Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #KO_LPS_versus_KO_NA.Nof1.cls #KO_LPS_versus_KO_NA_repos |
| Phenotype | Nof1.cls#KO_LPS_versus_KO_NA_repos |
| Upregulated in class | KO_LPS |
| GeneSet | HALLMARK_UNFOLDED_PROTEIN_RESPONSE |
| Enrichment Score (ES) | 0.47189656 |
| Normalized Enrichment Score (NES) | 1.2018144 |
| Nominal p-value | 0.082474224 |
| FDR q-value | 0.125927 |
| FWER p-Value | 0.31 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 49 | 4.852 | 0.0451 | Yes |
| 2 | NABP1 | nucleic acid binding protein 1 [Source:HGNC Symbol;Acc:HGNC:26232] | 446 | 3.300 | 0.0660 | Yes |
| 3 | HSPA5 | heat shock protein family A (Hsp70) member 5 [Source:HGNC Symbol;Acc:HGNC:5238] | 856 | 2.551 | 0.0793 | Yes |
| 4 | DCP2 | decapping mRNA 2 [Source:HGNC Symbol;Acc:HGNC:24452] | 861 | 2.535 | 0.1035 | Yes |
| 5 | SRPRA | SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307] | 945 | 2.413 | 0.1243 | Yes |
| 6 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 947 | 2.411 | 0.1473 | Yes |
| 7 | CEBPB | CCAAT enhancer binding protein beta [Source:HGNC Symbol;Acc:HGNC:1834] | 1087 | 2.179 | 0.1644 | Yes |
| 8 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 [Source:HGNC Symbol;Acc:HGNC:6968] | 1091 | 2.177 | 0.1852 | Yes |
| 9 | SDAD1 | SDA1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25537] | 1331 | 1.995 | 0.1978 | Yes |
| 10 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680] | 1405 | 1.910 | 0.2141 | Yes |
| 11 | ASNS | asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] | 1535 | 1.785 | 0.2277 | Yes |
| 12 | HERPUD1 | homocysteine inducible ER protein with ubiquitin like domain 1 [Source:HGNC Symbol;Acc:HGNC:13744] | 1786 | 1.556 | 0.2358 | Yes |
| 13 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein [Source:HGNC Symbol;Acc:HGNC:16829] | 1808 | 1.539 | 0.2500 | Yes |
| 14 | WFS1 | wolframin ER transmembrane glycoprotein [Source:HGNC Symbol;Acc:HGNC:12762] | 1854 | 1.505 | 0.2632 | Yes |
| 15 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [Source:HGNC Symbol;Acc:HGNC:12855] | 1872 | 1.491 | 0.2770 | Yes |
| 16 | ATF4 | activating transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:786] | 2007 | 1.425 | 0.2870 | Yes |
| 17 | SLC1A4 | solute carrier family 1 member 4 [Source:HGNC Symbol;Acc:HGNC:10942] | 2033 | 1.408 | 0.2998 | Yes |
| 18 | CCL2 | C-C motif chemokine ligand 2 [Source:HGNC Symbol;Acc:HGNC:10618] | 2180 | 1.310 | 0.3084 | Yes |
| 19 | LSM1 | LSM1 homolog, mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:20472] | 2345 | 1.221 | 0.3156 | Yes |
| 20 | DCP1A | decapping mRNA 1A [Source:HGNC Symbol;Acc:HGNC:18714] | 2421 | 1.178 | 0.3248 | Yes |
| 21 | PDIA5 | protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] | 2476 | 1.158 | 0.3345 | Yes |
| 22 | FUS | FUS RNA binding protein [Source:HGNC Symbol;Acc:HGNC:4010] | 2526 | 1.125 | 0.3439 | Yes |
| 23 | KIF5B | kinesin family member 5B [Source:HGNC Symbol;Acc:HGNC:6324] | 2544 | 1.113 | 0.3541 | Yes |
| 24 | EIF2S1 | eukaryotic translation initiation factor 2 subunit alpha [Source:HGNC Symbol;Acc:HGNC:3265] | 2582 | 1.086 | 0.3635 | Yes |
| 25 | CNOT4 | CCR4-NOT transcription complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:7880] | 2619 | 1.064 | 0.3727 | Yes |
| 26 | SERP1 | stress associated endoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:10759] | 2679 | 1.030 | 0.3809 | Yes |
| 27 | SLC7A5 | solute carrier family 7 member 5 [Source:HGNC Symbol;Acc:HGNC:11063] | 2791 | 0.986 | 0.3874 | Yes |
| 28 | TARS1 | threonyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:11572] | 2868 | 0.941 | 0.3943 | Yes |
| 29 | CALR | calreticulin [Source:HGNC Symbol;Acc:HGNC:1455] | 2979 | 0.894 | 0.3999 | Yes |
| 30 | HYOU1 | hypoxia up-regulated 1 [Source:HGNC Symbol;Acc:HGNC:16931] | 3062 | 0.852 | 0.4058 | Yes |
| 31 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434] | 3377 | 0.727 | 0.4043 | Yes |
| 32 | NOP14 | NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] | 3489 | 0.686 | 0.4078 | Yes |
| 33 | DDIT4 | DNA damage inducible transcript 4 [Source:HGNC Symbol;Acc:HGNC:24944] | 3502 | 0.682 | 0.4141 | Yes |
| 34 | SRPRB | SRP receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:24085] | 3531 | 0.669 | 0.4197 | Yes |
| 35 | SEC11A | SEC11 homolog A, signal peptidase complex subunit [Source:HGNC Symbol;Acc:HGNC:17718] | 3536 | 0.667 | 0.4260 | Yes |
| 36 | IARS1 | isoleucyl-tRNA synthetase 1 [Source:HGNC Symbol;Acc:HGNC:5330] | 3567 | 0.655 | 0.4314 | Yes |
| 37 | ZBTB17 | zinc finger and BTB domain containing 17 [Source:HGNC Symbol;Acc:HGNC:12936] | 3601 | 0.640 | 0.4367 | Yes |
| 38 | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] | 3612 | 0.635 | 0.4425 | Yes |
| 39 | TTC37 | tetratricopeptide repeat domain 37 [Source:HGNC Symbol;Acc:HGNC:23639] | 3700 | 0.597 | 0.4458 | Yes |
| 40 | BAG3 | BAG cochaperone 3 [Source:HGNC Symbol;Acc:HGNC:939] | 3760 | 0.578 | 0.4498 | Yes |
| 41 | BANF1 | BAF nuclear assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:17397] | 3861 | 0.540 | 0.4522 | Yes |
| 42 | TATDN2 | TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988] | 3990 | 0.492 | 0.4535 | Yes |
| 43 | LSM4 | LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:17259] | 4434 | 0.463 | 0.4459 | Yes |
| 44 | SPCS1 | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] | 4444 | 0.460 | 0.4501 | Yes |
| 45 | EDC4 | enhancer of mRNA decapping 4 [Source:HGNC Symbol;Acc:HGNC:17157] | 4486 | 0.448 | 0.4532 | Yes |
| 46 | EXOSC4 | exosome component 4 [Source:HGNC Symbol;Acc:HGNC:18189] | 4604 | 0.405 | 0.4540 | Yes |
| 47 | HSPA9 | heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244] | 4650 | 0.391 | 0.4565 | Yes |
| 48 | EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3288] | 4759 | 0.359 | 0.4570 | Yes |
| 49 | ARFGAP1 | ADP ribosylation factor GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:15852] | 4891 | 0.319 | 0.4565 | Yes |
| 50 | CNOT6 | CCR4-NOT transcription complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:14099] | 4915 | 0.312 | 0.4589 | Yes |
| 51 | EIF4A1 | eukaryotic translation initiation factor 4A1 [Source:HGNC Symbol;Acc:HGNC:3282] | 4917 | 0.311 | 0.4618 | Yes |
| 52 | CNOT2 | CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] | 4927 | 0.308 | 0.4645 | Yes |
| 53 | TSPYL2 | TSPY like 2 [Source:HGNC Symbol;Acc:HGNC:24358] | 4934 | 0.307 | 0.4673 | Yes |
| 54 | SSR1 | signal sequence receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:11323] | 4948 | 0.300 | 0.4698 | Yes |
| 55 | PDIA6 | protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168] | 5037 | 0.264 | 0.4700 | Yes |
| 56 | NPM1 | nucleophosmin 1 [Source:HGNC Symbol;Acc:HGNC:7910] | 5180 | 0.220 | 0.4682 | Yes |
| 57 | VEGFA | vascular endothelial growth factor A [Source:HGNC Symbol;Acc:HGNC:12680] | 5184 | 0.218 | 0.4702 | Yes |
| 58 | EXOSC1 | exosome component 1 [Source:HGNC Symbol;Acc:HGNC:17286] | 5234 | 0.206 | 0.4709 | Yes |
| 59 | XBP1 | X-box binding protein 1 [Source:HGNC Symbol;Acc:HGNC:12801] | 5414 | 0.154 | 0.4675 | Yes |
| 60 | CEBPG | CCAAT enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] | 5425 | 0.151 | 0.4687 | Yes |
| 61 | XPOT | exportin for tRNA [Source:HGNC Symbol;Acc:HGNC:12826] | 5446 | 0.143 | 0.4695 | Yes |
| 62 | CXXC1 | CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] | 5477 | 0.139 | 0.4700 | Yes |
| 63 | EIF4A2 | eukaryotic translation initiation factor 4A2 [Source:HGNC Symbol;Acc:HGNC:3284] | 5482 | 0.136 | 0.4712 | Yes |
| 64 | YIF1A | Yip1 interacting factor homolog A, membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:16688] | 5525 | 0.129 | 0.4713 | Yes |
| 65 | NFYA | nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] | 5548 | 0.123 | 0.4719 | Yes |
| 66 | PAIP1 | poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] | 5601 | 0.110 | 0.4715 | No |
| 67 | DKC1 | dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890] | 5753 | 0.064 | 0.4681 | No |
| 68 | EIF4G1 | eukaryotic translation initiation factor 4 gamma 1 [Source:HGNC Symbol;Acc:HGNC:3296] | 5852 | 0.027 | 0.4657 | No |
| 69 | SPCS3 | signal peptidase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26212] | 5859 | 0.025 | 0.4658 | No |
| 70 | EIF4E | eukaryotic translation initiation factor 4E [Source:HGNC Symbol;Acc:HGNC:3287] | 5899 | 0.019 | 0.4649 | No |
| 71 | HSP90B1 | heat shock protein 90 beta family member 1 [Source:HGNC Symbol;Acc:HGNC:12028] | 5915 | 0.013 | 0.4646 | No |
| 72 | IGFBP1 | insulin like growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5469] | 11558 | 0.000 | 0.3120 | No |
| 73 | DNAJA4 | DnaJ heat shock protein family (Hsp40) member A4 [Source:HGNC Symbol;Acc:HGNC:14885] | 18527 | 0.000 | 0.1236 | No |
| 74 | MTREX | Mtr4 exosome RNA helicase [Source:HGNC Symbol;Acc:HGNC:18734] | 28171 | -0.016 | -0.1370 | No |
| 75 | SEC31A | SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] | 28323 | -0.060 | -0.1405 | No |
| 76 | NOP56 | NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] | 28367 | -0.072 | -0.1410 | No |
| 77 | GOSR2 | golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] | 28456 | -0.091 | -0.1425 | No |
| 78 | NOLC1 | nucleolar and coiled-body phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:15608] | 28561 | -0.122 | -0.1442 | No |
| 79 | EXOSC10 | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] | 28888 | -0.203 | -0.1510 | No |
| 80 | EXOC2 | exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] | 28963 | -0.226 | -0.1509 | No |
| 81 | DDX10 | DEAD-box helicase 10 [Source:HGNC Symbol;Acc:HGNC:2735] | 29110 | -0.256 | -0.1524 | No |
| 82 | SHC1 | SHC adaptor protein 1 [Source:HGNC Symbol;Acc:HGNC:10840] | 29199 | -0.283 | -0.1520 | No |
| 83 | RPS14 | ribosomal protein S14 [Source:HGNC Symbol;Acc:HGNC:10387] | 29265 | -0.302 | -0.1509 | No |
| 84 | EXOSC9 | exosome component 9 [Source:HGNC Symbol;Acc:HGNC:9137] | 29468 | -0.358 | -0.1529 | No |
| 85 | DCTN1 | dynactin subunit 1 [Source:HGNC Symbol;Acc:HGNC:2711] | 29664 | -0.406 | -0.1543 | No |
| 86 | ATF6 | activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] | 29863 | -0.461 | -0.1553 | No |
| 87 | EXOSC2 | exosome component 2 [Source:HGNC Symbol;Acc:HGNC:17097] | 29990 | -0.498 | -0.1539 | No |
| 88 | POP4 | POP4 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:30081] | 30090 | -0.523 | -0.1516 | No |
| 89 | PREB | prolactin regulatory element binding [Source:HGNC Symbol;Acc:HGNC:9356] | 30314 | -0.559 | -0.1523 | No |
| 90 | FKBP14 | FKBP prolyl isomerase 14 [Source:HGNC Symbol;Acc:HGNC:18625] | 30332 | -0.564 | -0.1473 | No |
| 91 | EIF4A3 | eukaryotic translation initiation factor 4A3 [Source:HGNC Symbol;Acc:HGNC:18683] | 30354 | -0.571 | -0.1425 | No |
| 92 | EEF2 | eukaryotic translation elongation factor 2 [Source:HGNC Symbol;Acc:HGNC:3214] | 30469 | -0.611 | -0.1397 | No |
| 93 | PSAT1 | phosphoserine aminotransferase 1 [Source:HGNC Symbol;Acc:HGNC:19129] | 30579 | -0.644 | -0.1365 | No |
| 94 | NHP2 | NHP2 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:14377] | 30671 | -0.676 | -0.1325 | No |
| 95 | ATP6V0D1 | ATPase H+ transporting V0 subunit d1 [Source:HGNC Symbol;Acc:HGNC:13724] | 30853 | -0.730 | -0.1304 | No |
| 96 | ALDH18A1 | aldehyde dehydrogenase 18 family member A1 [Source:HGNC Symbol;Acc:HGNC:9722] | 30951 | -0.751 | -0.1258 | No |
| 97 | KDELR3 | KDEL endoplasmic reticulum protein retention receptor 3 [Source:HGNC Symbol;Acc:HGNC:6306] | 31256 | -0.846 | -0.1259 | No |
| 98 | EIF2AK3 | eukaryotic translation initiation factor 2 alpha kinase 3 [Source:HGNC Symbol;Acc:HGNC:3255] | 31375 | -0.883 | -0.1207 | No |
| 99 | PARN | poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] | 31427 | -0.903 | -0.1134 | No |
| 100 | GEMIN4 | gem nuclear organelle associated protein 4 [Source:HGNC Symbol;Acc:HGNC:15717] | 31990 | -1.090 | -0.1182 | No |
| 101 | NFYB | nuclear transcription factor Y subunit beta [Source:HGNC Symbol;Acc:HGNC:7805] | 32245 | -1.197 | -0.1136 | No |
| 102 | KHSRP | KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] | 32599 | -1.267 | -0.1111 | No |
| 103 | IMP3 | IMP U3 small nucleolar ribonucleoprotein 3 [Source:HGNC Symbol;Acc:HGNC:14497] | 32611 | -1.273 | -0.0992 | No |
| 104 | ERN1 | endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] | 32878 | -1.389 | -0.0931 | No |
| 105 | SLC30A5 | solute carrier family 30 member 5 [Source:HGNC Symbol;Acc:HGNC:19089] | 32967 | -1.434 | -0.0817 | No |
| 106 | STC2 | stanniocalcin 2 [Source:HGNC Symbol;Acc:HGNC:11374] | 33516 | -1.673 | -0.0806 | No |
| 107 | TUBB2A | tubulin beta 2A class IIa [Source:HGNC Symbol;Acc:HGNC:12412] | 33883 | -1.858 | -0.0727 | No |
| 108 | EDEM1 | ER degradation enhancing alpha-mannosidase like protein 1 [Source:HGNC Symbol;Acc:HGNC:18967] | 33901 | -1.868 | -0.0553 | No |
| 109 | ERO1A | endoplasmic reticulum oxidoreductase 1 alpha [Source:HGNC Symbol;Acc:HGNC:13280] | 34001 | -1.913 | -0.0397 | No |
| 110 | EXOSC5 | exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] | 34481 | -2.140 | -0.0321 | No |
| 111 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 34580 | -2.221 | -0.0135 | No |
| 112 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 36591 | -3.999 | -0.0296 | No |
| 113 | WIPI1 | WD repeat domain, phosphoinositide interacting 1 [Source:HGNC Symbol;Acc:HGNC:25471] | 36928 | -4.504 | 0.0044 | No |
