Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | MODULE_316 |
| Enrichment Score (ES) | -0.7575296 |
| Normalized Enrichment Score (NES) | -1.581841 |
| Nominal p-value | 0.0012562814 |
| FDR q-value | 0.016810196 |
| FWER p-Value | 0.263 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | AQP9 | aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] | 302 | 3.473 | 0.0887 | No |
| 2 | CLCN6 | chloride voltage-gated channel 6 [Source:HGNC Symbol;Acc:HGNC:2024] | 4547 | 0.456 | -0.0133 | No |
| 3 | FXYD1 | FXYD domain containing ion transport regulator 1 [Source:HGNC Symbol;Acc:HGNC:4025] | 6698 | 0.000 | -0.0713 | No |
| 4 | FXYD7 | FXYD domain containing ion transport regulator 7 [Source:HGNC Symbol;Acc:HGNC:4034] | 6700 | 0.000 | -0.0714 | No |
| 5 | AQP4 | aquaporin 4 [Source:HGNC Symbol;Acc:HGNC:637] | 7127 | 0.000 | -0.0829 | No |
| 6 | CLIC2 | chloride intracellular channel 2 [Source:HGNC Symbol;Acc:HGNC:2063] | 7939 | 0.000 | -0.1048 | No |
| 7 | ASIC1 | acid sensing ion channel subunit 1 [Source:HGNC Symbol;Acc:HGNC:100] | 8023 | 0.000 | -0.1070 | No |
| 8 | GRIA3 | glutamate ionotropic receptor AMPA type subunit 3 [Source:HGNC Symbol;Acc:HGNC:4573] | 9348 | 0.000 | -0.1428 | No |
| 9 | KCNA1 | potassium voltage-gated channel subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:6218] | 9756 | 0.000 | -0.1538 | No |
| 10 | KCNB2 | potassium voltage-gated channel subfamily B member 2 [Source:HGNC Symbol;Acc:HGNC:6232] | 9778 | 0.000 | -0.1544 | No |
| 11 | KCNH2 | potassium voltage-gated channel subfamily H member 2 [Source:HGNC Symbol;Acc:HGNC:6251] | 9816 | 0.000 | -0.1554 | No |
| 12 | KCNE1 | potassium voltage-gated channel subfamily E regulatory subunit 1 [Source:HGNC Symbol;Acc:HGNC:6240] | 9837 | 0.000 | -0.1559 | No |
| 13 | KCNK5 | potassium two pore domain channel subfamily K member 5 [Source:HGNC Symbol;Acc:HGNC:6280] | 9863 | 0.000 | -0.1566 | No |
| 14 | KCNJ3 | potassium inwardly rectifying channel subfamily J member 3 [Source:HGNC Symbol;Acc:HGNC:6264] | 9889 | 0.000 | -0.1572 | No |
| 15 | KCNJ4 | potassium inwardly rectifying channel subfamily J member 4 [Source:HGNC Symbol;Acc:HGNC:6265] | 9890 | 0.000 | -0.1572 | No |
| 16 | KCNJ6 | potassium inwardly rectifying channel subfamily J member 6 [Source:HGNC Symbol;Acc:HGNC:6267] | 9892 | 0.000 | -0.1573 | No |
| 17 | KCNK1 | potassium two pore domain channel subfamily K member 1 [Source:HGNC Symbol;Acc:HGNC:6272] | 9898 | 0.000 | -0.1574 | No |
| 18 | MS4A2 | membrane spanning 4-domains A2 [Source:HGNC Symbol;Acc:HGNC:7316] | 11158 | 0.000 | -0.1914 | No |
| 19 | RYR2 | ryanodine receptor 2 [Source:HGNC Symbol;Acc:HGNC:10484] | 11994 | 0.000 | -0.2140 | No |
| 20 | GLRA1 | glycine receptor alpha 1 [Source:HGNC Symbol;Acc:HGNC:4326] | 12990 | 0.000 | -0.2408 | No |
| 21 | GLRA2 | glycine receptor alpha 2 [Source:HGNC Symbol;Acc:HGNC:4327] | 12993 | 0.000 | -0.2409 | No |
| 22 | GLRA3 | glycine receptor alpha 3 [Source:HGNC Symbol;Acc:HGNC:4328] | 12994 | 0.000 | -0.2409 | No |
| 23 | P2RX1 | purinergic receptor P2X 1 [Source:HGNC Symbol;Acc:HGNC:8533] | 14223 | 0.000 | -0.2741 | No |
| 24 | HTR3A | 5-hydroxytryptamine receptor 3A [Source:HGNC Symbol;Acc:HGNC:5297] | 15602 | 0.000 | -0.3113 | No |
| 25 | SLC14A2 | solute carrier family 14 member 2 [Source:HGNC Symbol;Acc:HGNC:10919] | 16810 | 0.000 | -0.3439 | No |
| 26 | GABRE | gamma-aminobutyric acid type A receptor subunit epsilon [Source:HGNC Symbol;Acc:HGNC:4085] | 17334 | 0.000 | -0.3580 | No |
| 27 | GABRP | gamma-aminobutyric acid type A receptor subunit pi [Source:HGNC Symbol;Acc:HGNC:4089] | 17339 | 0.000 | -0.3581 | No |
| 28 | CHRNE | cholinergic receptor nicotinic epsilon subunit [Source:HGNC Symbol;Acc:HGNC:1966] | 17856 | 0.000 | -0.3721 | No |
| 29 | MLC1 | modulator of VRAC current 1 [Source:HGNC Symbol;Acc:HGNC:17082] | 18603 | 0.000 | -0.3922 | No |
| 30 | GABRB3 | gamma-aminobutyric acid type A receptor subunit beta3 [Source:HGNC Symbol;Acc:HGNC:4083] | 20020 | 0.000 | -0.4305 | No |
| 31 | GABRA2 | gamma-aminobutyric acid type A receptor subunit alpha2 [Source:HGNC Symbol;Acc:HGNC:4076] | 20063 | 0.000 | -0.4316 | No |
| 32 | GABRA1 | gamma-aminobutyric acid type A receptor subunit alpha1 [Source:HGNC Symbol;Acc:HGNC:4075] | 20064 | 0.000 | -0.4316 | No |
| 33 | GABRA6 | gamma-aminobutyric acid type A receptor subunit alpha6 [Source:HGNC Symbol;Acc:HGNC:4080] | 20065 | 0.000 | -0.4316 | No |
| 34 | GABRA5 | gamma-aminobutyric acid type A receptor subunit alpha5 [Source:HGNC Symbol;Acc:HGNC:4079] | 20066 | 0.000 | -0.4316 | No |
| 35 | CNGA3 | cyclic nucleotide gated channel subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:2150] | 20973 | 0.000 | -0.4561 | No |
| 36 | KCNJ11 | potassium inwardly rectifying channel subfamily J member 11 [Source:HGNC Symbol;Acc:HGNC:6257] | 20996 | 0.000 | -0.4567 | No |
| 37 | KCNJ12 | potassium inwardly rectifying channel subfamily J member 12 [Source:HGNC Symbol;Acc:HGNC:6258] | 20998 | 0.000 | -0.4567 | No |
| 38 | CHRNB3 | cholinergic receptor nicotinic beta 3 subunit [Source:HGNC Symbol;Acc:HGNC:1963] | 21914 | 0.000 | -0.4814 | No |
| 39 | CHRNA2 | cholinergic receptor nicotinic alpha 2 subunit [Source:HGNC Symbol;Acc:HGNC:1956] | 21942 | 0.000 | -0.4821 | No |
| 40 | CHRNA4 | cholinergic receptor nicotinic alpha 4 subunit [Source:HGNC Symbol;Acc:HGNC:1958] | 21945 | 0.000 | -0.4822 | No |
| 41 | CHRNA7 | cholinergic receptor nicotinic alpha 7 subunit [Source:HGNC Symbol;Acc:HGNC:1960] | 21946 | 0.000 | -0.4822 | No |
| 42 | KCNMB1 | potassium calcium-activated channel subfamily M regulatory beta subunit 1 [Source:HGNC Symbol;Acc:HGNC:6285] | 22047 | 0.000 | -0.4849 | No |
| 43 | GRIK3 | glutamate ionotropic receptor kainate type subunit 3 [Source:HGNC Symbol;Acc:HGNC:4581] | 22483 | 0.000 | -0.4966 | No |
| 44 | GRIK1 | glutamate ionotropic receptor kainate type subunit 1 [Source:HGNC Symbol;Acc:HGNC:4579] | 22485 | 0.000 | -0.4967 | No |
| 45 | GRIK2 | glutamate ionotropic receptor kainate type subunit 2 [Source:HGNC Symbol;Acc:HGNC:4580] | 22486 | 0.000 | -0.4967 | No |
| 46 | GABRR1 | gamma-aminobutyric acid type A receptor subunit rho1 [Source:HGNC Symbol;Acc:HGNC:4090] | 24847 | 0.000 | -0.5604 | No |
| 47 | CLCNKB | chloride voltage-gated channel Kb [Source:HGNC Symbol;Acc:HGNC:2027] | 24927 | 0.000 | -0.5625 | No |
| 48 | CACNB4 | calcium voltage-gated channel auxiliary subunit beta 4 [Source:HGNC Symbol;Acc:HGNC:1404] | 25344 | 0.000 | -0.5738 | No |
| 49 | CACNG1 | calcium voltage-gated channel auxiliary subunit gamma 1 [Source:HGNC Symbol;Acc:HGNC:1405] | 25392 | 0.000 | -0.5750 | No |
| 50 | SHROOM2 | shroom family member 2 [Source:HGNC Symbol;Acc:HGNC:630] | 25788 | 0.000 | -0.5857 | No |
| 51 | GJC2 | gap junction protein gamma 2 [Source:HGNC Symbol;Acc:HGNC:17494] | 25845 | 0.000 | -0.5872 | No |
| 52 | GJB1 | gap junction protein beta 1 [Source:HGNC Symbol;Acc:HGNC:4283] | 25854 | 0.000 | -0.5874 | No |
| 53 | GJB5 | gap junction protein beta 5 [Source:HGNC Symbol;Acc:HGNC:4287] | 25859 | 0.000 | -0.5876 | No |
| 54 | TPTE | transmembrane phosphatase with tensin homology [Source:HGNC Symbol;Acc:HGNC:12023] | 25944 | 0.000 | -0.5898 | No |
| 55 | GABRG2 | gamma-aminobutyric acid type A receptor subunit gamma2 [Source:HGNC Symbol;Acc:HGNC:4087] | 29303 | -0.243 | -0.6737 | No |
| 56 | RYR1 | ryanodine receptor 1 [Source:HGNC Symbol;Acc:HGNC:10483] | 30285 | -0.389 | -0.6894 | No |
| 57 | CLCNKA | chloride voltage-gated channel Ka [Source:HGNC Symbol;Acc:HGNC:2026] | 32808 | -1.135 | -0.7259 | Yes |
| 58 | CLCN2 | chloride voltage-gated channel 2 [Source:HGNC Symbol;Acc:HGNC:2020] | 32879 | -1.157 | -0.6955 | Yes |
| 59 | SCN1B | sodium voltage-gated channel beta subunit 1 [Source:HGNC Symbol;Acc:HGNC:10586] | 33637 | -1.448 | -0.6756 | Yes |
| 60 | KCNAB2 | potassium voltage-gated channel subfamily A regulatory beta subunit 2 [Source:HGNC Symbol;Acc:HGNC:6229] | 33690 | -1.468 | -0.6361 | Yes |
| 61 | CHRNB4 | cholinergic receptor nicotinic beta 4 subunit [Source:HGNC Symbol;Acc:HGNC:1964] | 34583 | -1.941 | -0.6061 | Yes |
| 62 | P2RX3 | purinergic receptor P2X 3 [Source:HGNC Symbol;Acc:HGNC:8534] | 34850 | -2.012 | -0.5572 | Yes |
| 63 | GABRD | gamma-aminobutyric acid type A receptor subunit delta [Source:HGNC Symbol;Acc:HGNC:4084] | 35054 | -2.140 | -0.5030 | Yes |
| 64 | KCNJ2 | potassium inwardly rectifying channel subfamily J member 2 [Source:HGNC Symbol;Acc:HGNC:6263] | 35509 | -2.454 | -0.4469 | Yes |
| 65 | FXYD2 | FXYD domain containing ion transport regulator 2 [Source:HGNC Symbol;Acc:HGNC:4026] | 36326 | -3.231 | -0.3789 | Yes |
| 66 | KCNC3 | potassium voltage-gated channel subfamily C member 3 [Source:HGNC Symbol;Acc:HGNC:6235] | 36358 | -3.270 | -0.2886 | Yes |
| 67 | SLC9A5 | solute carrier family 9 member A5 [Source:HGNC Symbol;Acc:HGNC:11078] | 36419 | -3.368 | -0.1963 | Yes |
| 68 | CHRNB1 | cholinergic receptor nicotinic beta 1 subunit [Source:HGNC Symbol;Acc:HGNC:1961] | 36521 | -3.504 | -0.1014 | Yes |
| 69 | GRIN1 | glutamate ionotropic receptor NMDA type subunit 1 [Source:HGNC Symbol;Acc:HGNC:4584] | 36881 | -4.187 | 0.0056 | Yes |
