Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_NA |
| GeneSet | HALLMARK_PANCREAS_BETA_CELLS |
| Enrichment Score (ES) | -0.65930873 |
| Normalized Enrichment Score (NES) | -1.2314279 |
| Nominal p-value | 0.15532735 |
| FDR q-value | 0.2169817 |
| FWER p-Value | 0.946 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | STXBP1 | syntaxin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11444] | 2665 | 1.037 | -0.0277 | No |
| 2 | AKT3 | AKT serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:393] | 3101 | 0.837 | -0.0036 | No |
| 3 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 3531 | 0.669 | 0.0134 | No |
| 4 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 3536 | 0.667 | 0.0417 | No |
| 5 | SRP9 | signal recognition particle 9 [Source:HGNC Symbol;Acc:HGNC:11304] | 4416 | 0.468 | 0.0380 | No |
| 6 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 4444 | 0.460 | 0.0569 | No |
| 7 | SRP14 | signal recognition particle 14 [Source:HGNC Symbol;Acc:HGNC:11299] | 5243 | 0.204 | 0.0441 | No |
| 8 | SCGN | secretagogin, EF-hand calcium binding protein [Source:HGNC Symbol;Acc:HGNC:16941] | 6166 | 0.000 | 0.0192 | No |
| 9 | CHGA | chromogranin A [Source:HGNC Symbol;Acc:HGNC:1929] | 10287 | 0.000 | -0.0920 | No |
| 10 | G6PC2 | glucose-6-phosphatase catalytic subunit 2 [Source:HGNC Symbol;Acc:HGNC:28906] | 12194 | 0.000 | -0.1435 | No |
| 11 | SST | somatostatin [Source:HGNC Symbol;Acc:HGNC:11329] | 12245 | 0.000 | -0.1448 | No |
| 12 | SYT13 | synaptotagmin 13 [Source:HGNC Symbol;Acc:HGNC:14962] | 13541 | 0.000 | -0.1798 | No |
| 13 | PAX4 | paired box 4 [Source:HGNC Symbol;Acc:HGNC:8618] | 14711 | 0.000 | -0.2113 | No |
| 14 | DCX | doublecortin [Source:HGNC Symbol;Acc:HGNC:2714] | 15943 | 0.000 | -0.2445 | No |
| 15 | PCSK2 | proprotein convertase subtilisin/kexin type 2 [Source:HGNC Symbol;Acc:HGNC:8744] | 16188 | 0.000 | -0.2511 | No |
| 16 | PCSK1 | proprotein convertase subtilisin/kexin type 1 [Source:HGNC Symbol;Acc:HGNC:8743] | 16189 | 0.000 | -0.2511 | No |
| 17 | GCG | glucagon [Source:HGNC Symbol;Acc:HGNC:4191] | 16883 | 0.000 | -0.2698 | No |
| 18 | GCK | glucokinase [Source:HGNC Symbol;Acc:HGNC:4195] | 16885 | 0.000 | -0.2699 | No |
| 19 | INS | insulin [Source:HGNC Symbol;Acc:HGNC:6081] | 17725 | 0.000 | -0.2925 | No |
| 20 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 17929 | 0.000 | -0.2980 | No |
| 21 | NKX2-2 | NK2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7835] | 19229 | 0.000 | -0.3330 | No |
| 22 | IAPP | islet amyloid polypeptide [Source:HGNC Symbol;Acc:HGNC:5329] | 19280 | 0.000 | -0.3344 | No |
| 23 | NEUROD1 | neuronal differentiation 1 [Source:HGNC Symbol;Acc:HGNC:7762] | 19286 | 0.000 | -0.3345 | No |
| 24 | NEUROG3 | neurogenin 3 [Source:HGNC Symbol;Acc:HGNC:13806] | 19405 | 0.000 | -0.3377 | No |
| 25 | FOXA2 | forkhead box A2 [Source:HGNC Symbol;Acc:HGNC:5022] | 20573 | 0.000 | -0.3692 | No |
| 26 | SLC2A2 | solute carrier family 2 member 2 [Source:HGNC Symbol;Acc:HGNC:11006] | 24629 | 0.000 | -0.4787 | No |
| 27 | NKX6-1 | NK6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7839] | 25310 | 0.000 | -0.4970 | No |
| 28 | PDX1 | pancreatic and duodenal homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6107] | 26066 | 0.000 | -0.5174 | No |
| 29 | INSM1 | INSM transcriptional repressor 1 [Source:HGNC Symbol;Acc:HGNC:6090] | 26724 | 0.000 | -0.5351 | No |
| 30 | ISL1 | ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132] | 26943 | 0.000 | -0.5410 | No |
| 31 | ABCC8 | ATP binding cassette subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:59] | 28088 | 0.000 | -0.5719 | No |
| 32 | PAK3 | p21 (RAC1) activated kinase 3 [Source:HGNC Symbol;Acc:HGNC:8592] | 28501 | -0.105 | -0.5785 | No |
| 33 | HNF1A | HNF1 homeobox A [Source:HGNC Symbol;Acc:HGNC:11621] | 31495 | -0.915 | -0.6202 | Yes |
| 34 | ELP4 | elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:1171] | 32624 | -1.281 | -0.5960 | Yes |
| 35 | VDR | vitamin D receptor [Source:HGNC Symbol;Acc:HGNC:12679] | 33102 | -1.492 | -0.5452 | Yes |
| 36 | PKLR | pyruvate kinase L/R [Source:HGNC Symbol;Acc:HGNC:9020] | 33701 | -1.753 | -0.4865 | Yes |
| 37 | LMO2 | LIM domain only 2 [Source:HGNC Symbol;Acc:HGNC:6642] | 34146 | -1.993 | -0.4133 | Yes |
| 38 | FOXO1 | forkhead box O1 [Source:HGNC Symbol;Acc:HGNC:3819] | 35661 | -3.028 | -0.3249 | Yes |
| 39 | MAFB | MAF bZIP transcription factor B [Source:HGNC Symbol;Acc:HGNC:6408] | 36630 | -4.036 | -0.1787 | Yes |
| 40 | PAX6 | paired box 6 [Source:HGNC Symbol;Acc:HGNC:8620] | 36909 | -4.476 | 0.0049 | Yes |
