Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_BILE_ACID_METABOLISM |
| Enrichment Score (ES) | -0.57910955 |
| Normalized Enrichment Score (NES) | -1.2577547 |
| Nominal p-value | 0.06998814 |
| FDR q-value | 0.3168053 |
| FWER p-Value | 0.902 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ABCA1 | ATP binding cassette subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:29] | 131 | 4.307 | 0.0281 | No |
| 2 | TFCP2L1 | transcription factor CP2 like 1 [Source:HGNC Symbol;Acc:HGNC:17925] | 232 | 3.800 | 0.0534 | No |
| 3 | AQP9 | aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] | 302 | 3.473 | 0.0771 | No |
| 4 | ATXN1 | ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] | 328 | 3.403 | 0.1014 | No |
| 5 | HAO1 | hydroxyacid oxidase 1 [Source:HGNC Symbol;Acc:HGNC:4809] | 423 | 3.161 | 0.1222 | No |
| 6 | BCAR3 | BCAR3 adaptor protein, NSP family member [Source:HGNC Symbol;Acc:HGNC:973] | 709 | 2.618 | 0.1337 | No |
| 7 | GCLM | glutamate-cysteine ligase modifier subunit [Source:HGNC Symbol;Acc:HGNC:4312] | 1014 | 2.184 | 0.1416 | No |
| 8 | LCK | LCK proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6524] | 1024 | 2.169 | 0.1573 | No |
| 9 | PRDX5 | peroxiredoxin 5 [Source:HGNC Symbol;Acc:HGNC:9355] | 1706 | 1.532 | 0.1501 | No |
| 10 | ACSL1 | acyl-CoA synthetase long chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] | 1730 | 1.518 | 0.1607 | No |
| 11 | PEX12 | peroxisomal biogenesis factor 12 [Source:HGNC Symbol;Acc:HGNC:8854] | 2318 | 1.263 | 0.1541 | No |
| 12 | CH25H | cholesterol 25-hydroxylase [Source:HGNC Symbol;Acc:HGNC:1907] | 2683 | 1.074 | 0.1522 | No |
| 13 | PEX11A | peroxisomal biogenesis factor 11 alpha [Source:HGNC Symbol;Acc:HGNC:8852] | 3280 | 0.842 | 0.1422 | No |
| 14 | ALDH8A1 | aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471] | 4637 | 0.432 | 0.1087 | No |
| 15 | PEX19 | peroxisomal biogenesis factor 19 [Source:HGNC Symbol;Acc:HGNC:9713] | 4639 | 0.431 | 0.1119 | No |
| 16 | LIPE | lipase E, hormone sensitive type [Source:HGNC Symbol;Acc:HGNC:6621] | 4938 | 0.358 | 0.1065 | No |
| 17 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 5121 | 0.307 | 0.1038 | No |
| 18 | SOAT2 | sterol O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:11178] | 5167 | 0.292 | 0.1047 | No |
| 19 | PIPOX | pipecolic acid and sarcosine oxidase [Source:HGNC Symbol;Acc:HGNC:17804] | 5187 | 0.288 | 0.1063 | No |
| 20 | PEX13 | peroxisomal biogenesis factor 13 [Source:HGNC Symbol;Acc:HGNC:8855] | 5618 | 0.186 | 0.0961 | No |
| 21 | AR | androgen receptor [Source:HGNC Symbol;Acc:HGNC:644] | 6103 | 0.066 | 0.0835 | No |
| 22 | RXRA | retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] | 6307 | 0.014 | 0.0781 | No |
| 23 | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 8026 | 0.000 | 0.0316 | No |
| 24 | GSTK1 | glutathione S-transferase kappa 1 [Source:HGNC Symbol;Acc:HGNC:16906] | 9702 | 0.000 | -0.0137 | No |
| 25 | SLC23A1 | solute carrier family 23 member 1 [Source:HGNC Symbol;Acc:HGNC:10974] | 9903 | 0.000 | -0.0191 | No |
| 26 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 10197 | 0.000 | -0.0270 | No |
| 27 | NEDD4 | NEDD4 E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727] | 10544 | 0.000 | -0.0364 | No |
| 28 | SLC27A2 | solute carrier family 27 member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 10997 | 0.000 | -0.0486 | No |
| 29 | AKR1D1 | aldo-keto reductase family 1 member D1 [Source:HGNC Symbol;Acc:HGNC:388] | 11643 | 0.000 | -0.0660 | No |
| 30 | AGXT | alanine--glyoxylate and serine--pyruvate aminotransferase [Source:HGNC Symbol;Acc:HGNC:341] | 12280 | 0.000 | -0.0832 | No |
| 31 | CYP39A1 | cytochrome P450 family 39 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:17449] | 12488 | 0.000 | -0.0888 | No |
| 32 | HSD3B1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5217] | 12627 | 0.000 | -0.0925 | No |
| 33 | TTR | transthyretin [Source:HGNC Symbol;Acc:HGNC:12405] | 12750 | 0.000 | -0.0958 | No |
| 34 | RBP1 | retinol binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9919] | 12911 | 0.000 | -0.1002 | No |
| 35 | DIO1 | iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883] | 15822 | 0.000 | -0.1789 | No |
| 36 | DIO2 | iodothyronine deiodinase 2 [Source:HGNC Symbol;Acc:HGNC:2884] | 15823 | 0.000 | -0.1789 | No |
| 37 | GC | GC vitamin D binding protein [Source:HGNC Symbol;Acc:HGNC:4187] | 16179 | 0.000 | -0.1885 | No |
| 38 | SERPINA6 | serpin family A member 6 [Source:HGNC Symbol;Acc:HGNC:1540] | 17829 | 0.000 | -0.2331 | No |
| 39 | OPTN | optineurin [Source:HGNC Symbol;Acc:HGNC:17142] | 18086 | 0.000 | -0.2400 | No |
| 40 | BMP6 | bone morphogenetic protein 6 [Source:HGNC Symbol;Acc:HGNC:1073] | 19144 | 0.000 | -0.2686 | No |
| 41 | HSD17B6 | hydroxysteroid 17-beta dehydrogenase 6 [Source:HGNC Symbol;Acc:HGNC:23316] | 19857 | 0.000 | -0.2878 | No |
| 42 | NR1H4 | nuclear receptor subfamily 1 group H member 4 [Source:HGNC Symbol;Acc:HGNC:7967] | 20069 | 0.000 | -0.2935 | No |
| 43 | SULT2B1 | sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] | 20866 | 0.000 | -0.3151 | No |
| 44 | SULT1B1 | sulfotransferase family 1B member 1 [Source:HGNC Symbol;Acc:HGNC:17845] | 21183 | 0.000 | -0.3236 | No |
| 45 | ALDH1A1 | aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] | 23003 | 0.000 | -0.3728 | No |
| 46 | CYP46A1 | cytochrome P450 family 46 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2641] | 23249 | 0.000 | -0.3794 | No |
| 47 | SLC22A18 | solute carrier family 22 member 18 [Source:HGNC Symbol;Acc:HGNC:10964] | 24109 | 0.000 | -0.4026 | No |
| 48 | ABCA6 | ATP binding cassette subfamily A member 6 [Source:HGNC Symbol;Acc:HGNC:36] | 24210 | 0.000 | -0.4053 | No |
| 49 | ABCA4 | ATP binding cassette subfamily A member 4 [Source:HGNC Symbol;Acc:HGNC:34] | 24213 | 0.000 | -0.4054 | No |
| 50 | ABCA9 | ATP binding cassette subfamily A member 9 [Source:HGNC Symbol;Acc:HGNC:39] | 24214 | 0.000 | -0.4054 | No |
| 51 | SLCO1A2 | solute carrier organic anion transporter family member 1A2 [Source:HGNC Symbol;Acc:HGNC:10956] | 24264 | 0.000 | -0.4067 | No |
| 52 | BBOX1 | gamma-butyrobetaine hydroxylase 1 [Source:HGNC Symbol;Acc:HGNC:964] | 25680 | 0.000 | -0.4450 | No |
| 53 | CYP8B1 | cytochrome P450 family 8 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2653] | 25734 | 0.000 | -0.4464 | No |
| 54 | CYP7B1 | cytochrome P450 family 7 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2652] | 26062 | 0.000 | -0.4553 | No |
| 55 | CYP7A1 | cytochrome P450 family 7 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2651] | 26085 | 0.000 | -0.4559 | No |
| 56 | ABCG8 | ATP binding cassette subfamily G member 8 [Source:HGNC Symbol;Acc:HGNC:13887] | 28309 | 0.000 | -0.5160 | No |
| 57 | PEX6 | peroxisomal biogenesis factor 6 [Source:HGNC Symbol;Acc:HGNC:8859] | 28523 | -0.043 | -0.5214 | No |
| 58 | ABCA8 | ATP binding cassette subfamily A member 8 [Source:HGNC Symbol;Acc:HGNC:38] | 28915 | -0.152 | -0.5309 | No |
| 59 | ACSL5 | acyl-CoA synthetase long chain family member 5 [Source:HGNC Symbol;Acc:HGNC:16526] | 29455 | -0.288 | -0.5433 | No |
| 60 | AMACR | alpha-methylacyl-CoA racemase [Source:HGNC Symbol;Acc:HGNC:451] | 30178 | -0.367 | -0.5602 | No |
| 61 | HSD17B11 | hydroxysteroid 17-beta dehydrogenase 11 [Source:HGNC Symbol;Acc:HGNC:22960] | 30616 | -0.479 | -0.5685 | No |
| 62 | ISOC1 | isochorismatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24254] | 30700 | -0.501 | -0.5670 | No |
| 63 | SOD1 | superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179] | 31017 | -0.594 | -0.5712 | No |
| 64 | NR1I2 | nuclear receptor subfamily 1 group I member 2 [Source:HGNC Symbol;Acc:HGNC:7968] | 31311 | -0.672 | -0.5742 | Yes |
| 65 | NR0B2 | nuclear receptor subfamily 0 group B member 2 [Source:HGNC Symbol;Acc:HGNC:7961] | 31374 | -0.696 | -0.5707 | Yes |
| 66 | PNPLA8 | patatin like phospholipase domain containing 8 [Source:HGNC Symbol;Acc:HGNC:28900] | 31507 | -0.734 | -0.5689 | Yes |
| 67 | PHYH | phytanoyl-CoA 2-hydroxylase [Source:HGNC Symbol;Acc:HGNC:8940] | 31656 | -0.776 | -0.5672 | Yes |
| 68 | GNPAT | glyceronephosphate O-acyltransferase [Source:HGNC Symbol;Acc:HGNC:4416] | 31910 | -0.851 | -0.5678 | Yes |
| 69 | SLC23A2 | solute carrier family 23 member 2 [Source:HGNC Symbol;Acc:HGNC:10973] | 31929 | -0.858 | -0.5619 | Yes |
| 70 | EFHC1 | EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16406] | 32027 | -0.883 | -0.5581 | Yes |
| 71 | KLF1 | Kruppel like factor 1 [Source:HGNC Symbol;Acc:HGNC:6345] | 32101 | -0.907 | -0.5534 | Yes |
| 72 | MLYCD | malonyl-CoA decarboxylase [Source:HGNC Symbol;Acc:HGNC:7150] | 32187 | -0.934 | -0.5488 | Yes |
| 73 | HSD17B4 | hydroxysteroid 17-beta dehydrogenase 4 [Source:HGNC Symbol;Acc:HGNC:5213] | 32403 | -1.002 | -0.5472 | Yes |
| 74 | PEX11G | peroxisomal biogenesis factor 11 gamma [Source:HGNC Symbol;Acc:HGNC:20208] | 32456 | -1.019 | -0.5411 | Yes |
| 75 | PEX7 | peroxisomal biogenesis factor 7 [Source:HGNC Symbol;Acc:HGNC:8860] | 32767 | -1.118 | -0.5413 | Yes |
| 76 | CAT | catalase [Source:HGNC Symbol;Acc:HGNC:1516] | 32898 | -1.165 | -0.5362 | Yes |
| 77 | LONP2 | lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] | 32973 | -1.193 | -0.5295 | Yes |
| 78 | ABCD3 | ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] | 33330 | -1.305 | -0.5295 | Yes |
| 79 | GNMT | glycine N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:4415] | 33340 | -1.309 | -0.5201 | Yes |
| 80 | PEX16 | peroxisomal biogenesis factor 16 [Source:HGNC Symbol;Acc:HGNC:8857] | 33480 | -1.377 | -0.5137 | Yes |
| 81 | FDXR | ferredoxin reductase [Source:HGNC Symbol;Acc:HGNC:3642] | 33615 | -1.440 | -0.5068 | Yes |
| 82 | PECR | peroxisomal trans-2-enoyl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:18281] | 33625 | -1.444 | -0.4964 | Yes |
| 83 | SLC27A5 | solute carrier family 27 member 5 [Source:HGNC Symbol;Acc:HGNC:10999] | 33764 | -1.503 | -0.4891 | Yes |
| 84 | SCP2 | sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] | 33990 | -1.614 | -0.4833 | Yes |
| 85 | RETSAT | retinol saturase [Source:HGNC Symbol;Acc:HGNC:25991] | 34151 | -1.695 | -0.4751 | Yes |
| 86 | RXRG | retinoid X receptor gamma [Source:HGNC Symbol;Acc:HGNC:10479] | 34247 | -1.740 | -0.4649 | Yes |
| 87 | IDH2 | isocitrate dehydrogenase (NADP(+)) 2 [Source:HGNC Symbol;Acc:HGNC:5383] | 34291 | -1.761 | -0.4531 | Yes |
| 88 | ABCG4 | ATP binding cassette subfamily G member 4 [Source:HGNC Symbol;Acc:HGNC:13884] | 34440 | -1.850 | -0.4435 | Yes |
| 89 | ABCA5 | ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35] | 34515 | -1.896 | -0.4315 | Yes |
| 90 | ALDH9A1 | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] | 34541 | -1.916 | -0.4181 | Yes |
| 91 | PEX26 | peroxisomal biogenesis factor 26 [Source:HGNC Symbol;Acc:HGNC:22965] | 34596 | -1.945 | -0.4053 | Yes |
| 92 | NPC1 | NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897] | 34815 | -1.989 | -0.3965 | Yes |
| 93 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 34911 | -2.047 | -0.3840 | Yes |
| 94 | FADS1 | fatty acid desaturase 1 [Source:HGNC Symbol;Acc:HGNC:3574] | 34930 | -2.058 | -0.3694 | Yes |
| 95 | NUDT12 | nudix hydrolase 12 [Source:HGNC Symbol;Acc:HGNC:18826] | 34978 | -2.090 | -0.3553 | Yes |
| 96 | PEX1 | peroxisomal biogenesis factor 1 [Source:HGNC Symbol;Acc:HGNC:8850] | 35042 | -2.131 | -0.3413 | Yes |
| 97 | ABCA3 | ATP binding cassette subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:33] | 35049 | -2.135 | -0.3258 | Yes |
| 98 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 35254 | -2.276 | -0.3145 | Yes |
| 99 | SLC35B2 | solute carrier family 35 member B2 [Source:HGNC Symbol;Acc:HGNC:16872] | 35460 | -2.410 | -0.3024 | Yes |
| 100 | DHCR24 | 24-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2859] | 35557 | -2.490 | -0.2866 | Yes |
| 101 | ABCD1 | ATP binding cassette subfamily D member 1 [Source:HGNC Symbol;Acc:HGNC:61] | 35761 | -2.661 | -0.2725 | Yes |
| 102 | SLC29A1 | solute carrier family 29 member 1 (Augustine blood group) [Source:HGNC Symbol;Acc:HGNC:11003] | 36045 | -2.930 | -0.2586 | Yes |
| 103 | PXMP2 | peroxisomal membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:9716] | 36115 | -2.992 | -0.2385 | Yes |
| 104 | PAOX | polyamine oxidase [Source:HGNC Symbol;Acc:HGNC:20837] | 36418 | -3.367 | -0.2219 | Yes |
| 105 | CYP27A1 | cytochrome P450 family 27 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2605] | 36580 | -3.609 | -0.1997 | Yes |
| 106 | CROT | carnitine O-octanoyltransferase [Source:HGNC Symbol;Acc:HGNC:2366] | 36592 | -3.627 | -0.1733 | Yes |
| 107 | HACL1 | 2-hydroxyacyl-CoA lyase 1 [Source:HGNC Symbol;Acc:HGNC:17856] | 36761 | -3.924 | -0.1490 | Yes |
| 108 | IDH1 | isocitrate dehydrogenase (NADP(+)) 1 [Source:HGNC Symbol;Acc:HGNC:5382] | 36786 | -3.986 | -0.1203 | Yes |
| 109 | PFKM | phosphofructokinase, muscle [Source:HGNC Symbol;Acc:HGNC:8877] | 36870 | -4.156 | -0.0920 | Yes |
| 110 | HSD3B7 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [Source:HGNC Symbol;Acc:HGNC:18324] | 36883 | -4.190 | -0.0615 | Yes |
| 111 | NR3C2 | nuclear receptor subfamily 3 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7979] | 36944 | -4.357 | -0.0310 | Yes |
| 112 | ABCD2 | ATP binding cassette subfamily D member 2 [Source:HGNC Symbol;Acc:HGNC:66] | 37040 | -4.753 | 0.0014 | Yes |
