193 | No |
| 131 | ANG | angiogenin [Source:HGNC Symbol;Acc:HGNC:483] | 35303 | -2.688 | -0.1037 | No |
| 132 | PROS1 | protein S [Source:HGNC Symbol;Acc:HGNC:9456] | 35411 | -2.765 | -0.0871 | No |
| 133 | CFH | complement factor H [Source:HGNC Symbol;Acc:HGNC:4883] | 35425 | -2.774 | -0.0679 | No |
| 134 | GSN | gelsolin [Source:HGNC Symbol;Acc:HGNC:4620] | 36048 | -3.379 | -0.0608 | No |
| 135 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 36139 | -3.470 | -0.0388 | No |
| 136 | PLAU | plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] | 36742 | -4.179 | -0.0255 | No |
| 137 | F8 | coagulation factor VIII [Source:HGNC Symbol;Acc:HGNC:3546] | 37069 | -4.945 | 0.0006 | No |
