Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | GNF2_RFC4 |
| Enrichment Score (ES) | -0.77670974 |
| Normalized Enrichment Score (NES) | -1.5880529 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.014789268 |
| FWER p-Value | 0.226 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | DKC1 | dyskerin pseudouridine synthase 1 [Source:HGNC Symbol;Acc:HGNC:2890] | 2296 | 1.276 | -0.0484 | No |
| 2 | CKS2 | CDC28 protein kinase regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:2000] | 3538 | 0.752 | -0.0738 | No |
| 3 | RANBP1 | RAN binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9847] | 3948 | 0.625 | -0.0782 | No |
| 4 | SNRPE | small nuclear ribonucleoprotein polypeptide E [Source:HGNC Symbol;Acc:HGNC:11161] | 4143 | 0.564 | -0.0774 | No |
| 5 | RAN | RAN, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9846] | 4465 | 0.480 | -0.0810 | No |
| 6 | SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide [Source:HGNC Symbol;Acc:HGNC:11158] | 5699 | 0.167 | -0.1125 | No |
| 7 | ZWINT | ZW10 interacting kinetochore protein [Source:HGNC Symbol;Acc:HGNC:13195] | 23509 | 0.000 | -0.5934 | No |
| 8 | CCT2 | chaperonin containing TCP1 subunit 2 [Source:HGNC Symbol;Acc:HGNC:1615] | 28482 | -0.032 | -0.7273 | No |
| 9 | CDK1 | cyclin dependent kinase 1 [Source:HGNC Symbol;Acc:HGNC:1722] | 28769 | -0.115 | -0.7338 | No |
| 10 | MCM10 | minichromosome maintenance 10 replication initiation factor [Source:HGNC Symbol;Acc:HGNC:18043] | 29088 | -0.200 | -0.7403 | No |
| 11 | MLH1 | mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] | 30018 | -0.328 | -0.7618 | No |
| 12 | FEN1 | flap structure-specific endonuclease 1 [Source:HGNC Symbol;Acc:HGNC:3650] | 30083 | -0.340 | -0.7599 | No |
| 13 | SSRP1 | structure specific recognition protein 1 [Source:HGNC Symbol;Acc:HGNC:11327] | 30279 | -0.388 | -0.7611 | No |
| 14 | CTPS1 | CTP synthase 1 [Source:HGNC Symbol;Acc:HGNC:2519] | 30537 | -0.460 | -0.7631 | No |
| 15 | TYMS | thymidylate synthetase [Source:HGNC Symbol;Acc:HGNC:12441] | 30615 | -0.478 | -0.7600 | No |
| 16 | TIMELESS | timeless circadian regulator [Source:HGNC Symbol;Acc:HGNC:11813] | 30948 | -0.574 | -0.7629 | No |
| 17 | PLK4 | polo like kinase 4 [Source:HGNC Symbol;Acc:HGNC:11397] | 31198 | -0.641 | -0.7628 | No |
| 18 | SLBP | stem-loop binding protein [Source:HGNC Symbol;Acc:HGNC:10904] | 31441 | -0.711 | -0.7617 | No |
| 19 | CKS1B | CDC28 protein kinase regulatory subunit 1B [Source:HGNC Symbol;Acc:HGNC:19083] | 31998 | -0.873 | -0.7674 | Yes |
| 20 | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit [Source:HGNC Symbol;Acc:HGNC:11465] | 31999 | -0.874 | -0.7580 | Yes |
| 21 | MCM3 | minichromosome maintenance complex component 3 [Source:HGNC Symbol;Acc:HGNC:6945] | 32174 | -0.931 | -0.7528 | Yes |
| 22 | RAD51AP1 | RAD51 associated protein 1 [Source:HGNC Symbol;Acc:HGNC:16956] | 32433 | -1.015 | -0.7489 | Yes |
| 23 | H2AZ1 | H2A.Z variant histone 1 [Source:HGNC Symbol;Acc:HGNC:4741] | 32447 | -1.017 | -0.7384 | Yes |
| 24 | UBE2C | ubiquitin conjugating enzyme E2 C [Source:HGNC Symbol;Acc:HGNC:15937] | 32593 | -1.049 | -0.7311 | Yes |
| 25 | ITGB3BP | integrin subunit beta 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6157] | 32667 | -1.077 | -0.7215 | Yes |
| 26 | PCNA | proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:HGNC:8729] | 32872 | -1.155 | -0.7147 | Yes |
| 27 | FANCI | FA complementation group I [Source:HGNC Symbol;Acc:HGNC:25568] | 33141 | -1.259 | -0.7085 | Yes |
| 28 | BIRC5 | baculoviral IAP repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:593] | 33403 | -1.341 | -0.7012 | Yes |
| 29 | CCNB2 | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 33668 | -1.457 | -0.6927 | Yes |
| 30 | RFC5 | replication factor C subunit 5 [Source:HGNC Symbol;Acc:HGNC:9973] | 33951 | -1.590 | -0.6834 | Yes |
| 31 | KNTC1 | kinetochore associated 1 [Source:HGNC Symbol;Acc:HGNC:17255] | 33994 | -1.617 | -0.6672 | Yes |
| 32 | RPA3 | replication protein A3 [Source:HGNC Symbol;Acc:HGNC:10291] | 34095 | -1.662 | -0.6522 | Yes |
| 33 | SMC2 | structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] | 34241 | -1.737 | -0.6375 | Yes |
| 34 | RFC3 | replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] | 34281 | -1.756 | -0.6198 | Yes |
| 35 | PCLAF | PCNA clamp associated factor [Source:HGNC Symbol;Acc:HGNC:28961] | 34472 | -1.873 | -0.6049 | Yes |
| 36 | MCM4 | minichromosome maintenance complex component 4 [Source:HGNC Symbol;Acc:HGNC:6947] | 34493 | -1.883 | -0.5853 | Yes |
| 37 | MCM2 | minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:HGNC:6944] | 34557 | -1.928 | -0.5664 | Yes |
| 38 | GINS1 | GINS complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:28980] | 34589 | -1.943 | -0.5465 | Yes |
| 39 | KIF11 | kinesin family member 11 [Source:HGNC Symbol;Acc:HGNC:6388] | 34903 | -2.041 | -0.5331 | Yes |
| 40 | SMC4 | structural maintenance of chromosomes 4 [Source:HGNC Symbol;Acc:HGNC:14013] | 34967 | -2.085 | -0.5125 | Yes |
| 41 | TOP2A | DNA topoisomerase II alpha [Source:HGNC Symbol;Acc:HGNC:11989] | 35009 | -2.109 | -0.4911 | Yes |
| 42 | PRIM1 | DNA primase subunit 1 [Source:HGNC Symbol;Acc:HGNC:9369] | 35024 | -2.115 | -0.4689 | Yes |
| 43 | CCNA2 | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] | 35057 | -2.142 | -0.4468 | Yes |
| 44 | RFC4 | replication factor C subunit 4 [Source:HGNC Symbol;Acc:HGNC:9972] | 35074 | -2.151 | -0.4243 | Yes |
| 45 | RRM1 | ribonucleotide reductase catalytic subunit M1 [Source:HGNC Symbol;Acc:HGNC:10451] | 35109 | -2.175 | -0.4019 | Yes |
| 46 | TTK | TTK protein kinase [Source:HGNC Symbol;Acc:HGNC:12401] | 35199 | -2.244 | -0.3804 | Yes |
| 47 | NDC80 | NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:16909] | 35206 | -2.250 | -0.3565 | Yes |
| 48 | RAD54L | RAD54 like [Source:HGNC Symbol;Acc:HGNC:9826] | 35241 | -2.264 | -0.3332 | Yes |
| 49 | CENPF | centromere protein F [Source:HGNC Symbol;Acc:HGNC:1857] | 35334 | -2.329 | -0.3108 | Yes |
| 50 | NCAPD2 | non-SMC condensin I complex subunit D2 [Source:HGNC Symbol;Acc:HGNC:24305] | 35551 | -2.485 | -0.2901 | Yes |
| 51 | MCM7 | minichromosome maintenance complex component 7 [Source:HGNC Symbol;Acc:HGNC:6950] | 35642 | -2.564 | -0.2651 | Yes |
| 52 | GINS2 | GINS complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:24575] | 35670 | -2.585 | -0.2382 | Yes |
| 53 | ASPM | assembly factor for spindle microtubules [Source:HGNC Symbol;Acc:HGNC:19048] | 36035 | -2.919 | -0.2168 | Yes |
| 54 | FOXM1 | forkhead box M1 [Source:HGNC Symbol;Acc:HGNC:3818] | 36042 | -2.928 | -0.1857 | Yes |
| 55 | PAICS | phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [Source:HGNC Symbol;Acc:HGNC:8587] | 36132 | -3.020 | -0.1558 | Yes |
| 56 | LIG1 | DNA ligase 1 [Source:HGNC Symbol;Acc:HGNC:6598] | 36175 | -3.068 | -0.1241 | Yes |
| 57 | MCM6 | minichromosome maintenance complex component 6 [Source:HGNC Symbol;Acc:HGNC:6949] | 36312 | -3.201 | -0.0936 | Yes |
| 58 | MSH6 | mutS homolog 6 [Source:HGNC Symbol;Acc:HGNC:7329] | 36407 | -3.364 | -0.0602 | Yes |
| 59 | MSH2 | mutS homolog 2 [Source:HGNC Symbol;Acc:HGNC:7325] | 36496 | -3.487 | -0.0253 | Yes |
| 60 | GMNN | geminin DNA replication inhibitor [Source:HGNC Symbol;Acc:HGNC:17493] | 36724 | -3.863 | 0.0099 | Yes |
