Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_NA |
| GeneSet | HALLMARK_CHOLESTEROL_HOMEOSTASIS |
| Enrichment Score (ES) | -0.49239448 |
| Normalized Enrichment Score (NES) | -1.0199201 |
| Nominal p-value | 0.44117647 |
| FDR q-value | 0.6834939 |
| FWER p-Value | 1.0 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | ACTG1 | actin gamma 1 [Source:HGNC Symbol;Acc:HGNC:144] | 382 | 3.251 | 0.0210 | No |
| 2 | ERRFI1 | ERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185] | 478 | 3.079 | 0.0480 | No |
| 3 | PPARG | peroxisome proliferator activated receptor gamma [Source:HGNC Symbol;Acc:HGNC:9236] | 762 | 2.531 | 0.0647 | No |
| 4 | ATF3 | activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] | 776 | 2.508 | 0.0885 | No |
| 5 | ATF5 | activating transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:790] | 982 | 2.231 | 0.1045 | No |
| 6 | LDLR | low density lipoprotein receptor [Source:HGNC Symbol;Acc:HGNC:6547] | 1018 | 2.177 | 0.1245 | No |
| 7 | TRIB3 | tribbles pseudokinase 3 [Source:HGNC Symbol;Acc:HGNC:16228] | 1220 | 1.934 | 0.1376 | No |
| 8 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 1235 | 1.913 | 0.1557 | No |
| 9 | S100A11 | S100 calcium binding protein A11 [Source:HGNC Symbol;Acc:HGNC:10488] | 1321 | 1.856 | 0.1712 | No |
| 10 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 1491 | 1.692 | 0.1830 | No |
| 11 | LPL | lipoprotein lipase [Source:HGNC Symbol;Acc:HGNC:6677] | 1724 | 1.521 | 0.1913 | No |
| 12 | CHKA | choline kinase alpha [Source:HGNC Symbol;Acc:HGNC:1937] | 1797 | 1.478 | 0.2036 | No |
| 13 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:5006] | 2154 | 1.371 | 0.2072 | No |
| 14 | ALCAM | activated leukocyte cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:400] | 2233 | 1.322 | 0.2178 | No |
| 15 | PLSCR1 | phospholipid scramblase 1 [Source:HGNC Symbol;Acc:HGNC:9092] | 2684 | 1.073 | 0.2160 | No |
| 16 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 2800 | 1.023 | 0.2227 | No |
| 17 | GNAI1 | G protein subunit alpha i1 [Source:HGNC Symbol;Acc:HGNC:4384] | 3298 | 0.837 | 0.2173 | No |
| 18 | CTNNB1 | catenin beta 1 [Source:HGNC Symbol;Acc:HGNC:2514] | 3660 | 0.702 | 0.2143 | No |
| 19 | ANXA5 | annexin A5 [Source:HGNC Symbol;Acc:HGNC:543] | 4361 | 0.507 | 0.2003 | No |
| 20 | NFIL3 | nuclear factor, interleukin 3 regulated [Source:HGNC Symbol;Acc:HGNC:7787] | 4596 | 0.442 | 0.1982 | No |
| 21 | ANTXR2 | ANTXR cell adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:21732] | 4633 | 0.433 | 0.2014 | No |
| 22 | IDI1 | isopentenyl-diphosphate delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:5387] | 5121 | 0.307 | 0.1912 | No |
| 23 | SC5D | sterol-C5-desaturase [Source:HGNC Symbol;Acc:HGNC:10547] | 5313 | 0.262 | 0.1886 | No |
| 24 | FASN | fatty acid synthase [Source:HGNC Symbol;Acc:HGNC:3594] | 5325 | 0.259 | 0.1908 | No |
| 25 | CYP51A1 | cytochrome P450 family 51 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2649] | 5691 | 0.169 | 0.1826 | No |
| 26 | PMVK | phosphomevalonate kinase [Source:HGNC Symbol;Acc:HGNC:9141] | 5905 | 0.122 | 0.1780 | No |
| 27 | TMEM97 | transmembrane protein 97 [Source:HGNC Symbol;Acc:HGNC:28106] | 6205 | 0.042 | 0.1703 | No |
| 28 | FBXO6 | F-box protein 6 [Source:HGNC Symbol;Acc:HGNC:13585] | 6875 | 0.000 | 0.1522 | No |
| 29 | GPX8 | glutathione peroxidase 8 (putative) [Source:HGNC Symbol;Acc:HGNC:33100] | 9533 | 0.000 | 0.0804 | No |
| 30 | GSTM2 | glutathione S-transferase mu 2 [Source:HGNC Symbol;Acc:HGNC:4634] | 9715 | 0.000 | 0.0756 | No |
| 31 | ADH4 | alcohol dehydrogenase 4 (class II), pi polypeptide [Source:HGNC Symbol;Acc:HGNC:252] | 11197 | 0.000 | 0.0356 | No |
| 32 | ANXA13 | annexin A13 [Source:HGNC Symbol;Acc:HGNC:536] | 14397 | 0.000 | -0.0509 | No |
| 33 | AVPR1A | arginine vasopressin receptor 1A [Source:HGNC Symbol;Acc:HGNC:895] | 16643 | 0.000 | -0.1115 | No |
| 34 | SEMA3B | semaphorin 3B [Source:HGNC Symbol;Acc:HGNC:10724] | 17905 | 0.000 | -0.1456 | No |
| 35 | CXCL16 | C-X-C motif chemokine ligand 16 [Source:HGNC Symbol;Acc:HGNC:16642] | 18950 | 0.000 | -0.1738 | No |
| 36 | PLAUR | plasminogen activator, urokinase receptor [Source:HGNC Symbol;Acc:HGNC:9053] | 22998 | 0.000 | -0.2831 | No |
| 37 | MAL2 | mal, T cell differentiation protein 2 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:13634] | 24725 | 0.000 | -0.3297 | No |
| 38 | GUSB | glucuronidase beta [Source:HGNC Symbol;Acc:HGNC:4696] | 29130 | -0.207 | -0.4467 | No |
| 39 | GLDC | glycine decarboxylase [Source:HGNC Symbol;Acc:HGNC:4313] | 29897 | -0.320 | -0.4643 | No |
| 40 | HSD17B7 | hydroxysteroid 17-beta dehydrogenase 7 [Source:HGNC Symbol;Acc:HGNC:5215] | 29926 | -0.320 | -0.4620 | No |
| 41 | SQLE | squalene epoxidase [Source:HGNC Symbol;Acc:HGNC:11279] | 31052 | -0.603 | -0.4866 | Yes |
| 42 | HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 [Source:HGNC Symbol;Acc:HGNC:5007] | 31140 | -0.626 | -0.4829 | Yes |
| 43 | LSS | lanosterol synthase [Source:HGNC Symbol;Acc:HGNC:6708] | 31389 | -0.699 | -0.4829 | Yes |
| 44 | FDFT1 | farnesyl-diphosphate farnesyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:3629] | 31432 | -0.708 | -0.4772 | Yes |
| 45 | SREBF2 | sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:11290] | 31464 | -0.721 | -0.4711 | Yes |
| 46 | NIBAN1 | niban apoptosis regulator 1 [Source:HGNC Symbol;Acc:HGNC:16784] | 31537 | -0.746 | -0.4659 | Yes |
| 47 | STX5 | syntaxin 5 [Source:HGNC Symbol;Acc:HGNC:11440] | 31576 | -0.756 | -0.4596 | Yes |
| 48 | FDPS | farnesyl diphosphate synthase [Source:HGNC Symbol;Acc:HGNC:3631] | 31610 | -0.767 | -0.4531 | Yes |
| 49 | NSDHL | NAD(P) dependent steroid dehydrogenase-like [Source:HGNC Symbol;Acc:HGNC:13398] | 32387 | -0.997 | -0.4645 | Yes |
| 50 | CPEB2 | cytoplasmic polyadenylation element binding protein 2 [Source:HGNC Symbol;Acc:HGNC:21745] | 32670 | -1.077 | -0.4618 | Yes |
| 51 | MVK | mevalonate kinase [Source:HGNC Symbol;Acc:HGNC:7530] | 33004 | -1.206 | -0.4592 | Yes |
| 52 | ATXN2 | ataxin 2 [Source:HGNC Symbol;Acc:HGNC:10555] | 33645 | -1.453 | -0.4625 | Yes |
| 53 | PDK3 | pyruvate dehydrogenase kinase 3 [Source:HGNC Symbol;Acc:HGNC:8811] | 33833 | -1.537 | -0.4527 | Yes |
| 54 | STARD4 | StAR related lipid transfer domain containing 4 [Source:HGNC Symbol;Acc:HGNC:18058] | 34323 | -1.780 | -0.4488 | Yes |
| 55 | ALDOC | aldolase, fructose-bisphosphate C [Source:HGNC Symbol;Acc:HGNC:418] | 34388 | -1.817 | -0.4331 | Yes |
| 56 | ACAT2 | acetyl-CoA acetyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:94] | 34433 | -1.844 | -0.4165 | Yes |
| 57 | PCYT2 | phosphate cytidylyltransferase 2, ethanolamine [Source:HGNC Symbol;Acc:HGNC:8756] | 34476 | -1.874 | -0.3996 | Yes |
| 58 | LGALS3 | galectin 3 [Source:HGNC Symbol;Acc:HGNC:6563] | 34774 | -1.959 | -0.3888 | Yes |
| 59 | ABCA2 | ATP binding cassette subfamily A member 2 [Source:HGNC Symbol;Acc:HGNC:32] | 34911 | -2.047 | -0.3727 | Yes |
| 60 | MVD | mevalonate diphosphate decarboxylase [Source:HGNC Symbol;Acc:HGNC:7529] | 34934 | -2.059 | -0.3535 | Yes |
| 61 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 34985 | -2.094 | -0.3347 | Yes |
| 62 | FADS2 | fatty acid desaturase 2 [Source:HGNC Symbol;Acc:HGNC:3575] | 35254 | -2.276 | -0.3201 | Yes |
| 63 | CBS | cystathionine beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550] | 35505 | -2.450 | -0.3032 | Yes |
| 64 | EBP | EBP cholestenol delta-isomerase [Source:HGNC Symbol;Acc:HGNC:3133] | 35533 | -2.472 | -0.2802 | Yes |
| 65 | DHCR7 | 7-dehydrocholesterol reductase [Source:HGNC Symbol;Acc:HGNC:2860] | 35613 | -2.535 | -0.2579 | Yes |
| 66 | ECH1 | enoyl-CoA hydratase 1 [Source:HGNC Symbol;Acc:HGNC:3149] | 35741 | -2.646 | -0.2359 | Yes |
| 67 | ACSS2 | acyl-CoA synthetase short chain family member 2 [Source:HGNC Symbol;Acc:HGNC:15814] | 36188 | -3.083 | -0.2183 | Yes |
| 68 | ETHE1 | ETHE1 persulfide dioxygenase [Source:HGNC Symbol;Acc:HGNC:23287] | 36245 | -3.142 | -0.1895 | Yes |
| 69 | JAG1 | jagged canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:6188] | 36261 | -3.182 | -0.1593 | Yes |
| 70 | TP53INP1 | tumor protein p53 inducible nuclear protein 1 [Source:HGNC Symbol;Acc:HGNC:18022] | 36415 | -3.365 | -0.1311 | Yes |
| 71 | PNRC1 | proline rich nuclear receptor coactivator 1 [Source:HGNC Symbol;Acc:HGNC:17278] | 36471 | -3.446 | -0.0994 | Yes |
| 72 | TM7SF2 | transmembrane 7 superfamily member 2 [Source:HGNC Symbol;Acc:HGNC:11863] | 36615 | -3.668 | -0.0680 | Yes |
| 73 | SCD | stearoyl-CoA desaturase [Source:HGNC Symbol;Acc:HGNC:10571] | 36682 | -3.791 | -0.0333 | Yes |
| 74 | FABP5 | fatty acid binding protein 5 [Source:HGNC Symbol;Acc:HGNC:3560] | 37005 | -4.598 | 0.0023 | Yes |
