Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING |
| Enrichment Score (ES) | 0.83796626 |
| Normalized Enrichment Score (NES) | 2.0069766 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | MX2 | MX dynamin like GTPase 2 [Source:HGNC Symbol;Acc:HGNC:7533] | 40 | 4.848 | 0.0491 | Yes |
| 2 | RSAD2 | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] | 67 | 4.644 | 0.0964 | Yes |
| 3 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 68 | 4.638 | 0.1444 | Yes |
| 4 | ISG20 | interferon stimulated exonuclease gene 20 [Source:HGNC Symbol;Acc:HGNC:6130] | 80 | 4.589 | 0.1916 | Yes |
| 5 | MX1 | MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532] | 110 | 4.400 | 0.2364 | Yes |
| 6 | IRF7 | interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122] | 115 | 4.370 | 0.2815 | Yes |
| 7 | OASL | 2'-5'-oligoadenylate synthetase like [Source:HGNC Symbol;Acc:HGNC:8090] | 118 | 4.359 | 0.3265 | Yes |
| 8 | IFIT1 | interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] | 119 | 4.357 | 0.3716 | Yes |
| 9 | USP18 | ubiquitin specific peptidase 18 [Source:HGNC Symbol;Acc:HGNC:12616] | 129 | 4.309 | 0.4159 | Yes |
| 10 | IFIT2 | interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] | 217 | 3.860 | 0.4535 | Yes |
| 11 | IFI35 | interferon induced protein 35 [Source:HGNC Symbol;Acc:HGNC:5399] | 271 | 3.577 | 0.4891 | Yes |
| 12 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 310 | 3.434 | 0.5236 | Yes |
| 13 | OAS1 | 2'-5'-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086] | 351 | 3.322 | 0.5569 | Yes |
| 14 | OAS3 | 2'-5'-oligoadenylate synthetase 3 [Source:HGNC Symbol;Acc:HGNC:8088] | 503 | 3.005 | 0.5839 | Yes |
| 15 | OAS2 | 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] | 521 | 2.963 | 0.6141 | Yes |
| 16 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 676 | 2.697 | 0.6379 | Yes |
| 17 | IFITM3 | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] | 744 | 2.555 | 0.6625 | Yes |
| 18 | ADAR | adenosine deaminase RNA specific [Source:HGNC Symbol;Acc:HGNC:225] | 1049 | 2.137 | 0.6764 | Yes |
| 19 | IFITM2 | interferon induced transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:5413] | 1259 | 1.891 | 0.6903 | Yes |
| 20 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 1363 | 1.809 | 0.7062 | Yes |
| 21 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 1391 | 1.786 | 0.7240 | Yes |
| 22 | IRF4 | interferon regulatory factor 4 [Source:HGNC Symbol;Acc:HGNC:6119] | 1398 | 1.771 | 0.7421 | Yes |
| 23 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 1689 | 1.542 | 0.7503 | Yes |
| 24 | GBP2 | guanylate binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4183] | 1883 | 1.434 | 0.7599 | Yes |
| 25 | IFITM1 | interferon induced transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:5412] | 2040 | 1.376 | 0.7699 | Yes |
| 26 | PSMB8 | proteasome 20S subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:9545] | 2462 | 1.188 | 0.7708 | Yes |
| 27 | ISG15 | ISG15 ubiquitin like modifier [Source:HGNC Symbol;Acc:HGNC:4053] | 2520 | 1.154 | 0.7812 | Yes |
| 28 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 2694 | 1.068 | 0.7876 | Yes |
| 29 | IRF5 | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:HGNC:6120] | 2777 | 1.035 | 0.7961 | Yes |
| 30 | IRF3 | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] | 2839 | 1.007 | 0.8049 | Yes |
| 31 | HLA-B | major histocompatibility complex, class I, B [Source:HGNC Symbol;Acc:HGNC:4932] | 2855 | 0.999 | 0.8148 | Yes |
| 32 | IRF8 | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] | 2872 | 0.987 | 0.8246 | Yes |
| 33 | IP6K2 | inositol hexakisphosphate kinase 2 [Source:HGNC Symbol;Acc:HGNC:17313] | 3272 | 0.845 | 0.8225 | Yes |
| 34 | HLA-F | major histocompatibility complex, class I, F [Source:HGNC Symbol;Acc:HGNC:4963] | 3320 | 0.829 | 0.8299 | Yes |
| 35 | HLA-E | major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] | 3404 | 0.800 | 0.8359 | Yes |
| 36 | HLA-C | major histocompatibility complex, class I, C [Source:HGNC Symbol;Acc:HGNC:4933] | 4052 | 0.590 | 0.8245 | Yes |
| 37 | HLA-H | major histocompatibility complex, class I, H (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4965] | 4091 | 0.579 | 0.8295 | Yes |
| 38 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 4097 | 0.578 | 0.8353 | Yes |
| 39 | HLA-A | major histocompatibility complex, class I, A [Source:HGNC Symbol;Acc:HGNC:4931] | 4317 | 0.518 | 0.8348 | Yes |
| 40 | KPNA1 | karyopherin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] | 4390 | 0.497 | 0.8380 | Yes |
| 41 | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:15925] | 5007 | 0.336 | 0.8248 | No |
| 42 | IFIT3 | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] | 5213 | 0.283 | 0.8222 | No |
| 43 | KPNB1 | karyopherin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6400] | 5557 | 0.205 | 0.8151 | No |
| 44 | ABCE1 | ATP binding cassette subfamily E member 1 [Source:HGNC Symbol;Acc:HGNC:69] | 5756 | 0.151 | 0.8113 | No |
| 45 | IFI27 | interferon alpha inducible protein 27 [Source:HGNC Symbol;Acc:HGNC:5397] | 6193 | 0.046 | 0.8000 | No |
| 46 | BST2 | bone marrow stromal cell antigen 2 [Source:HGNC Symbol;Acc:HGNC:1119] | 12511 | 0.000 | 0.6293 | No |
| 47 | IFNA13 | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] | 18228 | 0.000 | 0.4749 | No |
| 48 | IFNA14 | interferon alpha 14 [Source:HGNC Symbol;Acc:HGNC:5420] | 18229 | 0.000 | 0.4749 | No |
| 49 | IFNA16 | interferon alpha 16 [Source:HGNC Symbol;Acc:HGNC:5421] | 18231 | 0.000 | 0.4749 | No |
| 50 | IFNA17 | interferon alpha 17 [Source:HGNC Symbol;Acc:HGNC:5422] | 18233 | 0.000 | 0.4749 | No |
| 51 | IFNA10 | interferon alpha 10 [Source:HGNC Symbol;Acc:HGNC:5418] | 18240 | 0.000 | 0.4747 | No |
| 52 | IFNA21 | interferon alpha 21 [Source:HGNC Symbol;Acc:HGNC:5424] | 18247 | 0.000 | 0.4745 | No |
| 53 | IFNAR2 | interferon alpha and beta receptor subunit 2 [Source:HGNC Symbol;Acc:HGNC:5433] | 18518 | 0.000 | 0.4672 | No |
| 54 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18527 | 0.000 | 0.4670 | No |
| 55 | IFIT5 | interferon induced protein with tetratricopeptide repeats 5 [Source:HGNC Symbol;Acc:HGNC:13328] | 20342 | 0.000 | 0.4180 | No |
| 56 | IFNA5 | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] | 21848 | 0.000 | 0.3774 | No |
| 57 | IFNA4 | interferon alpha 4 [Source:HGNC Symbol;Acc:HGNC:5425] | 21849 | 0.000 | 0.3774 | No |
| 58 | IFNA7 | interferon alpha 7 [Source:HGNC Symbol;Acc:HGNC:5428] | 21851 | 0.000 | 0.3773 | No |
| 59 | IFNA6 | interferon alpha 6 [Source:HGNC Symbol;Acc:HGNC:5427] | 21853 | 0.000 | 0.3773 | No |
| 60 | IFNA1 | interferon alpha 1 [Source:HGNC Symbol;Acc:HGNC:5417] | 21854 | 0.000 | 0.3773 | No |
| 61 | IFNA2 | interferon alpha 2 [Source:HGNC Symbol;Acc:HGNC:5423] | 21855 | 0.000 | 0.3773 | No |
| 62 | IFNA8 | interferon alpha 8 [Source:HGNC Symbol;Acc:HGNC:5429] | 21857 | 0.000 | 0.3773 | No |
| 63 | IFNB1 | interferon beta 1 [Source:HGNC Symbol;Acc:HGNC:5434] | 21888 | 0.000 | 0.3765 | No |
| 64 | XAF1 | XIAP associated factor 1 [Source:HGNC Symbol;Acc:HGNC:30932] | 24669 | 0.000 | 0.3014 | No |
| 65 | IFI6 | interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] | 25458 | 0.000 | 0.2801 | No |
| 66 | JAK1 | Janus kinase 1 [Source:HGNC Symbol;Acc:HGNC:6190] | 28687 | -0.089 | 0.1938 | No |
| 67 | HLA-G | major histocompatibility complex, class I, G [Source:HGNC Symbol;Acc:HGNC:4964] | 28917 | -0.153 | 0.1892 | No |
| 68 | IRF6 | interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] | 29023 | -0.182 | 0.1882 | No |
| 69 | PTPN6 | protein tyrosine phosphatase non-receptor type 6 [Source:HGNC Symbol;Acc:HGNC:9658] | 29254 | -0.232 | 0.1844 | No |
| 70 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 29479 | -0.293 | 0.1814 | No |
| 71 | RNASEL | ribonuclease L [Source:HGNC Symbol;Acc:HGNC:10050] | 30189 | -0.370 | 0.1661 | No |
| 72 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 31994 | -0.872 | 0.1264 | No |
| 73 | IRF2 | interferon regulatory factor 2 [Source:HGNC Symbol;Acc:HGNC:6117] | 32696 | -1.088 | 0.1187 | No |
