Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | greenberg_collapsed_to_symbols.Nof1.cls #WT_GAQ_versus_WT_NA.Nof1.cls #WT_GAQ_versus_WT_NA_repos |
| Phenotype | Nof1.cls#WT_GAQ_versus_WT_NA_repos |
| Upregulated in class | WT_GAQ |
| GeneSet | HALLMARK_IL6_JAK_STAT3_SIGNALING |
| Enrichment Score (ES) | 0.723518 |
| Normalized Enrichment Score (NES) | 1.7670516 |
| Nominal p-value | 0.0 |
| FDR q-value | 7.0E-4 |
| FWER p-Value | 0.001 |
| SYMBOL | TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|
| 1 | IL1B | interleukin 1 beta [Source:HGNC Symbol;Acc:HGNC:5992] | 18 | 4.941 | 0.0511 | Yes |
| 2 | TNFRSF1B | TNF receptor superfamily member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 30 | 4.888 | 0.1019 | Yes |
| 3 | SOCS3 | suppressor of cytokine signaling 3 [Source:HGNC Symbol;Acc:HGNC:19391] | 68 | 4.638 | 0.1494 | Yes |
| 4 | TNF | tumor necrosis factor [Source:HGNC Symbol;Acc:HGNC:11892] | 144 | 4.221 | 0.1915 | Yes |
| 5 | STAT1 | signal transducer and activator of transcription 1 [Source:HGNC Symbol;Acc:HGNC:11362] | 310 | 3.434 | 0.2229 | Yes |
| 6 | CD36 | CD36 molecule [Source:HGNC Symbol;Acc:HGNC:1663] | 403 | 3.211 | 0.2540 | Yes |
| 7 | PIK3R5 | phosphoinositide-3-kinase regulatory subunit 5 [Source:HGNC Symbol;Acc:HGNC:30035] | 428 | 3.154 | 0.2863 | Yes |
| 8 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] | 499 | 3.020 | 0.3159 | Yes |
| 9 | CD44 | CD44 molecule (Indian blood group) [Source:HGNC Symbol;Acc:HGNC:1681] | 550 | 2.906 | 0.3450 | Yes |
| 10 | STAT2 | signal transducer and activator of transcription 2 [Source:HGNC Symbol;Acc:HGNC:11363] | 676 | 2.697 | 0.3698 | Yes |
| 11 | MYD88 | MYD88 innate immune signal transduction adaptor [Source:HGNC Symbol;Acc:HGNC:7562] | 696 | 2.644 | 0.3969 | Yes |
| 12 | CXCL10 | C-X-C motif chemokine ligand 10 [Source:HGNC Symbol;Acc:HGNC:10637] | 702 | 2.635 | 0.4243 | Yes |
| 13 | CSF1 | colony stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:2432] | 713 | 2.611 | 0.4513 | Yes |
| 14 | TNFRSF1A | TNF receptor superfamily member 1A [Source:HGNC Symbol;Acc:HGNC:11916] | 756 | 2.543 | 0.4767 | Yes |
| 15 | TGFB1 | transforming growth factor beta 1 [Source:HGNC Symbol;Acc:HGNC:11766] | 784 | 2.496 | 0.5021 | Yes |
| 16 | CD14 | CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] | 853 | 2.362 | 0.5249 | Yes |
| 17 | STAT3 | signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364] | 1019 | 2.176 | 0.5432 | Yes |
| 18 | TNFRSF12A | TNF receptor superfamily member 12A [Source:HGNC Symbol;Acc:HGNC:18152] | 1235 | 1.913 | 0.5574 | Yes |
| 19 | IRF9 | interferon regulatory factor 9 [Source:HGNC Symbol;Acc:HGNC:6131] | 1363 | 1.809 | 0.5729 | Yes |
| 20 | TLR2 | toll like receptor 2 [Source:HGNC Symbol;Acc:HGNC:11848] | 1372 | 1.801 | 0.5915 | Yes |
| 21 | SOCS1 | suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] | 1391 | 1.786 | 0.6096 | Yes |
| 22 | FAS | Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920] | 1478 | 1.700 | 0.6251 | Yes |
| 23 | CD9 | CD9 molecule [Source:HGNC Symbol;Acc:HGNC:1709] | 1491 | 1.692 | 0.6424 | Yes |
| 24 | HAX1 | HCLS1 associated protein X-1 [Source:HGNC Symbol;Acc:HGNC:16915] | 1575 | 1.633 | 0.6573 | Yes |
| 25 | PTPN11 | protein tyrosine phosphatase non-receptor type 11 [Source:HGNC Symbol;Acc:HGNC:9644] | 1689 | 1.542 | 0.6703 | Yes |
| 26 | HMOX1 | heme oxygenase 1 [Source:HGNC Symbol;Acc:HGNC:5013] | 1763 | 1.497 | 0.6840 | Yes |
| 27 | MAP3K8 | mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] | 1772 | 1.490 | 0.6994 | Yes |
| 28 | LTBR | lymphotoxin beta receptor [Source:HGNC Symbol;Acc:HGNC:6718] | 2236 | 1.321 | 0.7006 | Yes |
| 29 | PTPN1 | protein tyrosine phosphatase non-receptor type 1 [Source:HGNC Symbol;Acc:HGNC:9642] | 2694 | 1.068 | 0.6995 | Yes |
| 30 | IL2RG | interleukin 2 receptor subunit gamma [Source:HGNC Symbol;Acc:HGNC:6010] | 2812 | 1.018 | 0.7069 | Yes |
| 31 | IL6 | interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] | 2910 | 0.974 | 0.7145 | Yes |
| 32 | GRB2 | growth factor receptor bound protein 2 [Source:HGNC Symbol;Acc:HGNC:4566] | 2946 | 0.955 | 0.7235 | Yes |
| 33 | BAK1 | BCL2 antagonist/killer 1 [Source:HGNC Symbol;Acc:HGNC:949] | 3512 | 0.762 | 0.7162 | No |
| 34 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit [Source:HGNC Symbol;Acc:HGNC:6204] | 3883 | 0.647 | 0.7130 | No |
| 35 | ITGB3 | integrin subunit beta 3 [Source:HGNC Symbol;Acc:HGNC:6156] | 3954 | 0.623 | 0.7176 | No |
| 36 | STAM2 | signal transducing adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:11358] | 4552 | 0.455 | 0.7062 | No |
| 37 | LEPR | leptin receptor [Source:HGNC Symbol;Acc:HGNC:6554] | 5036 | 0.330 | 0.6966 | No |
| 38 | CCR1 | C-C motif chemokine receptor 1 [Source:HGNC Symbol;Acc:HGNC:1602] | 5340 | 0.254 | 0.6911 | No |
| 39 | PTPN2 | protein tyrosine phosphatase non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] | 5367 | 0.246 | 0.6929 | No |
| 40 | IL17RA | interleukin 17 receptor A [Source:HGNC Symbol;Acc:HGNC:5985] | 5628 | 0.182 | 0.6878 | No |
| 41 | ACVR1B | activin A receptor type 1B [Source:HGNC Symbol;Acc:HGNC:172] | 5740 | 0.155 | 0.6864 | No |
| 42 | IL13RA1 | interleukin 13 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:5974] | 6036 | 0.090 | 0.6794 | No |
| 43 | CNTFR | ciliary neurotrophic factor receptor [Source:HGNC Symbol;Acc:HGNC:2170] | 8897 | 0.000 | 0.6021 | No |
| 44 | TNFRSF21 | TNF receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] | 9379 | 0.000 | 0.5891 | No |
| 45 | CRLF2 | cytokine receptor like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] | 10990 | 0.000 | 0.5456 | No |
| 46 | PLA2G2A | phospholipase A2 group IIA [Source:HGNC Symbol;Acc:HGNC:9031] | 11752 | 0.000 | 0.5250 | No |
| 47 | CSF2RA | colony stimulating factor 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:2435] | 12057 | 0.000 | 0.5168 | No |
| 48 | PDGFC | platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] | 13602 | 0.000 | 0.4751 | No |
| 49 | IL4R | interleukin 4 receptor [Source:HGNC Symbol;Acc:HGNC:6015] | 13929 | 0.000 | 0.4663 | No |
| 50 | IL9R | interleukin 9 receptor [Source:HGNC Symbol;Acc:HGNC:6030] | 13998 | 0.000 | 0.4645 | No |
| 51 | IL15RA | interleukin 15 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:5978] | 14249 | 0.000 | 0.4577 | No |
| 52 | EBI3 | Epstein-Barr virus induced 3 [Source:HGNC Symbol;Acc:HGNC:3129] | 15126 | 0.000 | 0.4340 | No |
| 53 | IL17RB | interleukin 17 receptor B [Source:HGNC Symbol;Acc:HGNC:18015] | 15180 | 0.000 | 0.4326 | No |
| 54 | IL2RA | interleukin 2 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6008] | 15615 | 0.000 | 0.4209 | No |
| 55 | IL1R1 | interleukin 1 receptor type 1 [Source:HGNC Symbol;Acc:HGNC:5993] | 15895 | 0.000 | 0.4133 | No |
| 56 | IL1R2 | interleukin 1 receptor type 2 [Source:HGNC Symbol;Acc:HGNC:5994] | 15896 | 0.000 | 0.4133 | No |
| 57 | IL3RA | interleukin 3 receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:6012] | 16535 | 0.000 | 0.3961 | No |
| 58 | IL7 | interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] | 17758 | 0.000 | 0.3631 | No |
| 59 | IFNAR1 | interferon alpha and beta receptor subunit 1 [Source:HGNC Symbol;Acc:HGNC:5432] | 18527 | 0.000 | 0.3423 | No |
| 60 | CXCL13 | C-X-C motif chemokine ligand 13 [Source:HGNC Symbol;Acc:HGNC:10639] | 18946 | 0.000 | 0.3310 | No |
| 61 | CXCL11 | C-X-C motif chemokine ligand 11 [Source:HGNC Symbol;Acc:HGNC:10638] | 18985 | 0.000 | 0.3300 | No |
| 62 | OSMR | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] | 19072 | 0.000 | 0.3277 | No |
| 63 | CXCL9 | C-X-C motif chemokine ligand 9 [Source:HGNC Symbol;Acc:HGNC:7098] | 19526 | 0.000 | 0.3154 | No |
| 64 | CXCL1 | C-X-C motif chemokine ligand 1 [Source:HGNC Symbol;Acc:HGNC:4602] | 19537 | 0.000 | 0.3151 | No |
| 65 | CXCL3 | C-X-C motif chemokine ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] | 19539 | 0.000 | 0.3151 | No |
| 66 | IL12RB1 | interleukin 12 receptor subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:5971] | 19702 | 0.000 | 0.3107 | No |
| 67 | PF4 | platelet factor 4 [Source:HGNC Symbol;Acc:HGNC:8861] | 20084 | 0.000 | 0.3004 | No |
| 68 | CSF2 | colony stimulating factor 2 [Source:HGNC Symbol;Acc:HGNC:2434] | 21666 | 0.000 | 0.2577 | No |
| 69 | REG1A | regenerating family member 1 alpha [Source:HGNC Symbol;Acc:HGNC:9951] | 23743 | 0.000 | 0.2016 | No |
| 70 | A2M | alpha-2-macroglobulin [Source:HGNC Symbol;Acc:HGNC:7] | 24378 | 0.000 | 0.1845 | No |
| 71 | INHBE | inhibin subunit beta E [Source:HGNC Symbol;Acc:HGNC:24029] | 25105 | 0.000 | 0.1649 | No |
| 72 | IFNGR1 | interferon gamma receptor 1 [Source:HGNC Symbol;Acc:HGNC:5439] | 25257 | 0.000 | 0.1608 | No |
| 73 | IFNGR2 | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] | 25259 | 0.000 | 0.1608 | No |
| 74 | IL18R1 | interleukin 18 receptor 1 [Source:HGNC Symbol;Acc:HGNC:5988] | 25746 | 0.000 | 0.1476 | No |
| 75 | CCL7 | C-C motif chemokine ligand 7 [Source:HGNC Symbol;Acc:HGNC:10634] | 27952 | 0.000 | 0.0880 | No |
| 76 | CD38 | CD38 molecule [Source:HGNC Symbol;Acc:HGNC:1667] | 28049 | 0.000 | 0.0854 | No |
| 77 | CBL | Cbl proto-oncogene [Source:HGNC Symbol;Acc:HGNC:1541] | 28819 | -0.128 | 0.0660 | No |
| 78 | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 29479 | -0.293 | 0.0513 | No |
| 79 | LTB | lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] | 30273 | -0.386 | 0.0339 | No |
| 80 | DNTT | DNA nucleotidylexotransferase [Source:HGNC Symbol;Acc:HGNC:2983] | 30344 | -0.403 | 0.0362 | No |
| 81 | IRF1 | interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] | 31994 | -0.872 | 0.0007 | No |
| 82 | ACVRL1 | activin A receptor like type 1 [Source:HGNC Symbol;Acc:HGNC:175] | 32005 | -0.875 | 0.0096 | No |
| 83 | CSF2RB | colony stimulating factor 2 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:2436] | 34685 | -1.945 | -0.0425 | No |
| 84 | IL10RB | interleukin 10 receptor subunit beta [Source:HGNC Symbol;Acc:HGNC:5965] | 34844 | -2.007 | -0.0258 | No |
| 85 | IL6ST | interleukin 6 signal transducer [Source:HGNC Symbol;Acc:HGNC:6021] | 35031 | -2.122 | -0.0086 | No |
| 86 | CSF3R | colony stimulating factor 3 receptor [Source:HGNC Symbol;Acc:HGNC:2439] | 35309 | -2.312 | 0.0081 | No |
| 87 | ITGA4 | integrin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6140] | 36705 | -3.833 | 0.0104 | No |
