Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | HALLMARK_COAGULATION |
| Enrichment Score (ES) | 0.48377585 |
| Normalized Enrichment Score (NES) | 1.2597208 |
| Nominal p-value | 0.027586207 |
| FDR q-value | 0.101215966 |
| FWER p-Value | 0.33 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | SERPINB2 | serpin family B member 2 [Source:HGNC Symbol;Acc:HGNC:8584] | 54 | 4.750 | 0.0352 | Yes |
| 2 | MMP9 | matrix metallopeptidase 9 [Source:HGNC Symbol;Acc:HGNC:7176] | 66 | 4.648 | 0.0707 | Yes |
| 3 | TIMP1 | TIMP metallopeptidase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:11820] | 83 | 4.578 | 0.1056 | Yes |
| 4 | PDGFB | platelet derived growth factor subunit B [Source:HGNC Symbol;Acc:HGNC:8800] | 104 | 4.459 | 0.1394 | Yes |
| 5 | FURIN | furin, paired basic amino acid cleaving enzyme [Source:HGNC Symbol;Acc:HGNC:8568] | 136 | 4.283 | 0.1716 | Yes |
| 6 | CFB | complement factor B [Source:HGNC Symbol;Acc:HGNC:1037] | 196 | 3.925 | 0.2003 | Yes |
| 7 | MMP14 | matrix metallopeptidase 14 [Source:HGNC Symbol;Acc:HGNC:7160] | 229 | 3.810 | 0.2288 | Yes |
| 8 | SERPINE1 | serpin family E member 1 [Source:HGNC Symbol;Acc:HGNC:8583] | 239 | 3.764 | 0.2576 | Yes |
| 9 | MSRB2 | methionine sulfoxide reductase B2 [Source:HGNC Symbol;Acc:HGNC:17061] | 283 | 3.551 | 0.2838 | Yes |
| 10 | FBN1 | fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] | 317 | 3.408 | 0.3092 | Yes |
| 11 | SERPINC1 | serpin family C member 1 [Source:HGNC Symbol;Acc:HGNC:775] | 413 | 3.187 | 0.3312 | Yes |
| 12 | GNG12 | G protein subunit gamma 12 [Source:HGNC Symbol;Acc:HGNC:19663] | 650 | 2.738 | 0.3459 | Yes |
| 13 | PLEK | pleckstrin [Source:HGNC Symbol;Acc:HGNC:9070] | 781 | 2.497 | 0.3617 | Yes |
| 14 | WDR1 | WD repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:12754] | 1153 | 2.006 | 0.3671 | Yes |
| 15 | MAFF | MAF bZIP transcription factor F [Source:HGNC Symbol;Acc:HGNC:6780] | 1244 | 1.908 | 0.3794 | Yes |
| 16 | MMP2 | matrix metallopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:7166] | 1258 | 1.893 | 0.3936 | Yes |
| 17 | THBS1 | thrombospondin 1 [Source:HGNC Symbol;Acc:HGNC:11785] | 1360 | 1.810 | 0.4048 | Yes |
| 18 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 1491 | 1.692 | 0.4144 | Yes |
| 19 | CTSH | cathepsin H [Source:HGNC Symbol;Acc:HGNC:2535] | 1538 | 1.659 | 0.4259 | Yes |
| 20 | C3 | complement C3 [Source:HGNC Symbol;Acc:HGNC:1318] | 1949 | 1.391 | 0.4256 | Yes |
| 21 | F9 | coagulation factor IX [Source:HGNC Symbol;Acc:HGNC:3551] | 2255 | 1.307 | 0.4274 | Yes |
| 22 | MST1 | macrophage stimulating 1 [Source:HGNC Symbol;Acc:HGNC:7380] | 2282 | 1.286 | 0.4366 | Yes |
| 23 | CTSV | cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538] | 2516 | 1.160 | 0.4392 | Yes |
| 24 | F3 | coagulation factor III, tissue factor [Source:HGNC Symbol;Acc:HGNC:3541] | 2682 | 1.074 | 0.4430 | Yes |
| 25 | PROS1 | protein S [Source:HGNC Symbol;Acc:HGNC:9456] | 2737 | 1.053 | 0.4497 | Yes |
| 26 | CLU | clusterin [Source:HGNC Symbol;Acc:HGNC:2095] | 2800 | 1.023 | 0.4559 | Yes |
| 27 | ANXA1 | annexin A1 [Source:HGNC Symbol;Acc:HGNC:533] | 2905 | 0.975 | 0.4606 | Yes |
| 28 | RABIF | RAB interacting factor [Source:HGNC Symbol;Acc:HGNC:9797] | 3179 | 0.876 | 0.4600 | Yes |
| 29 | ADAM9 | ADAM metallopeptidase domain 9 [Source:HGNC Symbol;Acc:HGNC:216] | 3210 | 0.863 | 0.4658 | Yes |
| 30 | F10 | coagulation factor X [Source:HGNC Symbol;Acc:HGNC:3528] | 3242 | 0.854 | 0.4716 | Yes |
| 31 | F8 | coagulation factor VIII [Source:HGNC Symbol;Acc:HGNC:3546] | 3682 | 0.693 | 0.4650 | Yes |
| 32 | CRIP2 | cysteine rich protein 2 [Source:HGNC Symbol;Acc:HGNC:2361] | 3708 | 0.689 | 0.4697 | Yes |
| 33 | GNB2 | G protein subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:4398] | 3780 | 0.686 | 0.4730 | Yes |
| 34 | FYN | FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] | 3783 | 0.685 | 0.4783 | Yes |
| 35 | CTSK | cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536] | 3787 | 0.684 | 0.4835 | Yes |
| 36 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 3954 | 0.623 | 0.4838 | Yes |
| 37 | RAC1 | Rac family small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:9801] | 4276 | 0.524 | 0.4791 | No |
| 38 | PREP | prolyl endopeptidase [Source:HGNC Symbol;Acc:HGNC:9358] | 4338 | 0.513 | 0.4814 | No |
| 39 | CPN1 | carboxypeptidase N subunit 1 [Source:HGNC Symbol;Acc:HGNC:2312] | 4869 | 0.377 | 0.4700 | No |
| 40 | FN1 | fibronectin 1 [Source:HGNC Symbol;Acc:HGNC:3778] | 5177 | 0.291 | 0.4639 | No |
| 41 | ARF4 | ADP ribosylation factor 4 [Source:HGNC Symbol;Acc:HGNC:655] | 5289 | 0.268 | 0.4630 | No |
| 42 | RAPGEF3 | Rap guanine nucleotide exchange factor 3 [Source:HGNC Symbol;Acc:HGNC:16629] | 6720 | 0.000 | 0.4243 | No |
| 43 | PLAT | plasminogen activator, tissue type [Source:HGNC Symbol;Acc:HGNC:9051] | 9976 | 0.000 | 0.3362 | No |
| 44 | APOA1 | apolipoprotein A1 [Source:HGNC Symbol;Acc:HGNC:600] | 10197 | 0.000 | 0.3303 | No |
| 45 | APOC3 | apolipoprotein C3 [Source:HGNC Symbol;Acc:HGNC:610] | 10213 | 0.000 | 0.3299 | No |
| 46 | APOC2 | apolipoprotein C2 [Source:HGNC Symbol;Acc:HGNC:609] | 10215 | 0.000 | 0.3298 | No |
| 47 | APOC1 | apolipoprotein C1 [Source:HGNC Symbol;Acc:HGNC:607] | 10216 | 0.000 | 0.3298 | No |
| 48 | F13B | coagulation factor XIII B chain [Source:HGNC Symbol;Acc:HGNC:3534] | 10950 | 0.000 | 0.3100 | No |
| 49 | KLKB1 | kallikrein B1 [Source:HGNC Symbol;Acc:HGNC:6371] | 11224 | 0.000 | 0.3026 | No |
| 50 | TMPRSS6 | transmembrane serine protease 6 [Source:HGNC Symbol;Acc:HGNC:16517] | 11640 | 0.000 | 0.2914 | No |
| 51 | PROZ | protein Z, vitamin K dependent plasma glycoprotein [Source:HGNC Symbol;Acc:HGNC:9460] | 11687 | 0.000 | 0.2901 | No |
| 52 | PROC | protein C, inactivator of coagulation factors Va and VIIIa [Source:HGNC Symbol;Acc:HGNC:9451] | 11705 | 0.000 | 0.2897 | No |
| 53 | THBD | thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784] | 12737 | 0.000 | 0.2618 | No |
| 54 | P2RY1 | purinergic receptor P2Y1 [Source:HGNC Symbol;Acc:HGNC:8539] | 14206 | 0.000 | 0.2220 | No |
| 55 | MBL2 | mannose binding lectin 2 [Source:HGNC Symbol;Acc:HGNC:6922] | 15597 | 0.000 | 0.1844 | No |
| 56 | C8B | complement C8 beta chain [Source:HGNC Symbol;Acc:HGNC:1353] | 15667 | 0.000 | 0.1826 | No |
| 57 | C8A | complement C8 alpha chain [Source:HGNC Symbol;Acc:HGNC:1352] | 15668 | 0.000 | 0.1826 | No |
| 58 | C8G | complement C8 gamma chain [Source:HGNC Symbol;Acc:HGNC:1354] | 15670 | 0.000 | 0.1825 | No |
| 59 | HTRA1 | HtrA serine peptidase 1 [Source:HGNC Symbol;Acc:HGNC:9476] | 15694 | 0.000 | 0.1819 | No |
| 60 | CFD | complement factor D [Source:HGNC Symbol;Acc:HGNC:2771] | 15771 | 0.000 | 0.1799 | No |
| 61 | CFI | complement factor I [Source:HGNC Symbol;Acc:HGNC:5394] | 15772 | 0.000 | 0.1799 | No |
| 62 | DCT | dopachrome tautomerase [Source:HGNC Symbol;Acc:HGNC:2709] | 16031 | 0.000 | 0.1729 | No |
| 63 | C2 | complement C2 [Source:HGNC Symbol;Acc:HGNC:1248] | 16107 | 0.000 | 0.1709 | No |
| 64 | C9 | complement C9 [Source:HGNC Symbol;Acc:HGNC:1358] | 16112 | 0.000 | 0.1707 | No |
| 65 | F2 | coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535] | 16156 | 0.000 | 0.1696 | No |
| 66 | F12 | coagulation factor XII [Source:HGNC Symbol;Acc:HGNC:3530] | 16463 | 0.000 | 0.1613 | No |
| 67 | F11 | coagulation factor XI [Source:HGNC Symbol;Acc:HGNC:3529] | 16464 | 0.000 | 0.1613 | No |
| 68 | FGA | fibrinogen alpha chain [Source:HGNC Symbol;Acc:HGNC:3661] | 16700 | 0.000 | 0.1549 | No |
| 69 | FGG | fibrinogen gamma chain [Source:HGNC Symbol;Acc:HGNC:3694] | 16701 | 0.000 | 0.1549 | No |
| 70 | OLR1 | oxidized low density lipoprotein receptor 1 [Source:HGNC Symbol;Acc:HGNC:8133] | 16756 | 0.000 | 0.1535 | No |
| 71 | GP9 | glycoprotein IX platelet [Source:HGNC Symbol;Acc:HGNC:4444] | 17150 | 0.000 | 0.1428 | No |
| 72 | TIMP3 | TIMP metallopeptidase inhibitor 3 [Source:HGNC Symbol;Acc:HGNC:11822] | 17158 | 0.000 | 0.1427 | No |
| 73 | HRG | histidine rich glycoprotein [Source:HGNC Symbol;Acc:HGNC:5181] | 17509 | 0.000 | 0.1332 | No |
| 74 | HNF4A | hepatocyte nuclear factor 4 alpha [Source:HGNC Symbol;Acc:HGNC:5024] | 17690 | 0.000 | 0.1283 | No |
| 75 | SERPING1 | serpin family G member 1 [Source:HGNC Symbol;Acc:HGNC:1228] | 17812 | 0.000 | 0.1250 | No |
| 76 | SERPINA1 | serpin family A member 1 [Source:HGNC Symbol;Acc:HGNC:8941] | 17824 | 0.000 | 0.1247 | No |
| 77 | DPP4 | dipeptidyl peptidase 4 [Source:HGNC Symbol;Acc:HGNC:3009] | 17984 | 0.000 | 0.1204 | No |
| 78 | BMP1 | bone morphogenetic protein 1 [Source:HGNC Symbol;Acc:HGNC:1067] | 19149 | 0.000 | 0.0889 | No |
| 79 | MMP7 | matrix metallopeptidase 7 [Source:HGNC Symbol;Acc:HGNC:7174] | 19172 | 0.000 | 0.0883 | No |
| 80 | MMP1 | matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] | 19175 | 0.000 | 0.0883 | No |
| 81 | MMP3 | matrix metallopeptidase 3 [Source:HGNC Symbol;Acc:HGNC:7173] | 19179 | 0.000 | 0.0882 | No |
| 82 | MMP8 | matrix metallopeptidase 8 [Source:HGNC Symbol;Acc:HGNC:7175] | 19185 | 0.000 | 0.0881 | No |
| 83 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 20084 | 0.000 | 0.0638 | No |
| 84 | ACOX2 | acyl-CoA oxidase 2 [Source:HGNC Symbol;Acc:HGNC:120] | 20136 | 0.000 | 0.0624 | No |
| 85 | MEP1A | meprin A subunit alpha [Source:HGNC Symbol;Acc:HGNC:7015] | 20324 | 0.000 | 0.0573 | No |
| 86 | GP1BA | glycoprotein Ib platelet subunit alpha [Source:HGNC Symbol;Acc:HGNC:4439] | 20388 | 0.000 | 0.0556 | No |
| 87 | CPB2 | carboxypeptidase B2 [Source:HGNC Symbol;Acc:HGNC:2300] | 20586 | 0.000 | 0.0503 | No |
| 88 | TFPI2 | tissue factor pathway inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11761] | 22147 | 0.000 | 0.0081 | No |
| 89 | PRSS23 | serine protease 23 [Source:HGNC Symbol;Acc:HGNC:14370] | 22429 | 0.000 | 0.0005 | No |
| 90 | ITGA2 | integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] | 23791 | 0.000 | -0.0364 | No |
| 91 | ITIH1 | inter-alpha-trypsin inhibitor heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:6166] | 24312 | 0.000 | -0.0504 | No |
| 92 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 24378 | 0.000 | -0.0522 | No |
| 93 | HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Source:HGNC Symbol;Acc:HGNC:5008] | 24763 | 0.000 | -0.0626 | No |
| 94 | PLG | plasminogen [Source:HGNC Symbol;Acc:HGNC:9071] | 24797 | 0.000 | -0.0635 | No |
| 95 | C1QA | complement C1q A chain [Source:HGNC Symbol;Acc:HGNC:1241] | 24854 | 0.000 | -0.0650 | No |
| 96 | LEFTY2 | left-right determination factor 2 [Source:HGNC Symbol;Acc:HGNC:3122] | 24975 | 0.000 | -0.0682 | No |
| 97 | RGN | regucalcin [Source:HGNC Symbol;Acc:HGNC:9989] | 25277 | 0.000 | -0.0764 | No |
| 98 | KLK8 | kallikrein related peptidase 8 [Source:HGNC Symbol;Acc:HGNC:6369] | 25425 | 0.000 | -0.0804 | No |
| 99 | MMP10 | matrix metallopeptidase 10 [Source:HGNC Symbol;Acc:HGNC:7156] | 25658 | 0.000 | -0.0866 | No |
| 100 | MMP11 | matrix metallopeptidase 11 [Source:HGNC Symbol;Acc:HGNC:7157] | 25662 | 0.000 | -0.0867 | No |
| 101 | MMP15 | matrix metallopeptidase 15 [Source:HGNC Symbol;Acc:HGNC:7161] | 25667 | 0.000 | -0.0868 | No |
| 102 | F2RL2 | coagulation factor II thrombin receptor like 2 [Source:HGNC Symbol;Acc:HGNC:3539] | 26114 | 0.000 | -0.0989 | No |
| 103 | SPARC | secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219] | 28205 | 0.000 | -0.1554 | No |
| 104 | GDA | guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212] | 28395 | -0.010 | -0.1605 | No |
| 105 | PEF1 | penta-EF-hand domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30009] | 29038 | -0.186 | -0.1764 | No |
| 106 | MASP2 | mannan binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 29301 | -0.242 | -0.1816 | No |
| 107 | S100A13 | S100 calcium binding protein A13 [Source:HGNC Symbol;Acc:HGNC:10490] | 29403 | -0.271 | -0.1823 | No |
| 108 | COMP | cartilage oligomeric matrix protein [Source:HGNC Symbol;Acc:HGNC:2227] | 29663 | -0.320 | -0.1868 | No |
| 109 | LAMP2 | lysosomal associated membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:6501] | 30116 | -0.350 | -0.1964 | No |
| 110 | KLF7 | Kruppel like factor 7 [Source:HGNC Symbol;Acc:HGNC:6350] | 30360 | -0.408 | -0.1998 | No |
| 111 | SH2B2 | SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:17381] | 30386 | -0.415 | -0.1973 | No |
| 112 | HPN | hepsin [Source:HGNC Symbol;Acc:HGNC:5155] | 30488 | -0.443 | -0.1966 | No |
| 113 | CASP9 | caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511] | 30909 | -0.560 | -0.2036 | No |
| 114 | ISCU | iron-sulfur cluster assembly enzyme [Source:HGNC Symbol;Acc:HGNC:29882] | 31166 | -0.632 | -0.2057 | No |
| 115 | CTSB | cathepsin B [Source:HGNC Symbol;Acc:HGNC:2527] | 31379 | -0.697 | -0.2060 | No |
| 116 | CTSO | cathepsin O [Source:HGNC Symbol;Acc:HGNC:2542] | 32330 | -0.979 | -0.2242 | No |
| 117 | USP11 | ubiquitin specific peptidase 11 [Source:HGNC Symbol;Acc:HGNC:12609] | 32452 | -1.018 | -0.2196 | No |
| 118 | DUSP14 | dual specificity phosphatase 14 [Source:HGNC Symbol;Acc:HGNC:17007] | 32525 | -1.025 | -0.2137 | No |
| 119 | CAPN2 | calpain 2 [Source:HGNC Symbol;Acc:HGNC:1479] | 32773 | -1.120 | -0.2117 | No |
| 120 | SIRT2 | sirtuin 2 [Source:HGNC Symbol;Acc:HGNC:10886] | 32800 | -1.132 | -0.2037 | No |
| 121 | LTA4H | leukotriene A4 hydrolase [Source:HGNC Symbol;Acc:HGNC:6710] | 33105 | -1.246 | -0.2023 | No |
| 122 | C1R | complement C1r [Source:HGNC Symbol;Acc:HGNC:1246] | 33685 | -1.466 | -0.2067 | No |
| 123 | CTSE | cathepsin E [Source:HGNC Symbol;Acc:HGNC:2530] | 33965 | -1.599 | -0.2019 | No |
| 124 | C1S | complement C1s [Source:HGNC Symbol;Acc:HGNC:1247] | 33995 | -1.617 | -0.1902 | No |
| 125 | LRP1 | LDL receptor related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692] | 34126 | -1.684 | -0.1807 | No |
| 126 | DUSP6 | dual specificity phosphatase 6 [Source:HGNC Symbol;Acc:HGNC:3072] | 34160 | -1.700 | -0.1685 | No |
| 127 | CSRP1 | cysteine and glycine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:2469] | 34224 | -1.727 | -0.1569 | No |
| 128 | S100A1 | S100 calcium binding protein A1 [Source:HGNC Symbol;Acc:HGNC:10486] | 34576 | -1.939 | -0.1515 | No |
| 129 | LGMN | legumain [Source:HGNC Symbol;Acc:HGNC:9472] | 34985 | -2.094 | -0.1463 | No |
| 130 | TF | transferrin [Source:HGNC Symbol;Acc:HGNC:11740] | 35203 | -2.247 | -0.1349 | No |
| 131 | CAPN5 | calpain 5 [Source:HGNC Symbol;Acc:HGNC:1482] | 35714 | -2.621 | -0.1285 | No |
| 132 | GSN | gelsolin [Source:HGNC Symbol;Acc:HGNC:4620] | 35912 | -2.745 | -0.1126 | No |
| 133 | PLAU | plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052] | 36069 | -2.957 | -0.0941 | No |
| 134 | VWF | von Willebrand factor [Source:HGNC Symbol;Acc:HGNC:12726] | 36273 | -3.197 | -0.0749 | No |
| 135 | ANG | angiogenin [Source:HGNC Symbol;Acc:HGNC:483] | 36735 | -3.884 | -0.0574 | No |
| 136 | CPQ | carboxypeptidase Q [Source:HGNC Symbol;Acc:HGNC:16910] | 36893 | -4.207 | -0.0292 | No |
| 137 | CFH | complement factor H [Source:HGNC Symbol;Acc:HGNC:4883] | 36978 | -4.478 | 0.0030 | No |
