Fig 1: Enrichment plot: GOCC_IMMUNOGLOBULIN_COMPLEX_CIRCULATING
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | GOCC_IMMUNOGLOBULIN_COMPLEX_CIRCULATING |
| Enrichment Score (ES) | -0.9202787 |
| Normalized Enrichment Score (NES) | -1.8888903 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IGHV2-26 | immunoglobulin heavy variable 2-26 [Source:HGNC Symbol;Acc:HGNC:5575] | 6391 | 0.000 | -0.1726 | No |
| 2 | IGHV2-70 | immunoglobulin heavy variable 2-70 [Source:HGNC Symbol;Acc:HGNC:5577] | 6522 | 0.000 | -0.1761 | No |
| 3 | IGHV1-69 | immunoglobulin heavy variable 1-69 [Source:HGNC Symbol;Acc:HGNC:5558] | 7334 | 0.000 | -0.1980 | No |
| 4 | IGHV1-45 | immunoglobulin heavy variable 1-45 [Source:HGNC Symbol;Acc:HGNC:5553] | 7363 | 0.000 | -0.1988 | No |
| 5 | IGHV1-58 | immunoglobulin heavy variable 1-58 [Source:HGNC Symbol;Acc:HGNC:5555] | 7375 | 0.000 | -0.1991 | No |
| 6 | IGHV1-24 | immunoglobulin heavy variable 1-24 [Source:HGNC Symbol;Acc:HGNC:5551] | 7382 | 0.000 | -0.1992 | No |
| 7 | IGHV1-18 | immunoglobulin heavy variable 1-18 [Source:HGNC Symbol;Acc:HGNC:5549] | 7606 | 0.000 | -0.2052 | No |
| 8 | IGHV3-7 | immunoglobulin heavy variable 3-7 [Source:HGNC Symbol;Acc:HGNC:5620] | 9274 | 0.000 | -0.2503 | No |
| 9 | IGHV4-59 | immunoglobulin heavy variable 4-59 [Source:HGNC Symbol;Acc:HGNC:5654] | 11245 | 0.000 | -0.3035 | No |
| 10 | IGHV4-61 | immunoglobulin heavy variable 4-61 [Source:HGNC Symbol;Acc:HGNC:5655] | 11250 | 0.000 | -0.3036 | No |
| 11 | IGHV4-31 | immunoglobulin heavy variable 4-31 [Source:HGNC Symbol;Acc:HGNC:5649] | 11258 | 0.000 | -0.3038 | No |
| 12 | IGHV4-34 | immunoglobulin heavy variable 4-34 [Source:HGNC Symbol;Acc:HGNC:5650] | 11260 | 0.000 | -0.3038 | No |
| 13 | IGHV4-39 | immunoglobulin heavy variable 4-39 [Source:HGNC Symbol;Acc:HGNC:5651] | 11261 | 0.000 | -0.3038 | No |
| 14 | IGHV4-28 | immunoglobulin heavy variable 4-28 [Source:HGNC Symbol;Acc:HGNC:5645] | 11280 | 0.000 | -0.3043 | No |
| 15 | IGHD | immunoglobulin heavy constant delta [Source:HGNC Symbol;Acc:HGNC:5480] | 12541 | 0.000 | -0.3383 | No |
| 16 | IGHE | immunoglobulin heavy constant epsilon [Source:HGNC Symbol;Acc:HGNC:5522] | 12542 | 0.000 | -0.3383 | No |
| 17 | IGKC | immunoglobulin kappa constant [Source:HGNC Symbol;Acc:HGNC:5716] | 12547 | 0.000 | -0.3384 | No |
| 18 | IGHA1 | immunoglobulin heavy constant alpha 1 [Source:HGNC Symbol;Acc:HGNC:5478] | 17139 | 0.000 | -0.4624 | No |
| 19 | IGHA2 | immunoglobulin heavy constant alpha 2 (A2m marker) [Source:HGNC Symbol;Acc:HGNC:5479] | 17142 | 0.000 | -0.4624 | No |
| 20 | IGHG3 | immunoglobulin heavy constant gamma 3 (G3m marker) [Source:HGNC Symbol;Acc:HGNC:5527] | 17185 | 0.000 | -0.4636 | No |
| 21 | IGHG4 | immunoglobulin heavy constant gamma 4 (G4m marker) [Source:HGNC Symbol;Acc:HGNC:5528] | 17186 | 0.000 | -0.4636 | No |
| 22 | IGHG1 | immunoglobulin heavy constant gamma 1 (G1m marker) [Source:HGNC Symbol;Acc:HGNC:5525] | 17189 | 0.000 | -0.4636 | No |
| 23 | IGHG2 | immunoglobulin heavy constant gamma 2 (G2m marker) [Source:HGNC Symbol;Acc:HGNC:5526] | 17191 | 0.000 | -0.4637 | No |
| 24 | IGHV5-51 | immunoglobulin heavy variable 5-51 [Source:HGNC Symbol;Acc:HGNC:5659] | 17575 | 0.000 | -0.4740 | No |
| 25 | IGLC3 | immunoglobulin lambda constant 3 (Kern-Oz+ marker) [Source:HGNC Symbol;Acc:HGNC:5857] | 17767 | 0.000 | -0.4792 | No |
| 26 | IGLC1 | immunoglobulin lambda constant 1 [Source:HGNC Symbol;Acc:HGNC:5855] | 17770 | 0.000 | -0.4792 | No |
| 27 | IGLC2 | immunoglobulin lambda constant 2 [Source:HGNC Symbol;Acc:HGNC:5856] | 17771 | 0.000 | -0.4792 | No |
| 28 | IGLC7 | immunoglobulin lambda constant 7 [Source:HGNC Symbol;Acc:HGNC:5861] | 17792 | 0.000 | -0.4798 | No |
| 29 | IGLC6 | immunoglobulin lambda constant 6 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:5860] | 17795 | 0.000 | -0.4798 | No |
| 30 | IGHV3-20 | immunoglobulin heavy variable 3-20 [Source:HGNC Symbol;Acc:HGNC:5585] | 18042 | 0.000 | -0.4865 | No |
| 31 | IGHV3-21 | immunoglobulin heavy variable 3-21 [Source:HGNC Symbol;Acc:HGNC:5586] | 18043 | 0.000 | -0.4865 | No |
| 32 | IGHV3-23 | immunoglobulin heavy variable 3-23 [Source:HGNC Symbol;Acc:HGNC:5588] | 18045 | 0.000 | -0.4865 | No |
| 33 | IGHV3-30 | immunoglobulin heavy variable 3-30 [Source:HGNC Symbol;Acc:HGNC:5591] | 18063 | 0.000 | -0.4869 | No |
| 34 | IGHV3-33 | immunoglobulin heavy variable 3-33 [Source:HGNC Symbol;Acc:HGNC:5596] | 18066 | 0.000 | -0.4870 | No |
| 35 | IGHV3-35 | immunoglobulin heavy variable 3-35 (non-functional) [Source:HGNC Symbol;Acc:HGNC:5598] | 18068 | 0.000 | -0.4870 | No |
| 36 | IGHV3-38 | immunoglobulin heavy variable 3-38 (non-functional) [Source:HGNC Symbol;Acc:HGNC:5601] | 18074 | 0.000 | -0.4872 | No |
| 37 | IGHV3-11 | immunoglobulin heavy variable 3-11 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:5580] | 18105 | 0.000 | -0.4880 | No |
| 38 | IGHV3-13 | immunoglobulin heavy variable 3-13 [Source:HGNC Symbol;Acc:HGNC:5581] | 18108 | 0.000 | -0.4880 | No |
| 39 | IGHV3-15 | immunoglobulin heavy variable 3-15 [Source:HGNC Symbol;Acc:HGNC:5582] | 18110 | 0.000 | -0.4880 | No |
| 40 | IGHV3-16 | immunoglobulin heavy variable 3-16 (non-functional) [Source:HGNC Symbol;Acc:HGNC:5583] | 18111 | 0.000 | -0.4880 | No |
| 41 | IGHV3-64 | immunoglobulin heavy variable 3-64 [Source:HGNC Symbol;Acc:HGNC:5617] | 18259 | 0.000 | -0.4920 | No |
| 42 | IGHV3-66 | immunoglobulin heavy variable 3-66 [Source:HGNC Symbol;Acc:HGNC:5619] | 18261 | 0.000 | -0.4920 | No |
| 43 | IGHV3-72 | immunoglobulin heavy variable 3-72 [Source:HGNC Symbol;Acc:HGNC:5622] | 18270 | 0.000 | -0.4923 | No |
| 44 | IGHV3-73 | immunoglobulin heavy variable 3-73 [Source:HGNC Symbol;Acc:HGNC:5623] | 18271 | 0.000 | -0.4923 | No |
| 45 | IGHV3-74 | immunoglobulin heavy variable 3-74 [Source:HGNC Symbol;Acc:HGNC:5624] | 18272 | 0.000 | -0.4923 | No |
| 46 | IGHV3-43 | immunoglobulin heavy variable 3-43 [Source:HGNC Symbol;Acc:HGNC:5604] | 18283 | 0.000 | -0.4925 | No |
| 47 | IGHV3-48 | immunoglobulin heavy variable 3-48 [Source:HGNC Symbol;Acc:HGNC:5606] | 18286 | 0.000 | -0.4926 | No |
| 48 | IGHV3-49 | immunoglobulin heavy variable 3-49 [Source:HGNC Symbol;Acc:HGNC:5607] | 18287 | 0.000 | -0.4926 | No |
| 49 | IGHV3-53 | immunoglobulin heavy variable 3-53 [Source:HGNC Symbol;Acc:HGNC:5610] | 18295 | 0.000 | -0.4928 | No |
| 50 | IGLL5 | immunoglobulin lambda like polypeptide 5 [Source:HGNC Symbol;Acc:HGNC:38476] | 18496 | 0.000 | -0.4982 | No |
| 51 | IGLL1 | immunoglobulin lambda like polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:5870] | 18498 | 0.000 | -0.4982 | No |
| 52 | IGKV3-20 | immunoglobulin kappa variable 3-20 [Source:HGNC Symbol;Acc:HGNC:5817] | 22324 | 0.000 | -0.6015 | No |
| 53 | IGHV4-4 | immunoglobulin heavy variable 4-4 [Source:HGNC Symbol;Acc:HGNC:5652] | 22665 | 0.000 | -0.6107 | No |
| 54 | IGHV6-1 | immunoglobulin heavy variable 6-1 [Source:HGNC Symbol;Acc:HGNC:5662] | 23409 | 0.000 | -0.6307 | No |
| 55 | TRBC2 | T cell receptor beta constant 2 [Source:HGNC Symbol;Acc:HGNC:12157] | 24184 | 0.000 | -0.6517 | No |
| 56 | IGHV1-3 | immunoglobulin heavy variable 1-3 [Source:HGNC Symbol;Acc:HGNC:5552] | 24271 | 0.000 | -0.6540 | No |
| 57 | IGHV2-5 | immunoglobulin heavy variable 2-5 [Source:HGNC Symbol;Acc:HGNC:5576] | 24711 | 0.000 | -0.6658 | No |
| 58 | TRDC | T cell receptor delta constant [Source:HGNC Symbol;Acc:HGNC:12253] | 26582 | 0.000 | -0.7163 | No |
| 59 | IGHV7-81 | immunoglobulin heavy variable 7-81 (non-functional) [Source:HGNC Symbol;Acc:HGNC:5669] | 27657 | 0.000 | -0.7453 | No |
| 60 | PIGR | polymeric immunoglobulin receptor [Source:HGNC Symbol;Acc:HGNC:8968] | 27803 | 0.000 | -0.7493 | Yes |
| 61 | JCHAIN | joining chain of multimeric IgA and IgM [Source:HGNC Symbol;Acc:HGNC:5713] | 34137 | -1.688 | -0.5985 | Yes |
| 62 | IGHM | immunoglobulin heavy constant mu [Source:HGNC Symbol;Acc:HGNC:5541] | 36554 | -3.558 | 0.0145 | Yes |
