Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.72518444 |
| Normalized Enrichment Score (NES) | 1.7917749 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 3 | 4.998 | 0.0447 | Yes |
| 2 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 77 | 4.727 | 0.0850 | Yes |
| 3 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 78 | 4.727 | 0.1274 | Yes |
| 4 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 127 | 4.445 | 0.1659 | Yes |
| 5 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 135 | 4.408 | 0.2052 | Yes |
| 6 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] | 198 | 4.130 | 0.2405 | Yes |
| 7 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 249 | 3.962 | 0.2746 | Yes |
| 8 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 271 | 3.864 | 0.3087 | Yes |
| 9 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 283 | 3.829 | 0.3426 | Yes |
| 10 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 331 | 3.693 | 0.3744 | Yes |
| 11 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 341 | 3.647 | 0.4069 | Yes |
| 12 | FAS | Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] | 470 | 3.287 | 0.4328 | Yes |
| 13 | CD36 | CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] | 525 | 3.162 | 0.4597 | Yes |
| 14 | CD14 | CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] | 536 | 3.138 | 0.4875 | Yes |
| 15 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 543 | 3.130 | 0.5154 | Yes |
| 16 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 662 | 2.848 | 0.5377 | Yes |
| 17 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 841 | 2.586 | 0.5561 | Yes |
| 18 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 951 | 2.397 | 0.5746 | Yes |
| 19 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 1027 | 2.270 | 0.5929 | Yes |
| 20 | HAX1 | HCLS1 associated protein X-1 [Source:HGNC Symbol;Acc:HGNC:16915] | 1047 | 2.240 | 0.6124 | Yes |
| 21 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 1073 | 2.200 | 0.6315 | Yes |
| 22 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 1138 | 2.115 | 0.6487 | Yes |
| 23 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1375 | 1.947 | 0.6597 | Yes |
| 24 | PIK3R5 | phosphoinositide-3-kinase regulatory subunit 5 [Source:HGNC Symbol;Acc:HGNC:30035] | 1389 | 1.927 | 0.6766 | Yes |
| 25 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 1423 | 1.881 | 0.6926 | Yes |
| 26 | ACVR1B | activin A receptor type 1B [Source:HGNC Symbol;Acc:HGNC:172] | 1503 | 1.804 | 0.7066 | Yes |
| 27 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 2337 | 1.225 | 0.6951 | Yes |
| 28 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 2531 | 1.123 | 0.6999 | Yes |
| 29 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 2636 | 1.057 | 0.7066 | Yes |
| 30 | HMOX1 | heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] | 2659 | 1.039 | 0.7153 | Yes |
| 31 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 2798 | 0.981 | 0.7203 | Yes |
| 32 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] | 2924 | 0.920 | 0.7252 | Yes |
| 33 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 3624 | 0.631 | 0.7119 | No |
| 34 | LEPR | leptin receptor [Source:HGNC Symbol;Acc:HGNC:6554] | 4485 | 0.448 | 0.6927 | No |
| 35 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 4990 | 0.283 | 0.6816 | No |
| 36 | BAK1 | BCL2 antagonist/killer 1 [Source:HGNC Symbol;Acc:HGNC:949] | 5062 | 0.257 | 0.6820 | No |
| 37 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 5083 | 0.249 | 0.6837 | No |
| 38 | CBL | Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541] | 5339 | 0.177 | 0.6784 | No |
| 39 | LTBR | lymphotoxin beta receptor [Source:HGNC Symbol;Acc:HGNC:6718] | 7657 | 0.000 | 0.6158 | No |
| 40 | TNFRSF21 | TNF receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] | 8978 | 0.000 | 0.5801 | No |
| 41 | CRLF2 | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | 10666 | 0.000 | 0.5345 | No |
| 42 | PLA2G2A | phospholipase A2 group IIA [Source:HGNC Symbol;Acc:HGNC:9031] | 11437 | 0.000 | 0.5137 | No |
| 43 | CSF2RA | colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] | 11737 | 0.000 | 0.5056 | No |
| 44 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13382 | 0.000 | 0.4612 | No |
| 45 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 13710 | 0.000 | 0.4524 | No |
| 46 | IL9R | interleukin 9 receptor [Source:HGNC Symbol;Acc:HGNC:6030] | 13781 | 0.000 | 0.4505 | No |
| 47 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14026 | 0.000 | 0.4439 | No |
| 48 | EBI3 | Epstein-Barr virus induced 3 [Source:HGNC Symbol;Acc:HGNC:3129] | 14912 | 0.000 | 0.4200 | No |
| 49 | IL17RB | interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] | 14968 | 0.000 | 0.4185 | No |
| 50 | IL18R1 | interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] | 15330 | 0.000 | 0.4087 | No |
| 51 | IL2RA | interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] | 15523 | 0.000 | 0.4035 | No |
| 52 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15800 | 0.000 | 0.3961 | No |
| 53 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15801 | 0.000 | 0.3961 | No |
| 54 | IL3RA | interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] | 16460 | 0.000 | 0.3783 | No |
| 55 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 17698 | 0.000 | 0.3449 | No |
| 56 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18471 | 0.000 | 0.3240 | No |
| 57 | CXCL13 | C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] | 18895 | 0.000 | 0.3126 | No |
| 58 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18934 | 0.000 | 0.3115 | No |
| 59 | OSMR | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] | 19022 | 0.000 | 0.3092 | No |
| 60 | CXCL9 | C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] | 19479 | 0.000 | 0.2969 | No |
| 61 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19491 | 0.000 | 0.2966 | No |
| 62 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 19493 | 0.000 | 0.2965 | No |
| 63 | IL12RB1 | interleukin 12 receptor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:5971] | 19659 | 0.000 | 0.2921 | No |
| 64 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 21453 | 0.000 | 0.2436 | No |
| 65 | REG1A | regenerating family member 1 alpha [Source:HGNC Symbol;Acc:HGNC:9951] | 23488 | 0.000 | 0.1887 | No |
| 66 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 23524 | 0.000 | 0.1877 | No |
| 67 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 24131 | 0.000 | 0.1713 | No |
| 68 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 24679 | 0.000 | 0.1566 | No |
| 69 | IFNGR1 | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] | 25217 | 0.000 | 0.1420 | No |
| 70 | IFNGR2 | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] | 25219 | 0.000 | 0.1420 | No |
| 71 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 27823 | 0.000 | 0.0717 | No |
| 72 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 27899 | 0.000 | 0.0696 | No |
| 73 | CD38 | CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667] | 27927 | 0.000 | 0.0689 | No |
| 74 | PTPN2 | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] | 28672 | -0.150 | 0.0502 | No |
| 75 | IL17RA | interleukin 17 receptor A [Source:HGNC Symbol;Acc:HGNC:5985] | 29517 | -0.366 | 0.0306 | No |
| 76 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] | 30852 | -0.729 | 0.0011 | No |
| 77 | IL13RA1 | interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] | 31296 | -0.861 | -0.0032 | No |
| 78 | ACVRL1 | activin A receptor like type 1 [Source:HGNC Symbol;Acc:HGNC:175] | 31380 | -0.885 | 0.0025 | No |
| 79 | CNTFR | ciliary neurotrophic factor receptor [Source:HGNC Symbol;Acc:HGNC:2170] | 31403 | -0.894 | 0.0099 | No |
| 80 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 31462 | -0.914 | 0.0166 | No |
| 81 | INHBE | inhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029] | 32175 | -1.167 | 0.0078 | No |
| 82 | CSF2RB | colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] | 32523 | -1.236 | 0.0095 | No |
| 83 | DNTT | DNA nucleotidylexotransferase [Source:HGNC Symbol;Acc:HGNC:2983] | 32681 | -1.312 | 0.0170 | No |
| 84 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 34180 | -2.015 | -0.0055 | No |
| 85 | IL6ST | interleukin 6 signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] | 34722 | -2.300 | 0.0005 | No |
| 86 | CSF3R | colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] | 35733 | -3.066 | 0.0007 | No |
| 87 | ITGA4 | integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] | 36608 | -4.016 | 0.0130 | No |
