Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HALLMARK_PI3K_AKT_MTOR_SIGNALING |
| Enrichment Score (ES) | 0.3468838 |
| Normalized Enrichment Score (NES) | 0.8878403 |
| Nominal p-value | 0.92 |
| FDR q-value | 0.940113 |
| FWER p-Value | 0.985 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 249 | 3.962 | 0.0247 | Yes |
| 2 | NOD1 | nucleotide binding oligomerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16390] | 357 | 3.581 | 0.0501 | Yes |
| 3 | MAPK10 | mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872] | 502 | 3.217 | 0.0717 | Yes |
| 4 | SQSTM1 | sequestosome 1 [Source:HGNC Symbol;Acc:HGNC:11280] | 508 | 3.206 | 0.0970 | Yes |
| 5 | NFKBIB | NFKB inhibitor beta [Source:HGNC Symbol;Acc:HGNC:7798] | 609 | 2.969 | 0.1178 | Yes |
| 6 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 662 | 2.848 | 0.1390 | Yes |
| 7 | MAP2K3 | mitogen-activated protein kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6843] | 836 | 2.593 | 0.1549 | Yes |
| 8 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 1073 | 2.200 | 0.1659 | Yes |
| 9 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 1423 | 1.881 | 0.1714 | Yes |
| 10 | DDIT3 | DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] | 1513 | 1.792 | 0.1832 | Yes |
| 11 | CDKN1A | cyclin dependent kinase inhibitor 1A [Source:HGNC Symbol;Acc:HGNC:1784] | 1552 | 1.761 | 0.1961 | Yes |
| 12 | ADCY2 | adenylate cyclase 2 [Source:HGNC Symbol;Acc:HGNC:233] | 1671 | 1.672 | 0.2062 | Yes |
| 13 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 1694 | 1.650 | 0.2186 | Yes |
| 14 | UBE2D3 | ubiquitin conjugating enzyme E2 D3 [Source:HGNC Symbol;Acc:HGNC:12476] | 1782 | 1.559 | 0.2286 | Yes |
| 15 | ACTR2 | actin related protein 2 [Source:HGNC Symbol;Acc:HGNC:169] | 1814 | 1.532 | 0.2399 | Yes |
| 16 | TRIB3 | tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] | 1899 | 1.465 | 0.2493 | Yes |
| 17 | CFL1 | cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874] | 2074 | 1.377 | 0.2555 | Yes |
| 18 | ACTR3 | actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170] | 2082 | 1.372 | 0.2662 | Yes |
| 19 | TBK1 | TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] | 2249 | 1.276 | 0.2718 | Yes |
| 20 | PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [Source:HGNC Symbol;Acc:HGNC:8988] | 2272 | 1.261 | 0.2812 | Yes |
| 21 | TIAM1 | TIAM Rac1 associated GEF 1 [Source:HGNC Symbol;Acc:HGNC:11805] | 2282 | 1.258 | 0.2909 | Yes |
| 22 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 2337 | 1.225 | 0.2992 | Yes |
| 23 | FGF17 | fibroblast growth factor 17 [Source:HGNC Symbol;Acc:HGNC:3673] | 2375 | 1.205 | 0.3077 | Yes |
| 24 | SLC2A1 | solute carrier family 2 member 1 [Source:HGNC Symbol;Acc:HGNC:11005] | 2678 | 1.030 | 0.3077 | Yes |
| 25 | UBE2N | ubiquitin conjugating enzyme E2 N [Source:HGNC Symbol;Acc:HGNC:12492] | 2807 | 0.974 | 0.3120 | Yes |
| 26 | AKT1S1 | AKT1 substrate 1 [Source:HGNC Symbol;Acc:HGNC:28426] | 2891 | 0.930 | 0.3171 | Yes |
| 27 | RIPK1 | receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019] | 2930 | 0.916 | 0.3233 | Yes |
| 28 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 2979 | 0.894 | 0.3291 | Yes |
| 29 | ARPC3 | actin related protein 2/3 complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:706] | 3143 | 0.820 | 0.3312 | Yes |
| 30 | TRAF2 | TNF receptor associated factor 2 [Source:HGNC Symbol;Acc:HGNC:12032] | 3326 | 0.751 | 0.3322 | Yes |
| 31 | PFN1 | profilin 1 [Source:HGNC Symbol;Acc:HGNC:8881] | 3382 | 0.726 | 0.3365 | Yes |
| 32 | PAK4 | p21 (RAC1) activated kinase 4 [Source:HGNC Symbol;Acc:HGNC:16059] | 3509 | 0.680 | 0.3385 | Yes |
| 33 | CAB39 | calcium binding protein 39 [Source:HGNC Symbol;Acc:HGNC:20292] | 3556 | 0.661 | 0.3425 | Yes |
| 34 | AP2M1 | adaptor related protein complex 2 subunit mu 1 [Source:HGNC Symbol;Acc:HGNC:564] | 3673 | 0.609 | 0.3442 | Yes |
| 35 | ARF1 | ADP ribosylation factor 1 [Source:HGNC Symbol;Acc:HGNC:652] | 3896 | 0.522 | 0.3423 | Yes |
| 36 | RIT1 | Ras like without CAAX 1 [Source:HGNC Symbol;Acc:HGNC:10023] | 3921 | 0.515 | 0.3457 | Yes |
| 37 | NCK1 | NCK adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:7664] | 4020 | 0.480 | 0.3469 | Yes |
| 38 | CAB39L | calcium binding protein 39 like [Source:HGNC Symbol;Acc:HGNC:20290] | 4530 | 0.430 | 0.3365 | No |
| 39 | CLTC | clathrin heavy chain [Source:HGNC Symbol;Acc:HGNC:2092] | 4543 | 0.426 | 0.3396 | No |
| 40 | PRKCB | protein kinase C beta [Source:HGNC Symbol;Acc:HGNC:9395] | 4785 | 0.352 | 0.3359 | No |
| 41 | PPP2R1B | protein phosphatase 2 scaffold subunit Abeta [Source:HGNC Symbol;Acc:HGNC:9303] | 4965 | 0.294 | 0.3333 | No |
| 42 | YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Source:HGNC Symbol;Acc:HGNC:12849] | 5001 | 0.278 | 0.3346 | No |
| 43 | PIKFYVE | phosphoinositide kinase, FYVE-type zinc finger containing [Source:HGNC Symbol;Acc:HGNC:23785] | 5005 | 0.277 | 0.3367 | No |
| 44 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 5083 | 0.249 | 0.3366 | No |
| 45 | PPP1CA | protein phosphatase 1 catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:9281] | 5395 | 0.160 | 0.3295 | No |
| 46 | CSNK2B | casein kinase 2 beta [Source:HGNC Symbol;Acc:HGNC:2460] | 5522 | 0.130 | 0.3271 | No |
| 47 | GSK3B | glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617] | 5685 | 0.085 | 0.3234 | No |
| 48 | ATF1 | activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783] | 5731 | 0.071 | 0.3227 | No |
| 49 | SMAD2 | SMAD family member 2 [Source:HGNC Symbol;Acc:HGNC:6768] | 5758 | 0.062 | 0.3225 | No |
| 50 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 5899 | 0.019 | 0.3189 | No |
| 51 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 5915 | 0.013 | 0.3186 | No |
| 52 | PRKAA2 | protein kinase AMP-activated catalytic subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:9377] | 6442 | 0.000 | 0.3043 | No |
| 53 | FGF22 | fibroblast growth factor 22 [Source:HGNC Symbol;Acc:HGNC:3679] | 6561 | 0.000 | 0.3012 | No |
| 54 | PITX2 | paired like homeodomain 2 [Source:HGNC Symbol;Acc:HGNC:9005] | 7022 | 0.000 | 0.2887 | No |
| 55 | CAMK4 | calcium/calmodulin dependent protein kinase IV [Source:HGNC Symbol;Acc:HGNC:1464] | 8785 | 0.000 | 0.2411 | No |
| 56 | GNGT1 | G protein subunit gamma transducin 1 [Source:HGNC Symbol;Acc:HGNC:4411] | 16197 | 0.000 | 0.0407 | No |
| 57 | IL4 | interleukin 4 [Source:HGNC Symbol;Acc:HGNC:6014] | 17695 | 0.000 | 0.0002 | No |
| 58 | NGF | nerve growth factor [Source:HGNC Symbol;Acc:HGNC:7808] | 19309 | 0.000 | -0.0434 | No |
| 59 | FGF6 | fibroblast growth factor 6 [Source:HGNC Symbol;Acc:HGNC:3684] | 22450 | 0.000 | -0.1283 | No |
| 60 | PLCB1 | phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917] | 23147 | 0.000 | -0.1471 | No |
| 61 | GNA14 | G protein subunit alpha 14 [Source:HGNC Symbol;Acc:HGNC:4382] | 23928 | 0.000 | -0.1682 | No |
| 62 | FASLG | Fas ligand [Source:HGNC Symbol;Acc:HGNC:11936] | 24967 | 0.000 | -0.1962 | No |
| 63 | EGFR | epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] | 26997 | 0.000 | -0.2511 | No |
| 64 | THEM4 | thioesterase superfamily member 4 [Source:HGNC Symbol;Acc:HGNC:17947] | 27761 | 0.000 | -0.2717 | No |
| 65 | RALB | RAS like proto-oncogene B [Source:HGNC Symbol;Acc:HGNC:9840] | 28204 | -0.023 | -0.2835 | No |
| 66 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859] | 28345 | -0.065 | -0.2868 | No |
| 67 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 28771 | -0.176 | -0.2969 | No |
| 68 | PTEN | phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588] | 28780 | -0.179 | -0.2957 | No |
| 69 | ARHGDIA | Rho GDP dissociation inhibitor alpha [Source:HGNC Symbol;Acc:HGNC:678] | 29084 | -0.249 | -0.3019 | No |
| 70 | TSC2 | TSC complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:12363] | 29345 | -0.325 | -0.3063 | No |
| 71 | MAPKAP1 | MAPK associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18752] | 29713 | -0.419 | -0.3129 | No |
| 72 | RPS6KA3 | ribosomal protein S6 kinase A3 [Source:HGNC Symbol;Acc:HGNC:10432] | 30042 | -0.511 | -0.3178 | No |
| 73 | PRKAG1 | protein kinase AMP-activated non-catalytic subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:9385] | 30259 | -0.541 | -0.3193 | No |
| 74 | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:9829] | 30295 | -0.552 | -0.3159 | No |
| 75 | MAPK8 | mitogen-activated protein kinase 8 [Source:HGNC Symbol;Acc:HGNC:6881] | 30472 | -0.612 | -0.3158 | No |
| 76 | MAPK1 | mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] | 30490 | -0.620 | -0.3113 | No |
| 77 | AKT1 | AKT serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:391] | 30942 | -0.750 | -0.3176 | No |
| 78 | RPTOR | regulatory associated protein of MTOR complex 1 [Source:HGNC Symbol;Acc:HGNC:30287] | 31007 | -0.773 | -0.3132 | No |
| 79 | IRAK4 | interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] | 31060 | -0.793 | -0.3083 | No |
| 80 | MAPK9 | mitogen-activated protein kinase 9 [Source:HGNC Symbol;Acc:HGNC:6886] | 31157 | -0.810 | -0.3045 | No |
| 81 | HRAS | HRas proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:5173] | 31742 | -1.005 | -0.3123 | No |
| 82 | DAPP1 | dual adaptor of phosphotyrosine and 3-phosphoinositides 1 [Source:HGNC Symbol;Acc:HGNC:16500] | 32059 | -1.117 | -0.3120 | No |
| 83 | MKNK1 | MAPK interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:7110] | 32068 | -1.121 | -0.3034 | No |
| 84 | DUSP3 | dual specificity phosphatase 3 [Source:HGNC Symbol;Acc:HGNC:3069] | 32185 | -1.170 | -0.2972 | No |
| 85 | MKNK2 | MAPK interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:7111] | 33000 | -1.452 | -0.3077 | No |
| 86 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 33303 | -1.578 | -0.3034 | No |
| 87 | ACACA | acetyl-CoA carboxylase alpha [Source:HGNC Symbol;Acc:HGNC:84] | 33356 | -1.596 | -0.2922 | No |
| 88 | PIK3R3 | phosphoinositide-3-kinase regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:8981] | 33377 | -1.607 | -0.2800 | No |
| 89 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha [Source:HGNC Symbol;Acc:HGNC:9391] | 33433 | -1.634 | -0.2685 | No |
| 90 | RPS6KA1 | ribosomal protein S6 kinase A1 [Source:HGNC Symbol;Acc:HGNC:10430] | 33858 | -1.842 | -0.2654 | No |
| 91 | GRK2 | G protein-coupled receptor kinase 2 [Source:HGNC Symbol;Acc:HGNC:289] | 33866 | -1.847 | -0.2509 | No |
| 92 | CDK4 | cyclin dependent kinase 4 [Source:HGNC Symbol;Acc:HGNC:1773] | 33965 | -1.893 | -0.2386 | No |
| 93 | CDKN1B | cyclin dependent kinase inhibitor 1B [Source:HGNC Symbol;Acc:HGNC:1785] | 34467 | -2.131 | -0.2352 | No |
| 94 | SFN | stratifin [Source:HGNC Symbol;Acc:HGNC:10773] | 34608 | -2.237 | -0.2213 | No |
| 95 | CXCR4 | C-X-C motif chemokine receptor 4 [Source:HGNC Symbol;Acc:HGNC:2561] | 34720 | -2.299 | -0.2061 | No |
| 96 | CDK2 | cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] | 34953 | -2.448 | -0.1930 | No |
| 97 | ITPR2 | inositol 1,4,5-trisphosphate receptor type 2 [Source:HGNC Symbol;Acc:HGNC:6181] | 35115 | -2.570 | -0.1770 | No |
| 98 | ECSIT | ECSIT signaling integrator [Source:HGNC Symbol;Acc:HGNC:29548] | 35176 | -2.622 | -0.1578 | No |
| 99 | E2F1 | E2F transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:3113] | 35793 | -3.134 | -0.1496 | No |
| 100 | VAV3 | vav guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:12659] | 35825 | -3.168 | -0.1254 | No |
| 101 | PLCG1 | phospholipase C gamma 1 [Source:HGNC Symbol;Acc:HGNC:9065] | 35925 | -3.289 | -0.1020 | No |
| 102 | SLA | Src like adaptor [Source:HGNC Symbol;Acc:HGNC:10902] | 36235 | -3.546 | -0.0822 | No |
| 103 | PLA2G12A | phospholipase A2 group XIIA [Source:HGNC Symbol;Acc:HGNC:18554] | 36829 | -4.331 | -0.0640 | No |
| 104 | MAP2K6 | mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846] | 36863 | -4.397 | -0.0300 | No |
| 105 | PDK1 | pyruvate dehydrogenase kinase 1 [Source:HGNC Symbol;Acc:HGNC:8809] | 36943 | -4.558 | 0.0040 | No |
