Fig 1: Enrichment plot: HALLMARK_INTERFERON_ALPHA_RESPONSE
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HALLMARK_INTERFERON_ALPHA_RESPONSE |
| Enrichment Score (ES) | 0.8510799 |
| Normalized Enrichment Score (NES) | 2.14457 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 17 | 4.971 | 0.0208 | Yes |
| 2 | GBP4 | guanylate binding protein 4 [Source:HGNC Symbol;Acc:HGNC:20480] | 32 | 4.931 | 0.0416 | Yes |
| 3 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 35 | 4.928 | 0.0627 | Yes |
| 4 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 46 | 4.877 | 0.0833 | Yes |
| 5 | PARP14 | poly(ADP-ribose) polymerase family member 14 [Source:HGNC Symbol;Acc:HGNC:29232] | 57 | 4.823 | 0.1037 | Yes |
| 6 | CMPK2 | cytidine/uridine monophosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:27015] | 60 | 4.819 | 0.1243 | Yes |
| 7 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 66 | 4.776 | 0.1446 | Yes |
| 8 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 78 | 4.727 | 0.1646 | Yes |
| 9 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 85 | 4.682 | 0.1845 | Yes |
| 10 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 97 | 4.635 | 0.2041 | Yes |
| 11 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 101 | 4.617 | 0.2238 | Yes |
| 12 | HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 [Source:HGNC Symbol;Acc:HGNC:26072] | 106 | 4.605 | 0.2434 | Yes |
| 13 | IFI44 | interferon induced protein 44 [Source:HGNC Symbol;Acc:HGNC:16938] | 119 | 4.515 | 0.2624 | Yes |
| 14 | IFIH1 | interferon induced with helicase C domain 1 [Source:HGNC Symbol;Acc:HGNC:18873] | 126 | 4.446 | 0.2813 | Yes |
| 15 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 154 | 4.328 | 0.2991 | Yes |
| 16 | HELZ2 | helicase with zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:30021] | 162 | 4.295 | 0.3173 | Yes |
| 17 | TRIM21 | tripartite motif containing 21 [Source:HGNC Symbol;Acc:HGNC:11312] | 169 | 4.259 | 0.3354 | Yes |
| 18 | DHX58 | DExH-box helicase 58 [Source:HGNC Symbol;Acc:HGNC:29517] | 180 | 4.220 | 0.3532 | Yes |
| 19 | PROCR | protein C receptor [Source:HGNC Symbol;Acc:HGNC:9452] | 221 | 4.060 | 0.3696 | Yes |
| 20 | EIF2AK2 | eukaryotic translation initiation factor 2 alpha kinase 2 [Source:HGNC Symbol;Acc:HGNC:9437] | 228 | 4.036 | 0.3867 | Yes |
| 21 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 249 | 3.962 | 0.4031 | Yes |
| 22 | SAMD9L | sterile alpha motif domain containing 9 like [Source:HGNC Symbol;Acc:HGNC:1349] | 257 | 3.933 | 0.4198 | Yes |
| 23 | SAMD9 | sterile alpha motif domain containing 9 [Source:HGNC Symbol;Acc:HGNC:1348] | 264 | 3.882 | 0.4363 | Yes |
| 24 | TAP1 | transporter 1, ATP binding cassette subfamily B member [Source:HGNC Symbol;Acc:HGNC:43] | 267 | 3.874 | 0.4528 | Yes |
| 25 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 281 | 3.833 | 0.4689 | Yes |
| 26 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 283 | 3.829 | 0.4853 | Yes |
| 27 | PARP12 | poly(ADP-ribose) polymerase family member 12 [Source:HGNC Symbol;Acc:HGNC:21919] | 291 | 3.808 | 0.5014 | Yes |
| 28 | TRAFD1 | TRAF-type zinc finger domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24808] | 292 | 3.808 | 0.5177 | Yes |
| 29 | DDX60 | DExD/H-box helicase 60 [Source:HGNC Symbol;Acc:HGNC:25942] | 298 | 3.789 | 0.5338 | Yes |
| 30 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 307 | 3.781 | 0.5498 | Yes |
| 31 | TENT5A | terminal nucleotidyltransferase 5A [Source:HGNC Symbol;Acc:HGNC:18345] | 321 | 3.725 | 0.5654 | Yes |
| 32 | EPSTI1 | epithelial stromal interaction 1 [Source:HGNC Symbol;Acc:HGNC:16465] | 374 | 3.557 | 0.5793 | Yes |
| 33 | SP110 | SP110 nuclear body protein [Source:HGNC Symbol;Acc:HGNC:5401] | 379 | 3.545 | 0.5944 | Yes |
| 34 | UBE2L6 | ubiquitin conjugating enzyme E2 L6 [Source:HGNC Symbol;Acc:HGNC:12490] | 431 | 3.336 | 0.6073 | Yes |
| 35 | LGALS3BP | galectin 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6564] | 556 | 3.095 | 0.6172 | Yes |
| 36 | PARP9 | poly(ADP-ribose) polymerase family member 9 [Source:HGNC Symbol;Acc:HGNC:24118] | 580 | 3.035 | 0.6296 | Yes |
| 37 | UBA7 | ubiquitin like modifier activating enzyme 7 [Source:HGNC Symbol;Acc:HGNC:12471] | 587 | 3.016 | 0.6423 | Yes |
| 38 | TRIM25 | tripartite motif containing 25 [Source:HGNC Symbol;Acc:HGNC:12932] | 588 | 3.015 | 0.6553 | Yes |
| 39 | PNPT1 | polyribonucleotide nucleotidyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:23166] | 594 | 2.998 | 0.6680 | Yes |
| 40 | MOV10 | Mov10 RISC complex RNA helicase [Source:HGNC Symbol;Acc:HGNC:7200] | 638 | 2.891 | 0.6792 | Yes |
| 41 | PSME2 | proteasome activator subunit 2 [Source:HGNC Symbol;Acc:HGNC:9569] | 745 | 2.754 | 0.6881 | Yes |
| 42 | CASP8 | caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509] | 816 | 2.623 | 0.6975 | Yes |
| 43 | IL15 | interleukin 15 [Source:HGNC Symbol;Acc:HGNC:5977] | 828 | 2.609 | 0.7084 | Yes |
| 44 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 841 | 2.586 | 0.7191 | Yes |
| 45 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 842 | 2.584 | 0.7302 | Yes |
| 46 | RIPK2 | receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] | 920 | 2.458 | 0.7387 | Yes |
| 47 | TDRD7 | tudor domain containing 7 [Source:HGNC Symbol;Acc:HGNC:30831] | 941 | 2.418 | 0.7485 | Yes |
| 48 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 944 | 2.415 | 0.7588 | Yes |
| 49 | PSME1 | proteasome activator subunit 1 [Source:HGNC Symbol;Acc:HGNC:9568] | 1010 | 2.308 | 0.7669 | Yes |
| 50 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 1025 | 2.276 | 0.7763 | Yes |
| 51 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 1027 | 2.270 | 0.7860 | Yes |
| 52 | PSMB9 | proteasome 20S subunit beta 9 [Source:HGNC Symbol;Acc:HGNC:9546] | 1109 | 2.155 | 0.7930 | Yes |
| 53 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 1154 | 2.093 | 0.8008 | Yes |
| 54 | CD47 | CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] | 1350 | 1.972 | 0.8040 | Yes |
| 55 | CMTR1 | cap methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:21077] | 1430 | 1.875 | 0.8099 | Yes |
| 56 | CASP1 | caspase 1 [Source:HGNC Symbol;Acc:HGNC:1499] | 1452 | 1.852 | 0.8173 | Yes |
| 57 | TRIM14 | tripartite motif containing 14 [Source:HGNC Symbol;Acc:HGNC:16283] | 1511 | 1.795 | 0.8234 | Yes |
| 58 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 1576 | 1.741 | 0.8291 | Yes |
| 59 | B2M | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 1793 | 1.552 | 0.8299 | Yes |
| 60 | IFI44L | interferon induced protein 44 like [Source:HGNC Symbol;Acc:HGNC:17817] | 1912 | 1.458 | 0.8330 | Yes |
| 61 | PSMA3 | proteasome 20S subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:9532] | 1929 | 1.449 | 0.8388 | Yes |
| 62 | TRIM26 | tripartite motif containing 26 [Source:HGNC Symbol;Acc:HGNC:12962] | 2056 | 1.388 | 0.8413 | Yes |
| 63 | PLSCR1 | phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092] | 2072 | 1.379 | 0.8468 | Yes |
| 64 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 2290 | 1.253 | 0.8463 | Yes |
| 65 | OGFR | opioid growth factor receptor [Source:HGNC Symbol;Acc:HGNC:15768] | 2378 | 1.204 | 0.8491 | Yes |
| 66 | WARS1 | tryptophanyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:12729] | 2581 | 1.086 | 0.8483 | Yes |
| 67 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 2761 | 0.998 | 0.8478 | Yes |
| 68 | RNF31 | ring finger protein 31 [Source:HGNC Symbol;Acc:HGNC:16031] | 2848 | 0.954 | 0.8495 | Yes |
| 69 | LAP3 | leucine aminopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:18449] | 2936 | 0.913 | 0.8511 | Yes |
| 70 | TMEM140 | transmembrane protein 140 [Source:HGNC Symbol;Acc:HGNC:21870] | 4036 | 0.475 | 0.8234 | No |
| 71 | NCOA7 | nuclear receptor coactivator 7 [Source:HGNC Symbol;Acc:HGNC:21081] | 4985 | 0.285 | 0.7990 | No |
| 72 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 5211 | 0.211 | 0.7938 | No |
| 73 | NUB1 | negative regulator of ubiquitin like proteins 1 [Source:HGNC Symbol;Acc:HGNC:17623] | 5543 | 0.125 | 0.7854 | No |
| 74 | SELL | selectin L [Source:HGNC Symbol;Acc:HGNC:10720] | 6831 | 0.000 | 0.7506 | No |
| 75 | CCRL2 | C-C motif chemokine receptor like 2 [Source:HGNC Symbol;Acc:HGNC:1612] | 8450 | 0.000 | 0.7069 | No |
| 76 | BATF2 | basic leucine zipper ATF-like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:25163] | 8576 | 0.000 | 0.7035 | No |
| 77 | LY6E | lymphocyte antigen 6 family member E [Source:HGNC Symbol;Acc:HGNC:6727] | 8934 | 0.000 | 0.6939 | No |
| 78 | RTP4 | receptor transporter protein 4 [Source:HGNC Symbol;Acc:HGNC:23992] | 10255 | 0.000 | 0.6582 | No |
| 79 | IFI30 | IFI30 lysosomal thiol reductase [Source:HGNC Symbol;Acc:HGNC:5398] | 11280 | 0.000 | 0.6305 | No |
| 80 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12283 | 0.000 | 0.6034 | No |
| 81 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 13710 | 0.000 | 0.5649 | No |
| 82 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 15514 | 0.000 | 0.5161 | No |
| 83 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 17698 | 0.000 | 0.4571 | No |
| 84 | TRIM5 | tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276] | 17785 | 0.000 | 0.4548 | No |
| 85 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18934 | 0.000 | 0.4238 | No |
| 86 | NMI | N-myc and STAT interactor [Source:HGNC Symbol;Acc:HGNC:7854] | 19356 | 0.000 | 0.4124 | No |
| 87 | LAMP3 | lysosomal associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:14582] | 21464 | 0.000 | 0.3554 | No |
| 88 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 30264 | -0.543 | 0.1199 | No |
| 89 | ELF1 | E74 like ETS transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3316] | 30313 | -0.559 | 0.1210 | No |
| 90 | SLC25A28 | solute carrier family 25 member 28 [Source:HGNC Symbol;Acc:HGNC:23472] | 31171 | -0.816 | 0.1013 | No |
| 91 | MVB12A | multivesicular body subunit 12A [Source:HGNC Symbol;Acc:HGNC:25153] | 31869 | -1.046 | 0.0870 | No |
| 92 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 32464 | -1.232 | 0.0762 | No |
| 93 | CD74 | CD74 molecule [Source:HGNC Symbol;Acc:HGNC:1697] | 32753 | -1.341 | 0.0742 | No |
| 94 | LPAR6 | lysophosphatidic acid receptor 6 [Source:HGNC Symbol;Acc:HGNC:15520] | 33373 | -1.606 | 0.0643 | No |
| 95 | CNP | 2',3'-cyclic nucleotide 3' phosphodiesterase [Source:HGNC Symbol;Acc:HGNC:2158] | 33637 | -1.740 | 0.0647 | No |
| 96 | TXNIP | thioredoxin interacting protein [Source:HGNC Symbol;Acc:HGNC:16952] | 35184 | -2.627 | 0.0341 | No |
| 97 | GMPR | guanosine monophosphate reductase [Source:HGNC Symbol;Acc:HGNC:4376] | 36647 | -4.052 | 0.0120 | No |
