Fig 1: Enrichment plot: SRF_01
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | SRF_01 |
| Enrichment Score (ES) | 0.59967494 |
| Normalized Enrichment Score (NES) | 1.3641846 |
| Nominal p-value | 0.03515625 |
| FDR q-value | 1.0 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | FOSL1 | FOS like 1, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:13718] | 65 | 4.660 | 0.0755 | Yes |
| 2 | ASB2 | ankyrin repeat and SOCS box containing 2 [Source:HGNC Symbol;Acc:HGNC:16012] | 248 | 3.707 | 0.1321 | Yes |
| 3 | JUNB | JunB proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6205] | 371 | 3.286 | 0.1833 | Yes |
| 4 | ACTG2 | actin gamma 2, smooth muscle [Source:HGNC Symbol;Acc:HGNC:145] | 471 | 3.087 | 0.2318 | Yes |
| 5 | FOSB | FosB proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3797] | 528 | 2.958 | 0.2793 | Yes |
| 6 | IER2 | immediate early response 2 [Source:HGNC Symbol;Acc:HGNC:28871] | 698 | 2.643 | 0.3186 | Yes |
| 7 | ACTN1 | actinin alpha 1 [Source:HGNC Symbol;Acc:HGNC:163] | 971 | 2.245 | 0.3485 | Yes |
| 8 | FLNA | filamin A [Source:HGNC Symbol;Acc:HGNC:3754] | 1043 | 2.144 | 0.3822 | Yes |
| 9 | WDR1 | WD repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12754] | 1153 | 2.006 | 0.4125 | Yes |
| 10 | THBS1 | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] | 1360 | 1.810 | 0.4369 | Yes |
| 11 | ACTR3 | actin related protein 3 [Source:HGNC Symbol;Acc:HGNC:170] | 1520 | 1.670 | 0.4604 | Yes |
| 12 | ITGB1BP2 | integrin subunit beta 1 binding protein 2 [Source:HGNC Symbol;Acc:HGNC:6154] | 1542 | 1.656 | 0.4873 | Yes |
| 13 | CFL1 | cofilin 1 [Source:HGNC Symbol;Acc:HGNC:1874] | 1551 | 1.650 | 0.5144 | Yes |
| 14 | MYH11 | myosin heavy chain 11 [Source:HGNC Symbol;Acc:HGNC:7569] | 1760 | 1.499 | 0.5336 | Yes |
| 15 | MYL6 | myosin light chain 6 [Source:HGNC Symbol;Acc:HGNC:7587] | 1893 | 1.431 | 0.5538 | Yes |
| 16 | PFN1 | profilin 1 [Source:HGNC Symbol;Acc:HGNC:8881] | 1898 | 1.427 | 0.5774 | Yes |
| 17 | HOXB4 | homeobox B4 [Source:HGNC Symbol;Acc:HGNC:5115] | 1934 | 1.402 | 0.5997 | Yes |
| 18 | CNN2 | calponin 2 [Source:HGNC Symbol;Acc:HGNC:2156] | 3310 | 0.832 | 0.5763 | No |
| 19 | EGR3 | early growth response 3 [Source:HGNC Symbol;Acc:HGNC:3240] | 3855 | 0.658 | 0.5726 | No |
| 20 | EGR1 | early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] | 4097 | 0.578 | 0.5756 | No |
| 21 | TGFB1I1 | transforming growth factor beta 1 induced transcript 1 [Source:HGNC Symbol;Acc:HGNC:11767] | 4189 | 0.548 | 0.5823 | No |
| 22 | SCOC | short coiled-coil protein [Source:HGNC Symbol;Acc:HGNC:20335] | 4649 | 0.429 | 0.5770 | No |
| 23 | IRAG1 | inositol 1,4,5-triphosphate receptor associated 1 [Source:HGNC Symbol;Acc:HGNC:7237] | 5221 | 0.281 | 0.5663 | No |
| 24 | FOS | Fos proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:3796] | 5766 | 0.149 | 0.5540 | No |
| 25 | TPM1 | tropomyosin 1 [Source:HGNC Symbol;Acc:HGNC:12010] | 5957 | 0.109 | 0.5507 | No |
| 26 | CD248 | CD248 molecule [Source:HGNC Symbol;Acc:HGNC:18219] | 8206 | 0.000 | 0.4900 | No |
| 27 | CALD1 | caldesmon 1 [Source:HGNC Symbol;Acc:HGNC:1441] | 8866 | 0.000 | 0.4722 | No |
| 28 | NPAS4 | neuronal PAS domain protein 4 [Source:HGNC Symbol;Acc:HGNC:18983] | 9827 | 0.000 | 0.4463 | No |
| 29 | SUSD1 | sushi domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25413] | 10295 | 0.000 | 0.4337 | No |
| 30 | PRM1 | protamine 1 [Source:HGNC Symbol;Acc:HGNC:9447] | 11670 | 0.000 | 0.3966 | No |
| 31 | TNMD | tenomodulin [Source:HGNC Symbol;Acc:HGNC:17757] | 15040 | 0.000 | 0.3057 | No |
| 32 | CA3 | carbonic anhydrase 3 [Source:HGNC Symbol;Acc:HGNC:1374] | 15709 | 0.000 | 0.2876 | No |
| 33 | PHOX2B | paired like homeobox 2B [Source:HGNC Symbol;Acc:HGNC:9143] | 16319 | 0.000 | 0.2712 | No |
| 34 | GPR20 | G protein-coupled receptor 20 [Source:HGNC Symbol;Acc:HGNC:4475] | 17519 | 0.000 | 0.2388 | No |
| 35 | STX10 | syntaxin 10 [Source:HGNC Symbol;Acc:HGNC:11428] | 17707 | 0.000 | 0.2338 | No |
| 36 | KCNMB1 | potassium calcium-activated channel subfamily M regulatory beta subunit 1 [Source:HGNC Symbol;Acc:HGNC:6285] | 22047 | 0.000 | 0.1166 | No |
| 37 | IL17B | interleukin 17B [Source:HGNC Symbol;Acc:HGNC:5982] | 24426 | 0.000 | 0.0524 | No |
| 38 | IGF2-AS | IGF2 antisense RNA [Source:HGNC Symbol;Acc:HGNC:14062] | 25629 | 0.000 | 0.0200 | No |
| 39 | EGR4 | early growth response 4 [Source:HGNC Symbol;Acc:HGNC:3241] | 27263 | 0.000 | -0.0241 | No |
| 40 | PRUNE2 | prune homolog 2 with BCH domain [Source:HGNC Symbol;Acc:HGNC:25209] | 28449 | -0.023 | -0.0557 | No |
| 41 | CAP1 | cyclase associated actin cytoskeleton regulatory protein 1 [Source:HGNC Symbol;Acc:HGNC:20040] | 29422 | -0.277 | -0.0774 | No |
| 42 | SETD2 | SET domain containing 2, histone lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:18420] | 32421 | -1.009 | -0.1416 | No |
| 43 | EGR2 | early growth response 2 [Source:HGNC Symbol;Acc:HGNC:3239] | 32925 | -1.174 | -0.1357 | No |
| 44 | TAZ | tafazzin [Source:HGNC Symbol;Acc:HGNC:11577] | 33020 | -1.212 | -0.1181 | No |
| 45 | SLC25A4 | solute carrier family 25 member 4 [Source:HGNC Symbol;Acc:HGNC:10990] | 33036 | -1.217 | -0.0984 | No |
| 46 | VCL | vinculin [Source:HGNC Symbol;Acc:HGNC:12665] | 33216 | -1.293 | -0.0818 | No |
| 47 | PLCB3 | phospholipase C beta 3 [Source:HGNC Symbol;Acc:HGNC:9056] | 33380 | -1.333 | -0.0640 | No |
| 48 | MUS81 | MUS81 structure-specific endonuclease subunit [Source:HGNC Symbol;Acc:HGNC:29814] | 34120 | -1.680 | -0.0561 | No |
| 49 | ANXA6 | annexin A6 [Source:HGNC Symbol;Acc:HGNC:544] | 34292 | -1.763 | -0.0315 | No |
| 50 | TNNC1 | troponin C1, slow skeletal and cardiac type [Source:HGNC Symbol;Acc:HGNC:11943] | 35300 | -2.306 | -0.0205 | No |
| 51 | DIXDC1 | DIX domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23695] | 36869 | -4.145 | 0.0060 | No |
