Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | REN_BOUND_BY_E2F |
| Enrichment Score (ES) | -0.7993006 |
| Normalized Enrichment Score (NES) | -1.6447315 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.030596722 |
| FWER p-Value | 0.301 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | H3C4 | H3 clustered histone 4 [Source:HGNC Symbol;Acc:HGNC:4767] | 1299 | 1.873 | -0.0172 | No |
| 2 | CDC25A | cell division cycle 25A [Source:HGNC Symbol;Acc:HGNC:1725] | 2540 | 1.144 | -0.0398 | No |
| 3 | E2F3 | E2F transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:3115] | 3168 | 0.881 | -0.0484 | No |
| 4 | H2AC18 | H2A clustered histone 18 [Source:HGNC Symbol;Acc:HGNC:4736] | 3550 | 0.748 | -0.0515 | No |
| 5 | ORC1 | origin recognition complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:8487] | 4670 | 0.421 | -0.0777 | No |
| 6 | SUPT4H1 | SPT4 homolog, DSIF elongation factor subunit [Source:HGNC Symbol;Acc:HGNC:11467] | 6035 | 0.090 | -0.1137 | No |
| 7 | BRD2 | bromodomain containing 2 [Source:HGNC Symbol;Acc:HGNC:1103] | 6069 | 0.078 | -0.1139 | No |
| 8 | H2BC21 | H2B clustered histone 21 [Source:HGNC Symbol;Acc:HGNC:4760] | 24460 | 0.000 | -0.6105 | No |
| 9 | TP53 | tumor protein p53 [Source:HGNC Symbol;Acc:HGNC:11998] | 28514 | -0.040 | -0.7196 | No |
| 10 | CSTF1 | cleavage stimulation factor subunit 1 [Source:HGNC Symbol;Acc:HGNC:2483] | 28750 | -0.109 | -0.7249 | No |
| 11 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 28769 | -0.115 | -0.7243 | No |
| 12 | PTTG1 | PTTG1 regulator of sister chromatid separation, securin [Source:HGNC Symbol;Acc:HGNC:9690] | 28881 | -0.144 | -0.7259 | No |
| 13 | BUB3 | BUB3 mitotic checkpoint protein [Source:HGNC Symbol;Acc:HGNC:1151] | 29026 | -0.184 | -0.7280 | No |
| 14 | MLH1 | mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] | 30018 | -0.328 | -0.7517 | No |
| 15 | FEN1 | flap structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:HGNC:3650] | 30083 | -0.340 | -0.7501 | No |
| 16 | NAP1L4 | nucleosome assembly protein 1 like 4 [Source:HGNC Symbol;Acc:HGNC:7640] | 31904 | -0.850 | -0.7912 | Yes |
| 17 | HMGB1 | high mobility group box 1 [Source:HGNC Symbol;Acc:HGNC:4983] | 32162 | -0.925 | -0.7893 | Yes |
| 18 | MCM3 | minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] | 32174 | -0.931 | -0.7808 | Yes |
| 19 | H2AC6 | H2A clustered histone 6 [Source:HGNC Symbol;Acc:HGNC:4733] | 32343 | -0.982 | -0.7759 | Yes |
| 20 | H2AZ1 | H2A.Z variant histone 1 [Source:HGNC Symbol;Acc:HGNC:4741] | 32447 | -1.017 | -0.7690 | Yes |
| 21 | UMPS | uridine monophosphate synthetase [Source:HGNC Symbol;Acc:HGNC:12563] | 32657 | -1.074 | -0.7644 | Yes |
| 22 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 32872 | -1.155 | -0.7592 | Yes |
| 23 | CENPA | centromere protein A [Source:HGNC Symbol;Acc:HGNC:1851] | 33007 | -1.207 | -0.7513 | Yes |
| 24 | RAD51 | RAD51 recombinase [Source:HGNC Symbol;Acc:HGNC:9817] | 33193 | -1.285 | -0.7441 | Yes |
| 25 | POLA2 | DNA polymerase alpha 2, accessory subunit [Source:HGNC Symbol;Acc:HGNC:30073] | 33602 | -1.435 | -0.7414 | Yes |
| 26 | CENPE | centromere protein E [Source:HGNC Symbol;Acc:HGNC:1856] | 33695 | -1.469 | -0.7299 | Yes |
| 27 | MCM5 | minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:HGNC:6948] | 33849 | -1.543 | -0.7193 | Yes |
| 28 | RPA3 | replication protein A3 [Source:HGNC Symbol;Acc:HGNC:10291] | 34095 | -1.662 | -0.7101 | Yes |
| 29 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 34241 | -1.737 | -0.6975 | Yes |
| 30 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 34281 | -1.756 | -0.6818 | Yes |
| 31 | PRKDC | protein kinase, DNA-activated, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9413] | 34300 | -1.768 | -0.6654 | Yes |
| 32 | CKS1BP7 | CDC28 protein kinase regulatory subunit 1B pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:1999] | 34446 | -1.854 | -0.6517 | Yes |
| 33 | CHEK1 | checkpoint kinase 1 [Source:HGNC Symbol;Acc:HGNC:1925] | 34537 | -1.914 | -0.6359 | Yes |
| 34 | CDK2 | cyclin dependent kinase 2 [Source:HGNC Symbol;Acc:HGNC:1771] | 34747 | -1.948 | -0.6229 | Yes |
| 35 | CBX5 | chromobox 5 [Source:HGNC Symbol;Acc:HGNC:1555] | 34780 | -1.962 | -0.6051 | Yes |
| 36 | CDC6 | cell division cycle 6 [Source:HGNC Symbol;Acc:HGNC:1744] | 34829 | -1.998 | -0.5874 | Yes |
| 37 | BARD1 | BRCA1 associated RING domain 1 [Source:HGNC Symbol;Acc:HGNC:952] | 34845 | -2.009 | -0.5686 | Yes |
| 38 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 34967 | -2.085 | -0.5520 | Yes |
| 39 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 35009 | -2.109 | -0.5330 | Yes |
| 40 | DBF4 | DBF4 zinc finger [Source:HGNC Symbol;Acc:HGNC:17364] | 35030 | -2.121 | -0.5134 | Yes |
| 41 | PRIM2 | DNA primase subunit 2 [Source:HGNC Symbol;Acc:HGNC:9370] | 35046 | -2.132 | -0.4935 | Yes |
| 42 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 35057 | -2.142 | -0.4733 | Yes |
| 43 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 35074 | -2.151 | -0.4532 | Yes |
| 44 | RRM1 | ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451] | 35109 | -2.175 | -0.4334 | Yes |
| 45 | RBL1 | RB transcriptional corepressor like 1 [Source:HGNC Symbol;Acc:HGNC:9893] | 35112 | -2.177 | -0.4128 | Yes |
| 46 | POLD1 | DNA polymerase delta 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9175] | 35155 | -2.211 | -0.3928 | Yes |
| 47 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 35199 | -2.244 | -0.3726 | Yes |
| 48 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 35206 | -2.250 | -0.3513 | Yes |
| 49 | RAD54L | RAD54 like [Source:HGNC Symbol;Acc:HGNC:9826] | 35241 | -2.264 | -0.3307 | Yes |
| 50 | MAD2L1 | mitotic arrest deficient 2 like 1 [Source:HGNC Symbol;Acc:HGNC:6763] | 35313 | -2.314 | -0.3105 | Yes |
| 51 | POLA1 | DNA polymerase alpha 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9173] | 35535 | -2.473 | -0.2929 | Yes |
| 52 | DUT | deoxyuridine triphosphatase [Source:HGNC Symbol;Acc:HGNC:3078] | 35634 | -2.552 | -0.2713 | Yes |
| 53 | RFC2 | replication factor C subunit 2 [Source:HGNC Symbol;Acc:HGNC:9970] | 35707 | -2.615 | -0.2483 | Yes |
| 54 | HMGB3 | high mobility group box 3 [Source:HGNC Symbol;Acc:HGNC:5004] | 35757 | -2.659 | -0.2243 | Yes |
| 55 | H2AX | H2A.X variant histone [Source:HGNC Symbol;Acc:HGNC:4739] | 35972 | -2.829 | -0.2031 | Yes |
| 56 | HLTF | helicase like transcription factor [Source:HGNC Symbol;Acc:HGNC:11099] | 35994 | -2.857 | -0.1764 | Yes |
| 57 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36312 | -3.201 | -0.1545 | Yes |
| 58 | E2F2 | E2F transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3114] | 36416 | -3.365 | -0.1252 | Yes |
| 59 | MSH2 | mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] | 36496 | -3.487 | -0.0941 | Yes |
| 60 | UNG | uracil DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:12572] | 36532 | -3.511 | -0.0616 | Yes |
| 61 | RB1 | RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884] | 36681 | -3.791 | -0.0295 | Yes |
| 62 | TK1 | thymidine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11830] | 36908 | -4.248 | 0.0049 | Yes |
