Fig 1: Enrichment plot: GNF2_ESPL1
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | GNF2_ESPL1 |
| Enrichment Score (ES) | -0.8432381 |
| Normalized Enrichment Score (NES) | -1.5950837 |
| Nominal p-value | 0.0014204546 |
| FDR q-value | 0.013896851 |
| FWER p-Value | 0.193 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | KIF20A | kinesin family member 20A [Source:HGNC Symbol;Acc:HGNC:9787] | 29461 | -0.290 | -0.7904 | No |
| 2 | CDC20 | cell division cycle 20 [Source:HGNC Symbol;Acc:HGNC:1723] | 30121 | -0.351 | -0.8027 | No |
| 3 | ESPL1 | extra spindle pole bodies like 1, separase [Source:HGNC Symbol;Acc:HGNC:16856] | 31169 | -0.633 | -0.8209 | No |
| 4 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 31998 | -0.873 | -0.8294 | Yes |
| 5 | ASF1B | anti-silencing function 1B histone chaperone [Source:HGNC Symbol;Acc:HGNC:20996] | 32405 | -1.003 | -0.8245 | Yes |
| 6 | UBE2C | ubiquitin conjugating enzyme E2 C [Source:HGNC Symbol;Acc:HGNC:15937] | 32593 | -1.049 | -0.8129 | Yes |
| 7 | PLK1 | polo like kinase 1 [Source:HGNC Symbol;Acc:HGNC:9077] | 32612 | -1.058 | -0.7966 | Yes |
| 8 | TPX2 | TPX2 microtubule nucleation factor [Source:HGNC Symbol;Acc:HGNC:1249] | 32628 | -1.064 | -0.7802 | Yes |
| 9 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 32872 | -1.155 | -0.7684 | Yes |
| 10 | CENPA | centromere protein A [Source:HGNC Symbol;Acc:HGNC:1851] | 33007 | -1.207 | -0.7529 | Yes |
| 11 | CENPM | centromere protein M [Source:HGNC Symbol;Acc:HGNC:18352] | 33082 | -1.236 | -0.7354 | Yes |
| 12 | BIRC5 | baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] | 33403 | -1.341 | -0.7228 | Yes |
| 13 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 33668 | -1.457 | -0.7068 | Yes |
| 14 | CENPE | centromere protein E [Source:HGNC Symbol;Acc:HGNC:1856] | 33695 | -1.469 | -0.6842 | Yes |
| 15 | BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149] | 33841 | -1.541 | -0.6637 | Yes |
| 16 | SPAG5 | sperm associated antigen 5 [Source:HGNC Symbol;Acc:HGNC:13452] | 33926 | -1.576 | -0.6410 | Yes |
| 17 | CDCA8 | cell division cycle associated 8 [Source:HGNC Symbol;Acc:HGNC:14629] | 34050 | -1.644 | -0.6183 | Yes |
| 18 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 34241 | -1.737 | -0.5959 | Yes |
| 19 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 34493 | -1.883 | -0.5729 | Yes |
| 20 | KIF11 | kinesin family member 11 [Source:HGNC Symbol;Acc:HGNC:6388] | 34903 | -2.041 | -0.5516 | Yes |
| 21 | KIF2C | kinesin family member 2C [Source:HGNC Symbol;Acc:HGNC:6393] | 35003 | -2.106 | -0.5209 | Yes |
| 22 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 35009 | -2.109 | -0.4876 | Yes |
| 23 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 35057 | -2.142 | -0.4550 | Yes |
| 24 | AURKB | aurora kinase B [Source:HGNC Symbol;Acc:HGNC:11390] | 35118 | -2.180 | -0.4221 | Yes |
| 25 | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1148] | 35269 | -2.283 | -0.3899 | Yes |
| 26 | MAD2L1 | mitotic arrest deficient 2 like 1 [Source:HGNC Symbol;Acc:HGNC:6763] | 35313 | -2.314 | -0.3544 | Yes |
| 27 | NCAPD2 | non-SMC condensin I complex subunit D2 [Source:HGNC Symbol;Acc:HGNC:24305] | 35551 | -2.485 | -0.3215 | Yes |
| 28 | RRM2 | ribonucleotide reductase regulatory subunit M2 [Source:HGNC Symbol;Acc:HGNC:10452] | 35689 | -2.604 | -0.2839 | Yes |
| 29 | HMMR | hyaluronan mediated motility receptor [Source:HGNC Symbol;Acc:HGNC:5012] | 35737 | -2.641 | -0.2433 | Yes |
| 30 | MELK | maternal embryonic leucine zipper kinase [Source:HGNC Symbol;Acc:HGNC:16870] | 35760 | -2.660 | -0.2018 | Yes |
| 31 | ASPM | assembly factor for spindle microtubules [Source:HGNC Symbol;Acc:HGNC:19048] | 36035 | -2.919 | -0.1630 | Yes |
| 32 | FOXM1 | forkhead box M1 [Source:HGNC Symbol;Acc:HGNC:3818] | 36042 | -2.928 | -0.1167 | Yes |
| 33 | MKI67 | marker of proliferation Ki-67 [Source:HGNC Symbol;Acc:HGNC:7107] | 36044 | -2.930 | -0.0704 | Yes |
| 34 | PAICS | phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [Source:HGNC Symbol;Acc:HGNC:8587] | 36132 | -3.020 | -0.0249 | Yes |
| 35 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36312 | -3.201 | 0.0210 | Yes |
