Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS |
| Enrichment Score (ES) | -0.85077703 |
| Normalized Enrichment Score (NES) | -1.6532784 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0246089 |
| FWER p-Value | 0.228 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | TAAR8 | trace amine associated receptor 8 [Source:HGNC Symbol;Acc:HGNC:14964] | 12644 | 0.000 | -0.3413 | No |
| 2 | TAAR6 | trace amine associated receptor 6 [Source:HGNC Symbol;Acc:HGNC:20978] | 12645 | 0.000 | -0.3413 | No |
| 3 | TAAR5 | trace amine associated receptor 5 [Source:HGNC Symbol;Acc:HGNC:30236] | 12647 | 0.000 | -0.3413 | No |
| 4 | TAAR2 | trace amine associated receptor 2 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:4514] | 12649 | 0.000 | -0.3413 | No |
| 5 | TAAR1 | trace amine associated receptor 1 [Source:HGNC Symbol;Acc:HGNC:17734] | 12652 | 0.000 | -0.3414 | No |
| 6 | HTR4 | 5-hydroxytryptamine receptor 4 [Source:HGNC Symbol;Acc:HGNC:5299] | 15515 | 0.000 | -0.4186 | No |
| 7 | HTR6 | 5-hydroxytryptamine receptor 6 [Source:HGNC Symbol;Acc:HGNC:5301] | 15517 | 0.000 | -0.4187 | No |
| 8 | HTR7 | 5-hydroxytryptamine receptor 7 [Source:HGNC Symbol;Acc:HGNC:5302] | 15518 | 0.000 | -0.4187 | No |
| 9 | HTR1E | 5-hydroxytryptamine receptor 1E [Source:HGNC Symbol;Acc:HGNC:5291] | 15582 | 0.000 | -0.4204 | No |
| 10 | HTR1F | 5-hydroxytryptamine receptor 1F [Source:HGNC Symbol;Acc:HGNC:5292] | 15584 | 0.000 | -0.4204 | No |
| 11 | HTR1D | 5-hydroxytryptamine receptor 1D [Source:HGNC Symbol;Acc:HGNC:5289] | 15585 | 0.000 | -0.4204 | No |
| 12 | HTR1A | 5-hydroxytryptamine receptor 1A [Source:HGNC Symbol;Acc:HGNC:5286] | 15586 | 0.000 | -0.4204 | No |
| 13 | HTR2B | 5-hydroxytryptamine receptor 2B [Source:HGNC Symbol;Acc:HGNC:5294] | 15593 | 0.000 | -0.4206 | No |
| 14 | HTR2C | 5-hydroxytryptamine receptor 2C [Source:HGNC Symbol;Acc:HGNC:5295] | 15594 | 0.000 | -0.4206 | No |
| 15 | HTR2A | 5-hydroxytryptamine receptor 2A [Source:HGNC Symbol;Acc:HGNC:5293] | 15595 | 0.000 | -0.4206 | No |
| 16 | HTR5A | 5-hydroxytryptamine receptor 5A [Source:HGNC Symbol;Acc:HGNC:5300] | 15614 | 0.000 | -0.4210 | No |
| 17 | GPR143 | G protein-coupled receptor 143 [Source:HGNC Symbol;Acc:HGNC:20145] | 16468 | 0.000 | -0.4441 | No |
| 18 | ADRA1D | adrenoceptor alpha 1D [Source:HGNC Symbol;Acc:HGNC:280] | 16522 | 0.000 | -0.4455 | No |
| 19 | ADRA1B | adrenoceptor alpha 1B [Source:HGNC Symbol;Acc:HGNC:278] | 16523 | 0.000 | -0.4455 | No |
| 20 | ADRA1A | adrenoceptor alpha 1A [Source:HGNC Symbol;Acc:HGNC:277] | 16525 | 0.000 | -0.4455 | No |
| 21 | ADRA2C | adrenoceptor alpha 2C [Source:HGNC Symbol;Acc:HGNC:283] | 16531 | 0.000 | -0.4457 | No |
| 22 | ADRA2B | adrenoceptor alpha 2B [Source:HGNC Symbol;Acc:HGNC:282] | 16532 | 0.000 | -0.4457 | No |
| 23 | ADRA2A | adrenoceptor alpha 2A [Source:HGNC Symbol;Acc:HGNC:281] | 16533 | 0.000 | -0.4457 | No |
| 24 | CHRM2 | cholinergic receptor muscarinic 2 [Source:HGNC Symbol;Acc:HGNC:1951] | 17866 | 0.000 | -0.4816 | No |
| 25 | CHRM1 | cholinergic receptor muscarinic 1 [Source:HGNC Symbol;Acc:HGNC:1950] | 17868 | 0.000 | -0.4816 | No |
| 26 | CHRM5 | cholinergic receptor muscarinic 5 [Source:HGNC Symbol;Acc:HGNC:1954] | 17869 | 0.000 | -0.4816 | No |
| 27 | ADRB3 | adrenoceptor beta 3 [Source:HGNC Symbol;Acc:HGNC:288] | 17934 | 0.000 | -0.4834 | No |
| 28 | ADRB1 | adrenoceptor beta 1 [Source:HGNC Symbol;Acc:HGNC:285] | 17980 | 0.000 | -0.4846 | No |
| 29 | DRD1 | dopamine receptor D1 [Source:HGNC Symbol;Acc:HGNC:3020] | 18537 | 0.000 | -0.4996 | No |
| 30 | DRD2 | dopamine receptor D2 [Source:HGNC Symbol;Acc:HGNC:3023] | 18538 | 0.000 | -0.4996 | No |
| 31 | DRD3 | dopamine receptor D3 [Source:HGNC Symbol;Acc:HGNC:3024] | 18540 | 0.000 | -0.4996 | No |
| 32 | DRD4 | dopamine receptor D4 [Source:HGNC Symbol;Acc:HGNC:3025] | 18541 | 0.000 | -0.4996 | No |
| 33 | DRD5 | dopamine receptor D5 [Source:HGNC Symbol;Acc:HGNC:3026] | 18542 | 0.000 | -0.4996 | No |
| 34 | HRH1 | histamine receptor H1 [Source:HGNC Symbol;Acc:HGNC:5182] | 24150 | 0.000 | -0.6509 | No |
| 35 | HRH3 | histamine receptor H3 [Source:HGNC Symbol;Acc:HGNC:5184] | 24153 | 0.000 | -0.6510 | No |
| 36 | HRH2 | histamine receptor H2 [Source:HGNC Symbol;Acc:HGNC:5183] | 24155 | 0.000 | -0.6510 | No |
| 37 | HRH4 | histamine receptor H4 [Source:HGNC Symbol;Acc:HGNC:17383] | 24158 | 0.000 | -0.6511 | No |
| 38 | CHRM3 | cholinergic receptor muscarinic 3 [Source:HGNC Symbol;Acc:HGNC:1952] | 30090 | -0.342 | -0.7777 | Yes |
| 39 | CHRM4 | cholinergic receptor muscarinic 4 [Source:HGNC Symbol;Acc:HGNC:1953] | 30187 | -0.370 | -0.7442 | Yes |
| 40 | TAAR9 | trace amine associated receptor 9 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:20977] | 31643 | -0.772 | -0.7080 | Yes |
| 41 | ADRB2 | adrenoceptor beta 2 [Source:HGNC Symbol;Acc:HGNC:286] | 36932 | -4.314 | -0.4293 | Yes |
| 42 | HTR1B | 5-hydroxytryptamine receptor 1B [Source:HGNC Symbol;Acc:HGNC:5287] | 36967 | -4.437 | 0.0033 | Yes |
